Time-dependent changes in P2Y12 reaction unit values for predicting the different types of cardiovascular events in patients with ischemic heart disease
This study aimed to investigate the optimal cut-off and predictive ability of the PRU value for predicting cardiovascular events, while considering different endpoints and observation periods. We surveyed a total of 338 patients receiving P2Y12 inhibitors and measured PRU during cardiac catheterization. Using time-dependent receiver operating characteristic analysis, we evaluated the cut-off and area under curve (AUC) of the PRU value for two MACEs (MACE ①: composite of death, myocardial infarction, stent thrombosis, and cerebral infarction; MACE ②: composite of MACE ① and target vessel revascularization) at 6, 12, 2...
Source: Heart and Vessels - September 12, 2023 Category: Cardiology Source Type: research
Fibromuscular dysplasia of the brachial artery in patients with spontaneous coronary artery dissection: a case series and literature review
AbstractSpontaneous coronary artery dissection (SCAD) is diagnosed in a very small percentage of patients with suspected acute coronary syndromes who undergo emergency coronary angiography. Although fibromuscular dysplasia (FMD) is known to coexist in patients with SCAD, the vascular sites of FMD and their frequency have not yet been clarified. We retrospectively reviewed the medical records of 16 patients who were diagnosed with and treated for SCAD at our hospital between 1 January 2011 and 31 January 2023. We have summarized their baseline and clinical characteristics and medical variables, including coronary and upper ...
Source: Heart and Vessels - September 12, 2023 Category: Cardiology Source Type: research
Perspectives of hospitalized heart failure patients: preferred and perceived participation roles in treatment decisions
AbstractShared decision-making (SDM) is a pivotal process in seeking optimal individual treatment and incorporating clinical evidence and patients ’ autonomous preferences. However, patients’ actual attitudes toward participation in decision-making for state-of-the-art heart failure (HF) treatment remain unclear. We conducted a questionnaire-based survey distributed by nurses and physicians specializing in HF care to assess patients’ pre ferred and perceived participation roles in treatment decision-making during the index hospitalization, rated on five scales (from extremely passive to purely autonomous attitudes). ...
Source: Heart and Vessels - September 12, 2023 Category: Cardiology Source Type: research
Feasibility of rotational atherectomy in patients with acute coronary syndrome: favorable in-hospital outcomes and clinical importance of complexed coronary atherosclerosis
AbstractThe feasibility of rotational atherectomy (RA) during percutaneous coronary intervention (PCI) in patients who present with acute coronary syndrome (ACS) remains fully unsettled. We retrospectively evaluated 198 consecutive patients who underwent RA during PCI from 2009 to 2020. All patients underwent intracoronary imaging (intravascular ultrasound 96.5%, optical coherence tomography 9.1%, both 5.6%) during PCI. Patients who underwent RA during PCI were divided into two groups: ACS (n = 49; unstable angina pectoris,n = 27; non-ST-elevation myocardial infarction,n = 18, and ST-elevation myocardial infarc...
Source: Heart and Vessels - September 12, 2023 Category: Cardiology Source Type: research
Effect of dapagliflozin on ventricular repolarization in patients with heart failure with reduced ejection fraction
AbstractWhether sodium –glucose cotransporter-2 inhibitors (SGLT2is) reduce ventricular arrhythmias and sudden cardiac death is controversial. Ventricular repolarization heterogeneity is associated with ventricular arrhythmias; however, the effect of SGLT2is on ventricular repolarization in patients with heart failure w ith reduced ejection fraction (HFrEF) has not been fully investigated. We prospectively evaluated 31 HFrEF patients in sinus rhythm who were newly started on dapagliflozin 10 mg/day. Changes in QT interval, corrected QT interval (QTc), QT dispersion (QTD), corrected QTD (QTcD), T peak to T end (TpT e), T...
Source: Heart and Vessels - September 12, 2023 Category: Cardiology Source Type: research
Cardiovascular risk assessments in patients with cortisol-producing adenoma: impact of clinical features and genetic characteristics
AbstractThe causes of adrenal Cushing ’s syndrome (CS) encompass a wide spectrum of adrenal cortisol proliferations that exhibit clinical and molecular heterogeneity. The aims of our study were to investigate whether clinical and molecular heterogeneity influences endothelial function and metabolic abnormalities in patients with corti sol-producing adenoma (CPA). We retrospectively enrolled 25 patients with CPA and 45 patients with essential hypertension (EH). All CPAs were studied by direct sequencing ofPRKACA. Flow-mediated vasodilation (FMD), an index of vascular endothelial function, was significantly lower in CS and...
