Thioredoxin Domain Containing 5 (TXNDC5): Friend or Foe?
Curr Issues Mol Biol. 2024 Apr 4;46(4):3134-3163. doi: 10.3390/cimb46040197.ABSTRACTThis review focuses on the thioredoxin domain containing 5 (TXNDC5), also known as endoplasmic reticulum protein 46 (ERp46), a member of the protein disulfide isomerase (PDI) family with a dual role in multiple diseases. TXNDC5 is highly expressed in endothelial cells, fibroblasts, pancreatic β-cells, liver cells, and hypoxic tissues, such as cancer endothelial cells and atherosclerotic plaques. TXNDC5 plays a crucial role in regulating cell proliferation, apoptosis, migration, and antioxidative stress. Its potential significance in cancer...
Source: Mol Biol Cell - April 26, 2024 Category: Molecular Biology Authors: Seyed Hesamoddin Bidooki Mar ía A Navarro Susana C M Fernandes Jesus Osada Source Type: research
Thioredoxin Domain Containing 5 (TXNDC5): Friend or Foe?
Curr Issues Mol Biol. 2024 Apr 4;46(4):3134-3163. doi: 10.3390/cimb46040197.ABSTRACTThis review focuses on the thioredoxin domain containing 5 (TXNDC5), also known as endoplasmic reticulum protein 46 (ERp46), a member of the protein disulfide isomerase (PDI) family with a dual role in multiple diseases. TXNDC5 is highly expressed in endothelial cells, fibroblasts, pancreatic β-cells, liver cells, and hypoxic tissues, such as cancer endothelial cells and atherosclerotic plaques. TXNDC5 plays a crucial role in regulating cell proliferation, apoptosis, migration, and antioxidative stress. Its potential significance in cancer...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Seyed Hesamoddin Bidooki Mar ía A Navarro Susana C M Fernandes Jesus Osada Source Type: research
Profiling the molecular and clinical landscape of glioblastoma utilizing the Oncology Research Information Exchange Network brain cancer database
CONCLUSIONS: Herein, we report the first clinical, genomic, and transcriptomic analysis of ORIEN glioblastoma cases, incorporating sample reclassification under updated 2021 diagnostic criteria. These findings create multiple avenues for further investigation and reinforce the value of multi-institutional consortia such as ORIEN in deepening our knowledge of intractable diseases such as glioblastoma.PMID:38665799 | PMC:PMC11044707 | DOI:10.1093/noajnl/vdae046 (Source: Adv Data)
Source: Adv Data - April 26, 2024 Category: Epidemiology Authors: Alexandra N Demetriou Frances Chow David W Craig Michelle G Webb D Ryan Ormond James Battiste Arnab Chakravarti Howard Colman John L Villano Bryan P Schneider James K C Liu Michelle L Churchman Gabriel Zada Source Type: research
Long ‐term survival of a patient with epidermal growth factor receptor (EGFR)‐mutant non‐small cell lung cancer (NSCLC) and untreated multiple brain metastases treated with zorifertinib: A case report
Long OS achieved in NSCLC patients with EGFR mutation and untreated multiple BM after zorifertinib treatment. AbstractBrain metastases (BM) are common in patients with epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) and confer poor prognoses. Zorifertinib (AZD3759), an EGFR-tyrosine kinase inhibitor (TKI) with high blood-brain barrier penetration, has previously demonstrated promising systemic and intracranial antitumor activity in phase 1 –3 studies. This is the first report of a patient withEGFR-mutant (exon 21 L858R) NSCLC and symptomatic untreated multiple BM who achieved a long over...
Source: Thoracic Cancer - April 26, 2024 Category: Cancer & Oncology Authors: Kang Li,
Bolin Chen,
Jingyi Wang,
Lin Wu Tags: CASE REPORT Source Type: research
Prospective phase II study of radiotherapy dose escalation in grade 4 glioma using 68Ga-Pentixafor PET scan
Local failure remains the major concern in grade 4 glioma or glioblastoma (GBM). Pilot studies have shown radiotherapy (RT) dose response relationship in GBM. Here we present our preliminary data of RT dose escalation using 68Ga-Pentixafor PET scan. High 68Ga-pentixafor uptake in glioma cells helps in sharp demarcation between tumor and normal brain. (Source: Clinical Oncology)
Source: Clinical Oncology - April 26, 2024 Category: Radiology Authors: R. Madan, N. Kumar, C.B. Dracham, R. Kumar, G. Trivedi, M. Tripathi, S.K. Sahoo, N. Singla, C.K. Ahuja, D. Chatterjee, A. Yadav, S. Goyal, D. Khosla Source Type: research
CAR T-cell therapy: a potential treatment strategy for pediatric midline gliomas
AbstractPediatric brain tumors are the primary cause of death in children with cancer. Diffuse midline glioma (DMG) and diffuse intrinsic pontine glioma (DIPG) are frequently unresectable due to their difficult access location, and 5-year survival remains less than 20%. Despite significant advances in tumor biology and genetics, treatment options remain limited and ineffective. Immunotherapy using T cells with a chimeric antigen receptor (CAR) that has been genetically engineered is quickly emerging as a new treatment option for these patients. High levels of expression were detected for both disialoganglioside (GD2) and B...
