Evaluation of the content coverage of questionnaires containing basic and instrumental activities of daily living (ADL) used in adult patients with brain tumors
ConclusionThirty-one questionnaires previously used in brain tumor studies contained items on BADL and/or IADL and covered a wide range of content, in particular for IADL. It is currently unclear which BADL/IADL are most relevant for brain tumor patients, and this should therefore be evaluated. Next, existing questionnaires could be adapted or validated, or new measures can be developed to meet these needs. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 18, 2019 Category: Cancer & Oncology Source Type: research

A novel antisense oligonucleotide anchored on the intronic splicing enhancer of hTERT pre-mRNA inhibits telomerase activity and induces apoptosis in glioma cells
ConclusionsOur findings provided new targets and important clues for the gene therapy of gliomas by regulating the alternative splicing pattern of hTERT pre-mRNA. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 18, 2019 Category: Cancer & Oncology Source Type: research

Combined treatment with 2 ′-hydroxycinnamaldehyde and temozolomide suppresses glioblastoma tumorspheres by decreasing stemness and invasiveness
ConclusionOur findings suggest that HCA and BCA, combined with TMZ, are potential therapeutic agents in the treatment of GBM. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 18, 2019 Category: Cancer & Oncology Source Type: research

Targeted radioimmunotherapy for embryonal tumor with multilayered rosettes
Conclusions131I-Omburtamab appears safe with favorable dosimetry therapeutic index. When used as consolidation following surgery and chemoradiation therapy,131I-Omburtamab may have therapeutic benefit for patients with ETMR. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 16, 2019 Category: Cancer & Oncology Source Type: research

Natural history, clinical course and predictors of interval time from initial diagnosis to development of subsequent NSCLC brain metastases
AbstractPurposeNon-small cell lung cancer (NSCLC) brain metastases are associated with substantial morbidity and mortality. During recent years, accompanying dramatic improvements in systemic disease control, NSCLC brain metastases have emerged as an increasingly relevant clinical problem. However, optimal surveillance practices remain poorly defined. This purpose of this study was to further characterize the natural history, clinical course and risk factors associated with earlier development of subsequent NSCLC brain metastases to better inform clinical practice and help guide survivorship care.MethodsWe retrospectively ...
Source: Journal of Neuro-Oncology - March 14, 2019 Category: Cancer & Oncology Source Type: research

Fertility treatment is associated with multiple meningiomas and younger age at diagnosis
ConclusionsPatients in this cohort with a history of fertility treatment were more likely to present at a younger age and have multiple and convexity/falx meningiomas, emphasizing the importance of taking estrogen/progesterone exposure history when evaluating patients with meningioma. Future clinical studies at other centers in larger populations and laboratory investigations are needed to determine the role of fertility treatment in meningioma development. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 13, 2019 Category: Cancer & Oncology Source Type: research

A PHLDB1 variant associated with the nonfunctional pituitary adenoma
ConclusionsOur findings suggest that genetic variation ofPHLDB1 may be associated with the risk of NFPA. This is the first report of an association betweenPHLDB1 variants and NFPA. Further research is needed to confirm the impact of this SNP on NFPA susceptibility. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 13, 2019 Category: Cancer & Oncology Source Type: research

Impact of overall corticosteroid exposure during chemoradiotherapy on lymphopenia and survival of glioblastoma patients
This study evaluated the impact of overall corticosteroid exposure during chemoradiotherapy (CRT) on acute severe lymphopenia (ASL) and survival outcomes of GBM patients.MethodsGBM patients treated with CRT from 2007 to 2016 were retrospectively analyzed. Overall corticosteroid exposure was estimated as the average daily dexamethasone dose during 6  weeks of CRT. ASL was defined as grade 3 or higher lymphopenia within 3 months of starting CRT. ASL rates, overall survival (OS), and progression-free survival (PFS) were analyzed using Kaplan–Meier method. Multivariable analysis (MVA) was performed using logist...
Source: Journal of Neuro-Oncology - March 12, 2019 Category: Cancer & Oncology Source Type: research

Incidence and clinicopathologic features of H3 K27M mutations in adults with radiographically-determined midline gliomas
ConclusionsH3 K27M mutations are common in midline gliomas in adults and can present in all midline locations. Survival comparison between H3 K27M-mutant and wildtype midline gliomas suggests that survival may be similar or possibly improved if the mutation is present. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 12, 2019 Category: Cancer & Oncology Source Type: research

