Role of Vitamin D Supplementation in Prevention and Treatment of COVID-19
(Source: Indian Journal of Clinical Biochemistry)
Source: Indian Journal of Clinical Biochemistry - July 30, 2020 Category: Biochemistry Source Type: research

LAMP Assay: Could it be a Boon for the Molecular Diagnosis of COVID-19?
(Source: Indian Journal of Clinical Biochemistry)
Source: Indian Journal of Clinical Biochemistry - July 17, 2020 Category: Biochemistry Source Type: research

Fast Blue B Produces a Light Background on the Gel Surface
(Source: Indian Journal of Clinical Biochemistry)
Source: Indian Journal of Clinical Biochemistry - July 16, 2020 Category: Biochemistry Source Type: research

Curcumin and Coagulopathy in the COVID19 Era
(Source: Indian Journal of Clinical Biochemistry)
Source: Indian Journal of Clinical Biochemistry - July 15, 2020 Category: Biochemistry Source Type: research

Novel Stem Cells and Nucleic Acid-Based Vaccine Trials Against Viral Outbreak: A Systematic Evaluation During COVID-2019 Pandemic
AbstractThe current Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) outbreak, the cause of coronavirus disease (COVID-19), has influenced health globally. So far, there are no established management options and prophylaxis for those who have been exposed to SARS-CoV-2, and those who develop COVID-19. Documented scientific evidences in similar viral outbreaks in past suggested few therapy regimens. These rather have not shown promising results in management of current pandemic. So, in the current review, we are exploring novel treatment strategies and therapies that are being explored and are in clinical and pr...
Source: Indian Journal of Clinical Biochemistry - July 10, 2020 Category: Biochemistry Source Type: research

Obesity and COVID-19: A Fatal Alliance
AbstractMost people infected with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV2) are mildly symptomatic while few progress to critical illness and succumb to the infection. The disease severity is seen to be associated with increasing age and underlying comorbid conditions. Obesity, responsible for various metabolic disorders, appears to be a risk factor in determining the severity of infection despite any age group. Though this association is clinically relevant, the mechanisms underlying are not fully elucidated. SARS CoV2 enters host cell via Angiotensin Converting Enzyme 2 receptor, expression of which is ...
Source: Indian Journal of Clinical Biochemistry - July 10, 2020 Category: Biochemistry Source Type: research

Correlates of Metabolic Syndrome in Patients with Schizophrenia: An Exploratory Study
AbstractMetabolic syndrome (MS) is commonly reported in patients with severe mental illness including schizophrenia, but data is sparse from north-western India. The study was aimed to assess the metabolic profile in patients with schizophrenia. Patients with schizophrenia and healthy controls (N  = 55 in each group) were recruited from psychiatric outpatient clinic and evaluated for the presence of metabolic syndrome using the modified National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP-III) criteria. Prevalence of MS was significantly greater in patient group (34 .5%), compared to hea...
Source: Indian Journal of Clinical Biochemistry - July 6, 2020 Category: Biochemistry Source Type: research

IgA Monoclonal Gammopathy with Pseudohyperphosphatemia
We describe a case of IgA MG with pseudohyperphosphatemia. (Source: Indian Journal of Clinical Biochemistry)
Source: Indian Journal of Clinical Biochemistry - July 6, 2020 Category: Biochemistry Source Type: research

Sickle Cell Trait Presenting as Chronic Calcific Pancreatitis with Pseudocyst- A Case Report
We report a case of sickle cell trait presenting with chronic pancreatitis with pseudo cyst. USG abdomen and CT abdomen confirmed the diagnosis of chronic calcific pancreatitis with pseudocyst. Etiological work up for other causes did not reveal anything except sickle cell trait. This case represents a rare association between chronic calcific pancreatitis and sickle cell trait. (Source: Indian Journal of Clinical Biochemistry)
Source: Indian Journal of Clinical Biochemistry - July 1, 2020 Category: Biochemistry Source Type: research

