Resolution of high output pulmonary edema due to hyperviscosity with plasma exchange in a patient with multiple myeloma- A case report
We describe a case of a 61  year old lady who developed pulmonary infiltrates after being diagnosed with multiple myeloma. Treated as an infection with antibiotics and intravenous immunoglobulin, she had neurological symptoms which suggested the possibility of hyperviscosity syndrome. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - August 3, 2020 Category: Hematology Authors: Charanpreet Singh, Deepesh Lad, Arihant Jain, Gaurav Prakash, Alka Khadwal, Pankaj Malhotra Source Type: research

Apoptosis as an underlying mechanism in lymphocytes induced by riboflavin and ultraviolet light
Riboflavin plus UV light pathogen reduction technology (RF-PRT) is an effective method for inactivating donor-derived leukocytes (DDLs) in blood components. Literature data have shown that reactive oxygen species (ROS) increased in lymphocytes after RF-PRT treatment. Sustained high levels of ROS may abolish the endogenous antioxidant system, leading to damage to proteins, lipids, and nucleic acids, resulting in cell apoptosis. Nevertheless, whether riboflavin plus UV light can trigger leukocyte apoptosis remains obscure. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - August 3, 2020 Category: Hematology Authors: Hailiang Hu, Fei Xu, Wenle Yang, Jun Ren, Weihao Ge, Peng Yang Source Type: research

Hepatitis-associated aplastic anemia in pediatric patients: single center experience
This study investigated cases with hepatitis-associated aplastic anemia. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - August 3, 2020 Category: Hematology Authors: Derya Altay, Ebru Y ılmaz, Alper Özcan, Musa Karakükçü, Ekrem Ünal, Duran Arslan Source Type: research

Intravenous Immunoglobulin and Favipiravir treatment for A Kidney Transplant Patient with Severe Covid-19 Pneumonia
The kidney transplant patients are at serious risk in this outbreak due to their immunocompromised status. However, there is insufficient knowledge and experience in the management of COVID-19 in this patient group. Intravenous immunoglobulin (IVIg) is frequently used in kidney transplant practice both in the treatment of rejection and Polioma (BK) nephropathy. Considering its effectiveness particularly in Ebola virus disease patients with medium to high viremia, Favipiravir [1]; an RNA polymerase inhibitor against RNA viruses, received approval for clinical trials against COVID-19 [1,2]. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - August 3, 2020 Category: Hematology Authors: Erhan Tatar, Murat Karatas, Ilter Bozaci, Alpay Ari, Turker Acar, Cenk Simsek, Ali Murat Yildirim, Ozden Yildirim, Adam Uslu Tags: Letter to the Editor Source Type: research

Influence of AS-7 on the Storage Lesion in Young and Old Circulating Erythrocytes
Blood and its components are stored to meet the demands of blood transfusion. Erythrocytes undergo progressive modifications during storage known as storage lesions. Storage solutions were developed to improve shelf life and extend red cell viability. Therefore, the objective of this study is to analyze the effects of AS-7 on young and old erythrocytes during storage. Blood was collected from the blood bank at Kempegowda Institute of Medical Sciences (KIMS) hospital, Bengaluru. Erythrocytes were isolated from whole blood and separated based on its age using Percoll density gradient. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - August 3, 2020 Category: Hematology Authors: Carl Hsieh, N.C. Srinivasa Prabhu, Vani Rajashekaraiah Source Type: research

Blood exchange transfusion in viral hepatitis in a small infant: a case report
We report a case of blood exchange transfusion in acute liver failure following hepatitis B infection at the Infectious Disease Department of Children's Hospital No.2 in Ho Chi Minh City, Vietnam. A 3.5 months old baby boy was admitted to the hospital with a presentation of progressively worsening jaundice for one month. The patient was diagnosed with hepatitis B infection with a positive HBV DNA quantitative assay. Plasma exchange was indicated in the view of progressive liver failure and gradually increasing hepatic coma. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - August 3, 2020 Category: Hematology Authors: Thai Son Pham, Abdullah Reda, Thi Thu Ngan Nguyen, Sze Jia Ng, Vuong Thanh Huan, Do Chau Viet, Nguyen Tien Huy Source Type: research

