Melanoma brain metastases have lower T-cell content and microvessel density compared to matched extracranial metastases
ConclusionsAlthough responses to immune-modulating drugs in the body and the brain tend to be concordant, differences were found in MVD and T-cell content between these sites. Studies of these markers should be incorporated into prospective therapeutic clinical trials to determine their prognostic and predictive value. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 24, 2020 Category: Cancer & Oncology Source Type: research

A novel online calculator predicting short-term postoperative outcomes in patients with metastatic brain tumors
ConclusionsOur models predicting postoperative outcomes allow for individualized risk-estimation for patients following surgery for metastatic brain tumors. Our results may be useful in helping clinicians to provide resource-conscious, high-value care. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 22, 2020 Category: Cancer & Oncology Source Type: research

Weighing ependymoma as an epigenetic disease
ConclusionThis is a review of recent advancements in our understanding of the epigenetic basis of ependymoma and discussion of how these findings reveal potential therapeutic opportunities. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 22, 2020 Category: Cancer & Oncology Source Type: research

The ability to return to work: a patient-centered outcome parameter following glioma surgery
AbstractBackgroundWith refinements in diagnosis and therapy of gliomas, the importance of survival time as the sole outcome parameter has decreased, and patient-centered outcome parameters have gained interest. Pursuing a profession is an indispensable component of human happiness. The aim of this study was to analyze the professional outcomes besides their neuro-oncological and functional evaluation after surgery for gliomas in eloquent areas.MethodsWe assessed neuro-oncological and functional outcomes of patients with gliomas WHO grades II and III undergoing surgery between 2012 and 2018. All patients underwent routine f...
Source: Journal of Neuro-Oncology - September 22, 2020 Category: Cancer & Oncology Source Type: research

Identification of novel fusion transcripts in meningioma
ConclusionsFusion genes occur infrequently in meningiomas and are more likely to be found in tumors with greater degree of genomic instability (expression type C) or in patients with history of cranial irradiation. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 19, 2020 Category: Cancer & Oncology Source Type: research

Multiparametric MR-PET measurements in hypermetabolic regions reflect differences in molecular status and tumor grade in treatment-na ïve diffuse gliomas
ConclusionFDOPA hypermetabolic ROI may extract useful imaging features of gliomas, which can illuminate biological differences between different molecular status or tumor grades. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 14, 2020 Category: Cancer & Oncology Source Type: research

Serum microRNA is a biomarker for post-operative monitoring in glioma
ConclusionsWe identified a highly accurate 9-miRNA signature associated with glioma serum. Additionally, we observed dynamic changes in specific miRNAs correlating with tumor volume over long-term follow up. These results support a large prospective validation study of serum miRNA biomarkers in glioma. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 11, 2020 Category: Cancer & Oncology Source Type: research

Combined fluorescence-guided surgery and photodynamic therapy for glioblastoma multiforme using cyanine and chlorin nanocluster
ConclusionA multimodal theragnostic agent comprised solely of FDA-approved components was developed to couple optical imaging and PDT. The findings demonstrated evidence for the potential theragnostic benefit of ICS in surgical oncology that is conducive to clinical integration. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 10, 2020 Category: Cancer & Oncology Source Type: research

AKT/GSK-3 β/β-catenin signaling pathway participates in erythropoietin-promoted glioma proliferation
ConclusionsOur study identified the AKT/GSK-3 β/β-catenin axis as a critical mediator of EPO-induced glioma proliferation and further provided a clinically significant dimension to the biology of EPO. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 9, 2020 Category: Cancer & Oncology Source Type: research

Health-related quality of life and emotional well-being in patients with glioblastoma and their relatives
This study aimed to describe and compare the HRQoL of patients with glioblastoma and their relatives before surgery.MethodsA prospective cohort study including 89 patients diagnosed with glioblastoma and their relatives. HRQoL (Short Form Health Survey, SF-36) and emotional well-being (hospital anxiety and depression scale, HADS) were analysed with descriptive, comparative and multivariable regression analyses.ResultsRelatives scored worse for mental HRQoL (p  
Source: Journal of Neuro-Oncology - September 9, 2020 Category: Cancer & Oncology Source Type: research

