Exploring Micronutrient Dynamics in COVID-19 Severity and Mortality: Unraveling the Roles of Vitamin D, Calcium, Phosphorus, Magnesium and ALP

This study explores the impact of Vitamin D, calcium, phosphorus, magnesium, and alkaline phosphatase (ALP) on COVID-19 severity and mortality. The study involves 200 participants (100 COVID-19 patients, 100 controls), we meticulously analyzed micronutrient dynamics. Calcium, phosphorus, magnesium and ALP was measured spectrophotometrically. Vitamin D was measured using Chemiluminescent method. The study reveals that diminished levels of calcium, phosphorus, magnesium, and with elevated ALP, are significantly associated with COVID-19 cases. Whereas the Vitamin D levels in severe group was increased when compared to mild cases but decreased than control group. Disease severity correlated with declining calcium (r  = − 0.35,p <  0.01), phosphorus (r = − 0.26,p <  0.05), and magnesium (r = − 0.21,p <  0.05), and increased ALP (r = 0.42,p <  0.001). Post-discharge, calcium (p <  0.05) and phosphorus (p <  0.01) showed positive trends, while ALP (p <  0.001) decreased. Notably, calcium (OR = 0.63,p <  0.05) and ALP (OR = 1.87,p <  0.001) emerged as significant predictors of disease severity. The findings not only illuminate potential therapeutic avenues but also emphasize the need to optimize nutrient levels, including magnesium, for COVID-19 prevention and management. Given the complexities of these relationships, further rigorous exploration, including well-designed trials and unde...
Source: Indian Journal of Clinical Biochemistry - Category: Biochemistry Source Type: research