The IKAROS Transcription Factor Gene IKZF1 as a Critical Regulator in the Pathogenesis of Childhood Acute Lymphoblastic Leukemia: Insights from a Bangladeshi Population

This study investigated whether two specific IKZF1 variants, rs10272724 (T  >  C) and rs4132601 (T >  G), are potential risk factors for childhood ALL among Bangladeshi children. In this study, we found that ALL occurs with a significantly greater frequency in male children than in female children, shedding light on potential sex-specific susceptibility patterns. Subsequent association analyses u tilizing codominant, dominant, and recessive inheritance models demonstrated that rs10272724 is associated with a 2.36-fold increased risk of ALL development according to the codominant model, a 3.6-fold increased risk according to the dominant model, and a 1.84-fold increased risk according to the recessive model. Similarly, rs4132601 exhibited a substantial risk association, with a 3.58-fold increase in risk in the codominant model, a 3.85-fold increase in risk in the dominant model, and a 1.75-fold increase in risk in the recessive model. Furthermore, the analysis of haplotype frequencies r evealed that the predominant haplotype, CG, is associated with a 1.3-fold greater risk for ALL development. Notably, we observed significant linkage disequilibrium patterns and constancy in genotypic frequencies, further strengthening the association of IKZF1 polymorphisms with ALL susceptibility. I n conclusion, our study provides compelling evidence that two single-nucleotide polymorphisms (SNPs) located within the 3′ UTR of the IKZF1 gene are strongly associated with the deve...
Source: Indian Journal of Clinical Biochemistry - Category: Biochemistry Source Type: research