Development of a “Geo-Tagged” tumor sample registry: intra-operative linkage of sample location to imaging
ConclusionWe are using the results of this analysis to develop a prospective sample collection protocol. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 28, 2023 Category: Cancer & Oncology Source Type: research

A multi-site phase I trial of Veliparib with standard radiation and temozolomide in patients with newly diagnosed glioblastoma multiforme (GBM)
ConclusionsAlthough Veliparib 10  mg BID administered with TMZ 75 mg/m2 for six weeks was well tolerated, when this regimen was combined with standard partial brain irradiation it was severely myelosuppressive even when the dose was reduced by 50%. This study again highlights the potential of localized cranial radiotherapy to sig nificantly increase hematologic toxicity of marginally myelosuppressive systemic therapies. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 28, 2023 Category: Cancer & Oncology Source Type: research

Pyruvate kinase M2 (PKM-2) expression and prognostic significance in glioblastoma patients
ConclusionPKM2 is an independent prognostic factor for survival and is associated with poor prognosis in GBM patients treated with radiotherapy. It may be a potential therapeutic target for anticancer therapy. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 27, 2023 Category: Cancer & Oncology Source Type: research

Generation of patient-derived pediatric pilocytic astrocytoma in-vitro models using SV40 large T: evaluation of a modeling workflow
ConclusionA subset of primary PA cultures can be converted into long-term cell lines using SV40-TAg depending on sample intrinsic (patient age) and extrinsic workflow-related (e.g. type of medium, successful transduction) parameters. Careful monitoring of sample-intrinsic and extrinsic factors optimizes the process. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 24, 2023 Category: Cancer & Oncology Source Type: research

Effects of intrathecal pemetrexed on the survival of patients with leptomeningeal metastasis from lung adenocarcinoma: a propensity score matching analysis
ConclusionsIntrathecal pemetrexed did not enhance OS for the entire LUAC patient with LM compared to non-intrathecal chemotherapy. However, it exhibited the potential to reduce the risk of central nervous system-related mortality and improve survival in patients with poor ECOG PS. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 23, 2023 Category: Cancer & Oncology Source Type: research

Treatment and survival of patients with small cell lung cancer and brain metastasis
ConclusionAlthough WBRT combined with systemic therapy offer better intracranial control in patients with SCLC and BM, this approach is not superior to the other approaches in terms of OS benefits. Emerging systemic therapies, such as immunotherapy, may be used as alternative or adjunctive treatments for specific patient populations. Further studies are warranted to refine treatment selection. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 20, 2023 Category: Cancer & Oncology Source Type: research

Capturing evolving definitions of 12 select rare CNS tumors: a timely report from CBTRUS and NCI-CONNECT
ConclusionsThese data provide means to measure the impact of clinical care and evaluate new therapies and the evolving histopathology definitions in rare CNS tumor types. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 19, 2023 Category: Cancer & Oncology Source Type: research

Particle beam radiotherapy in the treatment of WHO grade 2 and 3 meningiomas: an early experience from Shanghai Proton and Heavy Ion Center
ConclusionsTreatment-induced efficacy and toxicities to PBRT in WHO grade 2 and 3 meningiomas were both highly acceptable. Longer follow-up is needed to evaluate the long-term outcome in terms of disease control, survival, as well as potential late effects. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 17, 2023 Category: Cancer & Oncology Source Type: research

The long non-coding RNA OTX2-AS1 promotes tumor growth and predicts response to BCL-2 inhibition in medulloblastoma
ConclusionsOur study revealed a pro-tumorigenic role ofOTX2-AS1 in medulloblastoma and identified BCL-2 inhibition as a potential therapeutic approach to targetOTX2-AS1 overexpressing medulloblastoma cells. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 17, 2023 Category: Cancer & Oncology Source Type: research

The ruse of reduction – comment to Zeng et al.
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 17, 2023 Category: Cancer & Oncology Source Type: research

Stereotactic radiosurgery for large vestibular schwannomas: 2.5  cm and beyond
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 17, 2023 Category: Cancer & Oncology Source Type: research

Is reduced-dose whole-brain radiotherapy also feasible in primary CNS lymphoma for curative or salvage purpose?
ConclusionReduced-dose WBRT in curative and salvage treatments for PCNSL had no significant negative effect on the intracranial disease control rate or survival. Therefore, without impaired efficacy, use of reduced-dose WBRT appears promising for reduction of neurotoxicity. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 14, 2023 Category: Cancer & Oncology Source Type: research

The outcome of central nervous system hemangioblastomas in Von Hippel-Lindau (VHL) disease treated with belzutifan: a single-institution retrospective experience
ConclusionBelzutifan appears to be an effective and safe treatment for CNS hemangioblastoma in VHL patients. Further clinical trials to assess the long-term effectiveness of the medication are required. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 13, 2023 Category: Cancer & Oncology Source Type: research

Postoperative stereotactic radiosurgery for intracranial solitary fibrous tumors: systematic review and pooled quantitative analysis
ConclusionsSRS is a safe and effective treatment for intracranial SFTs. In the setting of measurable disease, our pooled data suggests a potential dose response of improving LTC with increasing SRS margin dose. Our improved understanding of the aggressive biology of SFTs and the tolerated adjuvant SRS parameters supports potentially earlier use of SRS in the postoperative treatment paradigm for intracranial SFTs. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 13, 2023 Category: Cancer & Oncology Source Type: research

Safety of microneurosurgical interventions for superficial and deep-seated brain metastases: single-center cohort study of 637 consecutive cases
ConclusionsModern microneurosurgical resection can be considered an excellent option in the management of BM in terms of safety, as the overall rate of major AEs are very rare even in eloquent and deep-seated lesions. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 10, 2023 Category: Cancer & Oncology Source Type: research