Primary brain and other central nervous system tumors in Appalachia: regional differences in incidence, mortality, and survival
AbstractBackgroundThe Appalachian region is a large geographic and economic area, representing 7.69% of the United States (US). This region is more rural, whiter, older, and has a higher level of poverty as compared to the rest of the US. Limited research has been done on primary brain and other central nervous system tumors (PBT) epidemiology in this region. In this analysis we characterize incidence, mortality, and survival patterns.MethodsData from 2006 to 2015 were obtained from the central brain tumor registry of the US (provided by CDC and NCI). Appalachian counties were categorized using the Appalachia Regional Coun...
Source: Journal of Neuro-Oncology - December 12, 2018 Category: Cancer & Oncology Source Type: research

MiR-101-3p inhibits EMT to attenuate proliferation and metastasis in glioblastoma by targeting TRIM44
ConclusionsOur findings suggested miR-101-3p regulated proliferation and migration of glioblastoma cells through attenuating TRIM44 induced EMT via direct targeting 3 ′UTR of TRIM44, which provided preliminary study of potential therapeutic target in future GBM treatment. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - December 11, 2018 Category: Cancer & Oncology Source Type: research

Is 5-ALA fluorescence of cerebral metastases a prognostic factor for local recurrence and overall survival?
ConclusionThe 5-ALA fluorescence behaviour was related to the local progression-free and the overall survival in the present retrospective series and might be considered a prognostic marker. Further studies are required to appreciate the oncological impact of the 5-ALA induced fluorescence behaviour of cerebral metastases. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - December 10, 2018 Category: Cancer & Oncology Source Type: research

Baseline multicentric tumors, distant recurrences and leptomeningeal dissemination predict poor survival in patients with recurrent glioblastomas receiving bevacizumab
AbstractPurposeThere are no widely accepted MRI markers that predict treatment outcomes of bevacizumab among patients with recurrent glioblastoma (GB). We aimed to determine if conventional MRI features of recurrent GB predict survival of patients receiving bevacizumab.MethodsPatients with recurrent GB were retrospectively included if they received bevacizumab monotherapy between 2008 and 2017 after failure of standard treatment. Their MRI studies obtained at baseline and tumor recurrence, prior to bevacizumab treatment, were evaluated for multiple MRI features including measurable tumor, baseline multicentric tumors, dist...
Source: Journal of Neuro-Oncology - December 10, 2018 Category: Cancer & Oncology Source Type: research

Comprehensive genetic alteration profiling in primary and recurrent glioblastoma
ConclusionsCGP revealed that GA identified in GBM changed over time and with treatment. Mutations inTERT, CDKN2A/CDKN2B, EGFR, and PI3K pathway were commonly observed in both primary and recurrent GBM revealing their prognostic and therapeutic potential. This may have important implications for individualized therapies and needs further evaluation. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - December 9, 2018 Category: Cancer & Oncology Source Type: research

Tropomyosin Tpm 2.1 loss induces glioblastoma spreading in soft brain-like environments
ConclusionsWe propose that Tpm 2.1 down-regulation facilitates GBM colonisation of the soft brain environment. This specialisation of the GBM actin cytoskeleton organisation that is highly suited to the soft brain-like environment may provide novel therapeutic targets for arresting GBM invasion. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - December 9, 2018 Category: Cancer & Oncology Source Type: research

Etiology and prognosis of acute respiratory failure in patients with primary malignant brain tumors admitted to the intensive care unit
AbstractPurposeAcute respiratory failure (ARF) is common and potentially fatal in patients with primary malignant brain tumors (PMBT). However, few data are available regarding its precipitating factors and prognosis. We sought to: (1) compare the causes of ARF and the outcome between patients with PMBT and patients with other peripheral solid tumors (PST), (2) identify the factors influencing ICU survival in PMBT patients.MethodsTwo-center retrospective case-control study from March 1996 to May 2014. Primary central nervous system lymphomas were also included.ResultsEighty-four patients with PMBT and 133 patients with PST...
Source: Journal of Neuro-Oncology - December 7, 2018 Category: Cancer & Oncology Source Type: research

