Adolescents and primary herpetic gingivostomatitis: an Italian overview
ConclusionIn Italian adolescents, PHGS is diagnosed at least 48  h after onset and the antibiotic therapy is widely prescribed in order to prevent overinfections. Among topical therapies, an association of verbascoside and sodium hyaluronhate seems to favour a faster healing. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - May 15, 2021 Category: General Medicine Source Type: research

The use of genomic assays reduces rates of chemotherapy: a single-institution experience
ConclusionWithin our institution, overall rates of chemotherapy have reduced since the introduction of Oncotype DX with the results more marked in subgroups of traditional indicators of tumour aggression. As genomic assays provide a more accurate prediction of the benefit of chemotherapy, its overall reduction has potential cost saving implications as well as reducing risk in patients who will derive little benefit. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - May 15, 2021 Category: General Medicine Source Type: research

Psychological factors affecting COVID-19 vaccine hesitancy
This study, in which we planned to study the determinants of COVID-19 vaccine hesitancy, aims to reveal the relationship between “intolerance of uncertainty,” “belief in conspiracy theories,” and “COVID-19 phobia” with vaccine hesitancy.MethodsThis is a cross-sectional study conducted during a COVID-19 outbreak. Participants were reached via various social media platforms and e-mailing lists for convenience. Data were collected with an online survey using SurveyMonkey application. “Intolerance of Uncertainty Scale (IUS-12),” “Conspiracy Mentality Scale (CMS),” and...
Source: Irish Journal of Medical Science - May 14, 2021 Category: General Medicine Source Type: research

Assessing standards for prevention of early onset group B streptococcal (GBS) disease in Ireland
Conclusion:There is a lack of consistency in the methods for GBS screening and disease prevention across the country, highlighting the need for a national guideline accompanied by an implementation plan and budget to standardise care. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - May 14, 2021 Category: General Medicine Source Type: research

The progression of BMI status over time in Irish ambulant children with cerebral palsy
AbstractBackgroundAn increasing prevalence of overweight and obesity in children has been reported globally. Most studies examining the trajectory of BMI in children over time have tended to focus on children with typical development. Our group previously reported static prevalence rates in children with cerebral palsy. However, concern remains within our multi-disciplinary team that progression into higher BMI categories is apparent as children with cerebral palsy age.AimsTo examine the progression of BMI status as children with cerebral palsy age and determine the severity of obesity.MethodsA retrospective analysis was c...
Source: Irish Journal of Medical Science - May 14, 2021 Category: General Medicine Source Type: research

Changing attitudes towards annual influenza vaccination amongst staff in a Tertiary Care Irish University Hospital
DiscussionIn light of the increasing number of survey participants, more staff were interested in flu vaccination this year than ever before. The COVID-19 pandemic has had some influence on staff ’s likelihood to be vaccinated. Feasibility of immunisation and education posed the largest barriers to HCW vaccination. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - May 13, 2021 Category: General Medicine Source Type: research

Should continuous glucose monitoring systems be offered to all patients with type 1 diabetes mellitus?
AbstractType 1 diabetes mellitus (T1DM) is a chronic autoimmune condition characterised by autoimmune destruction of the pancreatic beta cell. It is associated with macrovascular and microvascular complications. Tight glycaemic control has been shown to ameliorate the long-term complications of T1DM, but this benefit has to be balanced with the risk and fear of hypoglycaemia. Monitoring glucose levels frequently helps patients to achieve more intensive glycaemic control. Finger prick blood glucose monitoring has traditionally been the most commonly used method to monitor glucose levels. More recently, continuous glucose mo...
Source: Irish Journal of Medical Science - May 13, 2021 Category: General Medicine Source Type: research

A preliminary prospective observational study of the effectiveness of high-concentration capsaicin cutaneous patch in the management of chronic post-surgical neuropathic pain
ConclusionsThis prospective study provides preliminary evidence for an improvement in patient outcomes with 8% capsaicin in surgically induced neuropathic pain. Improvements were noted in pain interference, and significant reductions in the painful surface area were noted for those who underwent subsequent treatments. Findings should be replicated in a randomised control trial to establish causation. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - May 13, 2021 Category: General Medicine Source Type: research

The first robotic transanal minimally invasive surgery in Ireland: a case-based review
AbstractTransanal minimally invasive surgery (TAMIS) has gained worldwide acceptance as a means of local excision of early rectal cancers and benign rectal lesions. However, it is technically challenging due to the limitations of rigid laparoscopic instruments in the narrow rectal lumen. Robotic platforms offer improved ergonomics that are valuable in operative fields with limited space. Robotic TAMIS represents an exciting new development that may be more versatile than traditional TAMIS. In this review, we describe the first case of robotic TAMIS performed in our country and a review of current literature on the techniqu...
Source: Irish Journal of Medical Science - May 12, 2021 Category: General Medicine Source Type: research