COVID-19: Current Trends in Invitro Diagnostics
AbstractThe novel coronavirus SARS-CoV-2 is the seventh known species of coronavirus, infectious to human beings. The pandemic COVID-19 spread all over the world with an unprecedented spreading rate after its first appearance in Wuhan, China. As a novel viral disease there in no antiviral treatment or vaccine for the COVID-19. At present, the early detection and the quarantine of infected patients are the ways to stop the spreading of the disease. This review will discuss about the current invitro diagnostic methods used worldwide for the early and accurate diagnosis of COVID-19. Currently the nucleic acid based polymerase...
Source: Indian Journal of Clinical Biochemistry - June 27, 2020 Category: Biochemistry Source Type: research

Study on Urinary Candidate Metabolome for the Early Detection of Breast Cancer
In conclusion, the combination of three urinary metabolomes with serum CA15-3 improves the diagnost ic sensitivity of breast cancer. (Source: Indian Journal of Clinical Biochemistry)
Source: Indian Journal of Clinical Biochemistry - June 27, 2020 Category: Biochemistry Source Type: research

Analysis of Intrinsic and Extrinsic Coagulation Pathway Factors in OCP Treated PCOS Women
AbstractHuman polycystic ovary syndrome (PCOS) —a cluster of diseases displays various symptoms associated with endocrine and gynecological disorders in childbearing women. Oral contraceptive pills (OCP) being a drug of choice minimizes symptoms and complications associated with the disorder. But, the controversial data available in literature regarding use of OCPs compels us to setup a study design regarding effect of OCP treatment in PCOS subjects and the possible outcomes specifically regarding coagulation pathways. Two PCOS study groups have been selected according to Rotterdam Criteria: one with OCP treatment (n...
Source: Indian Journal of Clinical Biochemistry - June 17, 2020 Category: Biochemistry Source Type: research

Curcumin: a Wonder Drug as a Preventive Measure for COVID19 Management
(Source: Indian Journal of Clinical Biochemistry)
Source: Indian Journal of Clinical Biochemistry - June 17, 2020 Category: Biochemistry Source Type: research

Oral Nicotine Induces Oxidative Stress and Inflammation but Does Not Subvert Tumor Suppressor and DNA Repair Responses in Mice
In conclusion, treatment with nicotine caused oxidative stress and inflammation which can cause widespread cellular damage from the very onset of treatment, without subverting the tumor suppressor and DNA repair responses. (Source: Indian Journal of Clinical Biochemistry)
Source: Indian Journal of Clinical Biochemistry - June 13, 2020 Category: Biochemistry Source Type: research

Association of TCF7L2 rs7903146 Polymorphism with the Risk of Type 2 Diabetes Mellitus (T2DM) Among Kurdish Population in Erbil Province, Iraq
AbstractThe genetic predispositions responsible for developing type 2 diabetes mellitus (T2DM) in the Middle East are poorly understood. The rs7903146 single nucleotide polymorphism (SNP) located in transcription factor 7-like-2 (TCF7L2) gene has been recognized to have a vital role in the development of T2DM disorder. The current study is the first to have researched the possible association betweenTCF7L2 rs7903146 SNP and T2DM among Kurdish population in Kurdistan region of Iraq. The study included 212 participants, half of them were T2DM patients, and the other half were disease-free and normoglycemic controls. Genotypi...
Source: Indian Journal of Clinical Biochemistry - June 13, 2020 Category: Biochemistry Source Type: research

Role of Oncofetal Protein CR-1 as a  Potential Tumor Marker for Oral Squamous Cell Carcinoma
AbstractCripto-1 (CR-1) is an oncofetal protein with its role as a key factor in early process of carcinoma has been evaluated in cases of various cancers. However, very few studies have reported its role in oral cancer, which is the sixth most common cancer around the world, particularly with high prevalence in developing countries. Oral squamous cell carcinoma (OSCC) is the most predominant (90%) of all the histological types of oral cancer. Late detection, associated with increased morbidity and mortality, is mainly attributed to non-availability of a suitable biomarker for the disease. In the present pilot study, we ha...
Source: Indian Journal of Clinical Biochemistry - June 12, 2020 Category: Biochemistry Source Type: research

