Subjective symptoms and their association with psychiatric symptoms 3 months after ICU discharge: sub-analysis of a single-center prospective observational study
ConclusionsThe presence of subjective symptoms is associated with worse psychiatric symptoms (post-traumatic stress disorder, anxiety, and depression) at 3 months after ICU discharge. We found insomnia was particularly strongly associated with psychiatric symptoms in our study group.Trial registrationUMIN Clinical Trial Registry no. UMIN000023743, September 1, 2016. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 24, 2021 Category: General Medicine Source Type: research

Outcomes of the arthroscopic Bankart procedure in Irish collision sport athletes
ConclusionThe arthroscopic Bankart procedure has a high rate of recurrence of dislocation in Irish collision sport athletes. The current international literature suggests that the arthroscopic Bankart has similar rates of recurrence to the open procedure in collision athletes; however, this may not hold true for Irish collision sport athletes. Further research is required to determine the optimum surgical procedure for anterior shoulder instability in this population, particularly those patients with subcritical bone loss. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 24, 2021 Category: General Medicine Source Type: research

General practitioners ’ views of advance care planning: a questionnaire-based study
ConclusionIn order to improve their implementation, workshops and courses should be developed to increase GPs ’ knowledge and confidence. Additionally, the healthcare system should be adapted, supporting GPs to facilitate these important discussions to take place. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 23, 2021 Category: General Medicine Source Type: research

Maxillofacial fractures in females: a 5-year retrospective review
ConclusionThis study confirms maxillofacial fractures are less common in females. The female age distribution demonstrates two peaks, one in early adult and a second in old age. This may be explained by females living longer and independently and at risk for falls. The most commonly reported fracture aetiology in females was “falls.” This raises concerns as to whether “falls” are used to explain an assault. There is an informal concern amongst maxillofacial surgeons that females presenting with facial trauma may be the victims of domestic violence, which may be denied by the victims. (Source: Irish ...
Source: Irish Journal of Medical Science - February 22, 2021 Category: General Medicine Source Type: research

Association between urine albumin to creatinine ratio and bone mineral density: a cross-sectional study
ConclusionACR was negatively associated with femoral neck BMD in the general US population. Future studies are warranted to confirm our results. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 21, 2021 Category: General Medicine Source Type: research

Abstracts From the 23 rd Annual Meeting of the Irish Society of Human Genetics
(Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 20, 2021 Category: General Medicine Source Type: research

Emergency urolithiasis management at a national level: exploring the need for a care pathway
ConclusionAt a national level in Ireland, many patients with urolithiasis present to hospitals that are unable to cater for their needs. Patients presenting with urolithiasis to model 2/3 hospitals have significantly longer LOS compared with patients who present directly to a model 4 hospital. A formal ‘stone pathway’ is required to provide timely care for these patients2—such a pathway would provide better patient care and result in improved bed utilisation. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 20, 2021 Category: General Medicine Source Type: research

Effects of early intake of amino acid on the neurodevelopmental outcomes in very low birth weight infants at correct age of 20  months and school age
This study aimed to investigate the beneficial effects of early amino acid intake on the neurodevelopmental outcomes in VLBWIs at 20  months of correct age and school age.MethodsThe information of VLBWIs that received amino acid intake were retrospectively analyzed in this study. The cases in early group (EAA) received amino acid within 24  h, but the cases in standard group (SAA) after 48 h post-natal. The body weight, height, and Bayley score of the infants at correct age of 20 months were compared between groups. And the cognitive outcomes at school age were evaluated using Wechsler Intelligence Scal...
Source: Irish Journal of Medical Science - February 19, 2021 Category: General Medicine Source Type: research

Timing of treatment of aneurysmal subarachnoid haemorrhage: are the goals set in international guidelines achievable?
ConclusionsIn centres with 7 day per week provision of interventional neuroradiology and vascular neurosurgery, the  majority of patients with aSAH can be treated within the timeframes recommended by international guidelines and this applies to all grades of aSAH. However, delays still occur in a significant proportion of patients and this particularly applies to delays in presentation and diagnosis in good gra de patients.  (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 18, 2021 Category: General Medicine Source Type: research

Sentiment analysis of user feedback on the HSE ’s Covid-19 contact tracing app
ConclusionThe HSE have responded to the public ’s desire for targeted feedback in newer versions, but should consider increasing the app’s proactive engagement. The results suggest they should also raise the backward compatibility issue, regarding older iPhones, with Apple. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 18, 2021 Category: General Medicine Source Type: research