Comment on: Effects of surgery on neurocognitive function in patients with glioma: a meta-analysis of immediate post-operative and long-term follow-up neurocognitive outcomes
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 12, 2019 Category: Cancer & Oncology Source Type: research

The epidemiology of central and extraventricular neurocytoma in the United States between 2006 and 2014
ConclusionCN and EVN are rare tumors with a peak incidence in the 20 –34 years age group. This study represents the largest population-based epidemiological study on CN and EVN in the US. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 11, 2019 Category: Cancer & Oncology Source Type: research

Correction to: Neuro-radiological characteristics of adult diffuse grade II and III insular gliomas classified according to WHO 2016
In the initial, online publication, the authors' given names were captured as family names and vice versa. The names are correctly shown here. The original article has been corrected. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 11, 2019 Category: Cancer & Oncology Source Type: research

Diffuse intrinsic pontine glioma cells are vulnerable to low intensity electric fields delivered by intratumoral modulation therapy
ConclusionsThis proof-of-concept study provides a novel demonstration of marked DIPG cell susceptibility to low intensity electric fields delivered using IMT. The potent impact as a monotherapy and when integrated into multi-modality treatment platforms justifies further investigations into the potential of IMT as a critically needed biomedical innovation for DIPG. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 9, 2019 Category: Cancer & Oncology Source Type: research

The impact of the time to start radiation therapy on overall survival in newly diagnosed glioblastoma
AbstractPurposeThe standard treatment for newly diagnosed glioblastoma includes maximal safe surgical resection followed by concurrent radiation therapy and temozolomide (TMZ) and maintenance TMZ. The impact of time to start radiation therapy (TRT) on overall survival (OS) in glioblastoma patients is controversial. The study aimed to evaluate the impact of TRT on OS in patients diagnosed with glioblastoma who received standard treatment.MethodsIn this retrospective study, we included patients with confirmed diagnosis of glioblastoma treated from 2011 to 2016. TRT was defined as the time between surgery (biopsy or resection...
Source: Journal of Neuro-Oncology - March 8, 2019 Category: Cancer & Oncology Source Type: research

Predictors of survival in metastatic melanoma patients with leptomeningeal disease (LMD)
AbstractPurposeAlthough the survival of most melanoma patients diagnosed with leptomeningeal disease (LMD) is short, some patients can have better outcomes and prolonged survival. A large retrospective cohort of patients was analyzed to identify features associated with survival with LMD from melanoma.MethodsClinical characteristics, treatments and survival were collected for melanoma patients diagnosed with LMD from 1999 to 2015. The Kaplan –Meier method was used to estimate overall survival (OS) and Cox proportional hazards regression was used to test statistical significance of associations with survival. Multivar...
Source: Journal of Neuro-Oncology - March 7, 2019 Category: Cancer & Oncology Source Type: research

Cognitive rehabilitation for executive dysfunction in brain tumor patients: a pilot randomized controlled trial
AbstractPurposePatients with brain tumors face unique quality of life challenges. Executive dysfunction is common and functionally limiting, with no established treatments as standard care. This pilot study evaluated the efficacy of Goal Management Training (GMT), a behavioral intervention combining mindfulness and strategy training, for improving executive and real-life functioning in this population.MethodsTwenty-five primary brain tumor survivors were randomized to GMT, an active control (Brain Health Program, BHP), or a wait-list (WAIT) control group. The BHP was a supportive care intervention offering education and ac...
Source: Journal of Neuro-Oncology - March 7, 2019 Category: Cancer & Oncology Source Type: research

SPINT2 is hypermethylated in both IDH1 mutated and wild-type glioblastomas, and exerts tumor suppression via reduction of c-Met activation
ConclusionsWe defined a previously under-recognized group of coordinately methylated CpG islands common to bothIDH1WT andIDH1MUT gliomas (GT-CMG). Within GT-CMG, we identifiedSPINT2 as a top cancer-related candidate and demonstrated thatSPINT2 suppressed GBM via down-regulation of c-Met activation. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 5, 2019 Category: Cancer & Oncology Source Type: research

Propensity for different vascular distributions and cerebral edema of intraparenchymal brain metastases from different primary cancers
This study seeks to ascertain whether different primary tumor types have a propensity for brain metastases (BMs) in different cerebral vascular territories and cerebral edema.MethodsConsecutive adult patients who underwent surgical resection of a BM at a tertiary care institution between 2001 and 2011 were retrospectively reviewed. Only patients with the most common primary cancers (lung, breast, skin-melanoma, colon, and kidney) were included. Preoperative MRIs were reviewed to classify all tumors by cerebral vascular territory (anterior cerebral artery-ACA, lenticulostriate, middle cerebral artery-MCA, posterior cerebral...
Source: Journal of Neuro-Oncology - March 5, 2019 Category: Cancer & Oncology Source Type: research