Hydroxychloroquine and Covid-19: A Cellular and Molecular Biology Based Update
AbstractAs the time for finding a definitive and safe cure as a vaccine for novel Corona Virus Disease 2019 (Covid-19) is still far, there is need to study in depth about the other potential drugs, which can save millions of lives due to Covid-19 pandemic. Right at the center of the debate is the use of drug “Hydroxychloroquine” as a prophylaxis as well as a treatment strategy against Covid-19 in conjunction with azithromycin. In this review, we will study the cellular and molecular aspects of hydroxychloroquine, which had driven its use in Covid-19 patients, as well as its chemistry and pharmacokin etics along...
Source: Indian Journal of Clinical Biochemistry - June 10, 2020 Category: Biochemistry Source Type: research

COVID-19 Pandemic in India: What Lies Ahead-Letter to the Editor
(Source: Indian Journal of Clinical Biochemistry)
Source: Indian Journal of Clinical Biochemistry - June 10, 2020 Category: Biochemistry Source Type: research

Interpreting HbA1c in Presence of Deficiency Anemias
AbstractHbA1c is used extensively for the diagnosis and management of diabetes mellitus. It constitutes 80% of glycated HbA1(Glycated haemoglobin(GHb)A), and depends upon blood glucose and RBC life span. RBC life span varies with anemia, leading to a consequent alteration in the HbA1c value irrespective of the circulating blood glucose concentration. But to the best of our knowledge no Hb cut offs have been derived for appropriate interpretation of HbA1c. The prevalence of anemia in Indian population is nearly 40% as per its definition by WHO —Hb 
Source: Indian Journal of Clinical Biochemistry - June 8, 2020 Category: Biochemistry Source Type: research

Genetic Association of rs2237572 Cyclin-Dependent Kinase 6 Gene with Breast Cancer in Iraq
AbstractThis case –control study is aimed to evaluate serum concentration of Cyclin-Dependent Kinase 6 (CDK6) and the genetic association between rs2237572CDK6 gene and breast cancer (BC) in Iraq. To attain this goal, 80 patients with BC as cases and 80 healthy individuals as controls were included. Further, BC patients were sorted according to the molecular classification into four subtypes of Luminal A, Luminal B, Her2/neu enriched and TPN. Serum concentration of CDK6 enzyme, allelic and genotypic frequencies of rs2237572CDK6, and the occurrence of BC phenotype and its subtypes in the studied population were invest...
Source: Indian Journal of Clinical Biochemistry - June 8, 2020 Category: Biochemistry Source Type: research

Inflammation, Immunity and Immunogenetics in COVID-19: A Narrative Review
AbstractThe novel Coronavirus Disease 2019 (COVID-19), that began in Wuhan Province, China was labelled as an International Public Health Emergency on January 30, 2020 and later was declared a pandemic by the World Health Organisation (WHO) on March 11, 2020. The causative agent, SARS-CoV-2 was the third coronavirus responsible for causing major disease outbreaks in human population after Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) caused by SARS-CoV and MERS-CoV respectively. The patients of COVID-19 present with a clinical feature resembling mild form of viral pneumonia which in c...
Source: Indian Journal of Clinical Biochemistry - June 6, 2020 Category: Biochemistry Source Type: research

Hypovitaminosis D and COVID-19: Matter of Concern in India?
(Source: Indian Journal of Clinical Biochemistry)
Source: Indian Journal of Clinical Biochemistry - May 27, 2020 Category: Biochemistry Source Type: research

Acute Ischemic Stroke is Associated with Increased Serum Levels of Pro-inflammatory Cytokines
(Source: Indian Journal of Clinical Biochemistry)
Source: Indian Journal of Clinical Biochemistry - May 27, 2020 Category: Biochemistry Source Type: research

How to Design an Individualised QC Procedure: Journey Towards Quality Destination
(Source: Indian Journal of Clinical Biochemistry)
Source: Indian Journal of Clinical Biochemistry - May 27, 2020 Category: Biochemistry Source Type: research