Automated apparent diffusion coefficient analysis for genotype prediction in lower grade glioma: association with the T2-FLAIR mismatch sign
ConclusionTumor subregions with high ADC were a robust indicator of IDHmut-Noncodel LGG, with VADC>1.5 achieving  >  90% classification specificity in both internal and validation cohorts. VADC>1.5 exhibited strong concordance with the T2-FLAIR mismatch sign and the combination of both parameters improved sensitivity in detecting IDHmut-Noncodel LGG. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 9, 2020 Category: Cancer & Oncology Source Type: research

Development of a clinical scale for assessment of patients with diffuse intrinsic pontine glioma (DIPG) receiving experimental therapy: the PONScore
AbstractPurposeMonitoring neurological side-effects in experimental therapy for diffuse intrinsic pontine glioma (DIPG) can be challenging. We aimed to develop a neurological scale that could be used by non-specialists to quantify neurological changes during experimental treatment of DIPG.MethodsWe developed the Pontine Observational Neurological Score (PONScore) to measure signs and symptoms of DIPG  by adapting validated assessment scales of neurological signs and symptoms in children. We developed a prototype score, taught it to paediatric intensive care nursing staff, who used the Score to assess children rec...
Source: Journal of Neuro-Oncology - September 9, 2020 Category: Cancer & Oncology Source Type: research

Intracranial disease control for EGFR -mutant and ALK -rearranged lung cancer with large volume or symptomatic brain metastases
ConclusionMost patients receiving TKIs as part of their initial therapy achieve an early and durable volumetric intracranial response, irrespective of presenting disease burden or neurologic symptoms. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 9, 2020 Category: Cancer & Oncology Source Type: research

Diagnostic accuracy of MR imaging of patients with leptomeningeal seeding from lung adenocarcinoma based on 2017 RANO proposal: added value of contrast-enhanced 2D axial T2 FLAIR
Conclusion3D T1-WI is the best for identifying leptomeningeal nodules. The sensitivity of 2D FLAIR is the highest for both LNE and CNE. Since both sequences are complementary, it can be helpful to take both sequences. Checking each feature according to the RANO proposal, especially CNE, may help you not to miss LM. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 8, 2020 Category: Cancer & Oncology Source Type: research

Intraventricular choroid plexus tumors: clinical characteristics and impact of current management on survival
ConclusionPatients with CPTs present at different stages of life, with sizable tumor burden and distinct WHO grade prevalence. Considering their favorable survival, efforts to improve tumor control should be meticulously weighed against the long-term risk associated with surgery, radiation, and chemotherapy. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 8, 2020 Category: Cancer & Oncology Source Type: research

Glioma consensus contouring recommendations from a MR-Linac International Consortium Research Group and evaluation of a CT-MRI and MRI-only workflow
This study proposes contouring recommendations for radiation treatment planning target volumes and organs-at-risk (OARs) for both low grade and high grade gliomas.MethodsTen cases consisting of 5 glioblastomas and 5 grade II or III gliomas, including their respective gross tumor volume (GTV), clinical target volume (CTV), and OARs were each contoured by 6 experienced neuro-radiation oncologists from 5 international institutions. Each case was first contoured using only MRI sequences (MRI-only), and then re-contoured with the addition of a fused planning CT (CT-MRI). The level of agreement among all contours was assessed us...
Source: Journal of Neuro-Oncology - August 29, 2020 Category: Cancer & Oncology Source Type: research