Covid-19-induced coagulopathy and observed benefits with anticoagulation
Recently, literature recognized an association between coronavirus disease-19 (COVID-19) and coagulopathy [1]. COVID-19 illness severity is positively correlated with coagulopathy markers, including prolonged prothrombin time, increased fibrin degradation products, decreased platelet count, and elevated D-dimer [2 –8]. However, the pathogenesis of COVID-19-induced coagulation and the role of anticoagulation treatment remain unclear. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - August 3, 2020 Category: Hematology Authors: Sedighe Karimzade, Vinh Dong, Osama Gamal Hassan, Akshay Raut, Ahmed Fouda, Allison Parrill, Kimberly Eaton, Nguyen Tien Huy Tags: Letter to the Editor Source Type: research

Using droplet digital PCR to screen for rare blood donors: Proof of principle
Digital droplet PCR (ddPCR) is a very sensitive high throughput genotyping methodology. To date, the use of ddPCR in immunohematology is restricted to fetal genotyping of red blood cell antigens. Our hypothesis is that this technology could be applied to screen for rare red blood cell genotypes, such as Di(b-). (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - July 25, 2020 Category: Hematology Authors: Marcia Regina Dezan, Ana Claudia Peron, Th éo Gremen Mimary Oliveira, Valéria Brito Oliveira, Carolina Nunes Gomes, Nanci A. Salles, Vanderson Rocha, Alfredo Mendrone, Carla Luana Dinardo Source Type: research

Sars cov 2 infection in chronic myelogenous leukemia: severe hematological presentation
We describe a case of life ‐threatening COVID-19 infection complicated by severe anemia in patients affected also by chronic myelogenous leukemia. The screening for RBC antibodies and the direct antiglobulin test (DAT) turned positive. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - July 22, 2020 Category: Hematology Authors: Federica Sora, Patrizia Chiusolo, Luca Laurenti, Idanna Innocenti, Francesco Autore, Eleonora Alma, Marcello Viscovo, Domernico Fusco, Maddalena Maresca, Mario Tumbarello, Simona Sica Tags: Case Report Source Type: research

Thrombocytopenia due to Rivaroxaban: A Rare Adverse Effect
Rivaroxaban is a novel, oral direct acting anticoagulant (DOAC) that is used for both treatment and prevention of thromboembolic diseases. Due to mechanism of action; most common side effect may be seen with hemorrhage. Here in we reported that a patient with chronic atrial fibrillation presented with thrombocytopenia while taking rivaroxaban. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - July 22, 2020 Category: Hematology Authors: Mesut T ığlıoğlu, Pınar Akyol, Buğra Sağlam, Merih Reis Aras, Hacer Berna Afacan Öztürk, Abdulkerim Yıldız, Murat Albayrak Tags: Case Report Source Type: research

Medical student education in transfusion medicine, part II: Moving forward to building up a "Know How" education program in transfusion medicine for under-graduate medical students
There is a general trend in changing paradigm in teaching medicine; the emerging concept relies on a competence-based approach. Transfusion is either a discipline or a subsidiary of others depending on the countries and systems; this variability can be explained because transfusion is a medical care that is transdisciplinary. As a collective of professionals in both transfusion medicine practice and education, authors aim to propose a revision of the way education in transfusion medicine is delivered in this era of the ‘global competency approach’. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - July 22, 2020 Category: Hematology Authors: Olivier Garraud, Tomislav Vuk, Anneke Brand, Vincenzo de Angelis, Constantina Politis, Antoine Haddad, Alexander Vlaar, Miquel Lozano, Nigar Ertugrul Oruc, Stefan Laspina, Jean-Daniel Tissot Source Type: research

Neonatal alloimmune thrombocytopenia due to anti-HPA 5a in a HPA-5a homozygous neonate
We report a case of FNAIT caused anti-HPA antibodies directed to the HPA-5a antigen. The thrombocytopenia was moderate with a minimal platelet count of 36  × 109/L by day 3, and spontaneously resolved by day 10.The pregnancy had been obtained by in vitro fertilization using embryo donation, creating a complete genetic disparity between the HPA 5b5b mother and the HPA 5a5a homozygous neonate. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - July 22, 2020 Category: Hematology Authors: R. Porta, P. Serrano, A. Paltrinieri, G. Ristic, Carme Canals, Miquel Lozano Tags: Case Report Source Type: research