Epigenetic Silencing of DAPK1 and p16 INK4a Genes by CpG Island Hypermethylation in Epithelial Ovarian Cancer Patients
AbstractTranscriptional silencing induced by hypermethylation of CpG islands in the promoter regions of genes is believed to be an important mechanism of carcinogenesis in human cancers including epithelial ovarian cancer (EOC). Previously published data on gene methylation of EOC focused mainly on single gene or on cancer tissues. Objectives of the study were to estimate the promoter hypermethylation status ofDAPK1 andp16INK4a genes in circulating blood of EOC patients and to determine their association with clinicopathological features of EOC. This case –control study included 50 EOC patients and 20 apparently heal...
Source: Indian Journal of Clinical Biochemistry - May 16, 2020 Category: Biochemistry Source Type: research

Pseudohyperkalemia in Serum and Plasma: The Phenomena and Its Clinical Implications
AbstractHyperkalemia is a life threatening electrolyte derangement that must be recognized and treated quickly. Pseudohyperkalemia is defined as a difference between serum and plasma potassium concentration of more than 0.4  meq/L with serum values on the higher side when both the samples are obtained at the same time, remain at room temperature and are tested within 1 h of sample collection. Given the implication of basing medical decisions on falsely elevated potassium levels, timely identification of the entity of pseudohyperkalemia and differentiating it from true hyperkalemia becomes utmost important. Here w...
Source: Indian Journal of Clinical Biochemistry - May 14, 2020 Category: Biochemistry Source Type: research

C677T MTHFR Gene Polymorphism is Contributing Factor in Development of Renal Impairment in Young Hypertensive Patients
AbstractHomocysteine concentration affected by the activities of the enzymes methylene tetra-hyrdofolate reductase (MTHFR). Polymorphisms inMTHFR gene associated with an impairment of MTHFR activity. Hyperhomocysteinemia is a result of single nucleotide polymorphisms (SNPs) inMTHFR 677 C>T that can cause homocysteine levels in the blood to increase. The purpose of this study is to investigate the relationships betweenMTHFR C677T (rs1801133) gene polymorphism, changes in homocysteine concentrations and progress of renal impairment in young adult hypertensive patients. Two hundred young hypertensive patients (age 21 &ndas...
Source: Indian Journal of Clinical Biochemistry - May 14, 2020 Category: Biochemistry Source Type: research

Hyperinsulinemia and Hypoadiponectinemia are Associated with Increased Risk for Occurrence of Ovarian Cancer in Non-diabetic Women of North Indian Population
AbstractOvarian cancer has been emerged as a most common and lethal gynecological malignancy in India. High serum insulin and low adiponectin have been associated with increased risk of ovarian cancer. But their role in development of ovarian cancer is conflicting and little evidence is available. We aimed to evaluate blood levels of insulin and adiponectin in epithelial ovarian cancer (EOC) patients and their association with the risk to develop EOC. The study included following three groups; Group 1: fifty cases of cytohistopathologically confirmed cases of EOC, Group 2: fifty age matched cases of benign ovarian conditio...
Source: Indian Journal of Clinical Biochemistry - May 13, 2020 Category: Biochemistry Source Type: research

COVID-19 Pandemic in India: What Lies Ahead
(Source: Indian Journal of Clinical Biochemistry)
Source: Indian Journal of Clinical Biochemistry - April 20, 2020 Category: Biochemistry Source Type: research

COVID 19 Outbreak: Potential of Biochemistry Speciality
(Source: Indian Journal of Clinical Biochemistry)
Source: Indian Journal of Clinical Biochemistry - April 18, 2020 Category: Biochemistry Source Type: research

Development and Troubleshooting in Lateral Flow Immunochromatography Assays
AbstractThe development of Lateral Flow Immunochromatography Assay can be divided into two levels; standardizing membrane characteristics and optimizing molecular level immunoassay reaction between analyte and detector molecules. In the preliminary phase the reaction specificity of capture and detector antibodies with the analyte has to be checked with other techniques like ELISA. Molarity and pH of conjugation buffer have prime importance in the immunoreaction among analyte and antibodies. Epitope mapping of the capture and detector antibodies is also recommended to confirm the specificity of the assay. Standardization of...
Source: Indian Journal of Clinical Biochemistry - April 17, 2020 Category: Biochemistry Source Type: research