Adjuvant radiation for WHO grade II and III intracranial meningiomas: insights on survival and practice patterns from a National Cancer Registry
AbstractIntroductionWHO grades II (atypical) and III (malignant) meningiomas are associated with significant morbidity and mortality. The role of adjuvant radiotherapy (RT) in management remains controversial. The goal of this study was to evaluate the impact of adjuvant RT on 5-year survival in patients with atypical and malignant meningiomas. We secondarily aimed to assess contemporary practice patterns and the impact of sociodemographic factors on outcome.MethodsWe queried the National Cancer Database for patients  ≥ 18 years of age with cranial atypical or malignant meningiomas from 2010 through 2...
Source: Journal of Neuro-Oncology - August 28, 2020 Category: Cancer & Oncology Source Type: research

Diagnostic yield of fluorescence-assisted frame-based stereotactic biopsies of intracerebral lesions in comparison with frozen-section analysis
ConclusionThe 5-ALA-fluorescence in stereotactic biopsies of unclear intracerebral pathologies exhibits a high PPV/NPV for intraoperative confirmation of diagnostic tissue and might increase the diagnostic yield of the procedure by overcoming some of the limitations of frozen-section. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - August 27, 2020 Category: Cancer & Oncology Source Type: research

JNO special issue: an update on pediatric neuro-oncology
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - August 26, 2020 Category: Cancer & Oncology Source Type: research

Medulloblastoma epigenetics and the path to clinical innovation
ConclusionThe widespread epigenetic alterations present in these tumors has generated intense interest in their use as therapeutic targets. We provide an assessment of the progress that has been made towards the development of molecular subtypes-targeted therapies and the current status of clinical trials that have leveraged these recent advances. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - August 20, 2020 Category: Cancer & Oncology Source Type: research

Temozolomide treatment outcomes and immunotherapy efficacy in brain tumor
ConclusionThe different levels of lymphopenia and tumor eradication discussed in this review suggest possible beneficial pairings between immunotherapy and TMZ treatment. Treatments resulting in profound lymphopenia will allow for expansion of vaccine specific T cells or of CAT T cells. Clinical and preclinical studies are currently comparing different combinations of TMZ and immunotherapy timing to treat GBM through a balance between tumor killing and immune cell expansion. More frequent immune monitoring time points in ongoing clinical trials are crucial for further development of these combinations. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - August 19, 2020 Category: Cancer & Oncology Source Type: research

Geographical variation in malignant and benign/borderline brain and CNS tumor incidence: a comparison between a high-income and a middle-income country
ConclusionAge-adjusted incidence rates of brain/CNS tumors were considerably higher in Zurich compared to Georgia, both for benign and malignant tumors, which is in line with other studies reporting higher rates in high-income than in low- and middle-income countries. The frequency distribution may be related to differences in diagnosing techniques and the population age structure. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - August 19, 2020 Category: Cancer & Oncology Source Type: research

Radiation therapy combined with intracerebral convection-enhanced delivery of cisplatin or carboplatin for treatment of the F98 rat glioma
ConclusionsThe results obtained using this combination therapy has, to the best of our knowledge, yielded the most promising survival data ever reported using the F98 glioma model. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - August 18, 2020 Category: Cancer & Oncology Source Type: research

Diffuse midline glioma: review of epigenetics
ConclusionWe continue to seek a comprehensive understanding of the mechanisms that govern chromatin dysregulation and DNA modification in DMG, and in parallel we forge ahead with clinical testing of epigenetic modifiers. The determined efforts from bench to bedside, along with collaborative mindset and unified mission, will ultimately result in improved outcomes for DMG. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - August 17, 2020 Category: Cancer & Oncology Source Type: research

Regulation of β-catenin by IGFBP2 and its cytoplasmic actions in glioma
ConclusionsIGFBP2 induces TRIM33 which regulates the nuclear β-catenin protein. In addition, IGFBP2 stabilizes the cytoplasmic β-catenin which is involved in the regulation of Oct4 transcript and consequently induction of stemness of glioma cells. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - August 16, 2020 Category: Cancer & Oncology Source Type: research

