Evolution of the neurosurgical management of progestin ‐associated meningiomas: a 23-year single‐center experience
ConclusionsConservative management, including progestin treatment discontinuation, has grown over time with promising results in terms of efficacy and safety. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - January 15, 2021 Category: Cancer & Oncology Source Type: research

Time from stereotactic radiosurgery to immunotherapy in patients with melanoma brain metastases and impact on outcome
ConclusionsImmunotherapy within 7  days of SRS shows a possible association with improve outcomes in patients with brain metastases from melanoma. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - January 11, 2021 Category: Cancer & Oncology Source Type: research

Neuroimmunological adverse events associated with immune checkpoint inhibitor: a retrospective, pharmacovigilance study using FAERS database
ConclusionICI use is associated with a higher risk of neurological complications, with dual ICI therapy posing a higher risk, while older age, sex, or metastasis were not. Patients at older age, with certain cancer types, or on dual ICI therapy may be at higher risk of fatal neurologic AEs. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - January 9, 2021 Category: Cancer & Oncology Source Type: research

Resected WHO grade I meningioma and predictors of local control
AbstractIntroductionDespite optimal surgical resection, meningiomas may recur, with increasing grade and the degree of resection being predictive of risk. We hypothesize that an increasing Ki67 correlates with a higher risk of recurrence of resected WHO grade I meningiomas.MethodsThe study population consisted of patients with resected WHO grade 1 meningiomas in locations outside of the base of skull. Digitally scanned slides stained for Ki67 were analyzed using automatic image analysis software in a standardized fashion.ResultsRecurrence was observed in 53 (17.7%) of cases with a median follow up time of 25.8 months. Ki67...
Source: Journal of Neuro-Oncology - January 9, 2021 Category: Cancer & Oncology Source Type: research

Molecular diagnosis of diffuse glioma using a chip-based digital PCR system to analyze IDH , TERT , and H3 mutations in the cerebrospinal fluid
ConclusionWe established a novel, non-invasive molecular diagnostic method using a chip-based digital PCR system targeting ctDNA derived from CSF with high sensitivity and specificity, especially for high-grade gliomas. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - January 8, 2021 Category: Cancer & Oncology Source Type: research

Predictors of long-term tumor control after stereotactic radiosurgery for Koos grade 4 vestibular schwannomas
AbstractPurposeTo evaluate the predictors of long-term tumor control following stereotactic radiosurgery (SRS) for Koos grade 4 vestibular schwannomas (VSs).MethodsOverall, 203 sporadic VS patients with compression of the brainstem were treated with SRS. The median tumor volume was 6.7  cm3 (range, 2.0 –28.9 cm3) and the median marginal dose was 12  Gy (range, 9–13.5 Gy).ResultsThe median follow-up period was 152  months (range, 12–277 months). Tumor control (TC) rates at 3, 5, and 10 years were 89%, 85%, and 82%, respectively. Operation-free survival (OFS) rates at 3, 5...
Source: Journal of Neuro-Oncology - January 7, 2021 Category: Cancer & Oncology Source Type: research

Improved survival and disease control following pembrolizumab-induced immune-related adverse events in high PD-L1 expressing non-small cell lung cancer with brain metastases
AbstractIntroductionImmune checkpoint inhibitors have become standard of care for many patients with non-small cell lung cancer (NSCLC). These agents often cause immune-related adverse events (IRAEs), which have been associated with increased overall survival (OS). Intracranial disease control and OS for patients experiencing IRAEs with metastatic NSCLC and brain metastases have not yet been described.MethodsWe performed a single-institution, retrospective review of patients with NSCLC and existing diagnosis of brain metastasis, who underwent pembrolizumab treatment and developed any grade IRAE. The primary outcome of the ...
Source: Journal of Neuro-Oncology - January 7, 2021 Category: Cancer & Oncology Source Type: research

