Membrane lipid remodeling eradicates Helicobacter pylori by manipulating the cholesteryl 6'-acylglucoside biosynthesis
Helicobacter pylori, the main cause of various gastric diseases, infects approximately half of the human population. This pathogen is auxotrophic for cholesterol which it converts to various cholesteryl α-glucosi... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - April 29, 2024 Category: Biomedical Science Authors: Lih-Lih Ong, Hau-Ming Jan, Hong-Hanh Thi Le, Tsai-Chen Yang, Chou-Yu Kuo, Ai-Feng Feng, Kwok-Kong Tony Mong and Chun-Hung Lin Tags: Research Source Type: research
Effect of Apheresis Plasma Donation on Plasma Uric Acid Levels, the Lipid Profile, and Major Plasma Proteins in Plasma Donors in China: A Multicenter, Prospective Cohort Study
Abnormal plasma uric acid (UA) levels, the lipid profile, and plasma proteins in blood are associated with a range of adverse health outcomes. This multicenter, prospective cohort study aimed to determine the possible effects of multiple apheresis plasma donations on plasma UA levels, the lipid profile, and major proteins in plasma donors. Participants were enrolled from 1 April 2021 to 31 August 2022. When their plasma UA (men:>420 µmol/L, women:>360 µmol/L) and/or lipid levels (total cholesterol [TC]: ≥6.2mmol/L, triglycerides [TGs]: ≥2.3mmol/L, low-density lipoprotein cholesterol: ≥4.1mmol/L, or high-density lip...
Source: Transfusion and Apheresis Science - April 29, 2024 Category: Hematology Authors: Qing Liu, Fengjuan Liu, Pan Sun, Xi Du, Liyuan Zhu, Jun Xu, Lu Cheng, Yaojing Huang, Chunyan Huang, Jielin Chen, Zhibo Wang, Aihong Lu, Yikuan Zhu, Huan Huang, Junli Huang, Jufeng Pan, Li Ma, Zongkui Wang, Changqing Li Source Type: research
Relationship between changes in blood glucose, glycosylated hemoglobin [HbA1c], cholesterol, and triglyceride and changes in hepatic enzymes
Cell Mol Biol (Noisy-le-grand). 2024 Apr 28;70(4):23-28. doi: 10.14715/cmb/2024.70.4.4.ABSTRACTThe main risk factors for non-alcoholic fatty liver disease (NAFLD) are strongly associated with obesity, diabetes, hyperlipidemia, and metabolic syndrome. The best clinical evaluation of the liver is done through studying changes in liver enzymes' activity, especially alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase. Therefore, this study aimed to investigate the relationship between changes in factors such as blood glucose, cholesterol, glycosylated hemoglobin, and triglyceride and changes in hepat...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Mahboobeh Talebi Mehrdar Wei Lu Adel Rahanjam Source Type: research
A comparative study of multiple biomarkers levels in complicated versus noncomplicated type 2 diabetic patients
In conclusion, there were significant differences in biomarker concentrations between all three groups. This indicates that the monitoring of multiple biomarkers may be of value in the controlling of T2DM in the future.PMID:38678628 | DOI:10.14715/cmb/2024.70.4.8 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Hemin Mohamad Hussein Ahmed Alkhuzai Christer Janson Kawa Amin Source Type: research
Sesamin ameliorates nonalcoholic hepatic steatosis by inhibiting CD36-mediated hepatocyte lipid accumulation in vitro and in vivo
In this study, we observed the anti-hepatic steatosis effects of Ses in palmitate/oleate (PA/OA)-incubated primary mouse hepatocytes, AML12 hepatocytes, and HepG2 cells, as well as in high-fat, high-cholesterol diet-induced NASH mice. RNA sequencing analysis revealed that cluster of differentiation 36 (CD36), a free fatty acid (FA) transport protein, was involved in the Ses-mediated inhibition of hepatic fat accumulation. Moreover, the overexpression of CD36 significantly increased hepatic steatosis in both Ses-treated PA/OA-incubated HepG2 cells and NASH mice. Furthermore, Ses treatment suppressed insulin-induced de novo ...