Telomere elongation via alternative lengthening of telomeres (ALT) and telomerase activation in primary metastatic medulloblastoma of childhood
ConclusionsOur metastatic cases frequently activate ALT pathway, suggesting that it is a common process for senescence escape in primary metastatic medulloblastomas. Furthermore, the activation of mechanisms for telomere elongation is not restricted to certain molecular subgroups in this high-risk group of MDBs. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 4, 2019 Category: Cancer & Oncology Source Type: research

Nimotuzumab and radiotherapy for treatment of newly diagnosed diffuse intrinsic pontine glioma (DIPG): a phase III clinical study
ConclusionsConcomitant treatment with RT and nimotuzumab was feasible in an outpatient setting. The PFS and OS were comparable to results achieved with RT and intensive chemotherapy in hospitalized setting. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 4, 2019 Category: Cancer & Oncology Source Type: research

Proton therapy for skull-base chondrosarcoma, a single-institution outcomes study
ConclusionHigh-dose, double-scattered 3D conformal proton therapy alone or following surgical resection for skull-base chondrosarcoma is an effective treatment with a high rate of local control with no acute grade 3 radiation-related toxicity. Further follow-up of this cohort is necessary to better characterize long-term disease control and late toxicities. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 2, 2019 Category: Cancer & Oncology Source Type: research

Cytometric analysis of cell suspension generated by cavitron ultrasonic surgical aspirator in pediatric brain tumors
ConclusionsWhen the analysis of the tumor cell immunophenotype is performed with markers for determining viability, the expression of the investigated markers can be evaluated. Suitable markers can be selected by high-throughput methods, such as mass cytometry, and those that are diagnostically relevant can be investigated using flow cytometry, which is more flexible in terms of time. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 2, 2019 Category: Cancer & Oncology Source Type: research

The prognostic significance of TERT promoter mutations in meningioma: a systematic review and meta-analysis
ConclusionThe current evidence indicates the presence of a TERTp mutation in meningioma can be associated with worse prognosis, and shorter overall survival. Routine detection in greater numbers will allow for further validation, as well as delineate the effect across histological grades. By identifying this subgroup of meningioma patients early in management, it may support more frequent follow-up and aggressive management to optimize survival outcomes. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 1, 2019 Category: Cancer & Oncology Source Type: research

Multiplex ligation-dependent probe amplification analysis is useful for detecting a copy number gain of the FGFR1 tyrosine kinase domain in dysembryoplastic neuroepithelial tumors
ConclusionsWith recent findings of less frequent or absentFGFR1-ITD in pilocytic astrocytomas or rosette-forming glioneuronal tumors, the analysis ofFGFR1 aberrations, especiallyFGFR1-ITD, was suggested to be helpful to discriminate DNTs from their histological mimics. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 1, 2019 Category: Cancer & Oncology Source Type: research

Increase of pseudoprogression and other treatment related effects in low-grade glioma patients treated with proton radiation and temozolomide
ConclusionsTMZ use, when added to PRT, was associated with increased PsP in patients with LGG; however, patients with PsP tended to achieve longer survival. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 1, 2019 Category: Cancer & Oncology Source Type: research

Quantifying radiation therapy response using apparent diffusion coefficient (ADC) parametric mapping of pediatric diffuse intrinsic pontine glioma: a report from the pediatric brain tumor consortium
ConclusionsBaseline ADC values are a stronger predictor of outcome compared to radiation related ADC changes in pediatric DIPG. We show the feasibility of employing parametric mapping techniques in multi-center studies to quantitate spatially heterogeneous treatment response in pediatric tumors, including DIPG. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 27, 2019 Category: Cancer & Oncology Source Type: research

pH-weighted amine chemical exchange saturation transfer echoplanar imaging (CEST-EPI) as a potential early biomarker for bevacizumab failure in recurrent glioblastoma
The objective of the current study was to explore the efficacy of using pH-weighted amine CEST-EPI as a potential non-invasive imaging biomarker for treatment response and/or failure in recurrent GBM patients treated with bevacizumab.MethodA total of 11 patients with recurrent GBM treated with bevacizumab were included in this prospective study. CEST-EPI, perfusion MRI, and standardized anatomic MRI were obtained in patients before and after bevacizumab administration. CEST-EPI measures of magnetization transfer ratio asymmetry (MTRasym) at 3  ppm were used for pH-weighted imaging contrast. Multiple measures were exam...
Source: Journal of Neuro-Oncology - February 26, 2019 Category: Cancer & Oncology Source Type: research

