Anti ‐Inflammatory Effect of High‐Density Lipoprotein Blunted by Delivery of Altered MicroRNA Cargo in Patients With Rheumatoid Arthritis
ConclusionHDL-miR-1246 was increased in RA versus control participants and delivery of miR-1246 to macrophages increased IL-6 expression by targetingDUSP3. The altered HDL-miRNA cargo in RA blunted HDL's anti-inflammatory effect. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 25, 2024 Category: Rheumatology Authors: Qiong Wu,
Quanhu Sheng,
Danielle Michell,
Marisol Ramirez ‐Solano,
Olivia Posey,
Anastasiia Phothisane,
Shahensha Shaik,
Kasey C. Vickers,
Michelle J. Ormseth Tags: Full Length Source Type: research
Interactions Between HDL and CD4+ T Cells: A Novel Understanding of HDL Anti-Inflammatory Properties
We present a model where HDL may modulate T cells through both direct and indirect mechanisms.PMID:38660807 | DOI:10.1161/ATVBAHA.124.320851 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 25, 2024 Category: Cardiology Authors: Laura Atehortua W Sean Davidson Claire A Chougnet Source Type: research
Differential Impact In Vivo of Pf4- ΔCre-Mediated and Gp1ba-ΔCre-Mediated Depletion of Cyclooxygenase-1 in Platelets in Mice
CONCLUSIONS: Both approaches to Cox-1 deletion similarly restrain thrombogenesis, but a differential impact on Cox-1-dependent prostanoid formation by the vasculature may contribute to an inflammatory phenotype and accelerated atherogenesis in Pf4-ΔCre mice.PMID:38660804 | DOI:10.1161/ATVBAHA.123.320295 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 25, 2024 Category: Cardiology Authors: Soon Yew Tang Ronan Lordan Hu Meng Benjamin J Auerbach Elizabeth J Hennessy Arjun Sengupta Ujjalkumar S Das Robin Joshi Oscar A Marcos-Contreras Ryan McConnell Gregory R Grant Emanuela Ricciotti Vladimir R Muzykantov Tilo Grosser Aalim M Weiljie Garret A Source Type: research
Risk Factors and Clinical Characterization of Cardiovascularand Cerebrovascular Events in Elderly Hemodialysis Patients
CONCLUSION: Patients with underlying diseases such as hypertensive or diabetic nephropathy are more likely to experience cardiovascular and cerebrovascular events. Longer dialysis duration, higher systolic and diastolic blood pressures, elevated uric acid, TC, TG, LDL-C, PTH and blood glucose levels, and boosted inflammatory reaction are risk factors for these events among elderly HD patients. The purpose of this study is to provide practical guidelines for clinical treatment. Comprehensive measures such as active intervention of risk factors, rational drug use and regular examination should be taken to improve the overall...
Source: Iranian Journal of Kidney Diseases - April 25, 2024 Category: Urology & Nephrology Authors: Wei Liu Hong Ze Wang Ying Shi Weiqiang Shen Mingyan Dai Source Type: research
Differential Impact In Vivo of Pf4- ΔCre-Mediated and Gp1ba-ΔCre-Mediated Depletion of Cyclooxygenase-1 in Platelets in Mice
CONCLUSIONS: Both approaches to Cox-1 deletion similarly restrain thrombogenesis, but a differential impact on Cox-1-dependent prostanoid formation by the vasculature may contribute to an inflammatory phenotype and accelerated atherogenesis in Pf4-ΔCre mice.PMID:38660804 | DOI:10.1161/ATVBAHA.123.320295 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 25, 2024 Category: Cardiology Authors: Soon Yew Tang Ronan Lordan Hu Meng Benjamin J Auerbach Elizabeth J Hennessy Arjun Sengupta Ujjalkumar S Das Robin Joshi Oscar A Marcos-Contreras Ryan McConnell Gregory R Grant Emanuela Ricciotti Vladimir R Muzykantov Tilo Grosser Aalim M Weiljie Garret A Source Type: research
Interactions Between HDL and CD4+ T Cells: A Novel Understanding of HDL Anti-Inflammatory Properties
We present a model where HDL may modulate T cells through both direct and indirect mechanisms.PMID:38660807 | DOI:10.1161/ATVBAHA.124.320851 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 25, 2024 Category: Cardiology Authors: Laura Atehortua W Sean Davidson Claire A Chougnet Source Type: research
Risk Factors and Clinical Characterization of Cardiovascularand Cerebrovascular Events in Elderly Hemodialysis Patients
CONCLUSION: Patients with underlying diseases such as hypertensive or diabetic nephropathy are more likely to experience cardiovascular and cerebrovascular events. Longer dialysis duration, higher systolic and diastolic blood pressures, elevated uric acid, TC, TG, LDL-C, PTH and blood glucose levels, and boosted inflammatory reaction are risk factors for these events among elderly HD patients. The purpose of this study is to provide practical guidelines for clinical treatment. Comprehensive measures such as active intervention of risk factors, rational drug use and regular examination should be taken to improve the overall...
Source: Iranian Journal of Kidney Diseases - April 25, 2024 Category: Urology & Nephrology Authors: Wei Liu Hong Ze Wang Ying Shi Weiqiang Shen Mingyan Dai Source Type: research
Dietary supplements: clinical cholesterol-lowering efficacy and potential mechanisms of action
Int J Food Sci Nutr. 2024 Apr 24:1-20. doi: 10.1080/09637486.2024.2342301. Online ahead of print.ABSTRACTThis review aims to analyse the efficacy of dietary supplements in reducing plasma cholesterol levels. Focusing on evidence from meta-analyses of randomised controlled clinical trials, with an emphasis on potential mechanisms of action as supported by human, animal, and cell studies. Certain dietary supplements including phytosterols, berberine, viscous soluble dietary fibres, garlic supplements, soy protein, specific probiotic strains, and certain polyphenol extracts could significantly reduce plasma total and low-dens...