Delivery of systemic anti-cancer therapy during the COVID-19 pandemic
ConclusionsWith careful systematic changes, safe and continued delivery of systemic anti-cancer therapy during the COVID-19 pandemic is possible. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - May 12, 2021 Category: General Medicine Source Type: research

Analysis of electric scooter injuries admitted to the emergency service
ConclusionsWe consider that serious injuries can be prevented by establishing legal regulations regarding the use of e-scooters and determining the appropriate routes for e-scooters, hence making e-scooters a safer means of transportation. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - May 12, 2021 Category: General Medicine Source Type: research

Anal squamous cell carcinoma: a retrospective case series
ConclusionOur study demonstrates that treatment for anal SCC and outcomes following definitive CRT in Ireland during the study period were comparable to international standards. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - May 11, 2021 Category: General Medicine Source Type: research

Evaluation of histopathological findings of cardiac deaths in forensic autopsies
In this study, we aimed to reveal the epidemiological differences between men and women and to investigate the most common pathologies that cause cardiac deaths.MethodsFive thousand seven hundred sixty-eight autopsy cases that were done in 2016 were reviewed for the autopsy information and histopathological findings. Of the 5768 autopsies performed, 866 were due to cardiac causes. Eight hundred thirty-two cases were reviewed due to lack of autopsy information in 34 cases.ResultsOne hundred sixteen (13.9%) were female, and 716 (86.1%) were male. Coronary artery disease was detected in 760 of 832 cases. There were findings o...
Source: Irish Journal of Medical Science - May 10, 2021 Category: General Medicine Source Type: research

Documentation of chaperone presence in breast clinic, a complete audit cycle
AbstractObjectiveThe General Medical Council (GMC) and Irish Medical Council (IMC) recommend the presence of a chaperone for all intimate examinations and that it should be clearly documented. The aim of this report is to assess doctors ’ compliance with obtaining a chaperone and documenting their presence, determining possible causes of non-compliance and implement interventions to increase compliance.MethodsProspective audit of patients seen in the breast clinic in Beaumont hospital over the week starting 8th February 2021. The medical charts were reviewed for documentation of chaperone presence. Doctors were surve...
Source: Irish Journal of Medical Science - May 10, 2021 Category: General Medicine Source Type: research

A national survey of workplace-related musculoskeletal disorder and ergonomic practices amongst Irish otolaryngologists
ConclusionThis study demonstrates a high prevalence of WRMD amongst otolaryngologists working in Ireland and demonstrates a need for ergonomic training for surgeons. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - May 8, 2021 Category: General Medicine Source Type: research

Postmortem pathological changes in extrapulmonary organs in SARS-CoV-2 rt-PCR –positive cases: a single-center experience
ConclusionAutopsies play an important role in systematically examining the damage caused by the virus in all organs in order to elucidate the pathogenesis of SARS-CoV-2 infection and contribute to the clinical management of infected patients. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - May 7, 2021 Category: General Medicine Source Type: research

Integrating hospital and community care: using a community virtual ward model to deliver combined specialist and generalist care to patients with severe chronic respiratory disease in their homes
ConclusionA CVW model facilitates the delivery of combined specialist and generalist care to patients with chronic respiratory disease in the community and improves symptoms and health status. The principles of the model are transferable to other conditions to improve overall health and reduce emergency hospital care. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - May 6, 2021 Category: General Medicine Source Type: research

What GDPR and the Health Research Regulations (HRRs) mean for Ireland: a research perspective
ConclusionsOur results confirm that the HRRs have had a significantly negative impact on health research in Ireland. Urgent meaningful engagement between patient advocate groups, the research community and legislators would help ameliorate these impacts. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - April 15, 2021 Category: General Medicine Source Type: research

5G in healthcare: how fast will be the transformation?
AbstractThe 5G technology, with its low latency, high speed, enhanced high-resolution bandwidth, superior reliability, and less energy consumption, is bound to transform telemedicine and the healthcare industry as a whole. This next-generation wireless networking technology has many far-reaching implications in both preventive and therapeutic care of the patients. Remote monitoring of patients is possible with wearables facilitated by robust sensors coupled to 5G network. Virtual patient consultation; augmented reality (AR) and virtual reality (VR)-based simulated surgeries; artificial intelligence (AI) –powered robo...
Source: Irish Journal of Medical Science - April 15, 2021 Category: General Medicine Source Type: research

