The centrally restricted diffusion sign on MRI for assessment of radiation necrosis in metastases treated with stereotactic radiosurgery
AbstractPurposeDifferentiation of radiation necrosis from tumor progression in brain metastases treated with stereotactic radiosurgery (SRS) is challenging. For this, we assessed the performance of the centrally restricted diffusion sign.MethodsPatients with brain metastases treated with SRS who underwent a subsequent intervention (biopsy/resection) for a ring-enhancing lesion on preoperative MRI between 2000 and 2020 were included. Excluded were lesions containing increased susceptibility limiting assessment of DWI. Two neuroradiologists classified the location of the diffusion restriction with respect to the post-contras...
Source: Journal of Neuro-Oncology - October 24, 2021 Category: Cancer & Oncology Source Type: research

A multi-center prospective study of re-irradiation with bevacizumab and temozolomide in patients with bevacizumab refractory recurrent high-grade gliomas
AbstractPurposeSurvival is dismal for bevacizumab refractory high-grade glioma patients. We prospectively investigated the efficacy of re-irradiation, bevacizumab, and temozolomide in bevacizumab-na ïve and bevacizumab-exposed recurrent high-grade glioma, without volume limitations, in a single arm trial.MethodsRecurrent high-grade glioma patients were stratified based on WHO grade (4 vs.
Source: Journal of Neuro-Oncology - October 24, 2021 Category: Cancer & Oncology Source Type: research

Combining 18F-DOPA PET and MRI with perfusion-weighted imaging improves delineation of high-grade subregions in enhancing and non-enhancing gliomas prior treatment: a biopsy-controlled study
ConclusionsThe addition of18F-DOPA PET to multimodal MRI (CE and PWI) enlarged the delineation volumes and enhanced overall accuracy for detection of high-grade subregions. Thus, combining18F-DOPA with advanced MRI may improve treatment planning in newly diagnosed gliomas. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 22, 2021 Category: Cancer & Oncology Source Type: research

Mitochondrial DNA sequence variation and risk of meningioma
ConclusionCommon mtDNA variants and major mtDNA haplogroups do not appear to have associations with the odds of developing meningioma. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 20, 2021 Category: Cancer & Oncology Source Type: research

Incidence and survival for childhood central nervous system tumours in Australia, 1983 –2016
AbstractPurposeTo investigate incidence and survival of childhood tumours of the central nervous system (CNS) by histological subtype, tumour behaviour and tumour grade.MethodsNational, population-based data on all children under 15  years old diagnosed with a CNS tumour between 1983 and 2016 were sourced from the Australian Childhood Cancer Registry. Incidence rate trends were calculated using Joinpoint regression. Relative survival was calculated using the cohort method, with changes in survival over time by cancer type and tumour grade assessed by multivariable flexible parametric survival modelling.ResultsThe stud...
Source: Journal of Neuro-Oncology - October 18, 2021 Category: Cancer & Oncology Source Type: research

Current state of therapeutic focused ultrasound applications in neuro-oncology
ConclusionsFocused ultrasound is a promising and actively expanding therapeutic modality for diverse neuro-oncological diseases. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 18, 2021 Category: Cancer & Oncology Source Type: research

Salvage resection of recurrent previously irradiated brain metastases: tumor control and radiation necrosis dependency on adjuvant re-irradiation
ConclusionIn this largest-known series evaluating SR outcomes in histopathologically-confirmed rBrM, we identify a significant LR risk that may be reduced with adjuvant PSRT and with minimal symptomatic RN. Prospective analysis is warranted. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 16, 2021 Category: Cancer & Oncology Source Type: research

Systemic chemotherapy of pediatric recurrent ependymomas: results from the German HIT-REZ studies
ConclusionNo survival advantage for the general use of chemotherapy in recurrent EPN was found. In cases with incomplete resection, chemotherapy was able to extend survival in individual cases. Sirolimus showed the best RR, DOR and TTP out of all drugs analyzed and may warrant further investigation. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 16, 2021 Category: Cancer & Oncology Source Type: research