Awake craniotomies for epileptic gliomas: intraoperative and postoperative seizure control and prognostic factors
ConclusionsIntraoperative seizures could be well-controlled during awake craniotomies. Early postoperative seizures extended hospitalization and strongly predicted late seizure recurrence. Awake craniotomies benefited long-term seizure control in patients with epileptic gliomas. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 25, 2019 Category: Cancer & Oncology Source Type: research

Longer genotypically-estimated leukocyte telomere length is associated with increased meningioma risk
ConclusionIncreased genotypically-estimated LTL was significantly associated with increased meningioma risk. A role for telomere length in the pathophysiology of meningioma is novel, and could lead to new insights on the etiology of meningioma. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 22, 2019 Category: Cancer & Oncology Source Type: research

Trans-eyebrow supraorbital keyhole approach to tuberculum sellae meningiomas: a series of 30 cases with long-term visual outcomes and recurrence rates
ConclusionThe TSKA is characterized by minimal invasion with a satisfactory cosmetic outcome. Based on the tumor characteristics and surgeon ’s experience, this approach can be employed as an alternative minimally invasive approach for the treatment of TSMs. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 22, 2019 Category: Cancer & Oncology Source Type: research

Role of postoperative tumor volume in patients with MGMT-unmethylated glioblastoma
AbstractPurposeThe aim of this study is to investigate the association between postoperative tumor volume and overall survival (OS) of O6-methylguanine DNA methyltransferase (MGMT)-unmethylated glioblastoma patients.MethodsOne hundred-twenty-six patients with MGMT-unmethylated glioblastoma who were treated either with surgical resection or needle biopsy between 2006 and 2015 were included in this retrospective cohort. Pre- and postcontrast T1 weighted images were evaluated in order to determine pre- and postoperative contrast-enhancing tumor volumes (CE-TV). Cox regression models adjusted for other significant prognostic f...
Source: Journal of Neuro-Oncology - February 21, 2019 Category: Cancer & Oncology Source Type: research

Monitoring of intracerebellarly-administered natural killer cells with fluorine-19 MRI
ConclusionsOur results show that NK cells present a novel opportunity for new strategies in MB treatment. Further,19F-labeled NK cells can suppress MB growth while enabling19F MRI to provide imaging feedback that can facilitate study and optimization of therapeutic paradigms. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 20, 2019 Category: Cancer & Oncology Source Type: research

Impact on survival of early tumor growth between surgery and radiotherapy in patients with de novo glioblastoma
AbstractPurposeSystematic pre-radiotherapy MRI in patients with newly resected glioblastoma (OMS 2016) sometimes reveals tumor growth in the period between surgery and radiotherapy. We evaluated the relation between early tumor growth and overall survival (OS) with the aim of finding predictors of regrowth.MethodsSeventy-five patients from 25 to 84  years old (Median age 62 years) with preoperative, immediate postoperative, and preradiotherapy MRI were included. Volumetric measurements were made on each of the three MRI scans and clinical and molecular parameters were collected for each case.ResultsFifty-four pat...
Source: Journal of Neuro-Oncology - February 19, 2019 Category: Cancer & Oncology Source Type: research

Withdrawal of antiepileptic drugs in patients with low grade and anaplastic glioma after long-term seizure freedom: a prospective observational study
ConclusionIn 65% of patients a shared decision was made to withdraw AEDs, of which 26% had seizure recurrence. AED withdrawal should only be considered in carefully selected patients with a presumed low risk of tumor progression. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 18, 2019 Category: Cancer & Oncology Source Type: research

High-dose radiation therapy is needed for intracranial control and long-term survival in patients with non-seminomatous germ cell tumor brain metastases
AbstractPurposeThe presence of brain metastases (BM) in patients with non-seminomatous germ cell tumor (NSGCT) is associated with poor prognosis. While radiation therapy (RT) is an important treatment for patients with NSGCT BM, there is a paucity of data on the optimal regimen. We sought to investigate the impact of RT on clinical outcomes in patients with NSGCT BM.MethodsPatients with NSGCT BM who received RT at our institution from 2002 to 2017 were included. Sixty-three consecutive patients were identified. Clinical factors associated with intracranial control (ICC) and overall survival (OS) were evaluated using cox re...
Source: Journal of Neuro-Oncology - February 15, 2019 Category: Cancer & Oncology Source Type: research