Source: International Journal of Food Sciences and Nutrition - April 25, 2024 Category: Nutrition Authors: Qian Ge Yue Yan Yang Luo Tai Teng Caixia Cao Danqing Zhao Jing Zhang Caihong Li Wang Chen Binkun Yang Zicheng Yi Tengwen Chang Xiang Chen Source Type: research
Interactions Between HDL and CD4+ T Cells: A Novel Understanding of HDL Anti-Inflammatory Properties
We present a model where HDL may modulate T cells through both direct and indirect mechanisms.PMID:38660807 | DOI:10.1161/ATVBAHA.124.320851 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 25, 2024 Category: Cardiology Authors: Laura Atehortua W Sean Davidson Claire A Chougnet Source Type: research
Differential Impact In Vivo of Pf4- ΔCre-Mediated and Gp1ba-ΔCre-Mediated Depletion of Cyclooxygenase-1 in Platelets in Mice
CONCLUSIONS: Both approaches to Cox-1 deletion similarly restrain thrombogenesis, but a differential impact on Cox-1-dependent prostanoid formation by the vasculature may contribute to an inflammatory phenotype and accelerated atherogenesis in Pf4-ΔCre mice.PMID:38660804 | DOI:10.1161/ATVBAHA.123.320295 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 25, 2024 Category: Cardiology Authors: Soon Yew Tang Ronan Lordan Hu Meng Benjamin J Auerbach Elizabeth J Hennessy Arjun Sengupta Ujjalkumar S Das Robin Joshi Oscar A Marcos-Contreras Ryan McConnell Gregory R Grant Emanuela Ricciotti Vladimir R Muzykantov Tilo Grosser Aalim M Weiljie Garret A Source Type: research
Risk Factors and Clinical Characterization of Cardiovascularand Cerebrovascular Events in Elderly Hemodialysis Patients
CONCLUSION: Patients with underlying diseases such as hypertensive or diabetic nephropathy are more likely to experience cardiovascular and cerebrovascular events. Longer dialysis duration, higher systolic and diastolic blood pressures, elevated uric acid, TC, TG, LDL-C, PTH and blood glucose levels, and boosted inflammatory reaction are risk factors for these events among elderly HD patients. The purpose of this study is to provide practical guidelines for clinical treatment. Comprehensive measures such as active intervention of risk factors, rational drug use and regular examination should be taken to improve the overall...
Source: Iranian Journal of Kidney Diseases - April 25, 2024 Category: Urology & Nephrology Authors: Wei Liu Hong Ze Wang Ying Shi Weiqiang Shen Mingyan Dai Source Type: research
Dietary supplements: clinical cholesterol-lowering efficacy and potential mechanisms of action
Int J Food Sci Nutr. 2024 Apr 24:1-20. doi: 10.1080/09637486.2024.2342301. Online ahead of print.ABSTRACTThis review aims to analyse the efficacy of dietary supplements in reducing plasma cholesterol levels. Focusing on evidence from meta-analyses of randomised controlled clinical trials, with an emphasis on potential mechanisms of action as supported by human, animal, and cell studies. Certain dietary supplements including phytosterols, berberine, viscous soluble dietary fibres, garlic supplements, soy protein, specific probiotic strains, and certain polyphenol extracts could significantly reduce plasma total and low-dens...
Source: International Journal of Food Sciences and Nutrition - April 25, 2024 Category: Nutrition Authors: Qian Ge Yue Yan Yang Luo Tai Teng Caixia Cao Danqing Zhao Jing Zhang Caihong Li Wang Chen Binkun Yang Zicheng Yi Tengwen Chang Xiang Chen Source Type: research
Effect of MEHP on testosterone synthesis via Sirt1/Foxo1/Rab7 signaling pathway inhibition of lipophagy in TM3 cells
This study improves our current understanding of the toxicity and molecular mechanisms of action of MEHP and provides new insights into the reproductive effects of phthalic acid esters.PMID:38663197 | DOI:10.1016/j.ecoenv.2024.116394 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - April 25, 2024 Category: Environmental Health Authors: Yu Hao Xuan'en Tian Fengmei Yan Xiuqin Wang Jing Huang Ling Li Source Type: research
Interactions Between HDL and CD4+ T Cells: A Novel Understanding of HDL Anti-Inflammatory Properties
We present a model where HDL may modulate T cells through both direct and indirect mechanisms.PMID:38660807 | DOI:10.1161/ATVBAHA.124.320851 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 25, 2024 Category: Cardiology Authors: Laura Atehortua W Sean Davidson Claire A Chougnet Source Type: research
Differential Impact In Vivo of Pf4- ΔCre-Mediated and Gp1ba-ΔCre-Mediated Depletion of Cyclooxygenase-1 in Platelets in Mice
CONCLUSIONS: Both approaches to Cox-1 deletion similarly restrain thrombogenesis, but a differential impact on Cox-1-dependent prostanoid formation by the vasculature may contribute to an inflammatory phenotype and accelerated atherogenesis in Pf4-ΔCre mice.PMID:38660804 | DOI:10.1161/ATVBAHA.123.320295 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 25, 2024 Category: Cardiology Authors: Soon Yew Tang Ronan Lordan Hu Meng Benjamin J Auerbach Elizabeth J Hennessy Arjun Sengupta Ujjalkumar S Das Robin Joshi Oscar A Marcos-Contreras Ryan McConnell Gregory R Grant Emanuela Ricciotti Vladimir R Muzykantov Tilo Grosser Aalim M Weiljie Garret A Source Type: research