The impact of a virtual cardiology outpatient clinic in the COVID-19 era
AbstractBackgroundRestrictions as a result of the COVID-19 pandemic have demanded an innovative approach to provide appropriate patient review. We have been running virtual cardiology clinics as per Health Service Executive guidance.AimsOur study aims to determine how virtual clinics change practice vs traditional clinics.MethodsA retrospective cohort analysis was conducted on patients attending cardiology clinics in our hospital from 6 January to 13 March 2020 ( ‘traditional clinic’,n = 1644), compared with clinics during the COVID-19 outbreak, from 16 March to 22 April 2020 (‘virtual clini...
Source: Irish Journal of Medical Science - April 14, 2021 Category: General Medicine Source Type: research

Letter to the Editor: Response to Assessment of operating room team members ’ ability to identify other team members in the operating room, a quality improvement exercise (Feb ‘21)
(Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - April 14, 2021 Category: General Medicine Source Type: research

Correction to: Assessing outcomes in hip fracture patients under the age of 60
A correction to this paper has been published: https://doi.org/10.1007/s11845-021-02624-0 (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - April 14, 2021 Category: General Medicine Source Type: research

Robotic versus laparoscopic anterior resections for rectal and rectosigmoid cancer: an institutional experience
AbstractIntroductionColorectal surgery has evolved with the advent of laparoscopic techniques and now robotic-assisted surgery. There is significant literature supporting the use of laparoscopic techniques over open surgery with evidence of enhanced post-operative recovery, reduced use of opioids, smaller incisions and equivalent oncological outcomes. Robotic minimally invasive surgery addresses some of the limitations of laparoscopic surgery, providing surgical precision and improvements in perception and dexterity with a resulting decrease in tissue damage.MethodsWe retrospectively reviewed the medical records of patient...
Source: Irish Journal of Medical Science - April 13, 2021 Category: General Medicine Source Type: research

Identifying patients with atrial fibrillation with a single CHA 2 DS 2 -VASC risk factor who are at higher risk of stroke
ConclusionPatients considered at low or intermediate risk using traditional risk stratification schemes, with  ≥ 2 points using this proposed low-risk index (65–74 years old, diabetics or a combination of chronic renal failure and an additional risk factor), had an overall stroke risk that may justify anticoagulation therapy. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - April 12, 2021 Category: General Medicine Source Type: research

Circulating miR-342-5p serves as a diagnostic biomarker in patients with carotid artery stenosis and predicts the occurrence of the cerebral ischemic event
AbstractBackgroundCarotid artery stenosis (CAS) is an important risk factor for cerebral ischemia events (CIE). Previous studies have shown that microRNAs (miRNAs) are involved in the occurrence and development of CAS.AimsThe purpose of this study was to reveal the clinical diagnostic value of miR-342-5p for asymptomatic CAS (ACAS) and to evaluate its predictive value for the occurrence of CIE in patients.MethodsA total of 92 ACAS patients and 86 healthy controls were enrolled as subjects. The expression level of serum miR-342-5p was detected by qRT-PCR. The receiver operating characteristic (ROC) curve was used to detect ...
Source: Irish Journal of Medical Science - April 12, 2021 Category: General Medicine Source Type: research

Correction to: Early warning scores and critical care transfer – patient heterogeneity, low sensitivity, high mortality
A correction to this paper has been published: https://doi.org/10.1007/s11845-021-02616-0 (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - April 12, 2021 Category: General Medicine Source Type: research

Clinical and molecular features of two diabetes families carrying mitochondrial ND1 T3394C mutation
ConclusionsOur study indicates that mitochondrialND1 T3394C mutation is involved in the pathogenesis of maternally inherited T2DM in these families. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - April 11, 2021 Category: General Medicine Source Type: research

Evaluation of the effects of the COVID-19 pandemic on children with cerebral palsy, caregivers ’ quality of life, and caregivers' fear of COVID-19 with telemedicine
This study aimed to investigate the impact of the novel coronavirus (COVID-19) pandemic on the utilization of health and rehabilitation services and the general health and physical status of children with CP. In addition, the second aim of the study was to examine the effects of the COVID-19 pandemic on caregivers ’ quality of life (QOL) and their fear of COVID-19.MethodsThe utilization of children health and rehabilitation services during the pandemic, the general health and physical status of the children during the pandemic, and the children and caregivers ’ history of COVID-19 infections were questioned. Fu...
Source: Irish Journal of Medical Science - April 9, 2021 Category: General Medicine Source Type: research

