Enhanced sensitivity of electrocorticography during awake craniotomy using a novel circular grid electrode
ConclusionWe demonstrate higher sensitivity in detecting ictal and interictal activity on ECoG during awake craniotomy with a novel circular grid compared to strip electrode, likely due to better spatial sampling during ECoG. We also found association between PFEDs and intraoperative seizures. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 7, 2023 Category: Cancer & Oncology Source Type: research

Correction to: Undetected pseudoprogressions in the CeTeG/NOA-09 trial: hints from postprogression survival and MRI analyses
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 3, 2023 Category: Cancer & Oncology Source Type: research

Qualitative MR features to identify non-enhancing tumors within glioblastoma ’s T2-FLAIR hyperintense lesions
ConclusionThe current investigation demonstrated that qualitative assessments of glioblastoma ’s MRI might help identify nCET in T2/FLAIR high-intensity lesions. The novel nCET score is expected to aid in expanding treatment targets within the T2/FLAIR high-intensity lesions.Graphical abstract (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 2, 2023 Category: Cancer & Oncology Source Type: research

Predictors for delayed awakening in adult glioma patients receiving awake craniotomy under monitored anesthesia care
ConclusionOur retrospective analysis of patients receiving monitored anesthesia care for awake craniotomy revealed that delayed awakening after propofol discontinuation occurred more often in patients with IDH1 wild-type tumors and repeated craniotomies. Also, delayed awakening was associated with somnolence during functional mapping and a lower gross total resection rate. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 2, 2023 Category: Cancer & Oncology Source Type: research

Focused ultrasound for brain metastases: an update on global clinical trials
ConclusionFurther work is required to establish FUS as a standard therapy for BMs. FUS has the potential to transform brain tumor treatment, particularly when combined with immunotherapy and targeted therapy as a non-invasive alternative to surgery and radiation therapy. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 1, 2023 Category: Cancer & Oncology Source Type: research

Decreased eukaryotic initiation factors expression upon temozolomide treatment —potential novel implications for eIFs in glioma therapy
ConclusionOur study provides novel insights into chemotherapeutic effects on eIF regulation in gliomas and suggests that eIFs are interesting candidates for future research to improve glioma therapy. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 31, 2023 Category: Cancer & Oncology Source Type: research

Identification of health-related quality of life profiles among long-term survivors of primary central nervous system tumors
ConclusionsIn the poor PCNST LTS HRQOL class, an overwhelming majority faced significant physical challenges, and the good HRQOL class experienced mood-related disturbance but limited physical challenges. These HRQOL profiles can be used to guide survivorship programs and tailored interventions. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 30, 2023 Category: Cancer & Oncology Source Type: research

Expertise in neuro-oncology: 10,000  h/10 years and opportunities for flattening the curve
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 30, 2023 Category: Cancer & Oncology Source Type: research

Cerebrospinal fluid circulating tumour DNA genotyping and survival analysis in lung adenocarcinoma with leptomeningeal metastases
ConclusionsCSF ctDNA could provide a more comprehensive genetic landscape of LM, indicating the potential metastasis-related and EGFR-TKI resistance mechanisms of LM patients. In addition, genotyping of CSF combined with clinical outcomes can predict the prognosis of LUAD patients with LM. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 28, 2023 Category: Cancer & Oncology Source Type: research

Immune checkpoint inhibition and single fraction stereotactic radiosurgery in brain metastases from non-small cell lung cancer: an international multicenter study of 395 patients
ConclusionThe risk of any grade RN and symptomatic RN following single fraction SRS and ICI for NSCLC brain metastases increases as V12 Gy exceeds 10 cm3. Concurrent ICI and SRS do not appear to increase this risk. Radiosurgical planning techniques should aim to minimize V12 Gy. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 27, 2023 Category: Cancer & Oncology Source Type: research

COX inhibitor use during definitive radiotherapy is associated with worse hearing preservation in patients with vestibular schwannoma
ConclusionCOX inhibitor use during definitive radiotherapy is associated with worse hearing loss in the affected ear but not for the contralateral side. This suggests the ototoxic effects of COX inhibitors may influence the effects of radiotherapy. These results could have clinical implications and warrant further investigation. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 27, 2023 Category: Cancer & Oncology Source Type: research

The Warburg effect in patients with brain tumors: a comprehensive analysis of clinical significance
ConclusionOur results show that brain tumor patients exhibit the Warburg effect and serum lactate may be a useful diagnostic and prognostic biomarker in patients with high-grade intra-axial brain tumors. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 27, 2023 Category: Cancer & Oncology Source Type: research

Metformin use is associated with longer survival in glioblastoma patients with MGMT gene silencing
ConclusionOur findings suggest a survival benefit with metformin use in patients with glioblastomas having methylation of the MGMT promoter. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 27, 2023 Category: Cancer & Oncology Source Type: research

Preoperative stereotactic radiosurgery as neoadjuvant therapy for resectable brain tumors
ConclusionEarly clinical data is very promising for neoadjuvant SRS in the setting of brain metastases. There are three ongoing phase III trials that will be more definitive in evaluating the potential benefits. While there is less data available for neoadjuvant SRS for gliomas, there remains a potential role, particularly to enable dose escalation and increase immunogenic effects. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 27, 2023 Category: Cancer & Oncology Source Type: research

Assessing survival outcomes and complication profiles following surgical excision and radiotherapy as interventions for skull base chordoma: a systematic review of operative margins and surgical approaches
ConclusionOverall, these results indicate good 5-year survival outcomes for patients with skull base chordoma; however, 10-year prognosis for skull base chordoma remains poor due to its radiotherapeutic resistance and high recurrence rate. Furthermore, mortality rates among patients undergoing midline versus lateral skull base approaches appear to be equivocal. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 25, 2023 Category: Cancer & Oncology Source Type: research