Source: Biochemical Pharmacology - April 28, 2024 Category: Drugs & Pharmacology Authors: Ya-Ping Bai Teng Zhang Zheng-Yan Hu Yan Zhang De-Guo Wang Meng-Yun Zhou Ying Zhang Fang Zhang Xiang Kong Source Type: research
Relationship between changes in blood glucose, glycosylated hemoglobin [HbA1c], cholesterol, and triglyceride and changes in hepatic enzymes
Cell Mol Biol (Noisy-le-grand). 2024 Apr 28;70(4):23-28. doi: 10.14715/cmb/2024.70.4.4.ABSTRACTThe main risk factors for non-alcoholic fatty liver disease (NAFLD) are strongly associated with obesity, diabetes, hyperlipidemia, and metabolic syndrome. The best clinical evaluation of the liver is done through studying changes in liver enzymes' activity, especially alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase. Therefore, this study aimed to investigate the relationship between changes in factors such as blood glucose, cholesterol, glycosylated hemoglobin, and triglyceride and changes in hepat...
Source: Mol Biol Cell - April 28, 2024 Category: Molecular Biology Authors: Mahboobeh Talebi Mehrdar Wei Lu Adel Rahanjam Source Type: research
A comparative study of multiple biomarkers levels in complicated versus noncomplicated type 2 diabetic patients
In conclusion, there were significant differences in biomarker concentrations between all three groups. This indicates that the monitoring of multiple biomarkers may be of value in the controlling of T2DM in the future.PMID:38678628 | DOI:10.14715/cmb/2024.70.4.8 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 28, 2024 Category: Molecular Biology Authors: Hemin Mohamad Hussein Ahmed Alkhuzai Christer Janson Kawa Amin Source Type: research
A comparative study of multiple biomarkers levels in complicated versus noncomplicated type 2 diabetic patients
In conclusion, there were significant differences in biomarker concentrations between all three groups. This indicates that the monitoring of multiple biomarkers may be of value in the controlling of T2DM in the future.PMID:38678628 | DOI:10.14715/cmb/2024.70.4.8 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Hemin Mohamad Hussein Ahmed Alkhuzai Christer Janson Kawa Amin Source Type: research
Relationship between changes in blood glucose, glycosylated hemoglobin [HbA1c], cholesterol, and triglyceride and changes in hepatic enzymes
Cell Mol Biol (Noisy-le-grand). 2024 Apr 28;70(4):23-28. doi: 10.14715/cmb/2024.70.4.4.ABSTRACTThe main risk factors for non-alcoholic fatty liver disease (NAFLD) are strongly associated with obesity, diabetes, hyperlipidemia, and metabolic syndrome. The best clinical evaluation of the liver is done through studying changes in liver enzymes' activity, especially alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase. Therefore, this study aimed to investigate the relationship between changes in factors such as blood glucose, cholesterol, glycosylated hemoglobin, and triglyceride and changes in hepat...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Mahboobeh Talebi Mehrdar Wei Lu Adel Rahanjam Source Type: research
Awareness of having hypertension, diabetes and dyslipidaemia among US adults: The 2011-2018 NHANES data
CONCLUSIONS: Large proportions of US adults with hypertension, dyslipidaemia and diabetes are not aware of having the conditions. Interventions targeting groups at higher risk of being unaware of these conditions are needed.PMID:38679806 | DOI:10.1177/14034948241247612 (Source: Scandinavian Journal of Public Health)
Source: Scandinavian Journal of Public Health - April 28, 2024 Category: International Medicine & Public Health Authors: Kien G To Corneel Vandelanotte Anh N V Huynh Stephanie Schoeppe Stephanie Alley Aamir Raoof Memon Nhung T Q Nguyen Quyen G To Source Type: research
Sesamin ameliorates nonalcoholic hepatic steatosis by inhibiting CD36-mediated hepatocyte lipid accumulation in vitro and in vivo
In this study, we observed the anti-hepatic steatosis effects of Ses in palmitate/oleate (PA/OA)-incubated primary mouse hepatocytes, AML12 hepatocytes, and HepG2 cells, as well as in high-fat, high-cholesterol diet-induced NASH mice. RNA sequencing analysis revealed that cluster of differentiation 36 (CD36), a free fatty acid (FA) transport protein, was involved in the Ses-mediated inhibition of hepatic fat accumulation. Moreover, the overexpression of CD36 significantly increased hepatic steatosis in both Ses-treated PA/OA-incubated HepG2 cells and NASH mice. Furthermore, Ses treatment suppressed insulin-induced de novo ...
