Indian Journal of Clinical Biochemistry This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Comparison of Serum Holotranscobalamin with Serum Vitamin B12 in Population Prone to Megaloblastic Anemia and their Correlation with Nerve Conduction Study
This study was conducted to compare serum holotranscobalamin level with serum vitamin B12 level as early biomarker in people prone to megaloblastic anemia and to evaluate co-relation between these biomarkers and nerve conduction study in study patients. 83 adult patients (Hb  >  12 gm/dl) prone to megaloblastic anemia were studied for basic haematological investigations, random blood sugar, thyroid function test, liver function test, kidney function test, serum vitamin B12, serum holotranscobalamin and serum folic acid levels. 45 patients among them underwent nerve condu ction studies. All study patients were classi...
Source: Indian Journal of Clinical Biochemistry - March 17, 2022 Category: Biochemistry Source Type: research

Possibility of Relapse of COVID19 in Asymptomatic Cases and Risk Assessment
(Source: Indian Journal of Clinical Biochemistry)
Source: Indian Journal of Clinical Biochemistry - March 15, 2022 Category: Biochemistry Source Type: research

Methylenetetrahydrofolate Reductase Polymorphisms (C677T and A1298C) and Migraine Susceptibility: Correspondence
(Source: Indian Journal of Clinical Biochemistry)
Source: Indian Journal of Clinical Biochemistry - March 5, 2022 Category: Biochemistry Source Type: research

Association of Micronutrients with Tuberculosis Development in HIV Infected Patients
AbstractHuman immunodeficiency virus (HIV) infection associated with weakened immune system due to decreased CD4 T cell count favors development of tuberculosis. Effector immune responses are also associated with micronutrient status due to their prominent role in maintaining immune functions. Micronutrient deficiencies are quite common among HIV patients that further result into compromised immunity thus making the conditions even more favorable for mycobacteria to establish disease. So, current study was designed to assess association of different micronutrients with development of TB in HIV patients. Micronutrient level...
Source: Indian Journal of Clinical Biochemistry - February 23, 2022 Category: Biochemistry Source Type: research

Identification of Plasma Proteomic Biomarkers in Patients with Mild Cognitive Impairment
AbstractPlasma proteomic profiling may provide novel biomarkers for the identification of mild cognitive impairment (MCI). The early diagnosis of MCI still remains a challenging task due to its diverse origin. Currently, molecular approaches have been used to identify MCI diversified origin as its onset is governed by a variety of molecular changes. Therefore, we aimed to find out molecular alteration in plasma using proteomics in patients with MCI for early detection of prodromal Alzheimer ’s disease (AD). To achieve this, we performed two-dimensional (2-D) gel electrophoresis coupled with MALDI-TOF/MS, which is used to...
Source: Indian Journal of Clinical Biochemistry - February 15, 2022 Category: Biochemistry Source Type: research

Detection of Human Serum Albumin on Gel from Sample Obtained from Different Cardiopulmonary Bypass (CPB) Filtrates in a Patient on Cardiopulmonary Bypass Surgery
(Source: Indian Journal of Clinical Biochemistry)
Source: Indian Journal of Clinical Biochemistry - February 5, 2022 Category: Biochemistry Source Type: research

Determination of Manganese in Serum Using GFAAS: Serum Reference Values for Manganese in the Adolescent Girls of the DERVAN Cohort
AbstractCurrent proposed method allows for the determination of manganese in serum sample using aqueous standard calibration technique on Graphite Furnace atomic absorption spectrophotometer (GFAAS) using deuterium background correction. This method involves determination of manganese from digested serum samples without the use of matrix modifier. Pyrolysis and atomization temperatures are 1200  °C and 2200 °C respectively. The limit of detection (LoD) and limit of quantitation (LoQ) of the method are 0.0097 ng/ml (0.18 nmol/l) and 0.032 ng/ml (0.58 nmol/l) respectively. Validation of the method was carried out usi...
Source: Indian Journal of Clinical Biochemistry - February 3, 2022 Category: Biochemistry Source Type: research

Retraction Note to: Modulatory Effects of Berberine Chloride on Lipid Profile, Oxidant Status and Insulin Signaling Molecules in Streptozotocin Induced Diabetic Rats
(Source: Indian Journal of Clinical Biochemistry)
Source: Indian Journal of Clinical Biochemistry - January 22, 2022 Category: Biochemistry Source Type: research