ESTIMATED PREVALENCE OF THE DUFFY NULL PHENOTYPE Fy (a −b−) AMONG BLACK BLOOD-DONORS IN SOUTHWESTERN COLOMBIA
Hemolytic reactions are adverse complications associated with red blood cell transfusion. These reactions are associated with clinically important erythrocyte antigens, such as those of Duffy blood Meny (2010). Individuals with the Duffy null phenotype Fy (a  − b−) are more likely to develop an alloimmunization reaction, resulting in an incompatibility with all available red blood cell units, thus increasing the risk of complications from their underlying disease Höher et al. (2018). Hence, it is important to determine the prevalence of the Fy (a − b−) phenotype in b...
Source: Transfusion and Apheresis Science - July 22, 2020 Category: Hematology Authors: Marcela Quintero-Santacruz, Liliana Fl órez Elvira, Ana Fernanda Mejía Hurtado, Carmenza Macia Mejía Source Type: research

Comparison of Low Fixed Dose Versus Standard-Dose Rituximab to Treat Thrombotic Thrombocytopenic Purpura in the Acute Phase and Preemptively During Remission
The standard dose of rituximab used in B-cell hematological malignancies, 375  mg/m2 weekly, may be excessive for autoimmune conditions. Successful use of a low, fixed dose of 100-200 mg of rituximab, weekly for 4 weeks, has been reported in the literature in the treatment of autoimmune thrombotic thrombocytopenic purpura (aTTP). We retrospectively analyzed our rituximab data in aTTP over a 13-year-period for 39 patients, with the aim of comparing response and outcomes with a standard lymphoma-dose course versus a low fixed 100 mg-dose course. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - July 22, 2020 Category: Hematology Authors: Manasa S. Reddy, Sandra Hofmann, Yu Min Shen, Srikanth Nagalla, Siayareh Rambally, Amena Usmani, Ravi Sarode Source Type: research

Potential challenges faced by blood bank services during COVID-19 pandemic and their mitigative measures: The Indian scenario
The current pandemic caused by SARS-CoV-2 virus is going to be a prolonged melee. Identifying crucial areas, proactive planning, coordinated strategies and their timely implication is essential for smooth functioning of any system during a crunch.Addressing the impact of COVID-19 on transfusion services, there are 4 potential challenges viz. blood/ component shortage, donor/ staff safety, consumable supply/ logistics and catering to the convalescent plasma need. In this review article, we will be discussing about these potential challenges in detail along with the necessary mitigative steps to be adopted to tide over the C...
Source: Transfusion and Apheresis Science - July 16, 2020 Category: Hematology Authors: Priyadarsini J. Arcot, Karan Kumar, Tapasyapreeti Mukhopadhyay, Arulselvi Subramanian Tags: Review Source Type: research

Convalescent plasma for covid19 – how long should a donor be excluded from donation?
Convalescent plasma (CP) has been used to treat emerging diseases in the past, and despite its empirical use, the results were positive and now has been tested for COVID19.1,2 The FDA (Food and Drug Administration, USA) the EC (European Commission, Belgium) and other regulatory agencies have authorized the use of CP from patients with resolved COVID19 with different regulations.3,4 Clinical and laboratory criteria are basically defined by the evidence of SARS-CoV-2 documented by clinical and/or laboratory evidence, and 14 to 28 days of resolution of symptoms prior to donation. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - July 14, 2020 Category: Hematology Authors: Jose M Kutner, Carolina Bonet-Bub, Ana Paula H Yokoyama, Araci M Sakashita, Joao R R Pinho, Nelson Hamerschlak, Luis V Rizzo Tags: Letter to the Editor Source Type: research

Vitamin B12 deficiency and metabolism-mediated thrombotic microangiopathy (MM-TMA)
(Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - July 14, 2020 Category: Hematology Authors: Hiroshi Ito Tags: Letter to the Editor Source Type: research