Examining the forgotten valve: outcomes of tricuspid valve surgery, a 15-year experience
ConclusionBeyond technical challenges, decision making regarding pacemaker requirement requires further exploration. Redo tricuspid valve surgery carries a significant mortality risk and consideration should be given to earlier intervention in this context. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - April 6, 2021 Category: General Medicine Source Type: research

Thirst for change in a challenging environment: healthcare providers ’ perceptions of safety culture in a large Irish teaching hospital
ConclusionThis study highlights the complex relationship between working conditions and safety culture. Hospital staff were committed to providing the best possible care for their patients but struggled to provide safe care in a challenging work environment. A clear appetite for change was identified amongst HCPs regarding patient safety culture in Irish healthcare. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - April 6, 2021 Category: General Medicine Source Type: research

Irish Endocrine Society 44th Annual Meeting
(Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - April 6, 2021 Category: General Medicine Source Type: research

Deprivation of patient liberty: a qualitative study of current practice among geriatricians in a tertiary setting
ConclusionsResults highlight a need for collaborative communication between doctors and legal professionals to achieve a structured and supportive framework to inform practice when working under any proposed legislation relating to deprivation of liberty. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - April 5, 2021 Category: General Medicine Source Type: research

Does postal consent for flexible cystoscopy work?
ConclusionPostal consent is commonly used for gastro-intestinal endoscopy procedures. Postal consent for flexible cystoscopy is not well reported in the literature. Our study shows postal consent to be a suitable form of gaining informed consent for flexible cystoscopy. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - April 5, 2021 Category: General Medicine Source Type: research

Graduates ’ perceptions of the role and availability of career guidance at medical school
ConclusionsCareer guidance at medical school is sparse, and recent graduates feel this should be improved upon. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - April 5, 2021 Category: General Medicine Source Type: research

Instant messaging apps and data protection: combining to improve hip fracture care?
ConclusionsIrish  Hip Fracture Database Standards present a challenge to orthopaedic departments competing with other hospital specialties for access to beds and theatre space. The introduction of a GDPR-compliant social media messaging service has contributed to significantly reducing the time to surgery for the se patients. Streamlining communication through messaging services has and continues to be vital to improving care for hip fracture patients, both in the healthcare environment and beyond. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - April 5, 2021 Category: General Medicine Source Type: research

Clinical significance of kinesin family member 2A as a facilitating biomarker of disease surveillance and prognostication in cervical cancer patients
AbstractBackgroundCervical cancer is one of the most common and fatal malignancies among females, and biomarkers are essential for assisting in its management. Kinesin family member 2A (KIF2A) has been exhibited to be a potential maker in various cancers; however, its role in cervical cancer has yet to be reported. Therefore, we aimed to assess the expression of KIF2A and its correlation with clinicopathological characteristics as well as survival profile in cervical cancer patients.MethodsA hundred and thirty-five cervical cancer patients who underwent simple trachelectomy or radical hysterectomy were retrospectively anal...
Source: Irish Journal of Medical Science - April 2, 2021 Category: General Medicine Source Type: research

An investigation into the rates of transmission of SARS-CoV-2 during the first 6 weeks of the 2020 –2021 academic year in primary and post-primary schools in Cork and Kerry, Ireland
ConclusionsDuring the first 6 weeks of the academic year, the rate of in-school SARS-CoV-2 transmission in the region was low, and schools did not contribute substantially to the overall burden of COVID-19. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - April 1, 2021 Category: General Medicine Source Type: research

Vigilance regarding immune thrombocytopenic purpura after COVID-19 vaccine
Conclusion:Emergency physicians should be aware of the occurrence of vaccine-induced ITP in patients who present with bleeding manifestations, especially after the current boost in COVID-19 vaccination drive worldwide. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - March 31, 2021 Category: General Medicine Source Type: research

Evaluating the impact of pharmaceutical care services on the clinical outcomes of epilepsy: a randomised controlled trial
ConclusionPharmaceutical care interventions may significantly reduce seizure frequency and severity in patients with epilepsy.Impact of findings on practiceThese findings provide justification for the integration of pharmaceutical care services with other elements of health care for epilepsy patients. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - March 27, 2021 Category: General Medicine Source Type: research

A multi-site review of second hip fractures across 6 Dublin teaching hospitals
ConclusionApproximately 1 in 11 hip fractures treated across the 6 teaching hospitals assessed in 2019 was a patient ’s second hip fracture. We advocate for the widespread availability of Fracture Liaison Services to patients throughout Ireland to assist secondary fracture prevention. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - March 26, 2021 Category: General Medicine Source Type: research

