Immune checkpoint inhibition and single fraction stereotactic radiosurgery in brain metastases from non-small cell lung cancer: an international multicenter study of 395 patients
ConclusionThe risk of any grade RN and symptomatic RN following single fraction SRS and ICI for NSCLC brain metastases increases as V12 Gy exceeds 10 cm3. Concurrent ICI and SRS do not appear to increase this risk. Radiosurgical planning techniques should aim to minimize V12 Gy. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 27, 2023 Category: Cancer & Oncology Source Type: research
COX inhibitor use during definitive radiotherapy is associated with worse hearing preservation in patients with vestibular schwannoma
ConclusionCOX inhibitor use during definitive radiotherapy is associated with worse hearing loss in the affected ear but not for the contralateral side. This suggests the ototoxic effects of COX inhibitors may influence the effects of radiotherapy. These results could have clinical implications and warrant further investigation. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 27, 2023 Category: Cancer & Oncology Source Type: research
The Warburg effect in patients with brain tumors: a comprehensive analysis of clinical significance
ConclusionOur results show that brain tumor patients exhibit the Warburg effect and serum lactate may be a useful diagnostic and prognostic biomarker in patients with high-grade intra-axial brain tumors. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 27, 2023 Category: Cancer & Oncology Source Type: research
Metformin use is associated with longer survival in glioblastoma patients with MGMT gene silencing
ConclusionOur findings suggest a survival benefit with metformin use in patients with glioblastomas having methylation of the MGMT promoter. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 27, 2023 Category: Cancer & Oncology Source Type: research
Preoperative stereotactic radiosurgery as neoadjuvant therapy for resectable brain tumors
ConclusionEarly clinical data is very promising for neoadjuvant SRS in the setting of brain metastases. There are three ongoing phase III trials that will be more definitive in evaluating the potential benefits. While there is less data available for neoadjuvant SRS for gliomas, there remains a potential role, particularly to enable dose escalation and increase immunogenic effects. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 27, 2023 Category: Cancer & Oncology Source Type: research
Assessing survival outcomes and complication profiles following surgical excision and radiotherapy as interventions for skull base chordoma: a systematic review of operative margins and surgical approaches
ConclusionOverall, these results indicate good 5-year survival outcomes for patients with skull base chordoma; however, 10-year prognosis for skull base chordoma remains poor due to its radiotherapeutic resistance and high recurrence rate. Furthermore, mortality rates among patients undergoing midline versus lateral skull base approaches appear to be equivocal. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 25, 2023 Category: Cancer & Oncology Source Type: research
Genetic predictors of neurocognitive outcomes in survivors of pediatric brain tumors
ConclusionsSNPs offer the potential to predict adverse neurocognitive outcomes in pediatric brain tumor survivors. Our results require validation in a larger patient cohort. Improving the ability to identify children at risk of treatment related neurocognitive deficits could allow for better treatment stratification and early cognitive interventions. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 25, 2023 Category: Cancer & Oncology Source Type: research
Long-term antiseizure medication use in patients after meningioma resection: identifying predictors for successful weaning and failures
ConclusionsPreoperative seizures, modified STAMPE2 score of 3 –5, non-skull base tumor location, intratumoral calcifications, and Ki67 > 7% were significant risk factors for inability to achieve seizure freedom without ASMs. In addition, the modified STAMPE2 score successfully predicted increased seizure risk following meningioma resection for patients with a score of 3 or higher. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 24, 2023 Category: Cancer & Oncology Source Type: research
Telomere maintenance mechanism subtype reveals different immune activity in vestibular schwannoma
ConclusionThese results suggest that personalized drug therapy could be developed from the perspective of precision medicine for patients with relatively high telomerase activity and a high ALT-like group. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 21, 2023 Category: Cancer & Oncology Source Type: research
Activity of a first-in-class oral HIF2-alpha inhibitor, PT2385, in patients with first recurrence of glioblastoma
ConclusionsPT2385 monotherapy had limited activity in first recurrent GBM. Drug exposure was variable. Signals of activity were observed in GBM patients with high systemic exposure and acidic lesions on CEST imaging. A second-generation HIF2 α inhibitor is being studied. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 21, 2023 Category: Cancer & Oncology Source Type: research
Impact of boost sequence in concurrent chemo-radiotherapy on newly diagnosed IDH-wildtype glioblastoma multiforme
ConclusionsThis study found no significant difference in OS between SEB and SIB for GBM patients treated with CCRT. Further research is needed to validate these findings and to determine the optimal boost techniques for this patient population. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 20, 2023 Category: Cancer & Oncology Source Type: research
Improved survival outcome with not-delayed radiotherapy and immediate PD-1/PD-L1 inhibitor for non-small-cell lung cancer patients with brain metastases
ConclusionsDelayed RT brought poor survival outcomes including iLPFS, iDPFS, and OS in NSCLC patients. The shorter interval of RT and ICI is associated with better BOR. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 17, 2023 Category: Cancer & Oncology Source Type: research
Glioblastomas at the white matter of temporo-parietal junction cause a poor postoperative independence level
ConclusionsGBMs involving the right WM-TPJ are more likely to result in poor postoperative KPS scores and prognoses. Impairments of several kinds of brain functions caused by tumor invasion to the WM-TPJ may be associated with lower KPS scores. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 17, 2023 Category: Cancer & Oncology Source Type: research
Single-fraction radiosurgery outcomes for large vestibular schwannomas in the upfront or post-surgical setting: a systematic review and International Stereotactic Radiosurgery Society (ISRS) Practice Guidelines
ConclusionsUpfront SRS resulted in high rates of tumor control with acceptable rates of facial palsy and hearing preservation as compared to the results in those series including patients with prior surgery (level C evidence). Therefore, although large VS are considered classic indication for microsurgical resection, upfront SRS can be considered in selected patients and we recommend a prescribed marginal dose from 11 to 13 Gy (level C evidence). (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 16, 2023 Category: Cancer & Oncology Source Type: research
Residual diffusion-weighted imaging hyperintense signal in primary central nervous system lymphoma can predict early recurrence
ConclusionA residual DWI hyperintense signal at the end of treatment was statistically associated with shorter PFS. Among patients who achieved CR/CRu evaluated based on postcontrast T1WI, DWI could be a valuable additional sequence to predict the early recurrence of PCNSL. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 13, 2023 Category: Cancer & Oncology Source Type: research
