Prognostic significance of high-sensitivity cardiac troponin in patients with heart failure with preserved ejection fraction
AbstractThe aim of this study was to investigate the prognostic significance of high-sensitivity troponin T (hs-TnT) in patients with heart failure (HF) with preserved ejection fraction (HFpEF). We enrolled consecutive patients admitted to Shinshu University Hospital for HF treatment between July 2014 and March 2017 and stratified them into HF with reduced ejection fraction and HFpEF groups (left ventricular ejection fraction,
Source: Heart and Vessels - September 7, 2019 Category: Cardiology Source Type: research

Hemodynamic comparison of CoreValve and SAPIEN-XT TAVI valves in Japanese patients
In this study, long-term clinical outcomes for CoreValve and SAPIEN XT were similar. The 3-year THV performance of both devices was maintained after TAVI. Serial change in mean aortic PGs for CoreValve decreases significantly from FPI to the 3-year follow-up point compared to that for SAPIEN-XT. (Source: Heart and Vessels)
Source: Heart and Vessels - September 7, 2019 Category: Cardiology Source Type: research

Clinical safety and efficacy of tolvaptan for acute phase therapy in patients with low-flow and normal-flow severe aortic stenosis
This study aimed to retrospectively investigate the safety and efficacy of tolvaptan in the acute phase in 56 consecutive patients with SAS and compared LF-SAS with normal-flow (NF) SAS. The primary endpoints were adverse clinical events (death, worsening heart failure, worsening renal failure, fatal arrhythmia, cardiogenic or hypovolemic shock, and use of inotropic agents) and the volume of urine within 48  h of tolvaptan administration. Among 56 patients, 16 had LF-SAS (29%), and 40 had NF-SAS (71%). Severe adverse clinical events were not observed 48 h after tolvaptan administration. In both groups, the urine ...
Source: Heart and Vessels - September 7, 2019 Category: Cardiology Source Type: research

Crossover comparison between CPAP and mandibular advancement device with adherence monitor about the effects on endothelial function, blood pressure and symptoms in patients with obstructive sleep apnea
AbstractMandibular advancement device (MAD) is an alternative therapeutic option for CPAP to treat obstructive sleep apnea (OSA). While MAD showed the better adherence, patients with over moderate OSA have been treated more frequently with CPAP despite increasing positive evidence on the cardiovascular outcome with MAD, even in severe patients. Thus, more information is needed regarding the cardiovascular and symptomatic outcome of MAD treatment objectively compared to CPAP. Forty-five supine-dependent OSA patients (apnea –hypopnea index 20–40/h) were randomized to either CPAP or MAD and treated for 8 week...
Source: Heart and Vessels - September 7, 2019 Category: Cardiology Source Type: research

Correction to: Magnetocardiographic recognition of abnormal depolarization and repolarization in patients with coronary artery lesions caused by Kawasaki disease
In the original publication of the article, the sentence “The integral value was computed for each channel, and isointegral maps were constructed during depolarization and repolarization.” was published incorrectly under the abstract section. (Source: Heart and Vessels)
Source: Heart and Vessels - September 7, 2019 Category: Cardiology Source Type: research

Real-world outcomes of rivaroxaban treatment in elderly Japanese patients with nonvalvular atrial fibrillation
AbstractDirect oral anticoagulants (DOACs), such as rivaroxaban, reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation (NVAF). However, it is still unclear whether the stroke reduction benefit outweighs the bleeding risk in elderly Japanese patients with NVAF. The Xarelto Post-Authorization Safety and Effectiveness Study in Japanese Patients with Atrial Fibrillation (XAPASS) was a real-world, prospective observational, post-marketing surveillance study on the safety and effectiveness of rivaroxaban in Japanese clinical practice. This sub-analysis evaluated the clinical outcomes of...
Source: Heart and Vessels - September 6, 2019 Category: Cardiology Source Type: research

Prognostic value of instrumental activity of daily living in initial heart failure hospitalization patients aged 65  years or older
In conclusion, l imited IADL indicated by TMIG-IC was associated with poorer long-term mortality rate in elderly patients with HF. This inexpensive and easily applicable tool will support decision making in cardiac rehabilitation. (Source: Heart and Vessels)
Source: Heart and Vessels - September 5, 2019 Category: Cardiology Source Type: research