Causes of death in pediatric neuro-oncology: the sickkids experience from 2000 to 2017
ConclusionDisease progression is the main cause of death in children with brain tumor, while treatment related mortality is low in this series. Research should continue to focus on improving treatment strategies for patients whose prognosis remains dismal. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - August 14, 2020 Category: Cancer & Oncology Source Type: research

Radiation therapy strategies for skull-base malignancies
ConclusionRadiation treatment plays a key and critical role in the management of patients with skull base tumors. Recent advancements continue to improve the risk/benefit ratio for radiotherapy in this setting. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - August 12, 2020 Category: Cancer & Oncology Source Type: research

Trametinib for the treatment of recurrent/progressive pediatric low-grade glioma
ConclusionTrametinib appears to be an effective treatment for patients with recurrent/progressive pLGG. The toxicities of this therapy warrant further investigation, with particular attention to the potential risk for intracranial hemorrhage. Early phase multi-institutional clinical trials are underway. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - August 11, 2020 Category: Cancer & Oncology Source Type: research

In situ vaccination with laser interstitial thermal therapy augments immunotherapy in malignant gliomas
ConclusionLITT continues to be studied as a possible technique to bridge the gap between exciting preclinical results and the limited successes seen in the field of neuro-oncology. Preliminary data suggests a substantial benefit for use of LITT as a combination therapy in several clinical trials. Further investigation is required to determine whether or not this treatment paradigm can translate into long-term durable results for primary intracranial malignancies. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - August 5, 2020 Category: Cancer & Oncology Source Type: research

Nanoparticles as immunomodulators and translational agents in brain tumors
ConclusionReview of early preclinical studies and clinical trials provides foundational safety, feasibility and toxicology data that can usher a new wave of nanotherapeutics in application of immunotherapy and translational oncology for patients with brain tumors. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - August 5, 2020 Category: Cancer & Oncology Source Type: research

Complete response to therapy: why do primary central nervous system lymphoma patients not return to work?
ConclusionOccupational (re)integration is of clinical relevance in PCNSL patients after complete response to therapy. Due to the small size of our cohort the present results should be considered an exploratory first step. Return to work might be a crucial aspect of QoL and (re)integration into society after cure of PCNSL. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - July 31, 2020 Category: Cancer & Oncology Source Type: research

Giant intracranial germinoma
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - July 31, 2020 Category: Cancer & Oncology Source Type: research

Pediatric primary central nervous system tumors registry in Thailand under National Health Security Office schemes
ConclusionsThe incidence of primary childhood CNS tumors in our study is lower compared with other reports. Improvement of OS in the second study period might be because of establishment of the Thai Pediatric Oncology Group, and national protocols for childhood CNS tumors. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - July 24, 2020 Category: Cancer & Oncology Source Type: research

Variations in attitudes towards stereotactic biopsy of adult diffuse midline glioma patients: a survey of members of the AANS/CNS Tumor Section
AbstractPurposeDiffuse midline gliomas are rare midline CNS malignancies that primarily affect children but can also affect adults. While radiation is standard treatment, prognosis remains fatal. Furthermore, due to its sensitive anatomic location, many physicians have been reluctant to perform biopsies without potential for improved prognosis. However, recent advancements in molecular-targeted therapeutics have encouraged greater tissue sampling. While the literature reflects this progress, the landscape of how clinicians actually manage these patients remains unclear. Our goal was to assess the attitudes of current pract...
Source: Journal of Neuro-Oncology - July 23, 2020 Category: Cancer & Oncology Source Type: research

Female gender and exogenous progesterone exposition as risk factors for spheno-orbital meningiomas
AbstractObjectiveThe great heterogeneity of meningiomas is challenging and we need to distinguish relevant subgroups. Spheno-orbital osteomeningiomas (SOOM) constitute a clinically specific entity, with slow-growing benign osteo-meningiomatous tumors, which recur after surgery in one fourth of cases. Neurosurgical daily practice, supported by the literature, shows that the vast majority of patients with SOOM are women, and we explored whether their epidemiological and hormonal profiles suggest a progesterone influence.MethodsWe retrospectively documented all radiologically and histologically confirmed cases of SOOM operate...
Source: Journal of Neuro-Oncology - July 23, 2020 Category: Cancer & Oncology Source Type: research