Radiographic assessment of contrast enhancement and T2/FLAIR mismatch sign in lower grade gliomas: correlation with molecular groups
ConclusionWe identify radiographic correlates of molecular groups in lower-grade gliomas, which join clinical demographic features in defining the characteristic presentation of these tumors. Radiographic correlates of prognosis in LGG require re-evaluation within molecular group. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - December 7, 2018 Category: Cancer & Oncology Source Type: research

Impact of ANXA5 polymorphisms on glioma risk and patient prognosis
ConclusionThis study firstly provided evidence for the impact ofANXA5 polymorphism on the susceptibility and prognosis of glioma, suggestingANXA5 variants might have potential roles in the etiology of glioma. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - December 7, 2018 Category: Cancer & Oncology Source Type: research

Use of optical fluorescence agents during surgery for pituitary adenomas: current state of the field
ConclusionWe conclude that selected optical fluorescent agents, including ICG and folate receptors, are most likely to hold promise for clinical use in differentiating PA from normal tissue. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - December 6, 2018 Category: Cancer & Oncology Source Type: research

Association of patterns of care, prognostic factors, and use of radiotherapy –temozolomide therapy with survival in patients with newly diagnosed glioblastoma: a French national population-based study
ConclusionIn non-progressive patients, prolonging the adjuvant temozolomide beyond 6 cycles may improve OS. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - December 6, 2018 Category: Cancer & Oncology Source Type: research

Re-irradiation for recurrent glioblastoma (GBM): a systematic review and meta-analysis
ConclusionThe available evidence, albeit mostly level III, suggests that re-irradiation provides encouraging disease control and survival rates. Toxicity was not uniformly reported, but seemed to be low from the included studies. Randomized  controlled trials (RCT) are needed to establish the optimal management strategy for recurrent GBM. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - December 6, 2018 Category: Cancer & Oncology Source Type: research

Re-irradiation for recurrent glioma: outcome evaluation, toxicity and prognostic factors assessment. A multicenter study of the Radiation Oncology Italian Association (AIRO)
Conclusionour data underline re-RT as a safe and feasible treatment with limited rate of toxicity, and a combined ones as a better option for selected patients. The identification of a BED threshold able to obtain a greater benefit on OS, can help in designing future prospective studies. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - December 4, 2018 Category: Cancer & Oncology Source Type: research

Increased compliance with tumor treating fields therapy is prognostic for improved survival in the treatment of glioblastoma: a subgroup analysis of the EF-14 phase III trial
AbstractBackgroundTumor treating fields (TTFields) is a non-invasive, antimitotic therapy. In the EF-14 phase 3 trial in newly diagnosed glioblastoma, TTFields plus temozolomide (TTFields/TMZ) improved progression free (PFS) and overall survival (OS) versus TMZ alone. Previous data indicate a ≥ 75% daily compliance improves outcomes. We analyzed compliance data from TTFields/TMZ patients in the EF-14 study to correlate TTFields compliance with PFS and OS and identify potential lower boundary for compliance with improved clinical outcomes.MethodsCompliance was assessed by usage data from the NovoTTF-100A device an...
Source: Journal of Neuro-Oncology - December 1, 2018 Category: Cancer & Oncology Source Type: research

Combined intracavitary thermotherapy with iron oxide nanoparticles and radiotherapy as local treatment modality in recurrent glioblastoma patients
ConclusionIntracavitary thermotherapy combined with radiotherapy can induce a prominent inflammatory reaction around the resection cavity which might trigger potent antitumor immune responses possibly leading to long-term stabilization of recurrent GBM patients. These results warrant further investigations in a prospective phase-I trial. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - December 1, 2018 Category: Cancer & Oncology Source Type: research

The impact of 5-aminolevulinic acid on extent of resection in newly diagnosed high grade gliomas: a systematic review and single institutional experience
AbstractBackgroundGlioma surgery at its nascency relied predominantly on visual and tactile feedback for the removal of grossly abnormal tissue. This technique has inherent limitations in delineating infiltrative tumor from normal brain, thus limiting the ability to achieve a gross total resection consistently. Since extent of resection (EOR) is consistently correlated with measures of survival, fluorescence-guided surgery shows promise in improving our ability to treat high-grade gliomas (HGG). 5-Aminolevulinic acid (5-ALA) is a prodrug preferentially metabolized by glioma cells that allows direct, real-time visualization...
Source: Journal of Neuro-Oncology - December 1, 2018 Category: Cancer & Oncology Source Type: research