How to implement of Patient Blood Management Pillar 1: an Italian expert opinion based on a “bundles” approach
Worldwide iron anemia is a common disorder with a significant economic burden on health-care systems. Red blood cell transfusion is the mainstay to correct anemia in surgical settings, but it is also an overused procedure and recent data support its possible role in worsening patient outcomes. Patient Blood Management (PBM) is a multidisciplinary approach to optimize hemostasis, manage anemia, minimize iatrogenic blood loss, and improve tolerance to anemia. The present paper aims to provide a “bundles” approach, based on several preoperative anemia management measures, to implement PBM Pillar 1 in clinical prac...
Source: Transfusion and Apheresis Science - July 14, 2020 Category: Hematology Authors: Abbruzzese Luciano, Agostini Vanessa, Livraghi Alessandra, Paola Maria Manzini, Marmifero Melania, Cristina Tirindelli Maria Source Type: research

Clinical Efficacy of Convalescent Plasma for Treatment of COVID-19 Infections: Results of a Multicenter Clinical Study
Since Dec. 2019 the new coronavirus (SARS-CoV-2) has infected millions and claimed life of several hundred thousand worldwide. However, so far no approved vaccine or drug therapy is available for treatment of virus infection. Convalescent plasma has been considered a potential modality for COVID-19 infection. One hundred eighty-nine COVID-19 positive patients including 115 patients in plasma therapy group and 74 patients in control group, registered in the hospitals with confirmed COVID-19 infection, entered this multi-center clinical study. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - July 14, 2020 Category: Hematology Authors: Hassan Abolghasemi, Peyman Eshghi, Abdol Majid Cheraghali, Abbas Ali Imani Fooladi, Farzaneh Bolouki Moghaddam, Sina Imanizadeh, Matin Moeini Maleki, Mohammad Ranjkesh, Mohammad Rezapour, Ali Bahramifar, Behzad Einollahi, Mohammad Javad Hosseini, Nematoll Source Type: research

Unit-to-Unit Variability in the Deformability of Red Blood Cells
The objective of the study was to analyze unit-to-unit variability in the deformability of PRBCs during their cold storage. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - July 14, 2020 Category: Hematology Authors: Gregory Barshtein, Alexander Gural, Orly Zelig, Dan Arbell, Saul Yedgar Source Type: research

Organization of the outdoor blood donation drives amid novel coronavirus pandemic and national lockdown: An experience from a tertiary care oncology institution in India
The conduct of blood donation drives became difficult amid novel coronavirus disease pandemic and national lockdown. Despite no restriction for the outdoor blood donation drives, voluntary blood donor organizations (VBDOs) and individual donors became apprehensive regarding the possible risk of spread of the infection during blood donation. Various confidence-building measures were taken to decrease this hesitation. Numerous preventive measures were taken at the blood bank and at the donation venue to limit the possible risk of the spread of infection. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - July 14, 2020 Category: Hematology Authors: Abhaykumar Malind Gupta, Shashank Ojha, Minal Poojary, S.H. Sumathi, P. Nagaraju, Rajendra Dhokle Tags: Letter to the Editor Source Type: research

Prolonged Viral Shedding in a Lymphoma Patient with COVID-19 Infection Receiving Convalescent Plasma
Acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first identified in Wuhan, China; and spread all over the world. Reverse-transcription polymerase chain reaction (RT-PCR) test for SARS-CoV-2 usually returns to negative in 20 days post-infection, but prolonged positivity has been reported up to 63 days. A case whose viral shedding lasted 60 days is reported from China. Herein we report a patient with a history of autologous stem cell transplantation (ASCT) for lymphoma whose RT-PCR test remained positive for SARS-CoV-2 for 74 days. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - July 3, 2020 Category: Hematology Authors: Ay şe Karataş, Ahmet Çağkan İnkaya, Haluk Demiroğlu, Salih Aksu, Tahmaz Haziyev, Olgu Erkin Çınar, Alpaslan Alp, Ömrüm Uzun, Nilgün Sayınalp, Hakan Göker Tags: Case Report Source Type: research

Anti-A and Anti-A,B monoclonal antisera with high titers favor the detection of A weak phenotypes
This study aimed to evaluate the reactivity and the titers of commercial anti-A and anti-A,B antisera in the detection of A weak antigen expression in human red blood cells. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - July 1, 2020 Category: Hematology Authors: Marcos Paulo Miola, Tatiana Elias Colombo, Roberta Maria Fachini, Oct ávio Ricci, Cinara de Cássia Brandão de Mattos, Luiz Carlos de Mattos Source Type: research

