Bone metastasis from glioblastoma: a systematic review
ConclusionMetastatic dissemination of GBM to bone occurs. While the true incidence is unknown, workup for metastatic disease, especially involving the spinal column, is warranted in symptomatic patients. Lastly, management of patients with GBM vertebral column metastases can follow the International Spine Oncology Consortium two-step multidisciplinary algorithm for the management of spinal metastases. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - May 17, 2022 Category: Cancer & Oncology Source Type: research

Adult diffuse midline gliomas H3 K27-altered: review of a redefined entity
ConclusionThe diagnosis of DMGs H3 K27-altered in adult patients should be considered upon neurological symptoms associated with an infiltrative midline brain tumor detected on imaging. Future studies are necessary to continue refining their characteristics in this age group. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - May 14, 2022 Category: Cancer & Oncology Source Type: research

Predictors of survival and time to progression following operative management of intramedullary spinal cord astrocytomas
ConclusionTumor grade and chemotherapy were associated with poorer survival and progression-free survival. Chemotherapy regimens were highly heterogeneous, and randomized trials are needed to determine if any optimal regimens exist. Additionally, GTR was associated with improved survival, and patients should be counseled about the benefits and risks of resection extent. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - May 11, 2022 Category: Cancer & Oncology Source Type: research

Brachytherapy for central nervous system tumors
AbstractRadiation is a mainstay of treatment for central nervous system (CNS) tumors. Brachytherapy involves the placement of a localized/interstitial radiation source into a tumor or resection bed and has distinct advantages that can make it an attractive form of radiation when used in the appropriate setting. However, the data supporting use of brachytherapy is clouded by variability in radiation sources, techniques, delivered doses, and trial designs. The goal of this manuscript is to identify consistent themes, review the highest-level evidence and potential indications for brachytherapy in CNS tumors, as well as highl...
Source: Journal of Neuro-Oncology - May 11, 2022 Category: Cancer & Oncology Source Type: research

Tumor-associated alterations in white matter connectivity have prognostic significance in MGMT-unmethylated glioblastoma
ConclusionIncreased TA-WMS and involvement of critical tracts are associated with decreased overall survival in MGMT-unmethylated GBM. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - May 7, 2022 Category: Cancer & Oncology Source Type: research

LIM and SH3 protein 1 (LASP1) differentiates malignant chordomas from less malignant chondrosarcomas
ConclusionLASP1 is strongly expressed in the majority of chordoma cases and shows low expression in chondrosarcoma tissue. Since LASP1  is known to function as oncogene and regulate cell proliferation in other tumor types, this study implicates a role for LASP1 in chordoma biology. Further studies are warranted to improve understanding of LASP1’s expression and functioning within chordoma, both in vitro and in vivo. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - May 4, 2022 Category: Cancer & Oncology Source Type: research

Correction to: Carnosic acid potentiates the anticancer effect of temozolomide by inducing apoptosis and autophagy in glioma
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - May 4, 2022 Category: Cancer & Oncology Source Type: research

Predicting access to postoperative treatment after glioblastoma resection: an analysis of neighborhood-level disadvantage using the Area Deprivation Index (ADI)
ConclusionMore disadvantaged glioblastoma patients had decreased odds of receiving gross total resection. They also exhibited decreased odds of receiving standard of care like chemoradiation as well as participating in a clinical trial, compared to the less disadvantaged group. More research is needed to identify modifiable SDoH barriers to post-operative treatment in disadvantaged patients with glioblastoma. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - May 3, 2022 Category: Cancer & Oncology Source Type: research

Cognitive function after concurrent temozolomide-based chemoradiation therapy in low-grade gliomas
ConclusionCognitive function remained stable following RT  + TMZ in LGG patients evaluated prospectively up to 2 years. The anticipated analysis of RTOG 0424 will provide valuable neurocognitive outcomes specifically for high risk LGG patients treated with RT + TMZ. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 29, 2022 Category: Cancer & Oncology Source Type: research

Next generation sequencing in adult patients with glioblastoma in Switzerland: a multi-centre decision analysis
ConclusionNGS is frequently applied in glioblastomas in adults in Neuro-Oncology centres in Switzerland despite seldom changing the course of treatment to date. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 29, 2022 Category: Cancer & Oncology Source Type: research

Retraction Note to: LncRNA RP11-84E24.3 drives tumorigenesis and epithelial-to-mesenchymal transition of glioma cells by promoting TFAP2C-mediated activation of SNAI1
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 28, 2022 Category: Cancer & Oncology Source Type: research

Survival outcomes associated with MGMT promoter methylation and temozolomide in gliosarcoma patients
ConclusionIn a national analysis of gliosarcoma patients, temozolomide was associated with prolonged OS irrespective ofMGMT status. These results provide support for the current practice of trimodal therapy for gliosarcoma. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 26, 2022 Category: Cancer & Oncology Source Type: research

The Clinical Frailty Scale as predictor of overall survival after resection of high-grade glioma
ConclusionCFS seems to be a reliable tool for functional assessment of patients suffering from high-grade glioma. CFS includes non-cancer related aspects and therefore is a contemporary approach for patient evaluation. Its projection of survival can be equally estimated before and after surgery. IDH-mutation caused longer survival and higher functionality. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 25, 2022 Category: Cancer & Oncology Source Type: research

Effect of distance from target on hypopituitarism after stereotactic radiosurgery for pituitary adenomas
ConclusionsGreater distance between the normal pituitary gland and the SRS target is associated with anterior pituitary function preservation and increasing this distance should be a goal of adenoma resection. Larger prospective, multi-center studies are necessary to corroborate this finding and establish the effects of distance on hypopituitarism after SRS for pituitary adenomas. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 24, 2022 Category: Cancer & Oncology Source Type: research

LINC02381-ceRNA exerts its oncogenic effect through regulation of IGF1R signaling pathway in glioma
ConclusionThe overall results indicated that LINC02381 exerts its oncogenic effect in glioma cells through sponging miR-128 and miR-150 to upregulate the IGF1R signaling pathway. Our results introduce LINC02381 and miR-128, and miR-150 as potential prognosis and therapy targets for the treatment of glioma. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 23, 2022 Category: Cancer & Oncology Source Type: research