Incidence of deep vein thrombosis from screening by venous ultrasonography in Japanese patients
In conclusion, of the patients, 10.3% were diagnosed with DVT, and only half received treatment with only anticoagulation. (Source: Heart and Vessels)
Source: Heart and Vessels - September 4, 2019 Category: Cardiology Source Type: research

Impact of gender on heart failure presentation in non-obstructive hypertrophic cardiomyopathy
AbstractHypertrophic cardiomyopathy (HCM) is a genetic cardiac disease that represents a broad spectrum of morphologic features and clinical presentations. However, little is known about the impact of gender differences in heart failure (HF) development in non-obstructive HCM. We assessed clinical and echocardiographic parameters according to gender in patients with non-obstructive HCM and evaluated the impact of gender on HF presentation and cardiovascular (CV) outcomes in this population. We investigated 202 consecutive patients with non-obstructive HCM. Clinical parameters and conventional echocardiographic measurements...
Source: Heart and Vessels - September 3, 2019 Category: Cardiology Source Type: research

Computational fluid dynamic-derived wall shear stress of non-significant left main bifurcation disease may predict acute vessel thrombosis at 3-year follow-up
In conclusion, in patients with angiographically non-significant LM bifurcation disease, both the mean WSSprox of each branch and WSSentire_lesion of each stenotic vessel predicted the occurrence of B-MI over the following 3  years. Moreover, the WSSentire_bifurcation ≥ 5.05 Pa seems to be a predictor of 3-year B-MI independently from the DS% and lesions lengths. (Source: Heart and Vessels)
Source: Heart and Vessels - September 3, 2019 Category: Cardiology Source Type: research

Additive prognostic significance of ejection fraction for ESC risk model in hypertrophic cardiomyopathy patients
We examined the validity of this model and investigated the significance of ejection fraction (EF) in predicting the prognosis using ESC risk model in HCM patients. 305 HCM patients (198 males) were followed (median follow-up 4.8  years) for life-threatening arrhythmic events (sudden death, aborted sudden death, sustained VT/VF, appropriate ICD intervention for VT/VF) and were divided using ESC risk model into low- (Group L), intermediate- (Group I) and high- (Group H) risk groups. There was a significant difference in the events rate among the 3 groups (L, 0.9%/year; I, 3.9%/year; H, 6.8%/year; log-rankp 
Source: Heart and Vessels - September 3, 2019 Category: Cardiology Source Type: research

Spontaneous coronary collateral recruitment in patients with recurrent ST elevation myocardial infarction (STEMI)
AbstractThe spontaneous recruitment of acute coronary collaterals in the setting of an ST elevation myocardial infarction (STEMI) is seen frequently in those patients undergoing primary percutaneous coronary intervention (pPCI) and is associated with improved clinical outcomes. However, it is unknown whether in patients who present with a recurrent STEMI, the degree of collateral recruitment remains the same as in the index procedure. We reviewed all patients presenting to our tertiary centre with a STEMI undergoing primary or rescue percutaneous coronary intervention (PCI) from July 2010 until December 2018. We identified...
Source: Heart and Vessels - September 3, 2019 Category: Cardiology Source Type: research

Small and intermediate Ca 2+ -sensitive K + channels do not play a role in vascular conductance during resting blood flow in the anaesthetised pig
AbstractFlow-induced dilation in resistance arteries is mediated by endothelium-dependent hyperpolarisation via small and intermediate conducting Ca2+ sensitive K+ channels. The aim of the current study was to assess the effect of blocking both channels, using the toxins apamin and charybdotoxin, on flow-induced dilation in a conduit artery and vascular conductance. Experiments were carried out on the iliac and its vascular bed in anaesthetised pigs (n = 4). Flow-induced dilation and vascular conductance (∆F/ ∆P) were assessed before and after administration of toxins intra-arterially (i.a.) at 50  &micr...
Source: Heart and Vessels - August 31, 2019 Category: Cardiology Source Type: research

