Results from a first-in-human phase i safety trial to evaluate the use of a vascularized pericranial/temporoparietal fascial flap to line the resection cavity following resection of newly diagnosed glioblastoma

ConclusionsThis pilot study suggests that insertion of pedicled autologous TPFF/PCF along a GBM resection cavity is safe and feasible. Based on the encouraging response rate in 6-month PFS and OS, larger phase II studies are warranted to assess and reproduce safety, feasibility, and efficacy.Trial registration number and date of registration for prospectively registered trialsClinicalTrials.gov ID NCT03630289, dated: 08/02/2018.
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research