Defining a prognostic score based on O6-methylguanine-DNA methyltransferase cut-off methylation level determined by pyrosequencing in patients with glioblastoma multiforme
ConclusionsThe present manuscript explored a novel scoring system capable to take into consideration the methylation status of each single CpGi, capable to better predict prognosis in GBM patients. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 28, 2018 Category: Cancer & Oncology Source Type: research

Characterization of genomic alterations in primary central nervous system lymphomas
ConclusionsThis study shows the most common genetic alterations in PCNSL as determined by a commercial next generation sequencing assay.MYD88 andCD79b are frequently mutated in PCNSL,IGH-BCL6 is the most frequent gene rearrangement and approximately 1/4 of cases show a high TMB. Mutations in multiple genes, in addition to high TMB and gene rearrangements, highlights the complex molecular heterogeneity of PCNSL. Knowledge about genetic alterations in PCNSL can inform the development of novel targets for diagnosis and treatment. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 28, 2018 Category: Cancer & Oncology Source Type: research

Oxaliplatin disrupts pathological features of glioma cells and associated macrophages independent of apoptosis induction
ConclusionsOXA can induce notable multi-faceted biological effects in glioma cells and BMDMs at relatively low drug concentrations. These findings may have significant therapeutic relevance against GBM and warrant further investigation. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 28, 2018 Category: Cancer & Oncology Source Type: research

Stereotactic radiosurgery for hypervascular intracranial tumors
ConclusionSRS for hypervascular tumors is associated with high rates of tumor regression with low risk of complications. No significant difference in rates of relative TV reduction were found between upfront and adjuvant SRS. Hence, upfront SRS may be considered in select patients. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 28, 2018 Category: Cancer & Oncology Source Type: research

Platelet count is associated with outcome in cancer patients with stroke
This study aimed to assess the relationship of thrombocytopenia with poor outcomes in cancer patients with CVD.Materials and methodsData on patients with concomitant CVD and cancer who were initially treated at a cancer referral center between January 2010 and December 2017 were included. Thrombocytopenia was defined as a platelet count  
Source: Journal of Neuro-Oncology - November 28, 2018 Category: Cancer & Oncology Source Type: research

Fluorescence guided surgery by 5-ALA and intraoperative MRI in high grade glioma: a systematic review
ConclusionBased on the currently available literature no superiority of one technique over the other can be found in the most important outcome parameters. Based on the available information a combined use of 5-ALA and iMRI seems very promising to achieve a resection beyond gadolinium-enhancement. However, only low quality of evidence exists for this approach. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 28, 2018 Category: Cancer & Oncology Source Type: research

Correction to: International experience in the development of patient-derived xenograft models of diffuse intrinsic pontine glioma
There are two errors and one omission in the original article. Author Gottardo ’s correct name is Nicholas G. Gottardo, author Hulleman’s correct affiliation is no. 3 (VUMC, Amsterdam), and the Acknowledgements should include the following sentence: “We would like to thank Dr Angel Montero Carcaboso (Hospital Sant Joan de Deu, Barcelona, Spain) for generously supplying t he HSJD-DIPG007 cells.” (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 27, 2018 Category: Cancer & Oncology Source Type: research

Repeated craniotomies for intracranial tumors: is the risk increased? Pooled analysis of two prospective, institutional registries of complications and outcomes
ConclusionsRepeated surgery for intracranial tumors does not increase the risk of morbidity. Mortality, and both the rate and severity of complications are comparable to primary operations. This information is of value for patient counseling and the informed consent process. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 24, 2018 Category: Cancer & Oncology Source Type: research

Antiepileptic and psychiatric medication in a nationwide cohort of patients with glioma WHO grade II –IV
ConclusionsPatients with glioma grade II –III on levetiracetam had an increased risk for drug-treated anxiety. The subgroup of patients with glioma grade II–III and epilepsy received less antidepressants than the general population. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 23, 2018 Category: Cancer & Oncology Source Type: research

