Extent of re-excision, sequence/timing of salvage re-irradiation, and disease-free interval impact upon clinical outcomes in recurrent/progressive ependymoma
ConclusionExtent of re-excision, sequence/timing of re-RT, and DFI impact upon outcomes in curative-intent, multi-modality salvage therapy for recurrent ependymoma. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 18, 2020 Category: Cancer & Oncology Source Type: research

Mapping distribution of brain metastases: does the primary tumor matter?
ConclusionDistribution of brain metastases is very heterogeneous for the distinct primaries, possibly reflecting the diversity of mechanisms involved in brain metastases formation. In daily clinical practice distribution patters may be beneficial to predict the primary cancer site, if unknown. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 17, 2020 Category: Cancer & Oncology Source Type: research

Rationale for the advancement of PI3K pathway inhibitors for personalized chordoma therapy
ConclusionTargeted therapies, especially those inhibiting PI3K, display promising effects in multiple chordoma cell line and xenograft models. Nevertheless, the limited effects of PI3K, EGFR, and CDK targeting agents in other models reveal the presence of resistance mechanisms, which motivates future research to both identify biomarkers of response and develop combination therapies. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 17, 2020 Category: Cancer & Oncology Source Type: research

Fertility preservation outcomes in women with gliomas: a retrospective case –control study
AbstractPurposeWith advances in cancer therapy, reproductive-aged women can look forward to a life post-malignancy. Fortunately, fertility preservation (FP) may provide relief from potential infertility caused by cancer or associated caustic treatments. Outcomes of FP in pre-treatment reproductive-aged women with gliomas have not been previously characterized.MethodsBetween 2007 and 2018, 10 patients undergoing FP prior to chemotherapy and/or radiation treatment for gliomas were identified at Brigham and Women ’s Hospital. They were matched 3:1 to male-factor infertility patients by age ± 1 ...
Source: Journal of Neuro-Oncology - February 14, 2020 Category: Cancer & Oncology Source Type: research

Disparities in glioblastoma survival by case volume: a nationwide observational study
ConclusionHigher glioblastoma case volumes were associated with improved survival. Future studies should assess whether this association is due to differences in patient-specific factors or treatment quality. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 14, 2020 Category: Cancer & Oncology Source Type: research

Reconstruction after open surgery for skull-base malignancies
ConclusionRefinements in flap selection and reconstructive technique continue to improve patient outcomes and decrease complication rates following open surgery for skull base malignancies. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 13, 2020 Category: Cancer & Oncology Source Type: research

A genome-wide association study on medulloblastoma
AbstractIntroductionMedulloblastoma is a malignant embryonal tumor of the cerebellum that occurs predominantly in children. To find germline genetic variants associated with medulloblastoma risk, we conducted a genome-wide association study (GWAS) including 244 medulloblastoma cases and 247 control subjects from Sweden and Denmark.MethodsGenotyping was performed using Illumina BeadChips, and untyped variants were imputed using IMPUTE2.ResultsFifty-nine variants in 11 loci were associated with increased medulloblastoma risk (p  
Source: Journal of Neuro-Oncology - February 13, 2020 Category: Cancer & Oncology Source Type: research

Integration of immuno-oncology with stereotactic radiosurgery in the management of brain metastases
ConclusionCombination therapy with SRS and ICI appears to improve survival in patients with brain metastases. The available data are largely retrospective; therefore, ongoing and planned prospective studies are needed to further validate these findings. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 12, 2020 Category: Cancer & Oncology Source Type: research

Ketogenic diets as an adjuvant therapy for glioblastoma (KEATING): a randomized, mixed methods, feasibility study
ConclusionRecruitment to a KD trial for patients with GBM is possible. A six-week intervention period is proposed for a phase III trial. The role of caregivers should not be underestimated. Future trials should optimize and adequately support the decision-making of patients. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 8, 2020 Category: Cancer & Oncology Source Type: research

LINAC-based stereotactic radiosurgery versus hypofractionated stereotactic radiotherapy delivered in 3 or 5 fractions for vestibular schwannomas: comparative assessment from a single institution
ConclusionSRS and hypo-FSRT with 3 or 5 fractions provided a high rate of local control with no significant differences between treatment schedules. SRS is a well-documented radiation technique for VS and is the recommendation for small- to medium-sized tumors. This report demonstrates excellent long-term outcomes after hypo-FSRT; this regimen can be delivered safely and is an alternative for selected patients. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 8, 2020 Category: Cancer & Oncology Source Type: research