Source: Acta Neurologica Belgica - April 26, 2024 Category: Neurology Source Type: research
Results from a first-in-human phase i safety trial to evaluate the use of a vascularized pericranial/temporoparietal fascial flap to line the resection cavity following resection of newly diagnosed glioblastoma
ConclusionsThis pilot study suggests that insertion of pedicled autologous TPFF/PCF along a GBM resection cavity is safe and feasible. Based on the encouraging response rate in 6-month PFS and OS, larger phase II studies are warranted to assess and reproduce safety, feasibility, and efficacy.Trial registration number and date of registration for prospectively registered trialsClinicalTrials.gov ID NCT03630289, dated: 08/02/2018. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 26, 2024 Category: Cancer & Oncology Source Type: research
Cancers, Vol. 16, Pages 1681: Extracellular Vesicles for Childhood Cancer Liquid Biopsy
ongtanate
Liquid biopsy involves the utilization of minimally invasive or noninvasive techniques to detect biomarkers in biofluids for disease diagnosis, monitoring, or guiding treatments. This approach is promising for the early diagnosis of childhood cancer, especially for brain tumors, where tissue biopsies are more challenging and cause late detection. Extracellular vesicles offer several characteristics that make them ideal resources for childhood cancer liquid biopsy. Extracellular vesicles are nanosized particles, primarily secreted by all cell types into body fluids such as blood and urine, and contain molecula...
Source: Cancers - April 26, 2024 Category: Cancer & Oncology Authors: Nilubon Singhto Pongpak Pongphitcha Natini Jinawath Suradej Hongeng Somchai Chutipongtanate Tags: Review Source Type: research
An exploration of causal relationships between nine neurological diseases and the risk of breast cancer: a Mendelian randomization study
CONCLUSIONS: This study found the trends towards a decreased risk of ER+ breast cancer in patients with Alzheimer's disease and an increased risk in patients with multiple sclerosis. However, due to the limitations of Mendelian randomization, we cannot determine whether there are definite causal relationships between neurological diseases and breast cancer risk. For conclusive evidences, more prospective randomized controlled trials will be needed in the future.PMID:38663930 | DOI:10.18632/aging.205745 (Source: Aging)
Source: Aging - April 25, 2024 Category: Biomedical Science Authors: Fei Ren Chenxuan Yang Kexin Feng Qingyao Shang Jiaxiang Liu Xiyu Kang Xin Wang Xiang Wang Source Type: research
An exploration of causal relationships between nine neurological diseases and the risk of breast cancer: a Mendelian randomization study
CONCLUSIONS: This study found the trends towards a decreased risk of ER+ breast cancer in patients with Alzheimer's disease and an increased risk in patients with multiple sclerosis. However, due to the limitations of Mendelian randomization, we cannot determine whether there are definite causal relationships between neurological diseases and breast cancer risk. For conclusive evidences, more prospective randomized controlled trials will be needed in the future.PMID:38663930 | DOI:10.18632/aging.205745 (Source: Atherosclerosis)
Source: Atherosclerosis - April 25, 2024 Category: Cardiology Authors: Fei Ren Chenxuan Yang Kexin Feng Qingyao Shang Jiaxiang Liu Xiyu Kang Xin Wang Xiang Wang Source Type: research
An exploration of causal relationships between nine neurological diseases and the risk of breast cancer: a Mendelian randomization study
CONCLUSIONS: This study found the trends towards a decreased risk of ER+ breast cancer in patients with Alzheimer's disease and an increased risk in patients with multiple sclerosis. However, due to the limitations of Mendelian randomization, we cannot determine whether there are definite causal relationships between neurological diseases and breast cancer risk. For conclusive evidences, more prospective randomized controlled trials will be needed in the future.PMID:38663930 | DOI:10.18632/aging.205745 (Source: Aging)
Source: Aging - April 25, 2024 Category: Biomedical Science Authors: Fei Ren Chenxuan Yang Kexin Feng Qingyao Shang Jiaxiang Liu Xiyu Kang Xin Wang Xiang Wang Source Type: research
Prognostic implications of combining EGFR ‐TKIs and radiotherapy in Stage IV lung adenocarcinoma with 19‐Del or 21‐L858R mutations: A real‐world study
ConclusionsPatients with Stage IV LUAD harboring 19-Del experience a notably prolonged OS following combined therapy with EGFR-TKIs and radiotherapy, while this OS benefit is observed despite the absence of substantial differences in the clinical characteristics between the19-Del and21-L858R groups. (Source: Cancer Medicine)
Source: Cancer Medicine - April 25, 2024 Category: Cancer & Oncology Authors: Shuai Liang,
Hanyu Wang,
Yingyun Zhang,
Haixia Tian,
Chengming Li,
Dong Hua Tags: RESEARCH ARTICLE Source Type: research
A Prognostic Methylation-Driven Two-Gene Signature in Medulloblastoma
In this study, we used six datasets totaling 1679 samples including RNA gene expression and DNA methylation data from primary MB as well as control samples from healthy cerebellum. We identified methylation-driven genes (MDGs) in MB, genes whose expression is correlated with their methylation. We employed LASSO regression, incorporating the MDGs as a parameter to develop the prognostic model. Through this approach, we deri ved a two-gene signature (GS-2) of candidate prognostic biomarkers for MB (CEMIP andNCBP3). Using a risk score model, we confirmed the GS-2 impact on overall survival (OS) with Kaplan-Meier analysis. We ...
Source: Journal of Molecular Neuroscience - April 25, 2024 Category: Neuroscience Source Type: research
Cancers, Vol. 16, Pages 1665: Stereotactic Radiosurgery for Patients with Brain Metastases from Hepatopancreaticobiliary Cancers
Conclusions: Metastatic spread to the brain from HPB cancers occurs late in the course of the primary disease. In this study, all deceased patients ultimately died from primary disease progression. SRS is a non-invasive strategy that maximally preserves quality of life, and our results reported favorable outcomes compared to the existing literature. SRS should be considered as one of the primary management strategies for patients with brain metastatic spread from HPB cancer. (Source: Cancers)
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: Wei Srinivasan Patel Bednarz Flickinger Hadjipanayis Niranjan Lunsford Tags: Article Source Type: research