Hypovitaminosis D Is Almost Universal with Negligible Vitamin D2 Levels in Population from Southern Coastal Andhra Pradesh
(Source: Indian Journal of Clinical Biochemistry)
Source: Indian Journal of Clinical Biochemistry - April 16, 2020 Category: Biochemistry Source Type: research

Prevalence of K-ras Codon 12 Mutations in Indian Patients with Head and Neck Cancer
AbstractIn human tumors, somatic mutation frequently occur inK-ras gene at codon 12, which makes theK-ras protein hyper active leading to uncontrolled signaling for cell division: one of the important hall mark of cancer. In order to correlate mutations inK-ras to cause, response to treatment, disease progression and recurrence of Head and Neck Squamous Cell Carcinoma (HNSCC) the following study was undertaken. By using PCR –RFLP method prevalence of codon 12 in K-ras gene was studied in 56 HNSCC patients. High frequency ofK-ras mutation was detected in codon 12 (60.71%). The result of this study helps us in understa...
Source: Indian Journal of Clinical Biochemistry - April 7, 2020 Category: Biochemistry Source Type: research

HLA Gene in 5 Cases of Liver Injury Related to Baikal Skullcap
AbstractHLA association with drug-induced liver injury has recently been pointed out about multiple medicines. The aim of this study was to evaluate relationship between HLA gene and liver injury related to Baikal skullcap-containing Kampo medicines (BSCK). We previously examined HLA genes in 3 cases of BSCK-induced liver injury. Recently we could encounter 2 cases diagnosed as “definitely-related case” of BSCK-induced liver injury. HLA genes of the 2 cases were analyzed by Sequencing Based Typing method with Next Generation Sequencer at HLA Laboratory in Kyoto. HLA-DPA1*02:02:02 and DPB1*05:01:01 were observed...
Source: Indian Journal of Clinical Biochemistry - April 7, 2020 Category: Biochemistry Source Type: research

Association of miRNA 30c, miRNA 181a and miRNA 570 SNPs with Bladder Cancer Risk in North Indian Population: A Pilot Study
AbstractmiRNA play role in post transcriptional regulation of genes and serves a range of biological functions such as initiation, development, metastasis etc. which are also hallmarks of cancer. Hence, we evaluated miRNA 181a, miRNA 30c and miRNA 570 in bladder cancer risk association among North Indians. miRNA 570 C/G (rs4143815), miRNA 30c A/G (rs928508) and miRNA 181a C/T (rs12537) single nucleotide polymorphisms (SNPs) were genotyped by allelic discrimination TaqMan assay in 100 bladder cancer (BC) patients and 100 healthy controls. No significant difference was found in the genotype frequencies of the candidate SNPs ...
Source: Indian Journal of Clinical Biochemistry - April 4, 2020 Category: Biochemistry Source Type: research

Association of Oxidative Stress with Disease Activity and Damage in Systemic Lupus Erythematosus: A Cross Sectional Study from a Tertiary Care Centre in Southern India
AbstractTo study oxidative stress in systemic lupus erythematosus (SLE) by estimating serum oxidised LDL (OxLDL), 8-hydroxy-2 ′-deoxyguanosine (8-OHdG), malondialdehyde (MDA), and total anti-oxidant status and to correlate with SLE disease activity and disease damage. Eighty SLE patients satisfying the Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) 2012 criteria and 80 hea lthy controls were studied. Exclusion criteria were infections, renal insufficiency, other connective tissue diseases, drug-induced lupus, smoking, alcohol consumption. Disease activity was measured ...
Source: Indian Journal of Clinical Biochemistry - March 24, 2020 Category: Biochemistry Source Type: research