Endothelial dysfunction and glycocalyx shedding in heart failure: insights from patients receiving cardiac resynchronisation therapy
AbstractTo determine (a) whether chronic heart failure with reduced ejection fraction (HFrEF) is associated with increased glycocalyx shedding; (b) whether glycocalyx shedding in HFrEF with left ventricular dyssynchrony is related to inflammation, endothelial dysfunction and/or redox stress and is ameliorated by cardiac resynchronisation therapy. Glycocalyx shedding has been reported to be increased in heart failure and is a marker of increased mortality. Its role in dyssynchronous systolic heart failure and the effects of cardiac resynchronisation therapy (CRT) are largely unknown. Twenty-six patients with dyssynchronous ...
Source: Heart and Vessels - August 27, 2019 Category: Cardiology Source Type: research

Major cardiovascular and bleeding events with long-term use of aspirin in patients with prior cardiovascular diseases: 1-year follow-up results from the Management of Aspirin-induced Gastrointestinal Complications (MAGIC) study
This study was conducted to clarify CV and bleeding events in Japanese aspirin users with a history of CV diseases. This study was a prospective, nationwide, multicenter cooperative registry of Japanese patients with CV diseases at risk of thromboembolism who were taking aspirin (75–325 mg) for at least 1 year. We observed major CV and bleeding events during follow-up. Patients with history of ischemic stroke (IS), transient ischemic attack (TIA), coronary artery disease (CAD), atrial fibrillation (AF), and venous thromboembolism (VTE) were included and analyzed in this sutdy. CV events included IS, TIA, CA...
Source: Heart and Vessels - August 24, 2019 Category: Cardiology Source Type: research

Clinically feasible method for assessing leukocyte rheology in whole blood
In conclusion we have developed a clinically feasible method for assessing leukocyte rheological activation in whole blood in ex vivo. (Source: Heart and Vessels)
Source: Heart and Vessels - August 23, 2019 Category: Cardiology Source Type: research

Clinical impact of improvement in the ankle –brachial index after endovascular therapy for peripheral arterial disease
AbstractPredictive ability of changes in the ankle –brachial index (ABI) after revascularization for long-term clinical outcomes remains unclear. Pre- and postprocedural ABI were recorded for 1307 consecutive patients who underwent their first successful EVT for symptomatic aortoiliac (n = 710) or femoropopliteal (n = 597) lesions. The patients were divided into two groups according to the increase in ABI: ∆ABI ≥ 0.15 (n = 980) and ∆ABI 
Source: Heart and Vessels - August 23, 2019 Category: Cardiology Source Type: research

The P wave morphology in lead V7 on the synthesized 18-lead ECG is a useful parameter for identifying arrhythmias originating from the right inferior pulmonary vein
This study evaluated the utility of the synthesized 18-lead ECG to differentiate atrial arrhythmias originating from 3 adjacent structures. Synthesized 18-lead ECGs were obtained during SVC-, RSPV-, and RIPV-pacing in 20 patients with lone paroxysmal atrial fibrillation to develop an algorithm. The P-wave morphologies were classified into 4 patterns: positive, negative, biphasic, and isoelectric. Subsequently, the algorithm ’s accuracy was validated prospectively in another 40 patients. In retrospective analyses, isoelectric P-waves in synthesized V7 distinguished RIPV-pacing from the others (sensitivity =&thi...
Source: Heart and Vessels - August 22, 2019 Category: Cardiology Source Type: research

Adjustment of CT-fractional flow reserve based on fluid –structure interaction underestimation to minimize 1-year cardiac events
AbstractThe purpose of the study was to evaluate the optimal cut-off value of CT-Fractional Flow Reserve (CT-FFR) using fluid –structure interaction and how to adjust the CT-FFR’s underestimation from a standpoint of minimize 1-year cardiac events. Subjects were 38 cases with 44 vessels in which stenosis of 30–90% was detected using one-rotation scanning by 320-row coronary CT angiography (CCTA) and invasive FFR (i-F FR) was performed within subsequent 90 days. CT-FFR was calculated using on-site from the multiple cardiac phases. A hypothetical 1-year cardiac event incidence was estimated using previ...
Source: Heart and Vessels - August 7, 2019 Category: Cardiology Source Type: research

