About the incompleteness of our models
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 12, 2024 Category: Cancer & Oncology Source Type: research

Fractionated stereotactic radiotherapy in craniopharyngiomas: A systematic review and single arm meta-analysis
ConclusionDespite limitations and risks, FSRT shows promise as a viable therapeutic option for craniopharyngiomas, offering notable benefits for visual functions and tumor control. Further research is required to better understand the associated risks, benefits, and clinical utility. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 8, 2024 Category: Cancer & Oncology Source Type: research

The role of adjuvant chemotherapy in patients with H3K27 altered diffuse midline gliomas: a multicentric retrospective study
ConclusionIn our series, adjuvant treatment after radiotherapy can be useful in improving OS of patients with H3K27-altered DMG. When feasible another systemic treatment after treatment progression could be proposed. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 8, 2024 Category: Cancer & Oncology Source Type: research

Peptide radionuclide radiation therapy with Lutathera in multirecurrent nonanaplastic meningiomas: antitumoral activity study by growth rate analysis
ConclusionIn nonanaplastic meningiomas, Lutathera ®’s antitumoral activity appeared delayed and more likely observed at six months, while no major response was observed under treatment. Moreover, its antitumoral activity persisted for 12–18 months following treatment initiation. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 7, 2024 Category: Cancer & Oncology Source Type: research

Inhibition of BMP signaling pathway induced senescence and calcification in anaplastic meningioma
ConclusionsThe GREM2-BMPR1A-tryptophan metabolic pathway in meningiomas is a potential new therapeutic target. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 6, 2024 Category: Cancer & Oncology Source Type: research

Correction to: Intrathecal chemotherapy for leptomeningeal disease in high-grade gliomas: a systematic review
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 6, 2024 Category: Cancer & Oncology Source Type: research

Cutaneous toxicities of mitogen-activated protein kinase inhibitors in children and young adults with neurofibromatosis-1
ConclusionsImprovement in characterization of MEKi toxicities and their management is important to develop treatment guidelines for pediatric and young adult patients with NF1 on MEKi therapy. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 5, 2024 Category: Cancer & Oncology Source Type: research

Prognostic value of cerebrospinal fluid tumor cell count in leptomeningeal disease from solid tumors
ConclusionsCSF-TC density may carry prognostic value in patients with LMD from solid tumors. Integrating CSF-TC density into LMD patient risk-stratification may help guide treatment decisions. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 5, 2024 Category: Cancer & Oncology Source Type: research

Impact of trametinib on the neuropsychological profile of NF1 patients
ConclusionThese preliminary results show a potential positive effect of trametinib on cognition in patients with NF1. We observed significant improvements in processing speed, visuo-motor and verbal abilities. This study demonstrates the importance of including neuropsychological evaluations into clinical trial when using MEK inhibitors for patients with NF1. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 5, 2024 Category: Cancer & Oncology Source Type: research

Correction to: The effectiveness and safety of proton beam radiation therapy in children and young adults with Central Nervous System (CNS) tumours: a systematic review
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 5, 2024 Category: Cancer & Oncology Source Type: research

Immunological signatures and predictive biomarkers for first-generation somatostatin receptor ligand resistance in Acromegaly
ConclusionPD-L1 expression and CD8  + T cell infiltration, either independently or combined with SSTR2 expression and T2WI-MRI intensity, could form a predictive model guiding clinical decisions on fg-SRL employment. Furthermore, targeting PD-L1 through immunotherapy and embracing second-generations of SRL with higher affinity to SSTR5 represent promising strategies to tackle fg-SRL resistance in somatotropinomas. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 5, 2024 Category: Cancer & Oncology Source Type: research

Clinical characteristics and predictive factors of delayed diagnosis in patients with sellar germ cell tumors
ConclusionIn patients with sellar GCTs, delayed diagnosis is common and linked to increased pituitary dysfunction. The initial symptoms of slow growth, polyuria/polydipsia, and amenorrhea, as well as germinoma with negative tumor markers, predict the possibility of a delayed diagnosis. Early diagnosis is crucial to minimize the impact of sellar GCTs on pituitary function. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 4, 2024 Category: Cancer & Oncology Source Type: research

Clinical presentation and extent of resection impacts progression-free survival in spinal ependymomas
ConclusionsIn this large, contemporary series of adult spinal ependymoma patients, we demonstrated improvements in PFS when GTR was achieved. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 4, 2024 Category: Cancer & Oncology Source Type: research

Preoperative patient-reported physical health-related quality of life predicts short-term postoperative outcomes in brain tumor patients
ConclusionThe PROMIS-29 PH summary score predicts short-term postoperative outcomes in brain tumor patients and may be incorporated into prospective clinical workflows. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 4, 2024 Category: Cancer & Oncology Source Type: research

Prognostic impact of clinical and radiological factors on leptomeningeal metastasis from solid cancers
ConclusionsThis study validated the efficacy of prognostication according to the EANO-ESMO guidelines for LM. Systemic therapy after LM diagnosis improves the survival of NSCLC patients. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 2, 2024 Category: Cancer & Oncology Source Type: research