Integrated clinical genomic analysis reveals xenobiotic metabolic genes are downregulated in meningiomas of current smokers
ConclusionIn this study, we conducted a comparative analysis of meningioma patients based on their smoking history, examining both their clinical trajectories and molecular changes. Meningiomas from current smokers were more likely to harborNOTCH2 mutations, andAKT1 mutations were absent in current or past smokers. Moreover, both current and past smokers exhibited a mutational signature associated with DNA mismatch repair. Meningiomas from current smokers demonstrate downregulation of xenobiotic metabolic enzymesUGT2A1 andUGT2A2, which are downregulated in other smoking related cancers. Furthermore, current smokers exhibit...
Source: Journal of Neuro-Oncology - June 15, 2023 Category: Cancer & Oncology Source Type: research

Conceptual development of an intensive exercise program for glioma patients (ActiNO): summary of clinical experience
ConclusionThis supervised training program with submaximal exertion was feasible and safe in glioma regardless of WHO grading. Based on these experiences, we initiated a prospective multicenter study to objectify improvements in physical performance and quality of life in patients with glioblastoma. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - June 12, 2023 Category: Cancer & Oncology Source Type: research

Towards the definition of progressive disease in brain metastasis treated with laser ablation: an evidence-based study
ConclusionVolume changes within the first 120 days after the procedure are not independent indicators of LP of metastatic brain lesions treated with LITT. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - June 12, 2023 Category: Cancer & Oncology Source Type: research

Multi-nuclear sodium, diffusion, and perfusion MRI in human gliomas
ConclusionSodium MRI is positively correlated with proton diffusion MRI measurements in gliomas, likely reflecting extracellular water. Unique areas of multinuclear MRI contrast may be useful in future studies to understand the chemistry of the tumor microenvironment. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - June 9, 2023 Category: Cancer & Oncology Source Type: research

Treatment benefit in patients aged 80 years or older with biopsy-proven and non-resected glioblastoma is dependent on MGMT promoter methylation status
ConclusionBenefit from tumor-specific treatment in patients with newly diagnosed glioblastoma aged≥80 years might be restricted toMGMTpos patients, especially to those with good clinical status and no polypharmacy. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - June 8, 2023 Category: Cancer & Oncology Source Type: research

Retrospective non-inferiority study of stereotactic radiosurgery for more than ten brain metastases
ConclusionsSRS for selected patients with  >  10 BM was non-inferior in terms of OS compared to those with 2–10 BM in a propensity score-matched dataset. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - June 7, 2023 Category: Cancer & Oncology Source Type: research

Tissue and plasma free amino acid detection by LC-MS/MS method in high grade glioma patients
ConclusionThis study demonstrated potential amino acids which may have diagnostic value for high-grade glioma patients by utilizing LC-MS/MS method. Our results are preliminary to compare serum and tissue levels of amino acids in patients with malignant gliomas. The data presented here may provide feature ideas about the metabolic pathways in the pathogenesis of gliomas. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - June 6, 2023 Category: Cancer & Oncology Source Type: research

Optimizing treatment of brain metastases in an era of novel systemic treatments: a single center consecutive series
ConclusionsAssessing prognosis in light of systemic treatment options is crucial after the diagnosis of brain metastasis for the consideration of radiotherapy versus best supportive care.Graphical Abstract (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - June 2, 2023 Category: Cancer & Oncology Source Type: research

Different clinical and cytogenetic features of primary skull base meningiomas and non-skull base meningiomas
ConclusionsThe clinical and cytogenetic features of SBMs were different from NSBMs. Moreover, the degree of resection and the total number of whole-genome CNVs were independent prognostic factors for tumor recurrence. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - June 2, 2023 Category: Cancer & Oncology Source Type: research

Association between thyroid function and regorafenib efficacy in patients with relapsed wild-type IDH glioblastoma: a large multicenter study
ConclusionIn recurrent wild-type IDH glioblastoma patients, baseline fT3/fT4 ratio showed a non-linear relationship with survival, with different impacts across the spectrum of fT3/fT4 ratio. Moreover, baseline TSH may be a predictor of regorafenib activity. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - June 1, 2023 Category: Cancer & Oncology Source Type: research

Re-irradiation for recurrent high-grade glioma: an analysis of prognostic factors for survival and predictors of radiation necrosis
ConclusionWe observe favorable OS rates following re-RT and identified prognostic factors, including methylation status, that can assist in patient selection and clinical trial design. Concurrent use of bevacizumab mitigated the risk of RN. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - May 31, 2023 Category: Cancer & Oncology Source Type: research

Safety and efficacy of Cesium-131 brachytherapy for brain tumors
ConclusionsCs-131 brachytherapy demonstrated a favorable safety and efficacy profile characterized by high rates of local control for all treated pathologies. The concept of brachytherapy has seen a resurgence given the excellent results when Cs-131 is used as a source. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - May 30, 2023 Category: Cancer & Oncology Source Type: research

Identification of incidental brain tumors in prostate cancer patients via PSMA PET/CT
ConclusionProstate cancer brain metastases are rare, especially in the absence of widespread metastatic disease. Nevertheless, incidentally detected brain foci of PSMA uptake may represent previously unknown prostate cancer metastases, even in small lesions and in the absence of systemic disease. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - May 29, 2023 Category: Cancer & Oncology Source Type: research

Chat GPT versus human touch in stereotactic radiosurgery
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - May 29, 2023 Category: Cancer & Oncology Source Type: research

Comparative analysis of deeply phenotyped GBM cohorts of ‘short-term’ and ‘long-term’ survivors
ConclusionOverall, comparison of STS and LTS GBM patients, identifies novel biomarkers and potential actionable therapeutic targets for the management of GBM.Graphical abstract (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - May 26, 2023 Category: Cancer & Oncology Source Type: research