Comparison of two-stage Gamma Knife radiosurgery outcomes for large brain metastases among primary cancers
ConclusionsTwo-stage SRS should be considered for BC and NSCLC if surgical resection is not indicated. For BMs from GIC, staged SRS should be carefully considered and adapted to each unique case given its lower tumor reduction rate and shorter OS. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 5, 2020 Category: Cancer & Oncology Source Type: research

Provider views on perioperative steroid use for patients with newly diagnosed pediatric brain tumors
AbstractPurposeCerebral edema from brain tumors can cause neurological impairment. Steroids treat edema but with possible adverse effects. We surveyed providers regarding steroid use in newly diagnosed patients with brain tumors to determine if practices are standard or markedly variable.MethodsAn anonymous voluntary online survey was sent to members of neuro-oncology consortiums. Four clinical scenarios were provided and questions regarding initiation of steroids, type, dose, formulation, and duration were asked. Demographic information was collected.Results369 providers received the survey, 76 responded (20.6% response r...
Source: Journal of Neuro-Oncology - February 5, 2020 Category: Cancer & Oncology Source Type: research

Impact of maintenance rituximab on duration of response in primary central nervous system lymphoma
ConclusionWe are evaluating the effectiveness of maintenance immunotherapy in PCNSL in a prospective multicenter randomized clinical trial. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 5, 2020 Category: Cancer & Oncology Source Type: research

Surgical management of anterior skull-base malignancies (endoscopic vs. craniofacial resection)
AbstractAnterior skull base (ASB) malignancies are rare entities characterized by delayed diagnosis and comprise a variety of distinct histological types. Their treatment involves clinical and surgical management, with the latter encompassing open and, more recently, endoscopic approaches. The craniofacial resection, as an open approach, has revolutionized the treatment of such diseases and is the gold standard, although significant morbidity and facial scars are a shortcoming. Seeking a less invasive alternative, many surgeons have approached these pathologies using the endoscopic endonasal approach, with the theoretical ...
Source: Journal of Neuro-Oncology - February 4, 2020 Category: Cancer & Oncology Source Type: research

Radiation dose response of neurologic symptoms during conformal radiotherapy for diffuse intrinsic pontine glioma
ConclusionsLow cumulative RT doses resulted in neurologic improvement in most patients with DIPG. The volume of brainstem spared by tumor influenced time to symptomatic improvement. Neurologic improvement during RT was associated with superior survival. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 3, 2020 Category: Cancer & Oncology Source Type: research

Rapamycin and hydroxychloroquine combination alters macrophage polarization and sensitizes glioblastoma to immune checkpoint inhibitors
ConclusionWe provide a rationale for manipulating the macrophage phenotype and increased the therapeutic effect of ICPi. To re-educate and re-empower the TAM/microglia opens an interesting avenue for GBM treatment.Graphic Abstract (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 1, 2020 Category: Cancer & Oncology Source Type: research

Relationships between recurrence patterns and subventricular zone involvement or CD133 expression in glioblastoma
AbstractIntroductionWe previously reported that CD133 expression correlated with the recurrence pattern of glioblastoma (GBM). Subventricular zone (SVZ) involvement may also be associated with distant recurrence in GBM. Therefore, we herein investigated whether the combined analysis of SVZ involvement and CD133 expression is useful for predicting the pattern of GBM recurrence.Materials and methodsWe retrospectively analyzed 167 cases of GBM. Tumors were divided into four groups based on spatial relationships between contrast-enhanced lesions (CEL) and the SVZ or cortex (Ctx) on MRI. The initial recurrence pattern (local/di...
Source: Journal of Neuro-Oncology - February 1, 2020 Category: Cancer & Oncology Source Type: research

Contemporary management of pediatric spinal tumors: a single institute's experience in Taiwan in the modern era
ConclusionsPediatric spinal tumor surgery carries low surgical morbidity and mortality under current standard of neurosurgical practice. Post-operative adjuvant therapy is required for nearly half of the cases. Spinal deformity requires special attention and sometimes surgical correction. Contemporary management of pediatric spinal tumors enables effective ablation of the lesion and delivers favorable outcome for the majority of patients. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 1, 2020 Category: Cancer & Oncology Source Type: research