Low MGMT digital expression is associated with a better outcome of IDH1 wildtype glioblastomas treated with temozolomide
AbstractIntroductionGlioblastoma (GBM) is the deadliest primary brain tumor. The standard treatment consists of surgery, radiotherapy, and temozolomide (TMZ). TMZ response is heterogeneous, andMGMT promoter (MGMTp) methylation has been the major predictive biomarker. We aimed to describe the clinical and molecular data of GBMs treated with TMZ, compareMGMT methylation withMGMT expression, and further associate with patient ’s outcome.MethodsWe evaluate 112 FFPE adult GBM cases. IDH1 and ATRX expression was analyzed by immunohistochemistry, hotspotTERT promoter (TERTp) mutations were evaluated by Sanger or pyrosequenc...
Source: Journal of Neuro-Oncology - January 5, 2021 Category: Cancer & Oncology Source Type: research

Brain stem gliomas and current landscape
ConclusionDespite the lack of treatment options using frequently practiced clinical techniques, immunotherapeutic strategies have recently been developed to target brainstem gliomas. To target brainstem gliomas, investigators are evaluating the use of broad non-targeted therapy with immune checkpoint inhibitors. Alternatively, others have begun to explore adoptive T cell strategies against these fatal malignancies. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - January 4, 2021 Category: Cancer & Oncology Source Type: research

Efficacy of clobazam as add-on therapy in brain tumor-related epilepsy
ConclusionsClobazam is an effective agent to use as add-on AED in TRE, with 94% of patients showing a significant response within 6  months. Furthermore, the addition of clobazam may yield a reduction in polypharmacy, as concomitant AEDs can be reduced and potentially withdrawn. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - January 4, 2021 Category: Cancer & Oncology Source Type: research

Characterization of primary glioma cell lines derived from the patients according to 2016 CNS tumour WHO classification and comparison with their parental tumours
ConclusionsHuman cancer cell lines represent a support in the knowledge of tumour biology and in drug discovery through its facile experimental manipulation.Trial registrationNCT 04180046. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - January 4, 2021 Category: Cancer & Oncology Source Type: research

Clear cell histology portends a worse prognosis than other WHO grade II histologies
ConclusionThis is the first study to compare overall and progression-free survivals between CCMs and other WHO grade II meningiomas. Clear cell histology predicts a higher risk of tumor recurrence and mortality than other grade II histologies. Future studies may help to understand the impact of these findings and the treatment implications. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - January 4, 2021 Category: Cancer & Oncology Source Type: research

Motor deficits at presentation and predictors of overall survival in central nervous system lymphomas
AbstractPurposeCentral nervous system lymphomas (CNSL) can present with motor and non-motor symptoms. In many central nervous system tumors, motor deficits are associated with significant morbidity and functional impairment, and correlate with worse prognosis. CNSLs however, often exhibit remarkable response to chemotherapy and radiotherapy with corresponding symptom improvement. We investigate the survival outcomes and trajectories of motor and functional recovery in a cohort of patients presenting with and without initial motor deficits.MethodsPatients who underwent biopsy and with a histologically confirmed CNSL between...
Source: Journal of Neuro-Oncology - January 4, 2021 Category: Cancer & Oncology Source Type: research

A single-center retrospective analysis of outcome measures and consolidation strategies for relapsed and refractory primary CNS lymphoma
We present a retrospective cohort of 66 consecutive patients with rrPCNSL treated at the University of Washington between 2000 and 2020. Immunosuppressed and secondary CNS lymphoma patients were excluded.ResultsDuring a median follow-up of 40.5  months from initial diagnosis, median OS for relapsed disease was 14.1 (0.2–88.5) months and median PFS was 11.0 (0.2–73.9) months. At diagnosis (r2 = 0.85, p 
Source: Journal of Neuro-Oncology - January 4, 2021 Category: Cancer & Oncology Source Type: research

Correction to: Global post ‑marketing safety surveillance of Tumor Treating Fields (TTFields) in patients with high‑grade glioma in clinical practice
The graphic abstract was missing in the original online publication. The original article has been corrected. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - January 4, 2021 Category: Cancer & Oncology Source Type: research