Repolarization of tumor infiltrating macrophages and increased survival in mouse primary CNS lymphomas after XPO1 and BTK inhibition
ConclusionsThese data highlight the pathogenic role of the innate immune microenvironment in PCNSL and provide pre-clinical evidence for the development of selinexor and ibrutinib as a new promising therapeutic option with cytotoxic and immunomodulatory potential. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - July 20, 2020 Category: Cancer & Oncology Source Type: research

Autoimmune disease-related primary CNS lymphoma: systematic review and meta-analysis
ConclusionsAD requiring immunosuppression appear over-represented in the population of PCNSL patients. Aggressive polychemotherapy can accomplish long term OS in AD-PCNSL comparable to immunocompetent patients. Age  >  60 may serve as a prognostic factor. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - July 18, 2020 Category: Cancer & Oncology Source Type: research

Boron neutron capture therapy for malignant brain tumors
AbstractBackgroundBoron neutron capture therapy (BNCT) is tumor-selective particle radiation therapy that depends on the nuclear capture and fission reactions. These reactions occur when a non-radioactive boron isotope (10B) is irradiated with low-energy thermal neutrons to yield high linear energy transfer α-particles and lithium-7 nuclei within a limited path length, i.e., an almost one-cell diameter. The10B-containing cells can then be selectively destroyed by these potent particles. BNCT has been applied in the field of malignant brain tumors for newly diagnosed and recurrent malignant gliomas (chiefly glioblasto...
Source: Journal of Neuro-Oncology - July 16, 2020 Category: Cancer & Oncology Source Type: research

Impact of insurance on hospital course and readmission after resection of benign meningioma
AbstractIntroductionSurgical outcomes and healthcare utilization have been shown to vary based on patient insurance status. We analyzed whether patients ’ insurance affects case urgency for and readmission after craniotomy for meningioma resection, using benign meningioma as a model system to minimize confounding from the disease-related characteristics of other neurosurgical pathologies.MethodsWe analyzed 90-day readmission for patients who underwent resection of a benign meningioma in the Nationwide Readmission Database from 2014 –2015.ResultsA total of 9783 meningioma patients with private insurance (46%), M...
Source: Journal of Neuro-Oncology - July 11, 2020 Category: Cancer & Oncology Source Type: research

Cognitive impairment three months after surgery is an independent predictor of survival time in glioblastoma patients
ConclusionThese findings suggest that impaired performances on tests of executive control and processing speed in the early phase of adjuvant treatment can reflect a worse prognostic outlook rather than an early treatment effect, and their assessment might allow for early refinement of current prognostic stratification. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - July 8, 2020 Category: Cancer & Oncology Source Type: research

Distinct topographic-anatomical patterns in primary and secondary brain tumors and their therapeutic potential
ConclusionsThe identified distinct anatomical patterns provide evidence for a specific interaction between tumor and anatomical structures, following a pathoclitic concept. Understanding differences in their anatomical behavior has the potential to improve our pathophysiological understanding and to tailor therapy of brain tumors. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - July 8, 2020 Category: Cancer & Oncology Source Type: research

Pontine gliomas a 10-year population-based study: a report from The Canadian Paediatric Brain Tumour Consortium (CPBTC)
ConclusionsOur study highlights the challenges associated with epidemiology studies on DIPG and the importance of central review for incidence rate estimations. It emphasizes that tissue biopsies are required for accurate histological and molecular diagnosis in patients presenting with pontine lesions and reinforces the limitations of radiological and clinical diagnosis in DIPG. Likewise, it underscores the urgent need to increase the availability and accessibility to clinical trials. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - July 7, 2020 Category: Cancer & Oncology Source Type: research

