Viruses, Vol. 16, Pages 635: Pathogenic and Apathogenic Strains of Lymphocytic Choriomeningitis Virus Have Distinct Entry and Innate Immune Activation Pathways
. Lukashevich
Lymphocytic choriomeningitis virus (LCMV) and Lassa virus (LASV) share many genetic and biological features including subtle differences between pathogenic and apathogenic strains. Despite remarkable genetic similarity, the viscerotropic WE strain of LCMV causes a fatal LASV fever-like hepatitis in non-human primates (NHPs) while the mouse-adapted Armstrong (ARM) strain of LCMV is deeply attenuated in NHPs and can vaccinate against LCMV-WE challenge. Here, we demonstrate that internalization of WE is more sensitive to the depletion of membrane cholesterol than ARM infection while ARM infection is more rel...
Source: Viruses - April 19, 2024 Category: Virology Authors: Dylan M. Johnson Nittaya Khakhum Min Wang Nikole L. Warner Jenny D. Jokinen Jason E. Comer Igor S. Lukashevich Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1859: A Systematic Review of Statins for the Treatment of Nonalcoholic Steatohepatitis: Safety, Efficacy, and Mechanism of Action
Bing Liu
Nonalcoholic fatty liver disease (NAFLD) is the liver component of a cluster of conditions, while its subtype, nonalcoholic steatohepatitis (NASH), emerges as a potentially progressive liver disorder that harbors the risk of evolving into cirrhosis and culminating in hepatocellular carcinoma (HCC). NASH and cardiovascular disease (CVD) have common risk factors, but compared to liver-related causes, the most common cause of death in NASH patients is CVD. Within the pharmacological armamentarium, statins, celebrated for their lipid-modulating prowess, have now garnered attention for their expansive therapeutic ...
Source: Molecules - April 19, 2024 Category: Chemistry Authors: Shiqin Zhang Xiaoling Ren Bingzheng Zhang Tian Lan Bing Liu Tags: Review Source Type: research
Thermal evaporation as sample preparation for silver –assisted laser desorption/ionization mass spectrometry imaging of cholesterol in amyloid tissues
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Štěpán Strnad, Vladimír Vrkoslav, Anna Mengr, Ondřej Fabián, Jiří Rybáček, Miloš Kubánek, Vojtěch Melenovský, Lenka Maletínská, Josef Cvačka Optimization and evaluation of thermal evaporation as a technique for silver deposition in MSI of cholesterol. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - April 18, 2024 Category: Chemistry Authors: Štěpán Strnad Source Type: research
Murine Alox8 versus the human ALOX15B ortholog: differences and similarities
Pflugers Arch. 2024 Apr 19. doi: 10.1007/s00424-024-02961-w. Online ahead of print.ABSTRACTHuman arachidonate 15-lipoxygenase type B is a lipoxygenase that catalyzes the peroxidation of arachidonic acid at carbon-15. The corresponding murine ortholog however has 8-lipoxygenase activity. Both enzymes oxygenate polyunsaturated fatty acids in S-chirality with singular reaction specificity, although they generate a different product pattern. Furthermore, while both enzymes utilize both esterified fatty acids and fatty acid hydro(pero)xides as substrates, they differ with respect to the orientation of the fatty acid in their su...
Source: Atherosclerosis - April 18, 2024 Category: Cardiology Authors: Megan A Palmer Yvonne Benatzy Bernhard Br üne Source Type: research
Value of the monocyte-to-high-density lipoprotein cholesterol ratio in refining the detection of prevalent heart failure: Insights from the NHANES 1999-2018
This study aimed to assess the association between the MHR and prevalent heart failure (HF) and to explore the value of the MHR in detecting prevalent HF in the general US population. Our study included 25,374 participants from the National Health and Nutrition Examination Survey (1999-2018). Among the participants, 749 (2.95%) reported a history of HF, and the HF group had a significantly higher MHR than the non-HF group. Adjusted analyses revealed that each standard deviation increase in the MHR was associated with a 27.8% increase in the risk of HF. The association between the MHR and prevalent HF was linear across the ...