Systemic coagulation is activated in patients with meningioma and glioblastoma
AbstractPurposeUp to 30% of patients with glioblastoma (GBM) develop venous thromboembolism (VTE) over the course of the disease. Although not as high, the risk for VTE is also increased in patients with meningioma. Direct measurement of peak thrombin generation (TG) allows quantitative assessment of systemic coagulation activation in patients with GBM and meningioma. Our aim was to determine the extent of systemic coagulation activation induced by brain tumors, to measure the shift between pre- and post-operative peak TG in patients with GBM, and to assess the relationship between pre-surgical peak TG and pre-operative br...
Source: Journal of Neuro-Oncology - October 15, 2021 Category: Cancer & Oncology Source Type: research

Radiomics-based prediction of multiple gene alteration incorporating mutual genetic information in glioblastoma and grade 4 astrocytoma, IDH-mutant
ConclusionWe built a radiomics-based multiple gene prediction chained model that incorporates mutual information of each genetic alteration in glioblastoma and grade 4 astrocytoma, IDH-mutant and performs better than a simple bundle of binary classifiers using prior classifiers ’ prediction probability. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 14, 2021 Category: Cancer & Oncology Source Type: research

Correction to: Tumor location-based classification of surgery-related language impairments in patients with glioma
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 12, 2021 Category: Cancer & Oncology Source Type: research

Surgical strategies for older patients with glioblastoma
AbstractObjectiveWhile adjuvant treatment regimens have been modified for older patients with glioblastoma (GBM), surgical strategies have not been tailored.MethodsClinical data of 48 consecutive patients aged 70 years or older, who underwent surgical resection for GBM with intraoperative ultrasonography (IoUS) alone or combination with intraoperative MRI (IoMRI) at Yale New Haven Hospital were retrospectively reviewed. Variables were analyzed, and comparative analyses were performed.ResultsThe addition of IoMRI was not superior to IoUS alone in terms of overall survival (OS) (P = 0.306), Karnofsky Performance Score (KPS) ...
Source: Journal of Neuro-Oncology - October 9, 2021 Category: Cancer & Oncology Source Type: research

Leptomeningeal disease in glioblastoma: endgame or opportunity?
ConclusionThough evidence remains lacking and there is no consensus, treatments show a trend towards improving survival and should be considered on a case-by-case basis. Further studies are necessary in the pursuit of a standard of care. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 8, 2021 Category: Cancer & Oncology Source Type: research

Biomarkers and focused ultrasound: the future of liquid biopsy for brain tumor patients
ConclusionsIn this review, we describe the concept of MRgFUS-enabled brain tumor liquid biopsy and present the available preclinical evidence, ongoing clinical trials, limitations, and future directions of this application. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 6, 2021 Category: Cancer & Oncology Source Type: research

Predictors of mortality and tumor recurrence in desmoplastic infantile ganglioglioma and astrocytoma —and individual participant data meta-analysis (IPDMA)
ConclusionOur IPDMA of DIA/DIG cases reported in the literature revealed that GTR was a predictor of survival while leptomeningeal metastasis at presentation was associated with mortality. Deep tumor location and chemotherapy were associated with tumor recurrence / progression. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 6, 2021 Category: Cancer & Oncology Source Type: research

Prognosticating survival of pineal parenchymal tumors of intermediate differentiation (PPTID) by grade
AbstractBackgroundPineal parenchymal tumors of intermediate differentiation (PPTID) are a rare group of pineal parenchymal tumors classified by histology as either World Health Organization (WHO) Grades 2 or 3. The rarity of these tumors in adults has left a number of clinical management questions open. Correspondingly, the aim of this study was to aggregate a large PPTID cohort with sufficient statistical power from a large national cancer database to analyze prognostic parameters.MethodsAll PPTID patients aged over 18  years in the U.S. National Cancer Database (NCDB) between 2005 and 2016 were retrospectively revie...
Source: Journal of Neuro-Oncology - October 4, 2021 Category: Cancer & Oncology Source Type: research

Repeated superselective intraarterial bevacizumab after blood brain barrier disruption for newly diagnosed glioblastoma: a phase I/II clinical trial
ConclusionsRepeated dosing of IA BV after BBBD offers an encouraging outcome in terms of PFS and OS. Phase III trials are warranted to determine whether repeated IA BV combined with Stupp protocol is superior to Stupp protocol alone for newly diagnosed GBM. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 3, 2021 Category: Cancer & Oncology Source Type: research