First case of convalescent plasma transfusion in a child with COVID-19-associated severe aplastic anemia
We present the case of a six-year-old girl with severe COVID-19, in whom SARS-CoV-2 was successfully eliminated after convalescent plasma transfusion. Children show a variable clinical course of COVID-19, from asymptomatic to critical. In our patient, we diagnosed COVID-19-associated aplastic anemia with severe pancytopenia. The correlation between SARS-CoV-2 infection with aplastic anemia remains unclear. At the beginning of the disease, we used antiviral drugs and immune modulators as therapy but without any positive results. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - July 1, 2020 Category: Hematology Authors: Magdalena Figlerowicz, Anna Mania, Karol Lubarski, Zuzanna Lewandowska, Wojciech S łużewski, Katarzyna Derwich, Jacek Wachowiak, Katarzyna Mazur-Melewska Tags: Case Report Source Type: research

Challenges in platelet inventory management at a tertiary care oncology center during the novel coronavirus disease (COVID-19) pandemic lockdown in India
The novel coronavirus disease (COVID-19) has been declared a pandemic by the world health organization and to limit the spread of the disease, many countries in the world, including India, had enforced a lockdown. Despite no restriction over the platelet donation activities, plateletpheresis donors became apprehensive regarding the possible risk of spread of the COVID-19 during the platelet donation and in the hospital premises. Many of them started hesitating for platelet donations. With this, the blood center started having an acute shortage of platelets. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - July 1, 2020 Category: Hematology Authors: Shashank Ojha, Abhaykumar Malind Gupta, P. Nagaraju, Poojary Minal, Sumathi S.H. Source Type: research

In vitro mass production of reproducible human cells destined for substitution therapy: Challenges for development of functional materials for what we need most in transfusion!
In this concise section of TRASCI What ’s Happening I am pleased to offer readers five mini-reports reflecting on mass production of transfusable human cultured cells destined for substitution therapy. Special thanks are due to my contributors for helping me to bring together this concise theme which highlights supportive studies for i mplementation of culturing blood cells with a focus on advances in cultured RBC [CRBC]. Also, I am, in particular, grateful to Prof. Jason Acker for reviewing my personal contributions to this theme. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - June 29, 2020 Category: Hematology Authors: Jerard Seghatchian Tags: Editorial Source Type: research

Cell culture – fact and fiction
(Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - June 29, 2020 Category: Hematology Authors: Cees Th. Smit Sibinga, Jerard Seghatchian Source Type: research

Spotlights on the current perspectives on applications of human blood cell culture and organoids: Introductory remarks
Culture of blood cells, mainly erythrocytes, at industrial levels complying with cGMP regulations, aim to make them available, at large scale, any time and everywhere, when needed for transfusion, or laboratory applications. Understanding how blood cells differentiate and develop in-vivo, and mechanisms of differentiation and growth factors, has opened newer strategies for in-vitro culture from multipotent stem cells or immortalized lines. This offers interesting perspectives for obtaining such cultured bioproduct cells for medical applications. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - June 29, 2020 Category: Hematology Authors: Jerard Seghatchian, Jean Amiral Source Type: research

How do I see the production of engineered blood cells available for transfusion?
The in vitro production of red blood cells and platelets is a groundbreaking technology that can —when optimized—surrogate for donated blood cells, in total or in part. Here we discuss questions that may arise when the technology is available, relative to safety issues (comprising both quantitative and qualitative parameters) and to ethics, an item often forgotten in the debates so far. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - June 29, 2020 Category: Hematology Authors: Olivier Garraud Source Type: research

In vitro platelet production for transfusion purposes: Where are we now?
Over the last decade there has been a worldwide increase in the demand of platelet concentrates (PCs) for transfusion. This is, to a great extent, due to a growing and aging population with the concomitant increase in the incidence of onco-hematological diseases, which require frequent platelet (PLT) transfusions. Currently, PLTs are sourced uniquely from donations, and their storage time is limited only to a few days. The necessity to store PCs at room temperature (to minimize loss of PLT functional integrity), poses a major risk for bacterial contamination. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - June 28, 2020 Category: Hematology Authors: Patricia Mart ínez-Botía, Andrea Acebes-Huerta, Jerard Seghatchian, Laura Gutiérrez Source Type: research