First-line bevacizumab contributes to survival improvement in glioblastoma patients complementary to temozolomide
ConclusionsOur findings imply that optional first-line administration of BEV can overcome the impact of conventional risk factors and prolong survival complementary to TMZ. The patient subgroups benefitting from TMZ and BEV did not seem to overlap, and stratification based on risk factors, includingMGMT methylation status, might be effective for selecting patients in whom BEV should be preferentially used as a first-line therapy. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 1, 2020 Category: Cancer & Oncology Source Type: research

Radiomics as prognostic factor in brain metastases treated with Gamma Knife radiosurgery
ConclusionsThe zone percentage of brain metastases, a radiomic feature derived from pre-GKRS contrast-enhanced T1-weighted MRIs, was found to be an independent prognostic factor of local tumor control following GKRS in patients with non-small cell lung cancer and brain metastases. Radiomic features indicate the biological basis and characteristics of tumors and could potentially be used as surrogate biomarkers for predicting tumor prognosis following GKRS. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 1, 2020 Category: Cancer & Oncology Source Type: research

Objective assessment of intraoperative tumor fluorescence reveals biological heterogeneity within glioblastomas: a biometric study
ConclusionsFluorescence may miss important tumor areas even if objective assessment is used. Histologically similar tumor areas may exhibit contrasting fluorescence properties, a phenomenon which needs further investigation and elucidation of underlying mechanisms which could potentially be manipulated to optimize the utility of fluorescence guidance. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 1, 2020 Category: Cancer & Oncology Source Type: research

Tumor treating fields plus temozolomide for newly diagnosed glioblastoma: a sub-group analysis of Korean patients in the EF-14 phase 3 trial
ConclusionMedian OS and 1- and 2-year survival rates were higher with TTFields/TMZ and similar to the entire EF-14 population. About 30% of patients reported skin irritation, a lower rate than seen in the entire EF-14 population. These results demonstrate the efficacy and safety of TTFields in Korean newly diagnosed glioblastoma patients.Clinical TrialsClinicaltrials.gov Identifier: NCT00916409. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 1, 2020 Category: Cancer & Oncology Source Type: research

Extracellular glutamate and IDH1 R132H inhibitor promote glioma growth by boosting redox potential
Conclusion3D culture is more relevant toIDH1R132H glioma biology. The importance of redox homeostasis inIDH1R132H glioma suggests that metabolic pathway(s) can be explored for therapeutic targeting, whereas IDH1R132H inhibitors may have counterproductive consequences in patient treatment. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 1, 2020 Category: Cancer & Oncology Source Type: research

KIF3C is associated with favorable prognosis in glioma patients and may be regulated by PI3K/AKT/mTOR pathway
AbstractPurposeGlioma is the most common malignant primary tumor in the central nervous system (CNS). KIF3C, a motor protein of the kinesin superfamily, is highly expressed in the CNS. Although KIF3C has been identified as a potential therapeutic target in malignant cancers, the expression and function of KIF3C in glioma remains unclear.MethodsThe clinical characteristics of 53 patients with graded glioma (WHO I –IV) were analyzed in this study. The expression of KIF3C in glioma was evaluated by immunohistochemistry (IHC). Survival analysis was compared between higher and lower KIF3C expression groups. Data regarding...
Source: Journal of Neuro-Oncology - February 1, 2020 Category: Cancer & Oncology Source Type: research

The pretemporal trans-cavernous trans-Meckel ’s trans-tentorial trans-petrosal approach: a combo skill in treating skull base meningiomas
AbstractPurposeSurgical treatments for skull base meningiomas are challenging. We found that most of these lesions (75%), despite locating at the anterior, middle or posterior fossa, could be dealt with a combo skill —the pretemporal trans-cavernous trans-Meckel’s trans-tentorial trans-petrosal approach (PCMTP), which adopted the same curvilinear skin incision as for the classic pterional approach. Our aim of this study is to validate the application of this technique in treating skull base meningiomas.MethodsPatients underwent surgical intervention at our institute during 2010 –2018 were retrospectively ...
Source: Journal of Neuro-Oncology - February 1, 2020 Category: Cancer & Oncology Source Type: research