Tumor location-based classification of surgery-related language impairments in patients with glioma
ConclusionsAccording to our classification, patients with type II tumors had the worst language prognosis and longest recovery time. Our classification, based on tumor location, can reliably predict postoperative language status and may be used to guide tumor resection. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 1, 2021 Category: Cancer & Oncology Source Type: research

18F-FET-PET-guided gross total resection improves overall survival in patients with WHO grade III/IV glioma: moving towards a multimodal imaging-guided resection
AbstractPurposePET using radiolabeled amino acid [18F]-fluoro-ethyl-L-tyrosine (FET-PET) is a well-established imaging modality for glioma diagnostics. The biological tumor volume (BTV) as depicted by FET-PET often differs in volume and location from tumor volume of contrast enhancement (CE) in MRI. Our aim was to investigate whether a gross total resection of BTVs defined as  
Source: Journal of Neuro-Oncology - October 1, 2021 Category: Cancer & Oncology Source Type: research

Immune checkpoint inhibitors in GBM
ConclusionsDespite the positive impact of immune checkpoint inhibitors in many cancers, only a small subset of GBM patients respond to these agents. Further research is needed to identify biomarkers of response and therapies to rationally combine with immune checkpoint inhibitors. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 1, 2021 Category: Cancer & Oncology Source Type: research

Comparison of hypothyroidism, growth hormone deficiency, and adrenal insufficiency following proton and photon radiotherapy in children with medulloblastoma
ConclusionsPrimary hypothyroidism occurs less often after PRT CSI, compared to XRT CSI. This suggests that the thyroid and pituitary glands receive less radiation after spine and posterior fossa boost RT, respectively, using PRT. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 1, 2021 Category: Cancer & Oncology Source Type: research

Molecular profiling of pediatric and adolescent ependymomas: identification of genetic variants using a next-generation sequencing panel
ConclusionsMolecular profiling by the OCCRA ® panel showed novel alterations in pediatric and adolescent EPNs, which highlights the clinical importance in identifying genetic variants for patients’ prognosis and therapeutic orientation. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 27, 2021 Category: Cancer & Oncology Source Type: research

Psychological resiliency explains the relationship between emotional distress and quality of life in neurofibromatosis
ConclusionsResiliency may buffer the high rates of emotional distress in NF. Mind –body interventions targeting multiple modifiable resiliency factors may be a promising path toward promoting QoL in adults with NF.Trial registrationClinical Trials.gov Identifier: NCT03406208. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 27, 2021 Category: Cancer & Oncology Source Type: research

Hyperintense signal on diffusion-weighted imaging for monitoring the acute response and local recurrence after photodynamic therapy in malignant gliomas
ConclusionsThe local recurrence in malignant glioma after PDT occurs in an area without hyperintense signal on DWI as an acute response to PDT. This characteristic finding could aid in the monitoring of local recurrence after PDT.Graphic abstract (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 22, 2021 Category: Cancer & Oncology Source Type: research

Identification of a high-risk group for brain metastases in non-small cell lung cancer patients
The objective of the study was to identify this group by generating a multivariable model with recognized and accessible risk factors.MethodsA retrospective cohort from patients seen at a single center during 2010 –2020, was divided into a training (TD) and validation (VD) datasets, associations with BM were measured in the TD with logit, variables significantly associated were used to generate a multivariate model. Model´s performance was measured with the AUC/C-statistic, Akaike information criterion, an d Brier score.ResultsFrom 570 patients with NSCLC who met the strict eligibility criteria a TD and VD were...
Source: Journal of Neuro-Oncology - September 21, 2021 Category: Cancer & Oncology Source Type: research

Five fraction stereotactic radiotherapy after brain metastasectomy: a single-institution experience and literature review
ConclusionPostoperative hfSRT can be delivered with 25 –30 Gy in 5 fractions with efficacy in excess of 82% and no significant toxicity when the dose to ‘brain−GTV’ does not exceed 20 cm3. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 21, 2021 Category: Cancer & Oncology Source Type: research