Source: Atherosclerosis - April 18, 2024 Category: Cardiology Authors: Letian Wang Yang Liu Wenrui Shi Xu Liu Mu Qin Source Type: research
GlycA Levels Independently Predict Coronary Artery Calcium Incidence and Progression in the ELSA-Brasil Cohort (Brazilian Longitudinal Study of Adult Health)
Am J Cardiol. 2024 Apr 16:S0002-9149(24)00265-0. doi: 10.1016/j.amjcard.2024.03.041. Online ahead of print.ABSTRACTAtherosclerosis is an inflammatory disease. Coronary artery calcium (CAC) is a marker of atherosclerotic disease events and mortality risk. Elevated GlycA, an emerging marker of inflammation, is associated with a higher risk for coronary artery disease (CAD). However, there is conflicting evidence on whether GlycA predicts subclinical CAD progression. We hypothesized that GlycA can predict subclinical CAC incidence/progression in healthy individuals. We included 2,690 ELSA-Brasil cohort participants without ca...
Source: Atherosclerosis - April 18, 2024 Category: Cardiology Authors: Ronaldo C Fabiano Filho Giuliano Generoso Rhanderson Cardoso Steven R Jones Raul D Santos Peter P Toth Isabela M Bensenor Paulo A Lotufo Marcio S Bittencourt Source Type: research
LDL-C and TC mediate the risk of PNPLA3 inhibition on cardiovascular diseases
CONCLUSION: This study suggests that PNPLA3 inhibition increases the risk of major CVDs. Moreover, blood LDL-C and TC may mediate a significant proportion of the associations between PNPLA3 inhibition and coronary atherosclerosis, coronary heart disease, or myocardial infarction.PMID:38636099 | DOI:10.1210/clinem/dgae264 (Source: Atherosclerosis)
Source: Atherosclerosis - April 18, 2024 Category: Cardiology Authors: Genshan Zhang Wei Jiang Fangxun He Jie Fu Xiangshang Xu Xuelai Luo Zhixin Cao Source Type: research
Pragmatic Trial of Messaging to Providers About Treatment of Hyperlipidemia (PROMPT-LIPID): A Randomized Clinical Trial
CONCLUSIONS: With a real-time, targeted, individualized EHR alert as compared with usual care, the proportion of patients with atherosclerotic cardiovascular disease with LLT intensification was numerically higher but not statistically significant. Among clinicians who did not dismiss the alert, there was a > 2-fold increase in LLT intensification. EHR alerts, coupled with strategies to reduce clinician dismissal, may help address persistent gaps in LDL-C management.REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT04394715, https://www.clinicaltrials.gov/ct2/show/study/NCT04394715.PMID:38634282 |...
Source: Atherosclerosis - April 18, 2024 Category: Cardiology Authors: Nimish N Shah Lama Ghazi Yu Yamamoto Sanchit Kumar Melissa Martin Michael Simonov Ralph J Riello Iii Kamil F Faridi Tariq Ahmad F Perry Wilson Nihar R Desai Source Type: research
Co-delivery of fucoxanthin and Twist siRNA using hydroxyethyl starch-cholesterol self-assembled polymer nanoparticles for triple-negative breast cancer synergistic therapy
CONCLUSION: Systematic studies revealed that this dual-functional nanomedicine that targets both tumor cells and tumor microenvironment significantly alleviates TNBC orthotopic tumor burden and inhibits lung metastasis, establishing a new paradigm for TNBC therapy.PMID:38636588 | DOI:10.1016/j.jare.2024.04.017 (Source: Cell Research)
Source: Cell Research - April 18, 2024 Category: Cytology Authors: Zeliang Wu Yuxiang Tang Yuanhui Liu Zhaozhao Chen Yuao Feng Hang Hu Hui Liu Gang Chen Youming Lu Yu Hu Rong Xu Source Type: research
Lower total cholesterol and triglyceride levels in ankylosing spondylitis than non-inflammatory rheumatic disease controls in a 1978-98 study: a potential effect of increased physical energetics in manual occupations in the pre-2000 chronologic era
CONCLUSIONS: In the 1978-98 survey, AS had significantly lower mean serum cholesterol and triglyceride levels than NIRD control patients. Associated manual labour occupations may have significantly contributed to results, possibly related to increased energy expenditures from physical activity in the pre-2000 era.PMID:38634375 | DOI:10.55563/clinexprheumatol/u41mn1 (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 18, 2024 Category: Rheumatology Authors: Alfonse T Masi Ponnaiah C Mohan Tsr Murugan Chadrick R Evans Michael J Ryan Megan L Brezka Vaughn Hanna Gerald R Cooper Jean C Aldag Source Type: research
In vitro cleavage of tumor necrosis factor α (TNFα) by Signal-Peptide-Peptidase-like 2b (SPPL2b) resembles mechanistic principles observed in the cellular context
We describe the details of developing an in vitro cleavage assay for SPPL2b and its model substrate TNFα and analyzed the influence of phospholipids, detergent supplements, and cholesterol on the SPPL2b in vitro activity. SPPL2b in vitro activity resembles mechanistic principles that have been observed in a cellular context, such as cleavage sites and consecutive turnover of the TNFα transmembrane domain. The novel in vitro cleavage assay is functional with separately isolated protease and substrate and amenable to a high throughput plate-based readout overcoming previous limitations and providing the basis for studying ...