A contemporary update on glioblastoma: molecular biology, current management, and a vision towards bio-adaptable personalized care
ConclusionIn this review, we are discussing our recent knowledge of the GBM genetic biologic landscape and the current advances in therapy, as well as providing a blueprint for an envisioned GBM management paradigm that should be personalized and adaptable to accommodate each patient ’s diverse genetic variations and therapy response/escape patterns. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - January 4, 2021 Category: Cancer & Oncology Source Type: research

Predictors of postoperative biochemical remission in acromegaly
This study aimed to investigate the clinical characteristics and predictors of biochemical remission after surgery for acromegaly using the China Acromegaly Patient Association (CAPA) database.MethodsA retrospective nationwide study was conducted using patient-reported data from CAPA database between 1998 and 2018. The principal component analysis (PCA) and logistic regression analysis were employed to determine independent predictors of biochemical remission at 3  months in patients after surgery.ResultsOf the 546 surgical cases (mean age: 36.8  years; 59.5% females), macroadenomas and invasive tumors (Knosp sco...
Source: Journal of Neuro-Oncology - January 4, 2021 Category: Cancer & Oncology Source Type: research

What effects does awake craniotomy have on functional and survival outcomes for glioblastoma patients?
ConclusionAC is an option for the resection of GB in critical locations. The observed survival outcomes are typical for GB patients in the Stupp era. However, the success of AC in terms of the recovery or preservation of language and/or motor functions cannot be guaranteed, given the aggressiveness of the tumor. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - January 4, 2021 Category: Cancer & Oncology Source Type: research

Stroke rate after external fractionated radiotherapy for benign meningioma
AbstractPurposePatients with a benign meningioma often have a long survival following the treatment of their meningioma. Since radiotherapy is frequently part of the treatment, long-term side effects are of considerable concern. A controversial long-term side effect of radiotherapy is stroke. Due to its severity, it is important to know the frequency of this side effect. The aim of this study was to assess the stroke incidence and risk factors among patients receiving radiotherapy for their benign meningioma.MethodsWe performed a retrospective database study of patients who underwent primary or adjuvant radiotherapy for th...
Source: Journal of Neuro-Oncology - January 4, 2021 Category: Cancer & Oncology Source Type: research

Stereotactic radiosurgery training patterns across neurosurgical programs: a multi-national survey
ConclusionsThis study provides a multi-national analysis of SRS residency training and practice patterns, and aims to stimulate improvement in SRS in training worldwide. Enhanced resident training in SRS must include wider exposure to vascular, neoplastic, functional and pediatric indications for SRS. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - January 4, 2021 Category: Cancer & Oncology Source Type: research

Cyproterone acetate and meningioma: a nationwide-wide population based study
AbstractBackgroundThe study the characteristics of surgical meningiomas in female patients who took CPA and to compare this population to a non-CPA control group.Materials and methodsWe processed the French Syst ème National des Données de Santé (SNDS) database to retrieve appropriate cases operated between 2007 and 2017.Results1 101 female patients (3.8%) who used to take CPA and underwent a meningioma surgery were extracted from a nationwide population based cohort of 28 924 patients. Median age at CPA prescription was 42  years IQR[36.7–48.9]. The median time between CPA start and surgery...
Source: Journal of Neuro-Oncology - January 4, 2021 Category: Cancer & Oncology Source Type: research

Meningiomas and cyproterone acetate: a retrospective, monocentric cohort of 388 patients treated by surgery or radiotherapy for intracranial meningioma
ConclusionsIn our study, patients with a history or current use of CPA had significantly more meningiomas and were significantly younger at the onset. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - January 3, 2021 Category: Cancer & Oncology Source Type: research

5-ALA kinetics in meningiomas: analysis of tumor fluorescence and PpIX metabolism in vitro and comparative analyses with high-grade gliomas
ConclusionsEligibility of established meningioma cell lines for in-vitro analyzes of tumor fluorescence significantly differs. Fluorescence in Ben-Men 1 and primary meningioma cell lines but less in IOMM Lee cells is 5-ALA dose-dependent, encouragingin-situ trials to encounter currently discussed shortcomings of FGS in meningiomas. Fluorescence is not related to expression of FECH, ABCB6 and ABCG2. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - January 3, 2021 Category: Cancer & Oncology Source Type: research