Surgical management of lower-grade glioma in the spotlight of the 2016 WHO classification system
AbstractPurposeAccording to the 2016 WHO classification lower-grade gliomas consist of three groups:IDH-mutated and 1p/19q co-deleted,IDH-mutated andIDH-wildtype tumors. The aim of this study was to evaluate the impact of surgical therapy for lower-grade gliomas with a particular focus on the molecular subgroups.MethodsThis is a bi-centric retrospective analysis including 299 patients, who underwent treatment for lower-grade glioma between 1990 and 2016. All tumors were re-classified according to the 2016 WHO classification. Data concerning baseline and tumor characteristics, overall survival, different treatment modalitie...
Source: Journal of Neuro-Oncology - November 22, 2018 Category: Cancer & Oncology Source Type: research

Computerized assessment of cognitive impairment among children undergoing radiation therapy for medulloblastoma
ConclusionsCogstate is sensitive to acute cognitive effects experienced by some children with medulloblastoma and demonstrates associations with clinical predictors established in the literature. Correlations with neuropsychological measures of similar constructs offer additional evidence of validity. The findings provide support for the utility of Cogstate in monitoring acute cognitive effects in pediatric cancer. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 22, 2018 Category: Cancer & Oncology Source Type: research

Neuropsychological outcomes of patients with low-grade glioma diagnosed during the first year of life
ConclusionsChildren diagnosed with LGG in infancy experience substantial neuropsychological deficits. Treatment factors, including number of chemotherapy regimens and tumor directed surgeries, may increase risk for neurodevelopmental disruption and need to be considered in treatment planning. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 22, 2018 Category: Cancer & Oncology Source Type: research

The impact of traveling distance and hospital volume on post-surgical outcomes for patients with glioblastoma
We examined post-operative outcomes between GBM patients that underwent treatment at local, low-volume hospitals with those that traveled long distances to high-volume hospitals.MethodsThe National Cancer Database was queried for GBM patients that underwent surgery (2010 –2014). We established two cohorts: patients in the lowest quartile of travel distance and volume (Short-travel/Low-Volume: STLV) and patients in the highest quartile of travel and volume (Long-travel/High-Volume: LTHV). Outcomes analyzed were 30-day, 90-day mortality, overall survival, 30-day rea dmission, and hospital length of stay.ResultsOf 35,52...
Source: Journal of Neuro-Oncology - November 20, 2018 Category: Cancer & Oncology Source Type: research

Carnosic acid potentiates the anticancer effect of temozolomide by inducing apoptosis and autophagy in glioma
ConclusionThese data suggest that the combination therapy of CA and TMZ strengthens the anticancer effect of TMZ by enhancing apoptosis and autophagy. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 20, 2018 Category: Cancer & Oncology Source Type: research

Infusion of 5-Azacytidine (5-AZA) into the fourth ventricle or resection cavity in children with recurrent posterior Fossa Ependymoma: a pilot clinical trial
Conclusion5-AZA can be infused into the fourth ventricle or posterior fossa tumor resection cavity without causing neurological toxicity. Future studies with higher doses and/or increased dosing frequency are warranted. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 20, 2018 Category: Cancer & Oncology Source Type: research

Neurocognitive function, performance status, and quality of life in pediatric intracranial germ cell tumor survivors
ConclusionsThe majority of GCT survivors had average intellectual functioning, satisfactory performance status and relatively good quality of life, except in the physical aspect. Comprehensive evaluation and long-term follow-up of GCT survivors are essential to provide timely support and improve long-term outcomes. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 20, 2018 Category: Cancer & Oncology Source Type: research

Variation in management of spinal gliobastoma multiforme: results from a national cancer registry
AbstractPurposePrimary glioblastoma of the spinal cord (spinal GBM) is a rare central nervous system tumor, relative to its cranial counterpart (cranial GBM). Our current knowledge of spinal GBM epidemiology, tumor characteristics and treatment are insufficient and mostly based on single-institution case series.MethodsAll patients diagnosed with grade-4 GBM from 2004 to 2014 were queried from the National Cancer Database. Chi square analysis was used to compare presenting characteristics while Kaplan –Meier and Cox regression analyses were employed for survival analyses.ResultsTotal 103,496 patients with cranial GBM ...
Source: Journal of Neuro-Oncology - November 20, 2018 Category: Cancer & Oncology Source Type: research