Source: Chemico-Biological Interactions - April 18, 2024 Category: Molecular Biology Authors: Kinda Sharrouf Christine Schlosser Sandra Mildenberger Regina Fluhrer Sabine Hoeppner Source Type: research
Association of a genetic variant in angiopoietin-like 3 with serum HDL-C and risk of cardiovascular disease: A study of the MASHAD cohort over 6 years
CONCLUSION: We have found that a rs10789117 C>A in ANGPTL3 gene polymorphism was associated with incident CVD events, and this may be of value as a risk stratification biomarker in CVD in the Iranian population.PMID:38634215 | DOI:10.1002/mgg3.2418 (Source: Molecular Medicine)
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Malihe Aghasizadeh Asieh Ahmadi Hoseini Reza Sahebi Tooba Kazemi Parisa Asadiyan-Sohan Habibollah Esmaily Sara Samadi Amir Avan Gordon A Ferns Saeede Khosravi Hamideh Ghazizadeh Ebrahim Miri-Moghaddam Majid Ghayour-Mobarhan Source Type: research
Impacts of pro-inflammatory cytokines variant on cardiometabolic profile and premature coronary artery disease: A systematic review and meta-analysis
J Cell Mol Med. 2024 Apr;28(8):e18311. doi: 10.1111/jcmm.18311.ABSTRACTInterleukin-6 (IL-6), a pivotal pro-inflammatory cytokine, is closely linked to vascular wall thickening and atherosclerotic lesion. Since serum IL-6 levels are largely determined by the genetic variant in IL-6, this study was conducted to investigate whether the IL-6 variant impacts cardiometabolic profile and the risk of premature coronary artery disease (PCAD). PubMed, Cochrane Library, Central, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and ClinicalTrials.gov were searched from May 13, 2022 to June 28, 2023. In total, 40 stud...
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Yang Liu Yuan Chen Yi Lin Baozhu Wei Zhi Luo Source Type: research
Murine Alox8 versus the human ALOX15B ortholog: differences and similarities
Pflugers Arch. 2024 Apr 19. doi: 10.1007/s00424-024-02961-w. Online ahead of print.ABSTRACTHuman arachidonate 15-lipoxygenase type B is a lipoxygenase that catalyzes the peroxidation of arachidonic acid at carbon-15. The corresponding murine ortholog however has 8-lipoxygenase activity. Both enzymes oxygenate polyunsaturated fatty acids in S-chirality with singular reaction specificity, although they generate a different product pattern. Furthermore, while both enzymes utilize both esterified fatty acids and fatty acid hydro(pero)xides as substrates, they differ with respect to the orientation of the fatty acid in their su...
Source: Pflugers Archiv : European Journal of Physiology - April 18, 2024 Category: Physiology Authors: Megan A Palmer Yvonne Benatzy Bernhard Br üne Source Type: research
Metabolomics of Mice with Type 2 Diabetes and Nonalcoholic Fatty Liver Treated by Acupuncture
CONCLUSION: Our study shows that acupuncture can regulate the liver metabolism mode of T2DM in NAFLD mice. It can reduce blood glucose and lipid accumulation in the liver, and these findings provide a new idea and theoretical basis for acupuncture in the treatment of diseases related to glucose and lipid metabolism.PMID:38633528 | PMC:PMC11023731 | DOI:10.1155/2024/5568337 (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - April 18, 2024 Category: Endocrinology Authors: Yihui Guo Liying Zhang Mengyuan Li Linan Lin Fuyu Xue Wanning Gao Xiaoru Xu Haipeng Huang Source Type: research