Introduction of Rezum system technology to Ireland for treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia: a pilot study on early outcomes and procedure cost analysis
AbstractObjectiveRezum technology uses heat from radiofrequency-generated water vapour to ablate prostate tissue. We evaluate the introduction of this thermal therapy to an Irish teaching hospital for the treatment of lower urinary tract symptoms related to benign prostatic hyperplasia.MethodsA pilot study of men with moderate to severe lower urinary tract symptoms who underwent Rezum treatment to the prostate was performed. Perioperative efficacy was evaluated using international prostate symptom score (IPSS), quality of life score (IPSS-QOL), uroflowmetry and post-void residual (PVR) volumes. Costs were evaluated and com...
Source: Irish Journal of Medical Science - February 18, 2021 Category: General Medicine Source Type: research

Letter to the Editor: Very high cortisol concentration in adrenal venous sampling in primary aldosteronism —physiological or pathological
(Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 18, 2021 Category: General Medicine Source Type: research

The role of taurine derivatives in the putative therapy of COVID-19-induced inflammation
(Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 18, 2021 Category: General Medicine Source Type: research

Rising resistance of urinary tract pathogens in children: a cause for concern
AbstractBackgroundUrinary tract infection (UTI) is one of the common infections in childhood. Prompt diagnosis and treatment reduces the risk of complications. The choice of antibiotic to treat UTI varies from region to region. Rational use and appropriately chosen antibiotic reduces the emergence of resistant uropathogens.ObjectiveWe investigated the resistance pattern of uropathogens for commonly used antibiotics to treat UTI locally.MethodsData was collected between 2009 and 2019 on all infants and children under 16 years of age with culture proven UTI. Results were compared with previously published figures between 200...
Source: Irish Journal of Medical Science - February 18, 2021 Category: General Medicine Source Type: research

Trauma workload during COVID19 lockdown: an analysis of incidence in 4 million people
AbstractBackgroundAim of this study is to report the trauma workload during COVID19 lockdown in a region of four million people and to compare it with the same period in 2019.MethodsThe regional register for A&E admissions and hospitalizations has been reviewed in order to compare the number of A&D admission, the triage colour codes rates, aetiology of trauma, number of patients hospitalized for trauma, number of fractures that required surgery, type of fractures and injuries and mean patients ’ age.ResultsDuring lockdown 7314 patients were admitted in A&E, while 22,508 patients were admitted in 2019. In ...
Source: Irish Journal of Medical Science - February 17, 2021 Category: General Medicine Source Type: research

Role of confirmed and potential predictors of an unfavorable outcome in heart failure in everyday clinical practice
AbstractHeart failure (HF) is the only cardiovascular disease with an ever increasing incidence. HF, through reduced functional capacity, frequent exacerbations of disease, and repeated hospitalizations, results in poorer quality of life, decreased work productivity, and significantly increased costs of the public health system. The main challenge in the treatment of HF is the availability of reliable prognostic models that would allow patients and doctors to develop realistic expectations about the prognosis and to choose the appropriate therapy and monitoring method. At this moment, there is a lack of universal parameter...
Source: Irish Journal of Medical Science - February 17, 2021 Category: General Medicine Source Type: research

The Erne Mobile Intensive Coronary Care Study
ConclusionsThere was no evidence of a direct, statistically significant, beneficial MICCU effect in either of the multi-factor mortality or survival models. However, the performance of the MICCU, measured in terms of crude survival, resulted from an adverse case-mix, which, when controlled for, suggested a small MICCU benefit. The findings relate to the first year of operation of the Erne MICCU study and may improve in later years. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 17, 2021 Category: General Medicine Source Type: research

Symptoms to script: delays in tuberculosis treatment in the west of Ireland
ConclusionTB patients experienced long symptom durations in the community prior to presentation. Many TB patients experienced delays in diagnosis and treatment following presentation. Both pre-hospital and in-hospital delays need to be addressed in order to ‘End-TB’. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 16, 2021 Category: General Medicine Source Type: research

Rate and predictive parameters of novel Coronavirus 2019 (Sars-CoV-2) infections in a German General Practice
ConclusionA total of 30% of patients had antibodies. It was not possible to identify one solid predictive symptom. Serological testing may be helpful for the diagnosis of suspected patients with negative RT-PCR results and for the identification of asymptomatic infections. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 16, 2021 Category: General Medicine Source Type: research