Source: Heart and Vessels - September 11, 2023 Category: Cardiology Source Type: research
Timing of prescription of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers in patients hospitalized for acute heart failure with reduced/mildly reduced ejection fraction: a retrospective analysis
AbstractAlthough angiotensin-converting enzyme inhibitors (ACEis) and angiotensin II receptor blockers (ARBs) play critical roles in the treatment of heart failure with reduced or mildly reduced ejection fraction (HFrEF/HFmrEF; left-ventricular ejection fraction ≤ 50%), the ideal timing for initiation in patients with acute heart failure (AHF) is unclear. We sought to clarify the timing and safety of ACEi/ARB prescription relative to hemodynamic stabilization (pre or post) in patients hospitalized with acute HFrEF/HFmrEF. This was a retrospective, ob servational analysis of electronic data of patients hospitalized f...
Source: Heart and Vessels - September 11, 2023 Category: Cardiology Source Type: research
Cardiovascular risk assessments in patients with cortisol-producing adenoma: impact of clinical features and genetic characteristics
AbstractThe causes of adrenal Cushing ’s syndrome (CS) encompass a wide spectrum of adrenal cortisol proliferations that exhibit clinical and molecular heterogeneity. The aims of our study were to investigate whether clinical and molecular heterogeneity influences endothelial function and metabolic abnormalities in patients with corti sol-producing adenoma (CPA). We retrospectively enrolled 25 patients with CPA and 45 patients with essential hypertension (EH). All CPAs were studied by direct sequencing ofPRKACA. Flow-mediated vasodilation (FMD), an index of vascular endothelial function, was significantly lower in CS and...
Source: Heart and Vessels - September 11, 2023 Category: Cardiology Source Type: research
Timing of prescription of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers in patients hospitalized for acute heart failure with reduced/mildly reduced ejection fraction: a retrospective analysis
AbstractAlthough angiotensin-converting enzyme inhibitors (ACEis) and angiotensin II receptor blockers (ARBs) play critical roles in the treatment of heart failure with reduced or mildly reduced ejection fraction (HFrEF/HFmrEF; left-ventricular ejection fraction ≤ 50%), the ideal timing for initiation in patients with acute heart failure (AHF) is unclear. We sought to clarify the timing and safety of ACEi/ARB prescription relative to hemodynamic stabilization (pre or post) in patients hospitalized with acute HFrEF/HFmrEF. This was a retrospective, ob servational analysis of electronic data of patients hospitalized f...
Source: Heart and Vessels - September 11, 2023 Category: Cardiology Source Type: research
Circulating level of β-aminoisobutyric acid (BAIBA), a novel myokine-like molecule, is inversely associated with fat mass in patients with heart failure
In conclusion, plasma BAIBA concentration is inversely correlated with indexes of fat mass, indicating that BAIBA may be a therapeutic target for excessive fat accumulation. (Source: Heart and Vessels)
Source: Heart and Vessels - September 3, 2023 Category: Cardiology Source Type: research
Clinical outcome of endovascular therapy using a VIABAHN VBX-covered stent for complex aortoiliac artery disease: the AVOCADO II study
AbstractClinical trials have demonstrated the efficacy of a balloon-expandable covered stent (CS) for aortoiliac occlusive disease (AIOD). However, the real-world clinical outcomes and the underlying factors remain unclear. We assessed the clinical outcomes and factors associated with primary patency after implantation of a balloon-expandable CS for patients with complex AIOD. This prospective multicenter observational study enrolled 149 consecutive patients undergoing VIABAHN® VBX-CS (W.L. Gore& Associates, Flagstaff, AZ) implantation for complex AIOD (age, 74 ± 9 years; male, 74%; diabetes mellitus, 46%; rena...
Source: Heart and Vessels - August 29, 2023 Category: Cardiology Source Type: research
Perspectives of hospitalized heart failure patients: preferred and perceived participation roles in treatment decisions
AbstractShared decision-making (SDM) is a pivotal process in seeking optimal individual treatment and incorporating clinical evidence and patients ’ autonomous preferences. However, patients’ actual attitudes toward participation in decision-making for state-of-the-art heart failure (HF) treatment remain unclear. We conducted a questionnaire-based survey distributed by nurses and physicians specializing in HF care to assess patients’ pre ferred and perceived participation roles in treatment decision-making during the index hospitalization, rated on five scales (from extremely passive to purely autonomous attitudes). ...
Source: Heart and Vessels - August 29, 2023 Category: Cardiology Source Type: research
Diagnostic accuracy of diastolic pressure ratio using a pressure microcatheter for intracoronary physiological assessment
In conclusion, dPRmicro measured using a microcatheter had good diagnostic accuracy and correlation with FFRmicro, hence, it can be useful for making revascularization decisions. However, re-studies in larger populations will be needed to better understand the properties of diastolic resting index measured using a microcatheter in clinical settings. (Source: Heart and Vessels)
Source: Heart and Vessels - August 26, 2023 Category: Cardiology Source Type: research
