Signal-transducing adaptor protein 1 (STAP1) in microglia promotes the malignant progression of glioma
ConclusionSTAP1 is positively associated with the degree of glioma malignancy and may represent a potential novel therapeutic target for glioma. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - July 18, 2023 Category: Cancer & Oncology Source Type: research

Cellular senescence in glioma
ConclusionIn this article, we delineate an overview of senescence in the context of gliomas, including the mechanisms that lead to senescence induction, bypass, and escape. Furthermore, we examine the role of senescent cells in the tumor microenvironment and their role in tumor progression and recurrence. Additionally, we highlight potential therapeutic opportunities for targeting senescence in glioma. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - July 17, 2023 Category: Cancer & Oncology Source Type: research

Hypo-fractionated accelerated radiotherapy with concurrent and maintenance temozolomide in newly diagnosed glioblastoma: updated results from phase II HART-GBM trial
ConclusionThe long-term results of the trial support HART as a promising treatment option with comparable survival outcomes to the current standard of care. Phase III trials are required for further validation of this regimen which has the potential to become the new standard of care in GBM. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - July 15, 2023 Category: Cancer & Oncology Source Type: research

Belzutifan in adults with VHL-associated central nervous system hemangioblastoma: a single-center experience
ConclusionWe showed that belzutifan is safe and well-tolerated with strong disease response for CNS hemangioblastoma in adults with VHL, supporting continued use of belzutifan in this patient population. Future studies should assess duration of treatment, effects of cessation after long-term use, and markers of therapeutic response. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - July 14, 2023 Category: Cancer & Oncology Source Type: research

The impact of a virtual mind-body program on resilience factors among international English-speaking adults with neurofibromatoses: secondary analysis of a randomized clinical trial
Conclusion3RP-NF showed promise in sustainably improving coping abilities amongst people with NF.Trial registration InformationClinicalTrials.gov Identifier: NCT03406208. Registration submitted December 6, 2017, first patient enrolled October 2017. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - July 13, 2023 Category: Cancer & Oncology Source Type: research

CHD5 gene variant predicts leptomeningeal metastasis after surgical resection of brain metastases of breast cancer
ConclusionsThese results suggested that theCHD5 gene alteration was associated with LM after surgical resection of breast cancer brain metastases. Searching for the gene alteration might predict the LM risk after surgical resection. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - July 13, 2023 Category: Cancer & Oncology Source Type: research

Associations of race and socioeconomic status with outcomes after intracranial meningioma resection: a systematic review and meta-analysis
ConclusionDisparities in outcomes exist for patients who undergo surgery for meningioma, such that Black and low SES patients have worse outcomes. The literature is quite sparse and contains confounding relationships not often accounted for appropriately. Further studies are needed to help understand these disparities to improve outcomes. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - July 13, 2023 Category: Cancer & Oncology Source Type: research

Prognostic factors for pediatric, adolescent, and young adult patients with non-DIPG grade 4 gliomas: a contemporary pooled institutional experience
ConclusionAge is a significant prognostic factor in WHO grade 4 glioma, which may reflect age-related molecular alterations in the tumor. DMG was associated with worse OS than glioblastoma. Reoperation and systemic therapy significantly increased survival after disease progression. Prospective studies in this population are warranted. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - July 13, 2023 Category: Cancer & Oncology Source Type: research

Response to “Large language model artificial intelligence: the current state and future of ChatGPT in neuro-oncology publishing”
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - July 13, 2023 Category: Cancer & Oncology Source Type: research

Letter: are there incidences of clinically relevant psychiatric symptoms during glioblastoma treatment?
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - July 13, 2023 Category: Cancer & Oncology Source Type: research

Comparison of direct cortical stimulation and transcranial magnetic stimulation in brain tumor surgery: systematic review and meta analyses
ConclusionTMS is a noninvasive imaging method for the evaluation of eloquent brain areas that is not inferior compared to the invasive gold-standard imaging method (DCS). However its role as adjuvant to DCS and alternative only when awake surgery is not available must be emphasized. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - July 12, 2023 Category: Cancer & Oncology Source Type: research

Tumor immune microenvironment in pituitary neuroendocrine tumors (PitNETs): increased M2 macrophage infiltration and PD-L1 expression in PIT1-lineage subset
ConclusionPIT1-lineage PitNETs exhibit a distinct immune profile with enrichment of M2 macrophage infiltration and PD-L1 expression, which may contribute to its clinical aggressiveness. Application of current immune checkpoint inhibitors and M2-targeted immunotherapy might be more beneficial to treat aggressive and metastatic PIT-lineage PitNETs. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - July 7, 2023 Category: Cancer & Oncology Source Type: research

Let ’s make size not matter: tumor control and toxicity outcomes of hypofractionated Gamma Knife radiosurgery for large brain metastases
ConclusionsWe present our institutional experience treating large brain metastases using mask-based HF-GKRS, representing one of the largest studies implementing this platform and technique. Our LF and ARE compare favorably with the literature, suggesting that target volumes less than 33.5  cc demonstrate excellent control rates with low ARE. Further investigation is needed to optimize treatment technique for larger tumors. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - July 6, 2023 Category: Cancer & Oncology Source Type: research

Tyrphostin A9 attenuates glioblastoma growth by suppressing PYK2/EGFR-ERK signaling pathway
ConclusionAltogether, this study report that increased phospho-PYK2 and EGFR expression in astrocytoma was associated with poor prognosis. The in-vitro and in-vivo evidence underlined translational implication of TYR A9 by suppressing PYK2/EGFR-ERK modulated signaling pathway.Graphical abstractThe schematic diagram displayed proof of concept of the current study indicating activated PYK2 either through the Ca2+/Calmodulin-dependent protein kinase II (CAMKII) signaling pathway or autophosphorylation at Tyr402 induces association to the SH2 domain of c-Src that leads to c-Src activation. Activated c-Src in turn activates PYK...
Source: Journal of Neuro-Oncology - July 6, 2023 Category: Cancer & Oncology Source Type: research

Dynamic interplay between corticosteroid treatment and the role of SRC-1 gene dysregulation in the progression of WHO-Grade 4 Astrocytoma
ConclusionsCorticosteroid treatment can directly affect the SRC-1 gene regulation but does not directly influence cytotoxic T-cells infiltration or tumor progression. However, SRC-1 gene downregulation can facilitate late tumor recurrence. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - July 4, 2023 Category: Cancer & Oncology Source Type: research