Human papilloma virus and vaccine: knowledge and acceptability in an Irish general hospital —a questionnaire-based study
ConclusionsThis study highlights the ongoing lack of knowledge surrounding HPV and the vaccine within this community. The importance of knowledge for vaccine acceptability is highlighted by vaccination considered less acceptable for boys. This may affect vaccine uptake within this subgroup and as such the authors suggest further education be directed towards boys. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - March 26, 2021 Category: General Medicine Source Type: research

An analysis of patient self-reported COVID-19 symptoms during the first wave of the pandemic in Ireland
ConclusionThese data represents an early picture of the clinical characteristics of COVID-19 in an Irish population. It also highlights the potential use of self-reported data globally as a powerful tool in helping with the pandemic. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - March 25, 2021 Category: General Medicine Source Type: research

Research progress in laboratory detection of SARS-CoV-2
ConclusionsWith the advancement of technology and the improvement of methods, the detection methods of SARSCoV-2 have become more mature. These advances provided great help to the detection of SARS-CoV-2. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - March 24, 2021 Category: General Medicine Source Type: research

Corona citizens ’ science project-repeated surveys of the Irish response to COVID-19 and subsequent lockdown and restrictive measures
ConclusionsAs a result of the COVID-19 pandemic, a number of restrictive measures, in particular lockdown, were implemented in Ireland to protect populations and healthcare systems. To record some of the major impacts on society, we launched a Corona Citizens Science Project, with the aim to support decision-making. This report provides detail of its findings. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - March 24, 2021 Category: General Medicine Source Type: research

The bowel and beyond: extracolonic findings from CT colonography
AbstractCT colonography has emerged as the investigation of choice for suspected colorectal cancer in patients when a colonoscopy in incomplete, is deemed high risk or is declined because of patient preference. Unlike a traditional colonoscopy, it frequently reveals extracolonic as well as colonic findings. Our study aimed to determine the prevalence, characteristics and potential significance of extracolonic findings on CT colonography within our own institution. A retrospective review was performed of 502 patients who underwent CT colonography in our institution between January 1, 2010 and January 4, 2015. Of 502  p...
Source: Irish Journal of Medical Science - March 24, 2021 Category: General Medicine Source Type: research

Clinical implication of aquaporin 9 in non-small cell lung cancer patients: its expression and relationship with clinical features and prognosis
This study contained two cohorts: in cohort A, AQP9 protein expression (from formalin fixed paraffin embedded tumor and paired adjacent tissue specimens) in 198 patients was detected by immunohistochemistry (IHC). In cohort B, AQP9 mRNA expression (from fresh-frozen tumor and paired adjacent tissues) in 108 patients (out of 198 patients) was detected by RT-qPCR.ResultsIn cohort A, increased AQP9 IHC score and greater proportion of AQP9 protein high expression cases were shown in tumor tissue than adjacent tissue (bothP 
Source: Irish Journal of Medical Science - March 23, 2021 Category: General Medicine Source Type: research

Reminiscence therapy serves as an optional nursing care strategy in attenuating cognitive impairment, anxiety, and depression in acute ischemic stroke patients
ConclusionReminiscence therapy cripples cognitive impairment, anxiety, and depression, but does not affect RFS in AIS patients, indicating its potential for post-stroke management. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - March 23, 2021 Category: General Medicine Source Type: research

Lower extremity amputations in Ireland: a registry-based study
ConclusionLEA has severe impact on patients ’ lives and hospital resources. Potential savings from effective prevention strategies may offer both health improvements and cost-savings. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - March 23, 2021 Category: General Medicine Source Type: research

COVID-19 autopsies of Istanbul
ConclusionsIn COVID-19 autopsies, pulmonary findings were found to be prominent and the main pathology was pneumonia. Older age and findings of chronic diseases indicate that the cases were in the multirisk group in terms of COVID-19 mortality. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - March 23, 2021 Category: General Medicine Source Type: research

Exploring parental experiences of virtual paediatric neurodevelopmental consultations
ConclusionsThis study highlights the high level of parental satisfaction with the service, but especially satisfaction with the unplanned transition to virtual clinics. Virtual clinics cannot replace the holistic approach gained from face-to-face consultations; however, we identified their benefits of convenience and accessibility for our vulnerable population. In response, we have developed an integrated outpatient service involving both forms of consultation to potentiate satisfaction and adapt to meet the needs of our patients. The suggested proforma that has been developed offers a simple structure for undertaking a vi...
Source: Irish Journal of Medical Science - March 23, 2021 Category: General Medicine Source Type: research