Circulating tumor DNA for malignant peripheral nerve sheath tumors in neurofibromatosis type 1
AbstractPurposeThe leading cause of early death in patients with neurofibromatosis type 1 (NF1) is malignant peripheral nerve sheath tumor (MPNST). The principles of management include early diagnosis, surgical clearance and close monitoring for tumor recurrence. Current methods for diagnosis, detection of residual disease and monitoring tumor burden are inadequate, as clinical and radiological features are non-specific for malignancy in patients with multiple tumors and lack the sensitivity to identify early evidence of malignant transformation or tumor recurrence. Circulating tumor DNA (ctDNA) is a promising tool in canc...
Source: Journal of Neuro-Oncology - September 16, 2021 Category: Cancer & Oncology Source Type: research

Paediatric atypical choroid plexus papilloma: is adjuvant therapy necessary?
ConclusionsThis limited case series suggests that paediatric aCPP can be successfully managed with surgical resection alone, followed by a ‘watch and wait’ approach thus avoiding adjuvant therapies. A deeper understanding of the biology of aCPP is required to identify objective markers which can help provide robust risk stratification and inform treatment strategies. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 16, 2021 Category: Cancer & Oncology Source Type: research

Impact of the COVID-19 pandemic on neuro-oncology outcomes
This study quantifies changes in neuro-oncological care during the height of the pandemic and investigates patient outcomes in 2020 compared to a historical control.MethodsWe performed a retrospective review of patients with malignant brain tumor diagnoses who were seen at our institution between March 13 and May 1 of 2020 and 2019. Alterations in care, including shift from in-person to telehealth, delays in evaluation and intervention, and treatment modifications were evaluated. These variables were analyzed with respect to brain tumor control and mortality.Results112 patients from 2020 to 166 patients from 2019 were incl...
Source: Journal of Neuro-Oncology - September 12, 2021 Category: Cancer & Oncology Source Type: research

Craniospinal irradiation as part of re-irradiation for children with recurrent medulloblastoma
ConclusionsRe-irradiation with CSI is a safe and effective treatment for children with relapsed medulloblastoma; improves disease control and survival compared with focal re-irradiation. However this approach carries a high neurocognitive cost. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 9, 2021 Category: Cancer & Oncology Source Type: research

Efficacy of osimertinib plus bevacizumab in glioblastoma patients with simultaneous EGFR amplification and EGFRvIII mutation
ConclusionsWhile the osimertinib/bevacizumab combination was marginally effective in most GB patients with simultaneousEGFR amplification plusEGFRvIII mutation, a subgroup experienced a long-lasting meaningful benefit. The findings of this brief cohort justify the continuation of the research in a clinical trial. The pattern of resistance after exposure to osimertinib/bevacizumab includes known mechanisms in the regulation ofEGFR, findings that contribute to the understanding and targeting in a stepwise rational this pathway. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 9, 2021 Category: Cancer & Oncology Source Type: research

Association of baseline frailty status and age with postoperative morbidity and mortality following intracranial meningioma resection
AbstractPurposeAlthough numerous studies have established advanced patient age as a risk factor for poor outcomes following intracranial meningioma resection, large-scale evaluation of frailty for preoperative risk assessment has yet to be examined.MethodsWeighted discharge data from the National Inpatient Sample were queried for adult patients undergoing benign intracranial meningioma resection from 2015 to 2018. Complex samples multivariable logistic regression models and receiver operating characteristic curve analysis were performed to evaluate adjusted associations and discrimination of frailty, quantified using the 1...
Source: Journal of Neuro-Oncology - September 8, 2021 Category: Cancer & Oncology Source Type: research