Assessement of Blood Lead and Cadmium Levels in Occupationally Exposed Workers of Jodhpur, Rajasthan
AbstractIn spite of the established knowledge regarding their toxicities, occupational exposure to heavy metals like lead and cadmium still continues because of their wide distribution in environment. Due to lack of awareness, most of the workers usually eat, smoke, drink at their workplace which may aggravate the metal exposure. The present study was planned to assess the blood levels of lead and cadmium in occupationally exposed workers of Jodhpur (India). A total of 110 individuals working in different industrial set ups (furniture, metal handicraft, welders) of Jodhpur district (exposed group), aged between 20 and 60 &...
Source: Indian Journal of Clinical Biochemistry - March 14, 2020 Category: Biochemistry Source Type: research

Relationship of Brain-Derived Neurotrophic Factor with Interleukin-23, Testosterone and Disease Severity in Schizophrenia
The objective of the study was to assess the serum levels of brain derived neurotrophic factor (BDNF) and its association with interleukin-23 (IL-23), testosterone and disease severity in schizophrenia. 40 cases and 40 controls were included in the study. Serum levels of BDNF, IL-23 and testosterone were estimated in all the subjects. Disease severity was assessed using Positive and Negative Syndrome Scale (PANSS). The study was designed in Tertiary care hospital, South India. The results were compared between two groups using Mann –Whitney U test. Spearman Correlation analysis was used to assess the association betw...
Source: Indian Journal of Clinical Biochemistry - March 14, 2020 Category: Biochemistry Source Type: research

Therapeutic Targets in Telomerase and Telomere Biology of Cancers
AbstractTelomeres play an important role to conserve genomic integrity by protecting the ends of chromosomes in normal cells. Since, their progressive shortening during successive cell division which lead to chromosomal instability. Notably, telomere length is perpetuated by telomerase in large majority of cancers, thereby ensure indefinite cell proliferation-a hallmark of cancer-and this unique feature has provided telomerase as the preferred target for drug development in cancer therapeutics. Cancer cells have acquired the potential to have telomere length maintenance by telomerase activation- up-regulation of hTERT gene...
Source: Indian Journal of Clinical Biochemistry - March 10, 2020 Category: Biochemistry Source Type: research

Genetic Variant XRCC1 rs1799782 (C194T) and Risk of Cancer Susceptibility in Indian Population: A Meta-analysis of Case –Control Studies
AbstractX-ray repair cross-complementing group 1 (XRCC1) plays a key role in the base excision repair pathway, as a scaffold protein that brings together proteins of the DNA repair complex. Several studies have reported contradictory results forXRCC1 exon 6 C>T (rs1799782) gene polymorphism and cancer risk in Indian population has provided inconsistent results. Therefore, we have performed this meta-analysis to evaluate the relationship betweenXRCC1 exon 6 C>T gene polymorphism and risk of cancer by published studies. We searched PubMed and Google scholar web databases to cover all studies published on association be...
Source: Indian Journal of Clinical Biochemistry - March 2, 2020 Category: Biochemistry Source Type: research

Current Situation of Molecular Diagnostic Assay in Iran: Is it Necessary to Revise of Health Surveillance System at Laboratory Level?
(Source: Indian Journal of Clinical Biochemistry)
Source: Indian Journal of Clinical Biochemistry - February 6, 2020 Category: Biochemistry Source Type: research

Significance of Vitamin D Binding Protein in Assessing Vitamin D Status Among Under-Five Children
AbstractDespite ample sunshine, 50 –90% Indian children have Vitamin D deficiency (VDD). This enigma of widespread VDD needs exploration especially among under-fives as physiological variations in Vitamin D Binding Protein (VDBP) levels could be potential confounders in the interpretation of total 25-hydroxyvitamin D [25(OH)D]. How ever, there is scarce information about relevance of VDBP levels in under-five age group. We therefore, explored association of VDBP levels among 1–5 year old children with VDD. Serum levels of 25(OH)D, VDBP, calcium, parathyroid hormone (PTH) and alkaline phosphatase were estim...
Source: Indian Journal of Clinical Biochemistry - February 1, 2020 Category: Biochemistry Source Type: research