Homelessness amongst psychiatric Inpatients: a cross-sectional study in the mid-west of Ireland
ConclusionHomelessness affects a significant number of psychiatric patients and can be both a contributory factor to, and consequence of, mental illness. With homelessness at unprecedented levels, there is a need for the development of tailored programmes aimed at supporting these vulnerable groups. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 15, 2021 Category: General Medicine Source Type: research

Harrington rods for periacetabular pathological lesion: is it an option?
AbstractAdvancement in cancer treatment has prolonged the survival of cancer patients; as a result, there are an increased number of patients with bone metastases and pathological fractures referred to orthopaedic surgeons for surgical intervention for a better quality of life. Metastasis around the hip joint can be painful and intervene with patients ’ daily activity, and reconstruction of the hip joint with periacetabular metastasis is complex and challenging especially longer cancer survivals might out-live their fixation. Several acetabular reconstruction techniques and implants have been described to overcome th...
Source: Irish Journal of Medical Science - February 15, 2021 Category: General Medicine Source Type: research

Discrepancies in post-ST-elevation myocardial infarction care in women compared with men: evaluating for implicit bias —a single-centre study
Conclusions Our study identified excellent adherence with recommended guidelines, challenging recent data both internationally and from the Victorian Cardiac Outcomes Registry (VCOR). Pharmacological and revascularisation management post-STEMI for both male and female patients was equal, suggesting implicit b ias is not universal and may be institutional. Health services should evaluate their practices to identify sources of implicit bias, which may influence their management of women presenting with a STEMI. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 13, 2021 Category: General Medicine Source Type: research

Assessing outcomes in hip fracture patients under the age of 60
ConclusionDHS remains the most widely used fixation technique in an effort to preserve the native hip. The use of THA has increased and surpassed the usage of hemi-arthroplasty in recent times. A high proportion of these patients will go on to develop complications requiring secondary surgery; therefore, they all need long-term follow-up. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 12, 2021 Category: General Medicine Source Type: research

SARS-CoV-2 is not found in the sweat of COVID-19 positive patients
ConclusionThis study showed that there is no transmission of SARS-CoV-2 virus via sweat. However, general precautions must be taken while doing interventional procedures. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 12, 2021 Category: General Medicine Source Type: research

Reference intervals for commonly requested biochemical and haematological parameters in a healthy Irish adult Caucasian population
ConclusionNormative biological intervals established in a healthy adult Irish population for 37 commonly requested biochemical/haematological parameters will be a valuable aid to result interpretation in clinical laboratories after appropriate verification in accordance with ISO 15189: 2012. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 11, 2021 Category: General Medicine Source Type: research

The early experience of doctors training in pediatrics: patient safety culture and the role and influence of the registrar
ConclusionsThrough a process designed to focus on exploring patient safety, it emerged that the registrar plays a crucial role in the working experience of their junior colleagues. The influence of the registrar needs to be recognized within clinical teams and by postgraduate training bodies. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 11, 2021 Category: General Medicine Source Type: research

There are similarities between rheumatic disease with lung involvement and COVID-19 pneumonia
DiscussionWe propose how lessons learned from the insights recently gained into each disorder can improve our insight into immunological mechanisms and application of therapeutic interventions in the other. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 10, 2021 Category: General Medicine Source Type: research

Sirtuin2 correlates with lymph node metastasis, increased FIGO stage, worse overall survival, and reduced chemosensitivity to cisplatin and paclitaxel in endometrial cancer
This study aimed to investigate the correlation of sirtuin2 (SIRT2) with clinical characteristics, prognosis in endometrial cancer (EC) patients, and its effect on chemosensitivity in EC cell lines.MethodsA total of 137 EC patients who underwent surgical resection were retrospectively enrolled. SIRT2 expression in tumor tissues (n = 137) and adjacent tissues (n = 61) was detected by immunohistochemistry (IHC) staining and evaluated by a semiquantitative scoring method. EC patients’ clinical characteristics and survival data were collected. Besides, SIRT2 was modulated by plasmid transfecti...
Source: Irish Journal of Medical Science - February 10, 2021 Category: General Medicine Source Type: research