High Fib4 index in patients with suspected NASH is associated with elevation of chymase-dependent angiotensin II-forming activity in circulating mononuclear leucocytes
This study investigated the association between CML chymase dAIIFA and NASH. Cardiovascular outpatients were recruited and the Fib4 index (F4I) was calculated. Patients with an F4I  >  2.67 were classified into the high F4I group and these patients were strongly suspected to have NASH, while patients with an F4I 
Source: Heart and Vessels - August 6, 2019 Category: Cardiology Source Type: research

Correction to: Clinical risk factors of stroke and major bleeding in patients with non-valvular atrial fibrillation under rivaroxaban: the EXPAND Study sub-analysis
In the original publication of the article, the Figure  2b and the Tables 2 and 3 were published incorrectly. The corrected figure and tables are provided below. (Source: Heart and Vessels)
Source: Heart and Vessels - August 2, 2019 Category: Cardiology Source Type: research

Relationship between circulating levels of angiotensin-converting enzyme 2-angiotensin-(1 –7)-MAS axis and coronary heart disease
AbstractAs a counter-regulatory arm of the renin angiotensin system (RAS), the angiotensin-converting enzyme 2-angiotensin-(1 –7)-MAS axis (ACE2-Ang-(1–7)-MAS axis) plays a protective role in cardiovascular diseases. However, the link between circulating levels of ACE2-Ang-(1–7)-Mas axis and coronary atherosclerosis in humans is not determined. The object of present study was to investigate the association of circula ting levels of ACE2, Ang-(1–7) and Ang-(1–9) with coronary heart disease (CHD) defined by coronary angiography (CAG). 275 patients who were referred to CAG for the evaluation of s...
Source: Heart and Vessels - July 29, 2019 Category: Cardiology Source Type: research

Association between left atrial reverse remodeling and maintenance of sinus rhythm after catheter ablation of persistent atrial fibrillation
AbstractThe success rate of catheter ablation of persistent atrial fibrillation (AF) is not satisfactory, for reasons that are unclear. The purpose of this study was to examine the relationship between left atrial reverse remodeling after ablation and recurrence of AF in patients with persistent AF. One hundred and thirty-two patients with persistent AF were enrolled. Extensive encircling pulmonary vein isolation plus ablation of complex fractionated atrial electrograms was performed. Bepridil or amiodarone was prescribed for 3  months after ablation. All patients were studied by serial echocardiography and 24-h ambul...
Source: Heart and Vessels - July 25, 2019 Category: Cardiology Source Type: research

The impact of kidney dysfunction categorized by urinary to serum creatinine ratio on clinical outcomes in patients with heart failure
AbstractKidney dysfunction (KD) is closely associated with poor clinical outcome in patients with heart failure (HF). KD is classified as intrinsic and pre-renal KD. However, the impact of each KD on the clinical outcome in patients with HF has not yet been fully elucidated. We measured the urinary to serum creatinine (UC/SC) ratio, a marker for intrinsic and pre-renal KD, in 1009 consecutive patients with HF at admission. There were 314 cardio-renal events including HF and advanced end-stage renal dysfunction during the median follow-up period of 1154  days. There were 63 (6%) patients with intrinsic KD (UC/SC ratio&...
Source: Heart and Vessels - July 22, 2019 Category: Cardiology Source Type: research

Significant impact of left ventricular assist device models on the value of flow-mediated dilation: effects of LVAD on endothelial function
We examined the impact of changes in hemodynamic state using LVAD on endothelial function. We measured flow-mediated vasodilation (FMD) to evaluate endothelial vasodilator function of the brachial artery in 53 patients (dilated cardiomyopathy: 39, ischemic cardiomyopathy: 4, and others: 10) with an implanted LVAD (DuraHeart, EVAHEART, or HeartMate II). We found that FMD value in the HeartMateII LVAD group (9.3%  ± 2.9%) was significantly higher than those in the other two groups (EVAHEART: 6.7% ± 2.8% and DuraHeart: 6.2% ± 4.0%). Other factors that affected the...
Source: Heart and Vessels - July 20, 2019 Category: Cardiology Source Type: research