Coomassie Brilliant Blue Can Visualize a Protein Band Without Destaining: A Quick Visualization Protocol on the Agarose Gel
(Source: Indian Journal of Clinical Biochemistry)
Source: Indian Journal of Clinical Biochemistry - February 1, 2020 Category: Biochemistry Source Type: research

The Effects of Self-cleavage Intein-ELK16 Tag in the Transcript Steric Hindrance of IFN
In this study, the transcript expression level of recombinant human Interferon beta (rhIFN β) connected to the self-cleavage Intein-ELK16 (LELELKLKLELELKLK) tag was measured by real-time PCR in HEK293T cell line. First, the sequence ofMycobacterium tuberculosis RecA (Mtu recA) was obtained from the InBase database to do appropriate changes including adding the restriction sites, kozak sequence, signal peptide and ELK16 sequence by SnapGene software. The RNA secondary structure were also examined using the online RNA Fold 2.2 web server. Next, the construct was inserted into pUC19 plasmid. The sequence of rhIFN β ...
Source: Indian Journal of Clinical Biochemistry - January 30, 2020 Category: Biochemistry Source Type: research

Increasing Use of Hair Dye and Associated Genotoxicity Needs to be Probed
(Source: Indian Journal of Clinical Biochemistry)
Source: Indian Journal of Clinical Biochemistry - January 13, 2020 Category: Biochemistry Source Type: research

ErbB4 3 ′-UTR Variant (c.*3622A & gt;G) is Associated with ER/PR Negativity and Advanced Breast Cancer
AbstractA genetic variant may alter a gene expression level and as a result be associated with pathological characteristics in breast cancer. In this research, the frequency and association of the ErbB4 3 ′-untranslated region (3′-UTR) variant, rs12471583 (c.*3622A>G) was studied in an Iranian breast cancer patients.In silico assessment was performed to predict the function of the rs12471583 variant located on the 3 ′-UTR of ErbB4. Furthermore, as a case–control study, this polymorphism was genotyped in 243 breast cancer patients and non-cancerous controls using the polymerase chain reaction&ndas...
Source: Indian Journal of Clinical Biochemistry - January 1, 2020 Category: Biochemistry Source Type: research

Copper and Zinc Status in Psoriasis: Correlation with Severity
In this study, 72 psoriatic patients and 50 controls were enrolled. On the basis of PASI score psoriatic group comprising of 48 mild and 24 severe psoriatic patients were grouped. The serum trace elements analysis in the subjects revealed that serum Cu levels and Cu/Zn ratio was significantly higher in the psoriatic patients as compared to controls. Interestingly, severity of the psoriasis was well correlated with the serum Cu levels. Taking together, all these findings suggest that Cu may be a major culprit in the pathogenesis as well as in the severity of the disease. (Source: Indian Journal of Clinical Biochemistry)
Source: Indian Journal of Clinical Biochemistry - January 1, 2020 Category: Biochemistry Source Type: research

Emerging Roles of Salivary lncRNAome in Oral Cancer
(Source: Indian Journal of Clinical Biochemistry)
Source: Indian Journal of Clinical Biochemistry - December 16, 2019 Category: Biochemistry Source Type: research

Comment on “Upgrading the Iranian National Laboratory Standard to Conform to ISO 15189:2012”
(Source: Indian Journal of Clinical Biochemistry)
Source: Indian Journal of Clinical Biochemistry - December 14, 2019 Category: Biochemistry Source Type: research

Activated Carbon Fabric Mask Reduces Lead Absorption and Improves the Heme Biosynthesis and Hematological Parameters of Battery Manufacturing Workers
AbstractActivated carbon fabrics (ACF) mask prevents the absorption of lead and reduce its adverse effects of human health. Aim of this study to know the blood lead level and its effects on heme biosynthesis and hematological parameters after using 2  months activated carbon fabric mask of battery manufacturing workers (BMW). Blood lead level, heme biosynthesis and hematological parameters were measured by using standard method. Blood lead level (P 
Source: Indian Journal of Clinical Biochemistry - December 13, 2019 Category: Biochemistry Source Type: research