The role of tailored intraoperative neurophysiological monitoring in glioma surgery: a single institute experience
ConclusionsIn our experience, tailored intraoperative functional mapping provides an effective neurological function preservation. Routine implementation of neurophysiological monitoring with adequate pre-operative planning and intraoperative teamwork in eloquent glioma can get more satisfied functional preservation. Due to the maturation and experience of our IONM team may also be the variation factor, prospective studies with a more prominent sample and proper multivariate analysis will be expected to determine the real benefit. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 1, 2020 Category: Cancer & Oncology Source Type: research

l -asparaginase and 6-diazo-5-oxo- l -norleucine synergistically inhibit the growth of glioblastoma cells
AbstractPurposeGlioblastoma is an aggressive central nervous system tumor with a 5-year survival rate of  
Source: Journal of Neuro-Oncology - February 1, 2020 Category: Cancer & Oncology Source Type: research

Editorial: advances in neuro-oncology and clinical treatment —from ASNO 2019
AbstractThe 16th Annual Meeting of the Asian Society for Neuro-Oncology was successfully held in Taipei, September 26 –29. The diverse, in-depth experiences sharing in the conference contributed the fruitful result. Here we selected several important manuscripts to represent the advance of neuro-oncology and clinical treatment in Asia. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 1, 2020 Category: Cancer & Oncology Source Type: research

Transcortical approach for insular gliomas: a series of 253 patients
ConclusionThis study demonstrated that the maximal safe resection of insular gliomas can be achieved by transcortical approach. Insular gliomas had the characteristic of forward distribution, anterior transcortical approach can provide enough surgical freedom for anterior type of insular gliomas. If anterior tumors can make route to the posterior parts, anterior transcortical approach was also applied to some anterior –posterior and giant types of insular gliomas without resection of excessive brain, which may reduce the incidence of neurological complications. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - January 31, 2020 Category: Cancer & Oncology Source Type: research

The role of TP53 gain-of-function mutation in multifocal glioblastoma
ConclusionThis data suggests that theTP53 mutation led to gain-of-function phenotypes and resulted in greater overall oncogenic potential of G53. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - January 30, 2020 Category: Cancer & Oncology Source Type: research

Prospective memory and brain metastases: a relevant target for rehabilitation in post-operative patients?
AbstractPurposeThe study investigated the prospective memory (PM) functioning among patients with brain metastases (BM), eligible for neurosurgy/radiosurgery, and its relationships with depression and quality of life (QoL).MethodsThis case-healthy-control, cross-sectional study, comprised 160 participants, including 49 patients with BM from various cancers treated with neurosurgery or radiosurgery. They were compared with 111 matched controls on a set of neuropsychological tests, including the MoCA global cognitive test and an experimental PM task ‘PROMESSE’. Participants also completed a depression scale (BDI-...
Source: Journal of Neuro-Oncology - January 30, 2020 Category: Cancer & Oncology Source Type: research

Finite element analysis of Tumor Treating Fields in a patient with posterior fossa glioblastoma
ConclusionsOur finite element modeling showed that the alternative array configurations offer an improved TTFields coverage to the cerebellar tumor compared to the conventional supratentorial configuration. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - January 27, 2020 Category: Cancer & Oncology Source Type: research

Three-institution study on applicability of initial brain metastasis velocity for breast cancer brain metastasis patients undergoing stereotactic radiosurgery
This study aimed to validate whether the recently-proposed prognostic grading system, initial brain metastasis velocity (iBMV), is applicable to breast cancer patients receiving stereotactic radiosurgery (SRS). We focused particularly on whether this grading system is useful for patients with all molecular types, i.e., positive versus negative for EsR, PgR and HER2.Methods and materialsThis was an institutional review board-approved, retrospective cohort study using our database, prospectively accumulated at three gamma knife institutes, during the 20-year-period since 1998. We excluded patients for whom the day of primary...
Source: Journal of Neuro-Oncology - January 27, 2020 Category: Cancer & Oncology Source Type: research

Is the anatomical distribution of low-grade gliomas linked to regions of gliogenesis?
ConclusionOur study suggests that the stem cell origin of IDH wild-type and IDH mutated low-grade gliomas may be different. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - January 25, 2020 Category: Cancer & Oncology Source Type: research

Rate of change in maximum 18 F-FDOPA PET uptake and non-enhancing tumor volume predict malignant transformation and overall survival in low-grade gliomas
ConclusionsThe change in maximum normalized18F-FDOPA PET uptake, with or without clinical information and rate of change in tumor volume, may be useful for predicting the risk of malignant transformation and estimating residual survival in patients with LGG. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - January 24, 2020 Category: Cancer & Oncology Source Type: research

