EGFR-mutated non-small lung cancer brain metastases and radiosurgery outcomes with a focus on leptomeningeal disease
ConclusionThe study shows that current-generation targeted therapy for EGFR-mutated NSCLC patients may prevent the development and progression of LMD, leading to improved survival outcomes. Nevertheless, LMD is associated with poor outcomes and neurologic death, making innovative strategies to treat LMD essential. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 10, 2023 Category: Cancer & Oncology Source Type: research
Dynamic contrast-enhanced MRI radiomics model predicts epidermal growth factor receptor amplification in glioblastoma, IDH-wildtype
ConclusionThe DCE MRI-based radiomics model that predictsEGFR amplification in glioblastoma,IDH wildtype, was developed and validated. The MRI-based radiomics model using the Ktrans map has higher AUROC than conventional MRI. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 10, 2023 Category: Cancer & Oncology Source Type: research
Decision system for extent of resection in WHO grade 3 gliomas: a Chinese Glioma Genome Atlas database analysis
ConclusionsExtensive resection benefits only a proportion of patients with WHO grade 3 IDH-mutant gliomas. Younger patients with astrocytomas had survival benefits from extensive resection. In addition to clinical characteristics (especially age), molecular pathology impacted prognosis in patients with gliomas. Our findings provide guiding information to neurosurgeons while planning surgeries. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 5, 2023 Category: Cancer & Oncology Source Type: research
Predicting survival in glioblastoma with multimodal neuroimaging and machine learning
ConclusionWe demonstrate that machine learning can accurately classify survival in GBM patients based on multimodal neuroimaging before any surgical or medical intervention. These results were achieved without information regarding presentation symptoms, treatments, postsurgical outcomes, or tumor genomic information. Our results suggest GBMs have a global effect on the brain ’s structural and functional organization, which is predictive of survival. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 5, 2023 Category: Cancer & Oncology Source Type: research
Intracranial intraoperative radiotherapy (IORT): evaluation of electrocorticography and peri-operative seizure risk
ConclusionsIORT is an option for delivery of definitive radiation in surgically resected brain tumors without increasing the peri-operative or long-term risk of seizure. ECoG data during the delivery of radiation fail to demonstrate any electrophysiological changes in response to ionizing radiation. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 5, 2023 Category: Cancer & Oncology Source Type: research
Neuropsychological impairment in primary malignant brain tumor patients with awake craniotomy: a hospital-based registration study
ConclusionIn awake craniotomy, patients with left-sided brain tumors had worse cognitive function than those with right-sided tumors in terms of global function, language, and attention. 77% of patients with right-sided tumors had neuropsychological impairment. Therefore, a comprehensive neuropsychological evaluation and awake craniotomy are necessary for patients with brain tumors. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 5, 2023 Category: Cancer & Oncology Source Type: research
Letter to the editor: outcome of glioblastoma patients after intensive care unit admission with invasive mechanical ventilation: a multicenter analysis
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 5, 2023 Category: Cancer & Oncology Source Type: research
Long-term treatment outcomes of temozolomide-based chemoradiation in patients with adult-type diffuse IDH-mutant grade 2 astrocytoma
ConclusionsTMZ-based chemoradiation is associated with survival benefit in patients with grade 2 IDH-mutant astrocytoma. For this group of patients, chemoradiation can be deferred until time of progression in younger patients receiving extensive resection, while early treatment should be recommended in high-risk patients. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 4, 2023 Category: Cancer & Oncology Source Type: research
Management of chordoma and chondrosarcoma with definitive dose-escalated single-fraction spine stereotactic radiosurgery
ConclusionDefinitive dose-escalated SSRS to 24 Gy in 1 fraction appears to be a safe and effective treatment for achieving durable local control in chordoma or chondrosarcoma involving the spine, and may hold particular importance as a low-morbidity alternative to surgery in selected cases. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 4, 2023 Category: Cancer & Oncology Source Type: research
Is it advisable to perform radiosurgery for EGFR-TKI-controlled brain metastases? A retrospective study of the role of radiosurgery in lung cancer treatment
ConclusionsWhile upfront TKI alone proved highly effective in BM control, this study also demonstrated the outcomes of SRS when implemented concurrently with TKI or as salvage therapy for TKI-uncontrolled BMs. This study also presents a strategy of the precise timing and targeting of SRS to lesions in progression. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 1, 2023 Category: Cancer & Oncology Source Type: research
Durable tumor regression and restoration of neurologic function after treatment with anti-PD-1 in patients with functionally unresectable cutaneous squamous cell carcinoma with perineural spread into the cavernous sinus
ConclusionAdministration of anti-PD-1 to patients with CSCC with perineural spread into the cavernous sinus can generate durable anti-tumor regressions and restore CN function, while sparing the morbidity associated with surgical resection and/or radiotherapy. Our findings add to emerging literature supporting this treatment approach for this patient population. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 1, 2023 Category: Cancer & Oncology Source Type: research
Cerebrospinal fluid exosomal protein alterations via proteomic analysis of NSCLC with leptomeningeal carcinomatosis
ConclusionWe investigated the application of label free and PRM based proteomics to detect key proteins related to LC. FN1 may serve as potential indicator to classify LC and NSCLC. Extracellular matrix (ECM) and epithelial-mesenchymal transition (EMT) are important in the process of LC. These data is promising for early prediction and diagnosis of LC. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 1, 2023 Category: Cancer & Oncology Source Type: research
Clinical characteristics and surgical outcomes of primary intracranial angiosarcomas
ConclusionIn this study, we found that PIAs have a higher incidence in males than in females, and most cases show evidence of old hemorrhage on preoperative MRI. Through our statistical analysis, GTR plays a crucial role in for treating this rare disease. Further clinical data are needed to validate our conclusions. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - August 31, 2023 Category: Cancer & Oncology Source Type: research
Prognostic value of cranial radiotherapy and optimal timing stratified by lung-molGPA for NSCLC patients with brain metastases
ConclusionUpfront CRT could bring significantly overall survival benefit for these patients with lung-molGPA2.5 –4 but not for patients with lung-molGPA0–2. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - August 30, 2023 Category: Cancer & Oncology Source Type: research
Long-term neurocognitive function and quality of life after multimodal therapy in adult glioma patients: a prospective long-term follow-up
ConclusionsMultimodal glioma therapy seems to affect neurocognition less than generally assumed. Even patients with unilateral hippocampal irradiation with > 50 Gy showed no profound cognitive decline in this series. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - August 30, 2023 Category: Cancer & Oncology Source Type: research