Working memory training for adult glioma patients: a proof-of-concept study
Conclusionswas found to be safe and acceptable in adult patients with glioma. Enrollment, retention rates, and treatment adherence were all adequate and comparable to studies recruiting similar populations. Only moderate perceived benefit was reported despite demonstrated improvements in objectively-assessed WM. This may indicate that the time commitment and intervention intensity (5  weeks of 50-min training sessions on 5 days/week) outweighed the perceived benefits of the program. (Trial Registration Number: NCT03323450 registered on 10/27/2017). (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 7, 2021 Category: Cancer & Oncology Source Type: research

eHealth cognitive rehabilitation for brain tumor patients: results of a randomized controlled trial
ConclusionsRecruitment at this early stage was difficult, resulting in limited statistical power. No significant effects were demonstrated, while adherence and satisfaction with the eHealth program were good. In clinical practice,ReMind may be helpful, if timing would be adapted to patients ’ needs. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 6, 2021 Category: Cancer & Oncology Source Type: research

LINC00152 acts as a potential marker in gliomas and promotes tumor proliferation and invasion through the LINC00152/miR-107/RAB10 axis
ConclusionOur data suggested thatLINC00152 is a candidate prognostic marker of glioma, and that theLINC00152/MIR-107/RAB10 axis plays a pivotal role in regulation of the glioma malignancy, and therefore, targeting the axis might be an effective therapeutic strategy to treat glioma.Graphic abstract (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 3, 2021 Category: Cancer & Oncology Source Type: research

Cytoskeleton-associated protein 4 (CKAP4) promotes malignant progression of human gliomas through inhibition of the Hippo signaling pathway
ConclusionCKAP4 has potential as a promising biomarker and can predict the prognosis of patients with gliomas. And targeting CKAP4 expression may be an effective therapeutic strategy for the treatment of human gliomas. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 2, 2021 Category: Cancer & Oncology Source Type: research

Risks and neurological benefits of meningioma surgery in elderly patients compared to young patients
This study investigated the postoperative risks and neurological benefits of meningioma surgery in elderly patients compared to young patients.MethodsIn total, 768 patients were included and divided into two main groups: group I (age: ≤ 64 years; 484 young patients) and group II (age: ≥ 65 years; 284 elderly patients). Group II was subdivided into: IIa (age: 65–69 years), IIb (age: 70–79 years); and IIc (age: ≥ 80 years).ResultsThe total tumor resection rate was higher in the elderly cohort than in the young cohort (84.5 and 76.2%, respectively). 154 young patients (31.8%) and 132 elderly patients (46....
Source: Journal of Neuro-Oncology - September 1, 2021 Category: Cancer & Oncology Source Type: research

Vision-related quality-of-life in pediatric primary brain tumor patients
AbstractPurposeBrain tumors are the leading cause of death from childhood cancer. Although overall survival has improved due to earlier detection, better therapies, and improved surveillance, visual dysfunction and impaired vision-related quality-of-life (VR-QOL) are often unrecognized in children. This project investigated VR-QOL in pediatric brain tumor patients.MethodsWe evaluated visual impairment and quality-of-life (QOL) in a quality improvement project at one tertiary care center. Patients  ≤ 18, greater than 6 months from diagnosis of brain tumor, excluding intrinsic anterior visual pathway tu...
Source: Journal of Neuro-Oncology - August 30, 2021 Category: Cancer & Oncology Source Type: research

Technical choices significantly alter the adaptive immune response against immunocompetent murine gliomas in a model-dependent manner
ConclusionsOur results suggest that the impact of foreign proteins like luciferase on the intracranial immune response is dependent upon the model, with CT2A being more sensitive to added markers. In particular, luciferase expression in CT2A could lead to meaningful misinterpretations of results from immune checkpoint inhibitor (ICI) studies. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - August 25, 2021 Category: Cancer & Oncology Source Type: research

IDH1 mutant glioma is preferentially sensitive to the HDAC inhibitor panobinostat
ConclusionThese data suggest that IDH1mut gliomas may be preferentially sensitive to HDAC inhibitors. Further, IDH1mut glioma cultures showed enhanced accumulation of acetylated histone residues in response to panobinostat treatment, suggesting a direct epigenetic mechanism for this sensitivity. This provides a rationale for further exploration of HDAC inhibitors against IDH1mut gliomas. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - August 23, 2021 Category: Cancer & Oncology Source Type: research