A multicenter phase II study of temozolomide plus disulfiram and copper for recurrent temozolomide-resistant glioblastoma
ConclusionsAddition of DSF/Cu to TMZ for TMZ-resistant IDH-wild type GBM appears well tolerated but has limited activity for unselected population. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 15, 2019 Category: Cancer & Oncology Source Type: research

Neuro-radiological characteristics of adult diffuse grade II and III insular gliomas classified according to WHO 2016
AbstractIntroductionThe phenotypic heterogeneity of diffuse gliomas is still inconsistently explained by known molecular abnormalities. Here, we report the molecular and radiological features of diffuse grade WHO II and III gliomas involving the insula and its potential impact on prognosis.MethodsClinical, pathological, molecular and neuro-radiological features of 43 consecutive patients who underwent a surgical resection between 2006 and 2013 for a grade II and III gliomas involving the insula was retrospectively analyzed.ResultsMedian age was 44.4  years. Eight patients had oligodendrogliomas,IDH mutant (IDHmut) and...
Source: Journal of Neuro-Oncology - February 11, 2019 Category: Cancer & Oncology Source Type: research

Gamma Knife Stereotactic Radiosurgery favorably changes the clinical course of hemangioblastoma growth in von Hippel-Lindau and sporadic patients
AbstractPurposeThis is the first single-institution study of its size to characterize the treatment impact and to address the question of whether hemangioblastoma treatment with Gamma Knife Stereotactic Radiosurgery (GKRS) in both sporadic and VHL patients changes the characteristic saltatory hemangioblastoma growth pattern.MethodsThe authors reviewed a single-institution tumor registry to identify patients who had received GKRS for hemangioblastomas between January 1st, 1999, and December 31st, 2017.Results15 patients with 101 lesions met search criteria with a median age of first GKRS of 39.2  years (interquartile r...
Source: Journal of Neuro-Oncology - February 7, 2019 Category: Cancer & Oncology Source Type: research

Modulating native GABA A receptors in medulloblastoma with positive allosteric benzodiazepine-derivatives induces cell death
ConclusionGABRA5 expression can serve as a diagnostic biomarker for group 3 tumors, while α5-GABAAR is a therapeutic target for benzodiazepine binding, enhancing an ion imbalance that induces apoptosis. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 6, 2019 Category: Cancer & Oncology Source Type: research

Multicenter, single arm, phase II trial on the efficacy of ortataxel in recurrent glioblastoma
ConclusionOverall ortataxel treatment fail to demonstrate a significant activity in recurrent GBM patients. However in a limited number of patients the drug produced a benefit that lasted for a long time.Trial registration: This study is registered with ClinicalTrials.gov, number NCT01989884. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 6, 2019 Category: Cancer & Oncology Source Type: research

Local control after brain-directed radiation in patients with cystic versus solid brain metastases
ConclusionsAmong patients with brain metastases, stereotactic radiation yields improved local control and less morbidity than WBRT, and consequently for many patients the cystic versus solid designation does not impact treatment selection. However, our results suggest that in patients with a large number of cystic brain metastases, a lower threshold to consider WBRT, as opposed to stereotactic radiation, should be employed. If our results can be confirmed, further investigation into the underlying mechanism(s) would be warranted. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 4, 2019 Category: Cancer & Oncology Source Type: research

Targeted next-generation sequencing panel (TruSight Tumor 170) in diffuse glioma: a single institutional experience of 135 cases
ConclusionsThe application of TST-170 panel based NGS in clinical and laboratory setting is expected to improve diagnostic accuracy and prognostication. Most benefits are expected inIDH-wildtype DG, a group of genetically heterogenous tumors harboring DNA sequence changes, copy number alterations, and fusions in a large number of oncogenes and tumor suppressor genes. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 1, 2019 Category: Cancer & Oncology Source Type: research

Race influences survival in glioblastoma patients with KPS ≥ 80 and associates with genetic markers of retinoic acid metabolism
ConclusionsAfrican Americans have prolonged survival with glioma which is influenced only by initial KPS score. Genes previously associated with both racial disparities in cancer and pathways associated with RA metabolism may play an important role in glioma etiology. In the future exploration of these genes and pathways may inform novel therapies for this incurable disease. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - January 31, 2019 Category: Cancer & Oncology Source Type: research