Abstract of the 47th National Conference of Association of Clinical Biochemists of India (ACBICON 2021)
(Source: Indian Journal of Clinical Biochemistry)
Source: Indian Journal of Clinical Biochemistry - January 19, 2022 Category: Biochemistry Source Type: research

New Horizons: Molecular Basis and Novel Therapeutics in Congenital Adrenal Hyperplasia
(Source: Indian Journal of Clinical Biochemistry)
Source: Indian Journal of Clinical Biochemistry - January 17, 2022 Category: Biochemistry Source Type: research

Micro (mi) RNA and Diabetic Retinopathy
AbstractDiabetic Retinopathy (DR), a debilitating microvascular complication of diabetes, is one of the leading cause of blindness. However, the pathogenesis of this disease is not fully understood. Few Studies have reported the role of MicroRNA (miRNA), which is deregulated or altered in many diseases. Further, few pathways linked genes which have been suggested to be regulated by miRNAs, may play an important role in the regulation of glucose homeostasis and eventually may contribute to the establishment of DR. However, the roles of microRNAs (miRNAs) in DR are still not very clear. In current review, we explored various...
Source: Indian Journal of Clinical Biochemistry - January 14, 2022 Category: Biochemistry Source Type: research

Improving the ACS Triage —Using High Sensitivity TroponinI and Copeptin for Early ‘Rule-Out’ of AMI
AbstractRule-out of acute myocardial infarction (AMI) in patients presenting with acute chest pain at the emergency department (ED) is a major challenge across the globe. Patients presenting very early with chest pain may provide a diagnostic challenge even when using a cardiac necrosis specific biomarker, high sensitivity troponin (hs-Tn) as they are elevated at 3 –6 h after the symptom onset. Copeptin is a marker of acute hemodynamic stress which is released within few minutes of the occurrence of MI and is elevated immediately at the presentation of patients with AMI. This indicates a complementary pathophysiology an...
Source: Indian Journal of Clinical Biochemistry - January 8, 2022 Category: Biochemistry Source Type: research

An Analysis of M-protein in Plasma cell Dyscrasia Patients Identifies that IgG Lambda Subtype is More Commonly Associated with Normal Serum Free Light Chain (SFLC) Ratio
AbstractThe determination of monoclonal protein (M-protein) by SPE, IFE and SFLC assay is fundamental in the diagnosis of Plasma cell proliferative disorder (PCPD). In the present study, we seek to assess the diagnostic performance and concordance of these three techniques in un-treated PCPD patients. All new patients with dysproteinemia and/or suspected PCPD were included in this retrospective observational study. The baseline parameters were retrieved from electronic medical records. SPE was performed on gel electrophoresis system; monoclonal component was identified by IFE. SFLC assays were performed by nephelometry usi...
Source: Indian Journal of Clinical Biochemistry - November 29, 2021 Category: Biochemistry Source Type: research

Use of Uncertainty of Measurement for Traceability of Test Results and Setting up of own Quality Goal for Methods having Lower Stability- A Tertiary Care Hospital study
AbstractUncertainty of measurement (UM) provides a quantitative estimate for traceability of test results. The Nordtest guide was applied for calculating UM of 26 analytes. For this, internal and external quality control data from July 2019 to April 2020 was used. UM of test results were compared to %TEa values of CLIA '2019, RiliB ÄK, and Ricos. It was observed that UM for all analytes were below %TEa values of RiliBÄK. UM value of Albumin, Calcium and Sodium could not meet CLIA '2019 and Ricos guidelines. For results of Albumin, Calcium and Sodium to be traceable, more frequent quality control protocols resulted in dec...
Source: Indian Journal of Clinical Biochemistry - November 29, 2021 Category: Biochemistry Source Type: research

SARS-CoV-2 IgG Antibody and its Clinical Correlates in Convalescent Plasma Donors: An Indian Experience
This study was planned to assess the Anti-SARS-CoV-2 IgG antibody levels in convalescent COVID-19 patients. In this study, serum samples from 210 persons infected by SARS-CoV-2, treated and discharged from the hospital were collected. Anti-SARS-CoV-2 IgG antibody levels were detected using a chemiluminescence assay. A directory of convalescent plasma donors was created. Anti-SARS-CoV-2 IgG antibody levels vary substantially in the study population with a mean of 51.2 AU/ml. On comparing the serum anti-SARS-CoV-2 IgG antibody levels, a significant difference was observed between the subjects who had cough and those who did ...
Source: Indian Journal of Clinical Biochemistry - November 18, 2021 Category: Biochemistry Source Type: research