Stereotactic reirradiation with temozolomide in patients with recurrent aggressive pituitary tumors and pituitary carcinomas
ConclusionRe-SRT and TMZ is a safe treatment offering high LC in patients with progressive APTs and PCs. The potential advantages of combined chemoradiation as up-front or salvage treatment need to be explored in prospective trials. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - July 6, 2020 Category: Cancer & Oncology Source Type: research

Temozolomide and seizure outcomes in a randomized clinical trial of elderly glioblastoma patients
ConclusionsThis study was not powered to detect differences in seizure outcomes, but temozolomide seemed to have minimal impact on seizure control in elderly patients with glioblastoma.Clinical Trial Registration: NCT00482677 2007-06-05. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - July 6, 2020 Category: Cancer & Oncology Source Type: research

Survival benefit of lobectomy for glioblastoma: moving towards radical supramaximal resection
AbstractPurposeExtent of resection remains a paramount prognostic factor for long-term outcomes for glioblastoma. As such, supramaximal resection or anatomic lobectomy have been offered for non-eloquent glioblastoma in an attempt to improve overall survival. Here, we conduct a propensity-matched analysis of patients with non-eloquent glioblastoma who underwent either lobectomy or gross total resection of lesion to investigate the efficacy of supramaximal resection of glioblastoma.MethodsPatients who underwent initial surgery for gross total resection or lobectomy for non-eloquent glioblastoma at our tertiary care referral ...
Source: Journal of Neuro-Oncology - July 5, 2020 Category: Cancer & Oncology Source Type: research

Immune checkpoint inhibition for pediatric patients with recurrent/refractory CNS tumors: a single institution experience
ConclusionImmune checkpoint inhibition was relatively well tolerated in a cohort of pediatric patients spanning several CNS tumor diagnoses. Results from prospective clinical trials will be critical to inform clinical decisions. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - July 5, 2020 Category: Cancer & Oncology Source Type: research

Racial and socioeconomic disparities differentially affect overall and cause-specific survival in glioblastoma
ConclusionsDespite the aggressive nature of glioblastoma, racial and socioeconomic factors influence glioblastoma-specific and non-glioblastoma associated mortality. Our study shows that patient race has an impact on glioblastoma-associated mortality independently of tumor and treatment related factors. Importantly, socioeconomic and racial differences largely contribute to non-glioblastoma mortality, including death from other cancers, cardio- and cerebrovascular events. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - July 2, 2020 Category: Cancer & Oncology Source Type: research

Long-term survival outcomes of pineal region gliomas
We present a surgical series of pineal region gliomas with focus on the survival outcome analysis.Methods17 histologically confirmed pineal region glioma patients classified as diffuse and non-diffuse gliomas were retrospectively analyzed. A detailed description of the series was followed by regression models to identify predictors of clinical outcomes. Uni- a multivariate survival analysis was performed to determine independent predictors of mortality.ResultsAlthough the number of treated patients was small, only WHO grade histopathology remained significant (p  = 0.02) after multivariate survival analysis w...
Source: Journal of Neuro-Oncology - July 1, 2020 Category: Cancer & Oncology Source Type: research

Hypofractionated stereotactic radiosurgery for large-sized skull base meningiomas
ConclusionsOur current results suggest a promising role of hypofractionated SRS for large-sized skull base megningiomas in terms of tumor control and neurological outcomes. It is a reasonable therapeutic option for select patients. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - July 1, 2020 Category: Cancer & Oncology Source Type: research

Laser interstitial thermal therapy (LITT) vs. bevacizumab for radiation necrosis in previously irradiated brain metastases
ConclusionsOur study suggests that patients undergoing LITT for RN have longer overall survival and better long-term lesional volume reduction than those treated with bevacizumab. However, it remains unclear whether our findings are due only to a difference in efficacy of the treatments or the implications of selection bias. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - June 29, 2020 Category: Cancer & Oncology Source Type: research