Source: Biochemical Pharmacology - April 28, 2024 Category: Drugs & Pharmacology Authors: Ya-Ping Bai Teng Zhang Zheng-Yan Hu Yan Zhang De-Guo Wang Meng-Yun Zhou Ying Zhang Fang Zhang Xiang Kong Source Type: research
Remnant cholesterol, LDL cholesterol, and apoB absolute mass changes explain results of the PROMINENT trial
CONCLUSIONS: Absolute mass changes in remnant cholesterol, LDL cholesterol, and apolipoprotein B can explain results of the PROMINENT trial. The 3 mg/dL (0.08 mmol/L) higher total atherogenic cholesterol together with 5 mg/dL (0.05 g/L) higher apolipoprotein B seem to explain the trend toward more ASCVD in the pemafibrate arm.PMID:38678642 | DOI:10.1016/j.atherosclerosis.2024.117556 (Source: Atherosclerosis)
Source: Atherosclerosis - April 28, 2024 Category: Cardiology Authors: Takahito Doi Anne Langsted B ørge G Nordestgaard Source Type: research
Transcriptomic analysis reveals the critical role of Chemokine signaling in the anti-atherosclerosis effect of Xuefu Zhuyu Decoction
CONCLUSION: Xuefu Zhuyu decoction demonstrates effective regulation of plaque components, retarding plaque progression and preserving plaque stability by modulating lipid metabolism and inflammatory responses. Subsequent transcriptome analysis identified the cytokine-cytokine receptor interaction and chemokine signaling pathway as potential key pathways for the therapeutic effects of Xuefu Zhuyu decoction. This insight not only provides crucial avenues for further exploration into the mechanisms underlying Xuefu Zhuyu decoction but also offers valuable perspectives and hypotheses for enhancing disease prevention and treatm...
Source: Atherosclerosis - April 28, 2024 Category: Cardiology Authors: Dongdong Jia Mengzhu Zhao Xinyue Zhang Xu Cheng Qiong Wei Lixia Lou Yizhou Zhao Qiushuo Jin Meng Chen Dongmei Zhang Source Type: research
A comparative study of multiple biomarkers levels in complicated versus noncomplicated type 2 diabetic patients
In conclusion, there were significant differences in biomarker concentrations between all three groups. This indicates that the monitoring of multiple biomarkers may be of value in the controlling of T2DM in the future.PMID:38678628 | DOI:10.14715/cmb/2024.70.4.8 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 28, 2024 Category: Molecular Biology Authors: Hemin Mohamad Hussein Ahmed Alkhuzai Christer Janson Kawa Amin Source Type: research
Relationship between changes in blood glucose, glycosylated hemoglobin [HbA1c], cholesterol, and triglyceride and changes in hepatic enzymes
Cell Mol Biol (Noisy-le-grand). 2024 Apr 28;70(4):23-28. doi: 10.14715/cmb/2024.70.4.4.ABSTRACTThe main risk factors for non-alcoholic fatty liver disease (NAFLD) are strongly associated with obesity, diabetes, hyperlipidemia, and metabolic syndrome. The best clinical evaluation of the liver is done through studying changes in liver enzymes' activity, especially alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase. Therefore, this study aimed to investigate the relationship between changes in factors such as blood glucose, cholesterol, glycosylated hemoglobin, and triglyceride and changes in hepat...
Source: Mol Biol Cell - April 28, 2024 Category: Molecular Biology Authors: Mahboobeh Talebi Mehrdar Wei Lu Adel Rahanjam Source Type: research