Measurements of liver stiffness in patients with left ventricular assist devices
(Source: Heart and Vessels)
Source: Heart and Vessels - July 19, 2019 Category: Cardiology Source Type: research

Early palliative balloon pulmonary valvuloplasty in neonates and young infants with tetralogy of Fallot
AbstractWe aim to clarify the efficacy of early palliative balloon pulmonary valvuloplasty (BPV) in neonates and young infants (
Source: Heart and Vessels - July 13, 2019 Category: Cardiology Source Type: research

Correction to: The potential of cardiac rehabilitation as a method of suppressing abdominal aortic aneurysm expansion: a pilot study
In the original publication of the article, under the result section. (Source: Heart and Vessels)
Source: Heart and Vessels - July 11, 2019 Category: Cardiology Source Type: research

Circulatory dynamics changes are an additional predictor of successful pulmonary vein isolation during cryoballoon ablation
AbstractThe association between circulatory dynamics changes during cryoballoon applications and a successful pulmonary vein isolation (PVI) is unknown. Seventy atrial fibrillation patients who underwent PVI with 28-mm second-generation cryoballoons and single 3-min freezes were included. Intra-procedural parameters including circulatory dynamics changes during cryoapplications, were compared between 113 successful applications (30 left superior PVs[LSPVs], 30 left inferior PVs[LIPVs], 25 right superior PVs[RSPVs], and 28 right inferior PVs[RIPVs]) and 47 failed applications (10 LSPVs, 9 LIPVs, 8 RSPVs, and 20 RIPVs). In a...
Source: Heart and Vessels - July 11, 2019 Category: Cardiology Source Type: research

Investigation of arterial –cardiac–pulmonary interaction
This study investigated 55 consecutive subjects not suffering from pulmonary, vascular and cardiac disease who underwent health screening test at our medical center. First, the presence of atherosclerotic disease (hypertension, dyslipidemia and diabetes) and smoking status of the patients were determined. Next, pulmonary function test, vascular function test including cardio-ankle vascular index, and echocardiography were performed. Then, we examined the correlation among the pulm onary, vascular and the heart. Our results revealed many correlations among these three factors. Especially left atrial dimension (LAD) andE/A r...
Source: Heart and Vessels - July 10, 2019 Category: Cardiology Source Type: research

Real-world survival data of device-related thrombus following left atrial appendage closure: 4-year experience from a single center
This study aimed to estimate the incidence and risk factors of device-related thrombus (DRT) following percutaneous left atrial appendage closure (LAAC) in real-world practices. Between February 2012 and December 2016, 319 consecutive patients with atrial fibrillation underwent percutaneous LAAC using WATCHMAN, WATCHMAN Flx, Amplatzer cardiac plug, and Amulet devices. All patients underwent transesophageal echocardiography (TEE) at a minimum of three time points; periprocedurally, at 45  days, and at 6 months. Other clinical parameters were also evaluated, and a comparison between patients with DRT and those not ...
Source: Heart and Vessels - July 10, 2019 Category: Cardiology Source Type: research

Impacts of the body size on the left atrial wall thickness and atrial fibrillation recurrence after catheter ablation
AbstractThe increased body size correlates with the occurrence of atrial fibrillation (AF); however, the impact of the body size on the AF recurrence after ablation remains unclear. We enrolled 283 AF patients (179 paroxysmal, 51 persistent, and 53 long-standing persistent) who received ablation and assessed the correlation between the body surface area (BSA) and the AF recurrence. Furthermore, we measured the left atrial wall thickness using computed tomography. During the 12-month follow-up period, the AF freedom rates for patients with paroxysmal AF, persistent AF, and long-standing persistent AF were 83%, 76%, and 77%,...
Source: Heart and Vessels - July 10, 2019 Category: Cardiology Source Type: research