Differential gene expression in peritumoral brain zone of glioblastoma: role of SERPINA3 in promoting invasion, stemness and radioresistance of glioma cells and association with poor patient prognosis and recurrence
ConclusionsSERPINA3 expression contributes to aggressive GBM phenotype by regulating pro-tumorigenic actions in vitro and is associated with adverse clinical outcome. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - January 3, 2021 Category: Cancer & Oncology Source Type: research

Immunologic aspects of viral therapy for glioblastoma and implications for interactions with immunotherapies
ConclusionsStudies combining viral and immunotherapeutic treatment modalities have provided exciting results thus far and hold great promise for patients with GBM. Additional studies assessing the clinical efficacy of these treatments as well as improved preclinical modeling systems, safety mechanisms, and the balance between treatment efficacy and immune-mediated viral clearance should be considered. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - January 3, 2021 Category: Cancer & Oncology Source Type: research

Diffuse astrocytic glioma, IDH-Wildtype, with molecular features of glioblastoma, WHO grade IV: A single-institution case series and review
We present a single-institution series of patients with DAG-G and IDH-mutant astrocytomas and compare their clinical, molecular, and radiographic characteristics.MethodsPatient data was retrospectively extracted from the EMR for all patients undergoing surgical biopsy/resection of a diffuse astrocytoma at our institution from 2018 to 2020. Clinical presentation, molecular alterations, radiographic appearance, surgery, and survival were reviewed for each patient.ResultsSix DAG-G patients were identified in our cohort. All patients had diffuse disease, and presented with expansile, T2 hyperintense lesions with minimal enhanc...
Source: Journal of Neuro-Oncology - January 3, 2021 Category: Cancer & Oncology Source Type: research

Type and timing of systemic therapy use predict overall survival for patients with brain metastases treated with radiation therapy
This study aimed to investigate whether systemic therapy (ST) use surrounding radiation therapy (RT) predicts overall survival (OS) after RT for patients with brain metastases (BMs).MethodsProvincial RT and pharmacy databases were used to review all adult patients in British Columbia, Canada, who received a first course of RT for BMs between 2012 and 2016 (n  = 3095). Multivariate analysis on a randomly selected subset was used to develop an OS nomogram.ResultsIn comparison to the 2096 non-recipients of ST after RT, the median OS of the 999 recipients of ST after RT was 5.0 (95% Confidence interval (CI) 4.1 &...
Source: Journal of Neuro-Oncology - November 18, 2020 Category: Cancer & Oncology Source Type: research

Extent of resection and survival outcomes in World Health Organization grade II meningiomas
ConclusionsExtent of resection independently predicts progression-free and overall survivals in patients with WHO grade II meningiomas. In an era of increasing support for adjuvant treatment modalities in the management of meningiomas, our data support maximal safe resection as the primary goal in treatment of these patients. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 17, 2020 Category: Cancer & Oncology Source Type: research

Characteristics of IDH -mutant gliomas with non-canonical IDH mutation
AbstractBackgroundApproximately 10% ofIDH-mutant gliomas harbour non-canonicalIDH mutations (non-p.R132H IDH1 andIDH2 mutations).ObjectiveThe aim of this study was to analyse the characteristics of non-canonicalIDH-mutant gliomas.Materials and methodsWe retrospectively analysed the characteristics of 166 patients with non-canonicalIDH mutant gliomas and compared them to those of 155 consecutive patients withIDH1 p.R132H mutant gliomas.ResultsThe median age at diagnosis was 38  years in patients with non-canonicalIDH mutant gliomas and 43  years in glioma patients withIDH1 p.R132H-mutant tumours. Family ...
Source: Journal of Neuro-Oncology - November 17, 2020 Category: Cancer & Oncology Source Type: research