Identification of epithelial membrane protein 2 (EMP2) as a molecular marker and correlate for angiogenesis in meningioma
AbstractPurposeAlthough intracranial meningiomas are the most common primary brain tumor in adults, treatment options are few and have traditionally been limited to surgical resection and radiotherapy. Additional targeted therapies and biomarkers are needed, especially as complete surgical resection is frequently not feasible in many patients.MethodsNon-pathologic brain tissue from 3 patients undergoing routine autopsies and tumor specimens from 16 patients requiring surgical resection for meningioma were collected. EMP2 protein expression was evaluated by immunohistochemistry and western blot analysis. EMP2 mRNA expressio...
Source: Journal of Neuro-Oncology - January 24, 2020 Category: Cancer & Oncology Source Type: research

Hypertension and proteinuria as clinical biomarkers of response to bevacizumab in glioblastoma patients
ConclusionOur data suggest that hypertension and proteinuria can be effective predictors of response to antiangiogenic therapy in recurrent glioblastoma and are associated with longer disease control. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - January 23, 2020 Category: Cancer & Oncology Source Type: research

Implantation of carmustine wafers (Gliadel ® ) for high-grade glioma treatment. A 9-year nationwide retrospective study
AbstractBackgroundCarmustine wafers (CW) are approved to treat newly or recurrent high-grade gliomas (HGG). Widespread use has been limited regarding some doubtful uncertainties about their efficacy, related increased risk of infection and expensive cost.ObjectiveTo describe the epidemiology of CW implantation, search for related complications, long-term survival and associated prognostic factors.MethodsWe processed the French medico-administrative national database to retrieve appropriate cases operated between 2010 and 2018. A survival analysis was conducted.ResultsWe identified 1659 patients treated in 39 institutions. ...
Source: Journal of Neuro-Oncology - January 23, 2020 Category: Cancer & Oncology Source Type: research

Perioperative fatigue in patients with diffuse glioma
AbstractPurposeFew studies have assessed fatigue in relation to glioma surgery. The purpose of this study was to explore the prevalence of pre- and postoperative high fatigue, perioperative changes, and factors associated with pre- and postoperative high fatigue in patients undergoing primary surgery for diffuse glioma.MethodsA total of 112 adult patients were prospectively included. Patient-reported fatigue was assessed before and one month after surgery using the cancer-specific European Organization for Research and Treatment of Cancer questionnaire fatigue subscale. The scores were dichotomized as high fatigue ( ≥&t...
Source: Journal of Neuro-Oncology - January 23, 2020 Category: Cancer & Oncology Source Type: research

Outcomes of whole-brain radiation with simultaneous in-field boost (SIB) for the treatment of brain metastases
ConclusionWBRT with SIB to gross lesions using VMAT planning appears to be safe and effective in the treatment of brain metastases without significant cognitive decline. This treatment strategy should be considered in those patients with a high number of metastases or ones not amenable for radiosurgery.Clinical Trial Registration CodeNCT01218542 (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - January 22, 2020 Category: Cancer & Oncology Source Type: research

Perioperative neurocognitive functions in patients with neuroepithelial intracranial tumors
This study aimed to assess perioperative neurocognitive functions in patients with surgery for intracranial neuroepithelial tumors.MethodsSeventy-one patients [38 male, 33 female, mean age 47.2  years (range 18 to 81)] with surgery for an intracranial neuroepithelial tumor were included in this prospective single-center study. Mini-mental status examination (MMSE) and extensive neurocognitive testing (divided into the categoriesattention,memory, andexecutive functions and adjusted for age, sex, and education) were performed pre-(t0) and early postoperatively (t1). Part of the patient cohort (n  = 32) als...
Source: Journal of Neuro-Oncology - January 22, 2020 Category: Cancer & Oncology Source Type: research

Alternative lengthening of telomeres is the major telomere maintenance mechanism in astrocytoma with isocitrate dehydrogenase 1 mutation
ConclusionALT is the major telomere maintenance mechanism in IDHR132H mutated astrocytomas, while TERT promoter mutations were associated with IDHwildtype glioma. IDH1R132H downregulates ATRX expression in vitro resulting in ALT, which may contribute to the strong association of IDH1R132H mutations, ATRX loss, and ALT. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - January 20, 2020 Category: Cancer & Oncology Source Type: research