Comparison of mid-term clinical outcomes after acute myocardial infarction in diabetic men between living alone and living together
In conclusion, living alone was significantly associated with the mid-term MACE after AMI in diabetic men. It may be important to provide multiple interventions including lifestyle guidance as well as sufficient acute medical care for such high-risk p atients. (Source: Heart and Vessels)
Source: Heart and Vessels - July 10, 2019 Category: Cardiology Source Type: research

Regional layer-specific longitudinal peak systolic strain using exercise stress two-dimensional speckle-tracking echocardiography for the detection of functionally significant coronary artery disease
AbstractThe present study aimed to investigate whether layer-specific regional peak-systolic longitudinal strain (LS) measurement on transthoracic echocardiogram (TTE) with exercise stress can be useful for the detection of functionally significant coronary artery disease as confirmed by invasive fractional flow reserve (FFR) in stable patients. This is a prospective analysis of 88 coronary arteries in 30 stable patients undergoing invasive FFR measurement and ergometer exercise stress TTE. Regional LS in the mid, endocardial and epicardial layers was calculated at rest, peak stress and early and late recovery phases after...
Source: Heart and Vessels - July 10, 2019 Category: Cardiology Source Type: research

Importance of sympathetic nervous system activity during left ventricular functional recovery and its association with in-hospital complications in Takotsubo syndrome
AbstractThe relationship between activation of the sympathetic nervous system (SNS) and improvement of left ventricular (LV) function and how this correlates with clinical outcomes are not fully explored in Takotsubo syndrome (TS). The purpose of this study is to evaluate the relationship between activation of the SNS and LV function improvement and how this correlates with clinical outcomes in TS. Patients with TS were retrospectively identified. Patients were divided into two groups according to the timing of LV function improvement:  
Source: Heart and Vessels - July 10, 2019 Category: Cardiology Source Type: research

Obstructive sleep apnea is associated with increased coronary plaque instability: an optical frequency domain imaging study
AbstractObstructive sleep apnea (OSA) is associated with coronary artery disease (CAD) and with an increased risk for myocardial infarction, stroke or death due to cardiovascular disease. Optical frequency-domain imaging (OFDI) is a useful modality for evaluating the characteristics of atherosclerotic plaque. The purpose of the study was to use OFDI to investigate the association of OSA with coronary plaque characteristics in patients undergoing percutaneous coronary intervention (PCI). We retrospectively analyzed OFDI data for coronary artery plaques from 15 patients with OSA and 35 non –OSA patients treated between...
Source: Heart and Vessels - July 10, 2019 Category: Cardiology Source Type: research

Linc00299/miR-490-3p/AURKA axis regulates cell growth and migration in atherosclerosis
AbstractLong non-coding RNA (lncRNA) plays a crucial role in regulating various cellular processes in atherosclerosis. The present study identified the regulation of Linc00299, via miR-490-3p targeting Aurora kinase A (AURKA), on migration and proliferation of endothelial cells and vascular smooth muscle cells (VSMCs) during atherosclerosis. The expression of RNAs was assessed by real-time PCR. The proliferation, apoptosis and migration were detected using MTT assay, Annexin V/PI staining and Transwell system, respectively. Bindings of Linc00299/miR-490-3p and subsequent miR-490-3p/AURKA were verified by luciferase and bio...
Source: Heart and Vessels - July 10, 2019 Category: Cardiology Source Type: research

Liraglutide suppresses atrial electrophysiological changes
In this study, we evaluated the effect of liraglutide (a GLP-1 analog) on atrial electrophysiological changes using the same canine AF model. We established a canine AF model using continuous 3-week rapid atrial stimulation in seven beagle dogs divided into two groups: a liraglutide group with four dogs (3-week atrial pacing with liraglutide (150  µg/kg/day) administration) and a pacing control group with three dogs (3-week pacing without any medicine). We evaluated the atrial effective refractory period (AERP), conduction velocity (CV), and AF inducibility every week during the protocol using implanted epicardi...
Source: Heart and Vessels - July 10, 2019 Category: Cardiology Source Type: research