Quantitative CEST and MT at 1.5T for monitoring treatment response in glioblastoma: early and late tumor progression during chemoradiation
ConclusionsWe observe the potential for multiparametric qMRI, including a novel pulsed CEST/MT approach, to show potential in distinguishing early from late progression GBM cohorts. Ultimately, the goal is to personalize therapeutic decisions and treatment adaptation based on non-invasive imaging-based biomarkers. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 16, 2020 Category: Cancer & Oncology Source Type: research

Pre-radiosurgery leucocyte ratios and modified glasgow prognostic score predict survival in non-small cell lung cancer brain metastases patients
AbstractIntroductionThe predictive value of the pre-radiosurgery Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), Lymphocyte-to-Monocyte Ratio (LMR) and the modified Glasgow Prognostic Score (mGPS) was assessed for the first time in a homogenous group of NSCLC brain metastaes (BM) patients.MethodsWe retrospectively evaluated 185 NSCLC-BM patients, who were treated with Gamma Knife Radiosurgery (GKRS). Patients with immunotherapy or targeted therapy were excluded. Routine laboratory parameters were reviewed within 14  days before GKRS1.ResultsMedian survival after GKRS1 was significantly longer...
Source: Journal of Neuro-Oncology - November 11, 2020 Category: Cancer & Oncology Source Type: research

Long-term outcomes of spinal ependymomas: an institutional experience of more than 60 cases
AbstractPurposeSpinal ependymomas represent the most common primary intramedullary tumors for which optimal management remains undefined. When possible, gross total resection (GTR) is often the mainstay of treatment, with consideration of radiotherapy (RT) in cases of residual or recurrent tumor. The impact of extent of resection and radiotherapy remain understudied.ObjectiveReport on a large institutional cohort with lengthy follow-up to provide information on long-term outcomes and to contribute to limited data assessing the value of extent of resection and RT.MethodsPatients with pathologically proven primary spinal epe...
Source: Journal of Neuro-Oncology - November 11, 2020 Category: Cancer & Oncology Source Type: research

Unexpected hubness: a proof-of-concept study of the human connectome using pagerank centrality and implications for intracerebral neurosurgery
ConclusionsWe demonstrated that lowly-ranked parcellations may serve as important hubs in a subset of individuals, highlighting the importance of studying parcellation ranks at the personalized level in planning supratentorial neurosurgery. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 10, 2020 Category: Cancer & Oncology Source Type: research

Awake surgery for right frontal lobe glioma can preserve visuospatial cognition and spatial working memory
ConclusionsWe statistically verified that awake surgery for right frontal lobe glioma results in successful preservation of VSC and SWM with satisfying resection rates. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 2, 2020 Category: Cancer & Oncology Source Type: research

The role of radiation therapy in treatment of adults with newly diagnosed glioblastoma multiforme: a systematic review and evidence-based clinical practice guideline update
AbstractTarget populationThese recommendations apply to adult patients diagnosed with newly diagnosed glioblastoma.Question 1In adult patients (aged 65 and under) with newly diagnosed glioblastoma, is the addition of radiation therapy (RT) more beneficial than management without RT in improving survival?RecommendationsLevel I: Radiation therapy (RT) is recommended for the treatment of newly diagnosed malignant glioblastoma in adults.Question 2In adult patients (aged 65 and under) with newly diagnosed glioblastoma, is the RT regimen of 60  Gy given in 2 Gy daily fractions more beneficial than alternative regimens ...
Source: Journal of Neuro-Oncology - November 1, 2020 Category: Cancer & Oncology Source Type: research

Congress of neurological surgeons systematic review and evidence-based clinical practice parameter guidelines for the treatment of adults with newly diagnosed glioblastoma: Introduction and Methods
ConclusionsThis series of guidelines is based upon relevant evidence in the literature related to the management of newly diagnosed glioblastomas. They set a benchmark for the management of this disease while highlighting key areas of weakness in our knowledge and suggest directions for future basic and clinical research to improve evidence quality and recommendation strength. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 1, 2020 Category: Cancer & Oncology Source Type: research