Post-traumatic stress disorders in patients with low-grade glioma and its association with survival
ConclusionsThe results showed that newly diagnosed LGG patients suffering from PTSD at 3  months after surgery had lower rates of 5-year survival. In clinical practice, psychological evaluation is suggested for LGG patients and proper psychotherapy should be considered for those with PTSD. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - January 31, 2019 Category: Cancer & Oncology Source Type: research

MicroRNA regulating stanniocalcin-1 is a metastasis and dissemination promoting factor in glioblastoma
ConclusionsSTC1 may be a novel metastasis/metastatic dissemination promoting factor regulated by several miRs in GBM. Because STC1 is a secreted glycoprotein and functions via the autocrine/paracrine signals, inhibiting STC1 signal may become a novel therapeutic strategy for GBM. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - January 30, 2019 Category: Cancer & Oncology Source Type: research

A novel 3D in vitro model of glioblastoma reveals resistance to temozolomide which was potentiated by hypoxia
ConclusionTaken together, these results suggest that micro-environmental factors influence GBM sensitivity to temozolomide. Knowledge of the mechanisms involved in temozolomide resistance in this 3D model might lead to the identification of new strategies that enable the more effective use of the current standard of care agents. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - January 29, 2019 Category: Cancer & Oncology Source Type: research

Correction to: Clinical features, radiological profiles, and surgical outcomes of primary intracranial solitary plasmacytomas: a report of 17 cases and a pooled analysis of individual patient data
The article Clinical features, radiological profiles, and surgical outcomes of primary intracranial solitary plasmacytomas: a report of 17 cases and a pooled analysis of individual patient data, written by Xiu-Jian Ma, Da Li, Liang Wang, Shu-Yu Hao, Li-Wei Zhang, Jun-Ting Zhang, Zhen Wu, was originally published electronically on the publisher ’s internet portal (currently SpringerLink) on 7 January 2019 with open access. With the authors’ decision to step back from Open Choice, the copyright of the article changed on 25 January 2019 to © Springer Science + Business Media, LLC, part of Spring...
Source: Journal of Neuro-Oncology - January 25, 2019 Category: Cancer & Oncology Source Type: research

Depressive symptoms and executive function in relation to survival in patients with glioblastoma
AbstractIntroductionDepression and neurocognitive function, particularly executive functioning (EF), have been associated with overall survival (OS) in patients with glioblastoma (GBM). However, the combined effect of depressive symptoms and impaired EF upon OS has not been reported.MethodsPatients with GBM (N  = 102) completed neuropsychological assessment postoperatively, including the Beck Depression Inventory-Second Edition (BDI-II) and the Trail Making Test Part B (TMTB). Median splits were used to determine cut-points denoting elevated depressive symptoms on the BDI-II and impaired EF on TMTB. P atients...
Source: Journal of Neuro-Oncology - January 24, 2019 Category: Cancer & Oncology Source Type: research

EGFR amplification and classical subtype are associated with a poor response to bevacizumab in recurrent glioblastoma
AbstractPurposeThe highly vascular malignant brain tumor glioblastoma (GBM) appears to be an ideal target for anti-angiogenic therapy; however, clinical trials to date suggest the VEGF antibody bevacizumab affects only progression-free survival. Here we analyze a group of patients with GBM who received bevacizumab treatment at recurrence and are stratified according to tumor molecular and genomic profile (TCGA classification), with the goal of identifying molecular predictors of the response to bevacizumab.MethodsWe performed a retrospective review of patients with a diagnosis of glioblastoma who were treated with bevacizu...
Source: Journal of Neuro-Oncology - January 24, 2019 Category: Cancer & Oncology Source Type: research

Effect of health disparities on overall survival of patients with glioblastoma
AbstractBackgroundExamine the potential effects of health disparities in survival of glioblastoma (GB) patients.MethodsWe conducted a retrospective chart review of newly diagnosed GB patients from 2000 to 2015 at a free standing dedicated cancer center (MD Anderson Cancer Center —MDACC) and a safety net county hospital (Ben Taub General Hospital—BT) located in Houston, Texas. We obtained demographics, insurance status, extent of resection, treatments, and other known prognostic variables (Karnofsky Score—KPS) to evaluate their role on overall GB survival (OS).ResultsWe identified 1073  GB patients co...
Source: Journal of Neuro-Oncology - January 22, 2019 Category: Cancer & Oncology Source Type: research