Cell salvage processing of residual cardiopulmonary bypass volume in minimally invasive cardiac surgery
AbstractSeveral reports demonstrated positive effects of processing residual cardiopulmonary bypass volume using a cell salvage device in conventional open heart surgery via sternotomy on hemostasis. The present study aimed to investigate whether cell salvage processing has the same effects on postoperative blood loss and transfusion in minimally invasive cardiac surgery. Between July 2015 and April 2018, 80 consecutive patients undergoing minimally invasive aortic valve replacement via right anterolateral minithoracotomy were enrolled in the present study. Perioperative outcomes and coagulation data of 40 patients who wer...
Source: Heart and Vessels - July 10, 2019 Category: Cardiology Source Type: research

Assessment of strut coverage of everolimus-eluting platinum chromium stent 2 weeks after implantation by optical coherence tomography
AbstractThe SYNERGY coronary stent is new-generation drug-eluting stents, which has a thin-strut platinum –chromium platform with everolimus in a biodegradable polymer applied to the abluminal surface. It would be speculated that favorable arterial healing with early strut coverage could be achieved. The present study investigated the degree of strut coverage using optical coherence tomography (OCT) 2  weeks after SYNERGY implantation and clinical factors contributing to strut coverage. A total of 29 patients who underwent staged percutaneous coronary intervention (PCI) to residual lesions 2 weeks after the...
Source: Heart and Vessels - July 10, 2019 Category: Cardiology Source Type: research

C1 esterase inhibitor in pediatric cardiac surgery with cardiopulmonary bypass plays a vital role in activation of the complement system
This study proposes the administration of C1-inh is an effective therapy to reduce the activation and improve the clinical capillary leak syndrome. (Source: Heart and Vessels)
Source: Heart and Vessels - July 5, 2019 Category: Cardiology Source Type: research

Associations of left ventricular shape with left ventricular volumes and functions assessed by ECG-gated SPECT in patients without significant perfusion abnormality
AbstractLeft ventricular (LV) remodeling often results from conditions with an elevated LV hemodynamic load or after myocardial infarction. The present study was undertaken to investigate the associations of LV shape with LV volumes and functions in patients without significant perfusion abnormality. One hundred and sixty-seven patients without significant perfusion abnormality on ECG-gated SPECT were enrolled. LV ejection fraction (LVEF) was obtained for assessing LV systolic function. Peak filling rate (PFR) and one-third mean filling rate (1/3 MFR) were obtained for assessing LV diastolic function. LV shape index (LVSI)...
Source: Heart and Vessels - July 2, 2019 Category: Cardiology Source Type: research

Sequential coronary bifurcation revascularization with the Xposition S ™ self-apposing stent: a comparative fractal bench study
AbstractCoronary bifurcation revascularization needs to take account of the diameter differential between vessels and to limit side-branch obstruction (SBO). The self-apposing properties of theXposition S ™ stent (STENTYS, France) seem interesting in this regard. The present experimental fractal bench study determined the best provisional stenting technique usingXposition S ™. Three sequential strategies were compared (n = 5/group): implantation alone, side-branch inflation (SBI), and re-POT (initial proximal optimization technique (POT) + SBI + final POT). 2D- and 3D-O...
Source: Heart and Vessels - June 27, 2019 Category: Cardiology Source Type: research

Pericardiectomy for constrictive pericarditis: a risk factor analysis for early and late failure
AbstractPredictors of early and late failure of pericardiectomy for constrictive pericarditis (CP) have not been established. Early and late outcomes of a cumulative series of 81 (mean age 60  years; mean EuroSCORE II, 3.3%) consecutive patients from three European cardiac surgery centers were reviewed. Predictors of a combined endpoint comprising in-hospital death or major complications (including multiple transfusion) were identified with binary logistic regression. Non-parametric est imates of survival were obtained with the Kaplan–Meier method. Predictors of poor late outcomes were established using Cox prop...
Source: Heart and Vessels - June 24, 2019 Category: Cardiology Source Type: research

Occurrence of right ventricular dysfunction immediately after pericardiocentesis
This study was performed to assess RV and LV function with echocardiography before and after pericardiocentesis. In total, 19 consecutive patients who underwent pericardiocentesis for more than moderate pericardial effusion were prospectively enrolled from August 2015 to October 2017. Comprehensive transthoracic echocardiography was performed before, immediately after (within 3  h), and 1 day after pericardiocentesis to investigate the changes in RV and LV function. The mean age of all patients was 72.6 ± 12.2 years. No pericardiocentesis-related complications occurred during the procedu...
Source: Heart and Vessels - June 22, 2019 Category: Cardiology Source Type: research