Intracranial solitary fibrous tumor/hemangiopericytoma: tumor reclassification and assessment of treatment outcome via the 2016 WHO classification
This study provides a clinical analysis of these tumors and describes the treatment outcomes of SFT/HPCs.MethodsThis retrospective study included 76 patients with histopathologically proven SFT/HPC. Reclassification according to the 2016 WHO guideline was done for patients who were diagnosed with SFT or HPC based on the 2007 WHO classification. Recurrence-free survival (RFS) and overall survival (OS) were evaluated for all patients and subgroups.ResultsThe median follow-up period was 77.9  months. The median RFS and OS were 126.5 and 136.8 months, respectively. The 1-, 5-, 10-, and 15-year RFS rates were 93%, 72%...
Source: Journal of Neuro-Oncology - August 20, 2021 Category: Cancer & Oncology Source Type: research

Intraoperative 3  T MRI is more correlative to residual disease extent than early postoperative MRI
ConclusionsIntraoperative 3  T MRI without further resection appears to better reflect the volume of residual tumor in LGG compared with early postoperative 3 T MRI. Early postoperative MRI may overestimate residual tumor. As such, intraoperative MRI performed after completion of tumor resection may be more useful for making decisions regarding adjuvant therapy. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - August 20, 2021 Category: Cancer & Oncology Source Type: research

Molecular description of meningeal solitary fibrous tumors/hemangiopericytomas compared to meningiomas: two completely separate entities
ConclusionsMeningeal SFT are molecular counterparts of extra-meningeal SFT, completely separate from meningiomas. They might develop from the same tissues and benefit from the same treatments as SFT. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - August 20, 2021 Category: Cancer & Oncology Source Type: research

Focused ultrasound: growth potential and future directions in neurosurgery
AbstractOver the past two decades, vast improvements in focused ultrasound (FUS) technology have made the therapy an exciting addition to the neurosurgical armamentarium. In this time period, FUS has gained US Food and Drug Administration (FDA) approval for the treatment of two neurological disorders, and ongoing efforts seek to expand the lesion profile that is amenable to ultrasonic intervention. In the following review, we highlight future applications for FUS therapy and compare its potential role against established technologies, including deep brain stimulation and stereotactic radiosurgery. Particular attention is p...
Source: Journal of Neuro-Oncology - August 19, 2021 Category: Cancer & Oncology Source Type: research

Depression explains the association between pain intensity and pain interference among adults with neurofibromatosis
ConclusionImproving depression has the potential to decrease pain interference among people with NF who experience pain.Trial registrationClinicaltrials.gov Registration #: NCT03406208 (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - August 19, 2021 Category: Cancer & Oncology Source Type: research

Cerebrospinal fluid diversion for leptomeningeal metastasis: palliative, procedural and oncologic outcomes
ConclusionsCSF diversion for LM with hydrocephalus and intracranial hypertension secondary to metastasis can achieve symptomatic relief, hospital discharge, and return to further oncologic therapy, with a complication profile unique to this pathophysiology. However, decision-making in this population must incorporate end-of-life goals of care given limited prognosis. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - August 18, 2021 Category: Cancer & Oncology Source Type: research

Correction to: Incidence and characteristics of metastatic intracranial lesions in stage III and IV melanoma: a single institute retrospective analysis
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - August 17, 2021 Category: Cancer & Oncology Source Type: research

Correction to: Role of 23.4  Gy upfront whole-brain radiation therapy following high-dose methotrexate for primary central nervous system lymphoma: a comparative analysis of whole-brain radiation therapy versus no radiation therapy
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - August 17, 2021 Category: Cancer & Oncology Source Type: research

A case of primary CNS embryonal rhabdomyosarcoma with PAX3-NCOA2 fusion and systematic meta-review
ConclusionsPrimary CNS rhabdomyosarcoma shares common histological, molecular, and demographic features with non-CNS rhabdomyosarcoma. A trimodal treatment approach with early introduction of radiation therapy may result in favorable survival outcomes. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - August 16, 2021 Category: Cancer & Oncology Source Type: research

Correction to: Focused ultrasound in neuro ‑oncology: the role of the Focused Ultrasound Foundation in driving adoption and innovation
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - August 16, 2021 Category: Cancer & Oncology Source Type: research