Efficacy of sequential radiation and chemotherapy in treating glioblastoma with poor performance status
AbstractIntroductionWhile the current standard of care after maximal safe resection for glioblastoma (GBM) is concomitant radiation and chemotherapy, the ideal therapy for patients with poor performance status remains in question due to concerns about treatment tolerance. We sought to evaluate an alternative regimen, sequential radiation and chemotherapy, to assess its efficacy as a treatment option for poorly performing patients.MethodsWe performed a retrospective analysis using the 2015 National Cancer Database in which the survival of patients with a KPS  ≤ 70 who received sequential radiation and chemo...
Source: Journal of Neuro-Oncology - January 20, 2020 Category: Cancer & Oncology Source Type: research

Postoperative oscillatory brain activity as an add-on prognostic marker in diffuse glioma
ConclusionsOur findings suggest that postoperative broadband power is of additional value in predicting PFS beyond already known predictors. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - January 17, 2020 Category: Cancer & Oncology Source Type: research

Hospital teaching status associated with reduced inpatient mortality and perioperative complications in surgical neuro-oncology
We present the first analysis comparing brain tumor surgery perioperative outcomes at academic and non-teaching centers.MethodsBrain tumor surgeries in the Nationwide Inpatient Sample (NIS) from 1998 to 2014 were identified. A teaching hospital, defined by the NIS, must have  ≥ 1 Accreditation Council of Graduate Medical Education (ACGME) approved residency programs, Council of Teaching Hospitals membership, or have a ratio ≥ 0.25 of full-time residents to hospital beds. Annual treatment trends were stratified by hospital teaching status, assessing yearly ca seload with linear regression. ...
Source: Journal of Neuro-Oncology - January 14, 2020 Category: Cancer & Oncology Source Type: research

Resection of recurrent glioblastoma multiforme in elderly patients: a pseudo-randomized analysis revealed clinical benefit
ConclusionTaken together, in elderly patients, re-resection is an acceptable treatment option in the recurrent state of a glioblastoma. The individual evaluation of the patients ′ medical status as well as the chances of withstanding general anesthesia needs to be done in close interdisciplinary consultation. If these requirements are met, elderly patients benefit from a re-resection. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - January 13, 2020 Category: Cancer & Oncology Source Type: research

Salvage gamma knife radiosurgery for active brain metastases from small-cell lung cancer after whole-brain radiation therapy: a retrospective multi-institutional study (JLGK1701)
ConclusionsGKS can safely preserve neurological function and prevent neurologic death in patients with 1 –10 small, active BMs after prophylactic and therapeutic WBRT. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - January 13, 2020 Category: Cancer & Oncology Source Type: research

Current status and treatment modalities in metastases to the pituitary: a systematic review
AbstractBackgroundMetastases to the pituitary (MP) are uncommon, accounting for 0.4% of intracranial metastases. Through advances in neuroimaging and oncological therapies, patients with metastatic cancers are living longer and MP may be more frequent. This review aimed to investigate clinical and oncological features, treatment modalities and their effect on survival.MethodsA systematic review was performed according to PRISMA recommendations. All cases of MP were included, excepted primary pituitary neoplasms and autopsy reports. Descriptive and survival analyses were then conducted.ResultsThe search identified 2143 reco...
Source: Journal of Neuro-Oncology - January 13, 2020 Category: Cancer & Oncology Source Type: research

Spatial distribution of malignant transformation in patients with low-grade glioma
ConclusionMalignant transformation occurs locally and within the T2w hyperintensities in most patients. Although LGG is an infiltrating disease, this data conceptually strengthens the role of loco-regional treatments in patients with LGG. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - January 9, 2020 Category: Cancer & Oncology Source Type: research

Short non-coding RNA sequencing of glioblastoma extracellular vesicles
ConclusionsNext generation short non-coding RNA sequencing on GBM EV ’s validates findings from earlier studies using miRNA arrays but also demonstrates expression of many additional non-coding RNA sequences and classes previously unassociated with GBM. This may yield important insights into pathophysiology, point to new therapeutic targets, and help develop new bi omarkers for disease burden and treatment response. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - January 7, 2020 Category: Cancer & Oncology Source Type: research