Clinical characteristics of patients with sustained ventricular arrhythmias after sacubitril/valsartan initiation
AbstractOur aim was to describe the clinical profile of patients presenting sustained ventricular arrhythmias after sacubitril/valsartan (SV) initiation. All cases of sustained ventricular arrhythmias in patients receiving SV were consecutively recorded in two centers. Nineteen patients had sustained ventricular arrhythmias after SV. All were men and were previously receiving angiotensin-converting enzyme inhibitors, or angiotensin II receptor blockers before SV initiation. Fifteen patients (78.9%) had electrical stability in the previous 6  months. Nine patients (47.4%) initiated SV at the lowest available dose (24/2...
Source: Heart and Vessels - June 22, 2019 Category: Cardiology Source Type: research

Predictors of responders for low-dose carperitide monotherapy in patients with acute heart failure
AbstractHuman atrial natriuretic peptide, known as carperitide, is approved for early relief of dyspnea in patients with acute heart failure (AHF). However, the diuretic effect of carperitide is sometimes insufficient for controlling volume overload. We investigated predictors for the carperitide response in patients with AHF. Forty-seven patients (age: 74  ± 10 years; left ventricular ejection fraction: 42.0% ± 15.9%) with AHF were enrolled and treated with carperitide monotherapy at a dose of 0.0125 μg/kg/min. Patients without sufficient diuresis (
Source: Heart and Vessels - June 21, 2019 Category: Cardiology Source Type: research

Effect of cigarette smoking on carotid artery atherosclerosis: a community-based cohort study
AbstractCigarette smoking is closely associated with the development of cardiovascular diseases. However, the relationship between cigarette smoking and subclinical atherosclerosis has not been fully studied. We sought to clarify the association between cigarette smoking and carotid intima-media thickness (cIMT) in a general Japanese population. Among 1,209 participants who received a medical check-up with cardiovascular examination at our institution, 450 participants (37.2%) were smokers (including both past and current smokers). We evaluated cIMT as a marker of subclinical atherosclerosis. The value of cIMT and rate of ...
Source: Heart and Vessels - June 20, 2019 Category: Cardiology Source Type: research

Regulation mechanism of aquaporin 9 gene on inflammatory response and cardiac function in rats with myocardial infarction through extracellular signal-regulated kinase1/2 pathway
AbstractThe aim of this study was to investigate the regulation mechanism of aquaporin 9 (AQP9) gene on inflammatory response and cardiac function in rats with myocardial infarction (MI) through extracellular signal-regulated kinase1/2 (ERK1/2) pathway. The constructed rats models of MI were randomly divided into 6 groups: control group (sham operation group, MI modeling sham operation), model group (MI modeling), NC group (MI modeling, tail vein injection of AQP9 negative control sequence vector), AQP9 shRNA group (MI modeling, tail vein injection of AQP9 shRNA plasmid vector), U0126 group (MI modeling, tail vein injectio...
Source: Heart and Vessels - June 19, 2019 Category: Cardiology Source Type: research

Effect of drug-coated balloon angioplasty on in-stent restenotic coronary lesions analyzed with optical coherence tomography and serial coronary artery angioscopy
This study aimed to determine the efficacy and mechanism of the DCBA using imaging studies both immediately after the DCBA and during the follow-up period. We enrolled 15 consecutive patients who underwent DCBA for in-stent restenosis (ISR). The in-stent neointimal volume was evaluated using optical coherence tomography (OCT), and the in-stent yellow grade was assessed using coronary angioscopy (CAS) immediately after DCBA and during the median follow-up period of 9 (8 –15) months. The neointimal volume was significantly reduced from 77.1 ± 36.2 mm3 at baseline to 60.2  ±&...
Source: Heart and Vessels - June 15, 2019 Category: Cardiology Source Type: research