Life-saving effect of convalescent plasma treatment in covid-19 disease: Clinical trial from eastern Anatolia
Convalescent Plasma (CP) therapy is of interest as no vaccine or specific treatment is available for emerging viruses such as severe acute respiratory syndrome coronavirus 2 causing Covid-19. It was aimed to report the results of our patients who underwent CP in the treatment of Covid-19. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - June 27, 2020 Category: Hematology Authors: Mehmet Ali Erkurt, Ahmet Sarici, İlhami Berber, İrfan Kuku, Emin Kaya, Mustafa Özgül Source Type: research

Impact of CD44 gene single nucleotide polymorphism (rs 13347) in mobilization of autologous HSCT
of stem cells into peripheral blood is a crucial step in the procedure of autologous stem cell transplantation. Mobilization can be affected by many variables;underlying diseases, prior treatment and age. Many genetic polymorphisms mainly in adhesion molecules are thought to affect mobilization success. The CD44 is a cell adhesion molecule which is highly heterogeneous structurally. Polymorphisms in this molecule may impair HSC lodgment in the bone marrow. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - June 27, 2020 Category: Hematology Authors: Neveen Mikhael, Amany Mossad, Mona Ayad, Dalia Nafae Source Type: research

Immunomodulation for the Management of Corona Virus Disease (COVID-19)
The corona virus disease (COVID-19) has caused a global health and economic crisis. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - June 27, 2020 Category: Hematology Authors: Dobri Kiprov, Michael J. Conboy, Irina M. Conboy Tags: Letter to the Editor Source Type: research

Passive immunotherapy with convalescent plasma against COVID-19? What about the evidence base and clinical trials?
Every severe viral infection since the Spanish Flu has stimulated interest in passive immunotherapy, in the absence of antiviral treatment and a vaccine program [1]. The rationale for convalescent plasmatherapy is very simple: it aims at providing neutralizing antibodies raised in donors having recovered from infection, to a mate recipient developing infection, in general, with a severe presentation [2,3]. The emergence of COVID-19 has swiftly elicited interest towards convalescent plasma as complications are not exceptional and even lethal [4 –6]. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - June 27, 2020 Category: Hematology Authors: Olivier Garraud Source Type: research

The Secrets of Human Stem Cell-derived Transfusable RBC for Targeted Large-Scale Production and Clinical Applications: A Fresh Look Into What We Need Most and Lessons to be Learned
Blood transfusion, using the safest conventional blood bioproducts, is an irreplaceable part of substitution therapy. It is considered the most essential supportive clinical intervention aimed to restore the health of patients in need. Nevertheless, numerous unresolved problems are still associated with current blood substitution therapy. To alleviate our dependency on blood donors, many investigators have been focusing on the quest for stem cell-derived blood cells in line with major developments in the field of regenerative medicine. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - June 27, 2020 Category: Hematology Authors: Jerard Seghatchian Source Type: research

Life-saving effect of convalescent plasma treatment in covid-19 d İsease: clinical trial from eastern anatolia
Convalescent Plasma (CP) therapy is of interest as no vaccine or specific treatment is available for emerging viruses such as severe acute respiratory syndrome coronavirus 2 causing Covid-19. It was aimed to report the results of our patients who underwent CP in the treatment of Covid-19. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - June 27, 2020 Category: Hematology Authors: Mehmet Ali Erkurt, Ahmet Sarici, İlhami Berber, İrfan Kuku, Emin Kaya, Mustafa Özgül Source Type: research