Altered mental status is an independent predictor of mortality in hospitalized COVID-19 patients
AbstractBackground/aimsLimited data exists on the outcomes of COVID-19 patients presenting with altered mental status (AMS). Hence, we studied the characteristics and outcomes of hospitalized COVID-19 patients who presented with AMS at our hospital in rural southwest Georgia.MethodsData from electronic medical records of all hospitalized COVID-19 patients from March 2, 2020, to June 17, 2020, were analyzed. Patients were divided in 2 groups, those presenting with and without AMS. Primary outcome of interest was in-hospital mortality. Secondary outcomes were needed for mechanical ventilation, need for intensive care unit (I...
Source: Irish Journal of Medical Science - February 10, 2021 Category: General Medicine Source Type: research

ADHD stimulant medication misuse and considerations for current prescribing practice: a literature review
ConclusionsConsideration of the impact that variable treatment trajectories may have on the risk of later SUD development is recommended, with further research potentially leading to the development of different management pathways based on an individual ’s multivariate treatment profile. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 9, 2021 Category: General Medicine Source Type: research

On-admission plasma levels of BNP, MR-proADM, and cTnI in pediatric heart failure: contributions to diagnosis, prognosis, and outcome
AbstractBackgroundThe aim of this study is to evaluate the use of on-admission plasma levels of BNP, MR-proADM, and cTnI in diagnosing the clinical severity and progression of heart failure (HF) in children with CHD. Also, to correlate the levels of these biomarkers with the HF outcome (survival versus in-hospital mortality).ResultsA prospective cohort study conducted in period from January 2017 to March 2018. All children presenting with HF had a Ross score assessment, echocardiography, and on-admission plasma level assay of BNP, MR-proADM, and cTnI. Patients were followed clinically throughout their hospital stay. The di...
Source: Irish Journal of Medical Science - February 9, 2021 Category: General Medicine Source Type: research

Oral health literacy among third-level university students in cork city; Ireland
ConclusionApproximately, one-in-four third-level university students in Cork City have adequate OHL which is lower compared to the general Irish population but still significantly high in specific groups. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 9, 2021 Category: General Medicine Source Type: research

Transoral robotic surgery in Ireland: the beginning
ConclusionsWe anticipate the integration of TORS into routine practice in the investigation and management of a number of ENT pathologies following robust clinical trials. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 9, 2021 Category: General Medicine Source Type: research

Knowledge of face masks and attitudes to re-sterilisation among healthcare workers
DiscussionEnsuring an adequate understanding of face masks is crucial among healthcare workers (HCWs) and this study highlights a need for further education. It also demonstrates a general acceptability among HCWs towards the use of re-sterilised face masks. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 8, 2021 Category: General Medicine Source Type: research

Internship commencement during COVID-19: the impact of an extended induction model
AbstractBackgroundThe COVID-19 pandemic necessitated an enforced 8-week induction period (18 May to 12 July 2020) for all new interns in Ireland. These unprecedented circumstances presented a unique opportunity to assess this induction period.AimTo assess the impact of a prolonged induction period on the technical abilities of interns embarking on their clinical careers.MethodWe distributed a 12-item questionnaire to new interns at our institution during the COVID-19 pandemic. Section  1 of the questionnaire was designed to assess the rate of self-reported improvement in the successful and independent execution of pra...
Source: Irish Journal of Medical Science - February 8, 2021 Category: General Medicine Source Type: research

Assessment of operating room team members ’ ability to identify other team members in the operating room, a quality improvement exercise
(Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 7, 2021 Category: General Medicine Source Type: research

Open, prospective, multicenter study on postoperative intranasal phototherapy in nasal polyposis
ConclusionsRhinophototherapy together with standard nasal steroid application may have a supportive role in the treatment of recurrent bilateral nasal polyps. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 5, 2021 Category: General Medicine Source Type: research

miR-3178 as a prognostic indicator and tumor suppressor of gastric cancer
ConclusionmiR-3178 may be involved in the progression of gastric cancer, which provides new insights into the treatment of gastric cancer. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 5, 2021 Category: General Medicine Source Type: research

The audiovestibular manifestations as early symptoms of multiple sclerosis: a scoping review of the literature
ConclusionAn understanding of the sensitivity of evoked potentials in the detection of demyelinating lesions as well as the most common audiovestibular presentations of the disease allows the practitioner to provide an appropriate onward referral for MRI which may lead to early diagnosis and intervention of MS. We suggest that there is enough evidence to include evoked potentials complementary to MRI in the detection and monitoring of MS. As the review suggests evidence of involvement of the immune-mediated mechanisms of MS on peripheral structures like the inner ear, further clinical research is recommended to explore thi...
Source: Irish Journal of Medical Science - February 5, 2021 Category: General Medicine Source Type: research