Congress of neurological surgeons systematic review and evidence-based guidelines update on the role of emerging developments in the management of newly diagnosed glioblastoma
AbstractTarget populationThese recommendations apply to adult patients with newly diagnosed or suspected glioblastoma.ImagingQuestion What imaging modalities are in development that may be able to provide improvements in diagnosis, and therapeutic guidance for individuals with newly diagnosed glioblastoma?RecommendationLevel III: It is suggested that techniques utilizing magnetic resonance imaging for diffusion weighted imaging, and to measure cerebral blood and magnetic spectroscopic resonance imaging of N-acetyl aspartate, choline and the choline to N-acetyl aspartate index to assist in diagnosis and treatment planning i...
Source: Journal of Neuro-Oncology - November 1, 2020 Category: Cancer & Oncology Source Type: research

The role of neuropathology in the management of newly diagnosed glioblastoma: a systematic review and evidence-based clinical practice guideline
AbstractTarget PopulationThese recommendations apply to adult patients with newly diagnosed or suspected glioblastoma (GBM)QuestionFor adult patients with newly diagnosed GBM does testing forIsocitrate Dehydrogenase 1 or2 (IDH1/2) mutations afford benefit beyond standard histopathology in providing accurate classification and outcome prognostication?Level IIIIDH1/2 mutational status by immunohistochemistry (IHC) and/or sequencing is suggested for classification and prognostic information.Level III Non-canonicalIDH1/2 mutations are very rare in patients aged 55 or older and universal testing of variant mutations by sequence...
Source: Journal of Neuro-Oncology - November 1, 2020 Category: Cancer & Oncology Source Type: research

The role of imaging for the management of newly diagnosed glioblastoma in adults: a systematic review and evidence-based clinical practice guideline update
AbstractTarget populationThese recommendations apply to adults with a newly diagnosed lesion with a suspected or histopathologically proven glioblastoma (GBM).QuestionWhat are the optimal imaging techniques to be used in the management of a suspected glioblastoma (GBM), specifically: which imaging sequences are critical for most accurately identifying or diagnosing a GBM and distinguishing this tumor from other tumor types?RecommendationsCritical Imaging for the Identification and Diagnosis of Glioblastoma Level II: In patients with a suspected GBM, it is recommended that the minimum magnetic resonance imaging (MRI) exam s...
Source: Journal of Neuro-Oncology - November 1, 2020 Category: Cancer & Oncology Source Type: research

Cytoreductive surgery in the management of newly diagnosed glioblastoma in adults: a systematic review and evidence-based clinical practice guideline update
AbstractTarget populationThese recommendations apply to adults with newly diagnosed or suspected glioblastoma.QuestionWhat is the effect of extent of surgical resection on patient outcome in the initial management of adult patients with suspected newly diagnosed glioblastoma?RecommendationLevel II: Maximal cytoreductive surgery is recommended in adult patients with suspected newly diagnosed supratentorial glioblastoma with gross total resection defined as removal of contrast enhancing tumor.Level III: Biopsy, subtotal resection, or gross total resection is suggested depending on medical comorbidities, functional status, an...
Source: Journal of Neuro-Oncology - November 1, 2020 Category: Cancer & Oncology Source Type: research

Congress of neurological surgeons systematic review and evidence-based guidelines update on the role of chemotherapeutic management and antiangiogenic treatment of newly diagnosed glioblastoma in adults
AbstractQuestionWhat is the role of temozolomide in the management of adult patients (aged 65 and under) with newly diagnosed glioblastoma?Target populationThese recommendations apply to adult patients diagnosed with newly diagnosed glioblastoma.RecommendationLevel I: Concurrent and post-irradiation Temozolomide (TMZ) in combination with radiotherapy and post-radiotherapy as described by Stupp et al. is recommended to improve both PFS and OS in adult patients with newly diagnosed GBM. There is no evidence that alterations in the dosing regimen have additional beneficial effect.QuestionIs there benefit to adjuvant temozolom...
Source: Journal of Neuro-Oncology - November 1, 2020 Category: Cancer & Oncology Source Type: research