Impact of CD44 gene single nucleotide polymorphism (rs 13347) inmobilization of autologous HSCT
Mobilization of stem cells into peripheral blood is a crucial step in the procedure of autologous stem cell transplantation. Mobilization can be affected by many variables; underlying diseases, prior treatment and age. Many genetic polymorphisms mainly in adhesion molecules are thought to affect mobilization success. The CD44 is a cell adhesion molecule which is highly heterogeneous structurally. Polymorphisms in this molecule may impair HSC lodgment in the bone marrow.The aim of the work was to assess the impact of CD44 single nucleotide polymorphism (rs13347) on the efficacy of mobilization of CD34+ hematopoietic progeni...
Source: Transfusion and Apheresis Science - June 27, 2020 Category: Hematology Authors: Neveen Mikhael, Amany Mossad, Mona Ayad, Dalia Nafae Source Type: research

RHD genotyping of serological weak D phenotypes in the Iranian blood donors and patients
Most prevalent weak D types in the Caucasians molecularly defined weak D types 1, 2 or 3 and can be managed safely as RhD-positive, conserving limited supplies of RhD-negative RBCs. Therefore, identification of RHD alleles prevalence in each population could improve the policies related to accuracy of RhD typing. The aim of this study was to determine the frequency of RHD variant alleles among donors and patients for the first time in Iran. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - June 27, 2020 Category: Hematology Authors: Arezoo Oodi, Zahra Daneshvar, Samira Goudarzi, Naser Amirizadeh Source Type: research

Editorial: Information on the COVID-19 Pandemic continued
This issue of the journal, #59.4, continues the Theme topic of "Information on the Covid-19 Pandemic". This is an unusual approach for the journal but, as we all are aware, these are, to say the least, unusual times. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - June 26, 2020 Category: Hematology Authors: Gail Rock Source Type: research

A Canadian Perspective on the Use and Preparation of Cryopreserved Red Cell Concentrates
Canadian Blood Services (CBS) operates a national rare blood program to meet the needs of a highly diverse Canadian civilian population. This program manages the frozen inventory of red blood cell products maintaining upwards of 800 units of strategically identified phenotypes for patient use. Red cell concentrates (RCCs) are collected from identified donors with rare blood types as whole blood and are further processed into leukocyte reduced red cell concentrates in SAGM. These units can be stored for up to 21 days prior to glycerolization and frozen storage. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - June 26, 2020 Category: Hematology Authors: Tracey R. Turner, Jason P. Acker Source Type: research

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This issue of the journal, #59.4, continues the Theme topic of "Information on the Covid-19 Pandemic". This is an unusual approach for the journal but, as we all are aware, these are, to say the least, unusual times. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - June 26, 2020 Category: Hematology Authors: Gail Rock Tags: Editorial: Information on the COVID-19 Pandemic continued. Source Type: research

Total nucleated cell counts are driving clinician's choice rather than cryopreservation period: Lesson for cord blood banks
According to the increase in both the number of cryopreserved cord blood (CB) units and the cryopreservation period for each CB unit in the largest public CB bank in Korea, we are pursuing greater efficiency in CB bank management. Thus, we analyzed whether the cryopreservation period has a negative impact on the selection of CB units for CB transplantation (CBT). Until December 2019, 468 CB units were used for transplantation. The cryopreservation period, total nucleated cell (TNC), and CD34+ cell counts were analyzed among the CB units according to the CBT-year and the donation year. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - June 25, 2020 Category: Hematology Authors: Hye Ryun Lee, Eun Youn Roh, Namhee Kim, Eun Young Song, Hyunwoong Park, Jong Hyun Yoon, Sue Shin Source Type: research

Extracorporeal Blood Purification Treatment Options for COVID-19: The Role of Immunoadsorption
The activation of theinnate and adaptive immune systems by SARS-CoV-2 causes the release of several inflammatory cytokines, including IL-6. The inflammatory hypercytokinemia causes immunopathological changes in the lungs including vascular leakage, and alveolar edema. As a result of these changes in the lungs, hypoxia and acute respiratory distress syndrome occur in patients with COVID-19. Even though there are clinical trials on the development of therapeutics and vaccines, there are currently no licensed vaccines or therapeutics for COVID-19. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - June 25, 2020 Category: Hematology Authors: Tu ğçe Nur Yiğenoğlu, Turgay Ulas, Mehmet Sinan Dal, Serdal Korkmaz, Mehmet Ali Erkurt, Fevzi Altuntaş Source Type: research