Clinical factors associated with mortality within three months after radiosurgery of asymptomatic brain metastases from non-small cell lung cancer
ConclusionPhysicians require data to provide high-value, cost-conscious health care. Clinical metrics can screen patients with asymptomatic NSCLC brain metastases likely to die prior to the standard screening interval and observation could be considered. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 20, 2018 Category: Cancer & Oncology Source Type: research

Characterization of iPSCs derived from low grade gliomas revealed early regional chromosomal amplifications during gliomagenesis
ConclusionsThese results indicate that there exists a subpopulation of cells harboring gene amplification but withoutIDH1 mutation in the LGG primary cell pool. Further analysis of TCGA LGG database demonstrates that these regional chromosomal amplifications are also present in some cases of low grade gliomas indicating they are reoccurring lesions in glioma albeit at a low frequency. Taken together, these data suggest that regional chromosomal alterations may exist prior to the acquisition ofIDH mutations in at least some cases of LGGs. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 20, 2018 Category: Cancer & Oncology Source Type: research

Transcriptome profiling reveals PDZ binding kinase as a novel biomarker in peritumoral brain zone of glioblastoma
ConclusionsWe show that several genes of TC are expressed even in PT contributing to the vulnerability of PT for tumour recurrence. PBK is identified as a novel gene up-regulated in PT of GBM with a strong role in conferring aggressiveness, including radio-chemoresistance, thus contributing to recurrence in GBM tumours. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 20, 2018 Category: Cancer & Oncology Source Type: research

Functional relevance of genes predicted to be affected by epigenetic alterations in atypical teratoid/rhabdoid tumors
ConclusionsThese results suggest that a subset of genes affected by differential histone modification in ATRT is involved in the detrimental effects of SMARCB1-deficiency and also relevant in the biology of ATRT. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 16, 2018 Category: Cancer & Oncology Source Type: research

Histopathologic quantification of viable tumor versus treatment effect in surgically resected recurrent glioblastoma
ConclusionIn patients with glioblastoma undergoing repeat resection following chemoradiotherapy, high Ki-67 index in the recurrent specimen, short time to recurrence, and poor PS are independently associated with worse OS. Histopathologic quantification of viable tumor versus therapy-related changes has limited prognostic influence. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 16, 2018 Category: Cancer & Oncology Source Type: research

Lower expression of Bax predicts poor clinical outcome in patients with glioma after curative resection and radiotherapy/chemotherapy
AbstractBackgroundThe prognosis in patients with gliomas after surgical resection followed by radiotherapy and/or chemotherapy is still very poor. The pro-apoptotic protein Bax, a short-lived protein in cancers, plays important roles in the sensitivity of glioma cells to spontaneous and therapy-induced apoptosis but and its prognostic value in gliomas is unknown.MethodsBy an immunohistochemical method, we determined Bax protein expression from 96 patients with gliomas after curative resection. Two statistical analyses were performed to evaluate the prognostic significance of Bax protein: an independent continuous and a mul...
Source: Journal of Neuro-Oncology - November 16, 2018 Category: Cancer & Oncology Source Type: research

International experience in the development of patient-derived xenograft models of diffuse intrinsic pontine glioma
ConclusionThis multi-center study provides valuable information on the success rate of establishing patient-derived pre-clinical models of DIPG. The results can lead to further optimization of DIPG model development and ultimately assist in the investigation of new therapies for this aggressive pediatric brain tumor. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 16, 2018 Category: Cancer & Oncology Source Type: research