Quantifying the impact of COVID-19 on chronic pain services in the Republic of Ireland
ConclusionThis survey of consultant pain physicians in the Republic of Ireland has revealed how chronic pain services have been affected during the pandemic and how they have evolved. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 5, 2021 Category: General Medicine Source Type: research

An international experience of electronic communication and implementation of eHealth solutions in a vascular surgery clinic
DiscussionWithin this patient population, the use of technologies decreases with increasing age of the patients. This demonstrates a large population of service users who are contented with conventional methods of communication. Change within healthcare ICT is inevitable, and therefore, these patients need to be guided and educated to allow a smooth transition from the old to the new. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - January 29, 2021 Category: General Medicine Source Type: research

Anakinra for colchicine-intolerant/colchicine-resistant acute gout flare precipitated by decompensated heart failure
(Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - January 29, 2021 Category: General Medicine Source Type: research

Severe symptomatic hyponatremia secondary to fluoxetine
(Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - January 29, 2021 Category: General Medicine Source Type: research

Correction to: Anakinra for colchicine-intolerant/colchicine-resistant acute gout flare precipitated by decompensated heart failure
The published version of the original article has the corresponding author last name switched with first name. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - January 29, 2021 Category: General Medicine Source Type: research

Community optometrist-led post-operative cataract care: how many patients re-present to the hospital ophthalmic department?
ConclusionsCommunity optometrist-led post-operative care for uncomplicated patients is an effective way of reducing the workload associated with cataract surgery. Re-referral pathways must be in place to facilitate timely management of post-operative complications. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - January 25, 2021 Category: General Medicine Source Type: research

Review of claudin proteins as potential biomarkers for necrotizing enterocolitis
ConclusionsAlterations to claudin proteins may reflect changes seen to intestinal permeability and inflammation in the context of NEC. Further research is necessary to understand the relevance of claudin proteins in the pathophysiology of NEC and their use as a biomarker. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - January 25, 2021 Category: General Medicine Source Type: research

European food safety guidelines on dietary phosphate additives: implications for people with chronic kidney disease
(Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - January 25, 2021 Category: General Medicine Source Type: research

The hospital difficult airway team: experience and implications for patient care
AbstractThe difficult airway involves the complex interaction between patient factors, the clinical setting and the practitioner ’s skills (Apfelbaum in Anesthesiology 118(2):251–70, 2013 and Mark et al. in Anesth Analg 121(1):127–139, 2015). It can also be a result of preparedness and system failures. Our institution developed a protocol to enhance emergency airway management in settings outside of the operating theatr e—the difficult airway (DA) team. The aims of this report are to perform a retrospective review to describe the patient profiles as well as our difficult airway code workflow, and to...
Source: Irish Journal of Medical Science - January 22, 2021 Category: General Medicine Source Type: research

Test-retest reliability of the functional reach test and the hand grip strength test in older adults using nursing home services
This study aimed to determine the absolute and relative test-retest reliability of the functional reach test (FRT) and the handgrip strength test (HGST) in older adults using nursing homes.MethodsParticipants ( ≥ 65 years old), living in nursing homes or using their day care services, were distributed into a group without cognitive impairment (GWCI,n = 43) and a group with mild cognitive impairment (GCI;n = 22). A 1-week test-retest was performed for the FRT and the HGST. Relative reliability was measured by the intraclass correlation coefficient (ICC3.1), and absolute reliability by the standard error of measurement (S...
Source: Irish Journal of Medical Science - January 21, 2021 Category: General Medicine Source Type: research

Diagnostic utility of circulating plasma microRNA-101a in severity of coronary heart disease
AbstractBackgroundFor evaluating the severity of coronary heart disease (CHD), coronary arteriography may not be available everywhere due to technical limitations. MicroRNA-101a (miR-101a) associated with inflammation and cholesterol homeostasis. However, whether it related to presence and stratification of CHD is still unknown.AimWe aim to evaluate the value of miR-101a in stratifying CHD patients.MethodsWe enrolled 200 CHD patients and 100 controls, and 200 CHD patients were divided into two groups of low and high SYNTAX score (SYNTAX score ≤ 22 versus SYNTAX score ≥ 33). Intergroup comparisons of miR...
Source: Irish Journal of Medical Science - January 21, 2021 Category: General Medicine Source Type: research