AANS/CNS Endorsement
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 1, 2020 Category: Cancer & Oncology Source Type: research

The use and efficacy of chemotherapy and radiotherapy in children and adults with pilocytic astrocytoma
AbstractPurposeThe aim of this study was to understand the use of chemotherapy (CMT) and radiotherapy (RT) in pilocytic astrocytoma (PA) and their impact on overall survival (OS).MethodsData from the National Cancer Database (NCDB) for patients with non-metastatic WHO grade I PA from 2004 to 2014 were analyzed. Pearson ’s chi-squared test and multivariate logistic regression analyses were performed to assess the distribution of demographic, clinical, and treatment factors. Inverse probability of treatment weighting (IPTW) was used to account for differences in baseline characteristics. Kaplan–Meier analyses an ...
Source: Journal of Neuro-Oncology - October 31, 2020 Category: Cancer & Oncology Source Type: research

LncRNA RP11-84E24.3 drives tumorigenesis and epithelial-to-mesenchymal transition of glioma cells by promoting TFAP2C-mediated activation of SNAI1
ConclusionsLncRNA RP11-84E24.3 increased SNAI1 expression by forming a complex with TFAP2C protein, promoting EMT in glioma cells and tumor formation. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 30, 2020 Category: Cancer & Oncology Source Type: research

Facial nerve management in patients with malignant skull base tumors
ConclusionTemporal bone, parotid gland, and cerebellopontine angle malignancies pose a tremendous risk to the facial nerve. When possible, the facial nerve is preserved. If the facial nerve is sacrificed, static and dynamic reanimation strategies are used to enhance facial function. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 28, 2020 Category: Cancer & Oncology Source Type: research

Impact of contemporary regimens on the outcomes and toxicity of primary CNS lymphoma: a single-center retrospective analysis of 73 patients
AbstractIntroductionPrimary central nervous system lymphoma (PCNSL) is a rare disease with a dismal prognosis compared to its systemic large B-cell lymphoma counterpart. Real world data are limited, when considering a uniform backbone treatment.MethodsA retrospective study of all adult patients treated sequentially with a high-dose methotrexate (HD MTX)-based regimen in a single tertiary medical center between 2003 and 2019.ResultsThe 2015 –2019 period differed from its predecessor in that most patients were treated with an HD MTX-based polychemotherapy regimen as opposed to HD MTX monotherapy (81% vs. 13%, P 
Source: Journal of Neuro-Oncology - October 24, 2020 Category: Cancer & Oncology Source Type: research

Embryonal tumors with multi-layered rosettes: a disease of dysregulated miRNAs
ConclusionDespite the use of multi-modal therapeutic regimens, ETMR patients have dismal survival. Understanding the unique biology of these tumors has provided new insights towards novel therapeutic targets. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 22, 2020 Category: Cancer & Oncology Source Type: research

Surgical treatment and neurological outcome of infiltrating intramedullary astrocytoma WHO II –IV: a multicenter retrospective case series
ConclusionInfiltrating intramedullary astrocytomas WHO II –IV present rare entities with dismal prognosis. Due to the high incidence of surgery-related neurological impairment, the aim of the surgical approach should be limited to obtaining the histological tissue via a biopsy or, tumor debulking in cases with rapidly progressive severe preoperative defi cits. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 22, 2020 Category: Cancer & Oncology Source Type: research

Journal of Neuro Oncology: immunotherapy for brain tumors
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 20, 2020 Category: Cancer & Oncology Source Type: research

Determinants and predictors for the long-term disease burden of intracranial meningioma patients
ConclusionsThe identified determinants help clinicians to better understand long-term meningioma disease burden. Prediction models can help early identification of individual patients at risk for long-term neurocognitive or HRQoL impairment, facilitating tailored provision of information and allocation of scarce supportive care services to those most likely to benefit. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 19, 2020 Category: Cancer & Oncology Source Type: research