Tubular brain tumor biopsy to improves diagnostic yield for subcortical lesions
AbstractPurposeMolecular data has become an essential part of the updated World Health Organization (WHO) grading of central nervous system tumors. However, stereotactic needle biopsies provide only small volume specimens and limit the extent of histologic and molecular testing that can be performed. We assessed the use of a tubular retractor-based minimally invasive biopsy technique to provide improved tissue yield and diagnostic data compared to needle biopsy.MethodsEighteen patients underwent an open transtubular biopsy compared to 146 stereotactic biopsies during the years of 2010 –2018.ResultsTubular biopsies re...
Source: Journal of Neuro-Oncology - November 16, 2018 Category: Cancer & Oncology Source Type: research

Effects of surgery on neurocognitive function in patients with glioma: a meta-analysis of immediate post-operative and long-term follow-up neurocognitive outcomes
ConclusionsThis meta-analysis suggests that surgery for glioma confers a benefit for the domains of complex attention, language, learning and memory, while negatively affecting executive function, in the periods immediately after surgery and at 6 months follow-up. In addition, awake surgery seemed to confer a beneficial effect on neurocognitive functions. Future research should attempt to standardize a battery of neuropsychological tests for patients undergoing surgical resection for glioma, perhaps with a particular focus on executive function. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 16, 2018 Category: Cancer & Oncology Source Type: research

The use of 5-aminolevulinic acid in resection of pediatric brain tumors: a critical review
AbstractThe compound, 5-aminolevulinic acid (5-ALA) is approved for fluorescence-guided resections of malignant gliomas in Europe and other countries for use in adults, but not for children. The application of 5-ALA in children remains an off-label use. Several case reports on fluorescence-guided surgery use in children have been published, yet no prospective study has been conducted. Here we systematically review the reported studies and discuss the usefulness, application, and safety of 5-ALA use in resection of pediatric brain tumors. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 15, 2018 Category: Cancer & Oncology Source Type: research

Use of hyperbaric oxygen therapy in pediatric neuro-oncology: a single institutional experience
ConclusionsHBOT is safe and well-tolerated in pediatric and young adult patients with CNS tumors. Clinical and radiographic improvements were observed in over half of patients. Clinical trials are needed to establish safety and efficacy of HBOT as adjunct therapy in pediatric CNS tumors. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 13, 2018 Category: Cancer & Oncology Source Type: research

Possible effects of radiofrequency electromagnetic fields on in vivo C6 brain tumors in Wistar rats
ConclusionsOur data suggested an action of RF –EMF by reducing immune cell invasion and glioblastoma cell apoptosis, at probably too low amplitude to impact survival. Further replication studies are needed to confirm these observations. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 12, 2018 Category: Cancer & Oncology Source Type: research

Survival of glioma patients in relation to mobile phone use in Denmark, Finland and Sweden
ConclusionsWe found no evidence of reduced survival among glioma patients in relation to previous mobile phone use. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 12, 2018 Category: Cancer & Oncology Source Type: research

Acknowledgement of reviewers 2016 and 2017
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 12, 2018 Category: Cancer & Oncology Source Type: research

Imaging tryptophan uptake with positron emission tomography in glioblastoma patients treated with indoximod
ConclusionsHere, we have validated the ability to use PET of the Trp probe, AMT, for use in visualizing and quantifying intratumoral Trp uptake in GBM patients treated with an IDO1 pathway inhibitor. These data serve as rationale to utilize AMT-PET imaging in the future evaluation of GBM patients treated with IDO1 enzyme inhibitors. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 10, 2018 Category: Cancer & Oncology Source Type: research

The consistency of neuropathological diagnoses in patients undergoing surgery for suspected recurrence of glioblastoma
ConclusionsConfidence in any clinical diagnostic assay requires that very similar results are obtained from identical specimens evaluated by sophisticated clinicians and institutions. The findings of this study illustrate that the diagnostic agreement between different cases of repeat resection for suspected recurrent glioblastoma can be variable. This raises concerns as pathological diagnoses are critical in directing standard and experimental care in this setting. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 9, 2018 Category: Cancer & Oncology Source Type: research

Incidence of initial spinal metastasis in glioblastoma patients and the importance of spinal screening using MRI
ConclusionsThis study revealed a relatively high incidence of spinal metastasis. A subset of glioblastoma patients benefited from spinal screening, through which early detection of asymptomatic spinal metastasis was achieved. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 9, 2018 Category: Cancer & Oncology Source Type: research