Restrictive versus liberal transfusion strategies in patients with malignant neoplasm -a meta-analysis of randomized controlled trials
Transfusion strategies are involving the survival and prognosis of patients with malignant neoplasm and the rational utilization of medical resources, but there are still controversy between different transfusion strategies. The aim of this article is to compare the benefit and harm of restrictive and liberal red blood cell(RBC) transfusion strategies in patients with malignant tumors. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - June 16, 2020 Category: Hematology Authors: Xin-xin Yang, Sheng-yun Lin Tags: Review Source Type: research

Thrombin generation in children with sickle cell Anemia is Higher in the presence of platelets ⋆ and ⋆
Sickle cell disease (SCD) is a hemoglobin disorder leading to chronic hemolysis and multi-organ morbidity. Increasing evidence suggests that activation of coagulation contributes to its complications such as stroke, pulmonary hypertension, venous thromboembolism and avascular necrosis [1]. The effects are most profound in homozygous state Hemoglobin SS (HbSS) and Hemoglobin S-Beta zero thalassemia referred together as sickle cell anemia (SCA). With improved survival of patients with SCA in the current era, early recognition of long-term complications is a priority, but there is a paucity of biomarkers to identify SCA hyper...
Source: Transfusion and Apheresis Science - June 15, 2020 Category: Hematology Authors: Neethu Menon, Janna Journeycake, Rong Huang, Paul Riley, Ayesha Zia Source Type: research

Thrombin Generation in Children with Sickle Cell Anemia is Higher in the Presence of Platelets
(Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - June 15, 2020 Category: Hematology Authors: Neethu Menon, Janna Journeycake, Rong Huang, Paul Riley, Ayesha Zia Source Type: research

The true historical origin of convalescent plasma therapy
The use of convalescent plasma, a strategy of passive immunization that has been applied in the prevention and treatment of epidemic infections for more than 100 years [1], has been proposed and performed also during the recent COVID-19 pandemic [2]. Generally the convalescent plasma use during the Spanish influenza A (H1N1) pneumonia (pandemic of 1918 –1920) has been reported as its first application [3–6]. In fact, several studies conducted during this pandemic suggested that the convalescent plasma could be effective in reducing mortality risk, as later confirmed by the meta-analysis carried out by Luke et a...
Source: Transfusion and Apheresis Science - June 11, 2020 Category: Hematology Authors: Piero Marson, Andrea Cozza, Giustina De Silvestro Tags: Letter to the Editor Source Type: research

Reduced Deformability of Stored Red Blood Cells is Associated with Generation of Extracellular Vesicles
Throughout storage, red blood cells (RBCs) undergo detrimental changes in viability and their ability to effectively transport oxygen. RBC storage lesions are mediated, in part, by a progressive loss of cell deformability, and associated with the release of extracellular vesicles (EVs). Accumulation of EVs during the storage of RBCs correlates with a decrease in RBC surface area to volume ratio. Similarly, the loss of RBC-deformability is associated with loss of RBC surface area to volume ratio. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - June 11, 2020 Category: Hematology Authors: M.J. McVey, W.M. Kuebler, A. Orbach, D. Arbell, O. Zelig, G. Barshtein, S. Yedgar Tags: Short Report Source Type: research

Correlation of platelet crossmatch results by solid phase red cell adherence assay (SPRCA) with post-transfusion platelet count increment in adult hemato-oncology patients of a tertiary care oncology centre in India
To assess platelet crossmatch result by SPRCA and find its correlation with post-transfusion platelet count increment among adult hemato-oncology patients (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - June 9, 2020 Category: Hematology Authors: P. Desai, P. Sontakke, S. Rajadhyaksha, A. Navkudkar Source Type: research

The impact of transfusion burden and comorbidities on the prognosis of patients with myelodysplastic syndromes
Early comorbidity detection has been reported to be associated with treatment-related outcomes in several diseases. Two main goals of the present study were to investigate both the impact of comorbidities and transfusion frequencies on the survival and quality of life of patients with myelodysplastic syndromes (MDS). (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - June 9, 2020 Category: Hematology Authors: Ahmet Sarici, Muhlis Cem Ar, Osman Yokus, Seniz Ongoren, Mesut Ayer, Sermin Altindal, Hilal Tan Koker, Omer Faruk Kuzu Source Type: research