Imaging as an early biomarker to predict sensitivity to everolimus for progressive NF2-related vestibular schwannoma
ConclusionsVolumetric imaging at 3 months can serve as an early biomarker to predict long-term sensitivity to everolimus treatment. Everolimus may represent a safe treatment option to decrease the growth of NF2-related VS in patients who have stable hearing and neurological condition. TRN: NCT01345136 (April 29, 2011). (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 19, 2024 Category: Cancer & Oncology Source Type: research

Ki-67 labeling index predicts tumor progression patterns and survival in patients with atypical meningiomas following stereotactic radiosurgery
ConclusionPatients with high Ki-67 LI showed significantly more tumor progression and tumor-related death. Ki-67 LI might offer valuable predictive insights for the post-SRS management of atypical meningiomas. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 18, 2024 Category: Cancer & Oncology Source Type: research

Effect of Pneumocystis jirovecii pneumonia prophylaxis on hematologic toxicity in patients receiving chemoradiation for primary brain tumors
ConclusionThese findings suggest that the type of PJP prophylaxis does not significantly affect the risk for hematologic toxicity in brain tumor patients receiving radiation and temozolomide. Additional studies are merited to evaluate the higher rate of neutropenia in patients on TMP/SMX observed in this study. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 16, 2024 Category: Cancer & Oncology Source Type: research

The development of a custom RNA-sequencing panel for the identification of predictive and diagnostic biomarkers in glioma
ConclusionsTOP2-RNA is a highly sensitive assay for detecting fusion genes, exon skipping, and aberrant gene expression. Alterations in targetable driver genes were identified in more than 50% of glioblastoma. Molecular profiling by TOP2-RNA provides ample predictive, prognostic, and diagnostic biomarkers that may not be identified by conventional assays and, therefore, is expected to increase treatment options for individual patients with glioma. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 16, 2024 Category: Cancer & Oncology Source Type: research

Stereotactic radiosurgery and bevacizumab for recurrent glioblastoma
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 16, 2024 Category: Cancer & Oncology Source Type: research

Stereotactic radiosurgery for intracranial adenoid cystic carcinoma
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 16, 2024 Category: Cancer & Oncology Source Type: research

Predictive role of intracranial PD-L1 expression in a real-world cohort of NSCLC patients treated with immune checkpoint inhibition following brain metastasis resection
ConclusionOur study highlights the potential role of intracranial PD-L1 TPS in NSCLC, which could be used to predict ICI response in cases where extracranial tissue is not available for PD-L1 assessment as well as to specifically predict intracranial response. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 15, 2024 Category: Cancer & Oncology Source Type: research

Correction to: CDKN2A/B deletion in IDH-mutant astrocytomas: An evaluation by Fluorescence in-situ hybridization
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 15, 2024 Category: Cancer & Oncology Source Type: research

The role of spine stereotactic radiosurgery for patients with breast cancer metastases
ConclusionsSpinal radiosurgery is a safe and highly effective long-term treatment modality for metastases to the spine that originate from breast cancer. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 14, 2024 Category: Cancer & Oncology Source Type: research

Imaging predictors of 4q12 amplified and RB1 mutated glioblastoma IDH-wildtype
ConclusionsPatients with glioblastoma IDH-wildtype harboring 4q12 amplification rarely have restricting DWI patterns compared to their wildtype counterparts, in which this DWI pattern is present in ~  50% of patients. This suggests that some phenotypic imaging characteristics can be identified among molecular subtypes of IDH-wildtype glioblastoma. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 13, 2024 Category: Cancer & Oncology Source Type: research

Repeated surgical resections for management of high-grade glioma and its impact on quality of life
ConclusionsThese results suggest that repeated resection is a viable strategy in certain cases for management of HGG recurrence, with similar impact on QoL as observed in patients undergoing first time surgery. These encouraging outcomes provide useful insight to guide treatment strategies and patient and clinician decision making to optimize surgical and functional outcomes. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 13, 2024 Category: Cancer & Oncology Source Type: research

Comment: Additional factors affecting cognitive function in low grade glioma patients
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 13, 2024 Category: Cancer & Oncology Source Type: research

Diffuse Midline H3K27-Altered Gliomas in the Spinal Cord: A Systematic Review
ConclusionsOutcomes for DMG-SCs are poor overall but appear to be favorable compared to intracranial DMGs. Despite the recent WHO 2021 grade 4 classification for all DMGs, given the differences in overall survival reported based on historical grading systems, future studies on DMG-SCs are needed to further define if DMG-SCs may represent a heterogeneous group of tumors with different prognoses. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 12, 2024 Category: Cancer & Oncology Source Type: research

Incidence and imaging characteristics of difficult to detect retrospectively identified brain metastases in patients receiving repeat courses of stereotactic radiosurgery
ConclusionRadiographic evidence of brain metastases requiring future treatment was occasionally present on brain MRIs from prior SRS treatments. Most RIMs were  + DC, and some subsequent SRS courses treated only + DC RIMs. These findings suggest enhanced BM detection might enable earlier treatment and reduce the need for additional SRS. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 10, 2024 Category: Cancer & Oncology Source Type: research

The importance of considering competing risks in recurrence analysis of intracranial meningioma
ConclusionThe importance of considering competing events in recurrence risk analysis is poorly recognized as only 6% of the studies we surveyed employed Aalen-Johansen analyses. Consequently, most of the previous literature has overestimated the risk of recurrence. The overestimation was negligible for studies involving low-grade lesions in younger individuals; however, overestimation might have been substantial for studies on high-grade lesions. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 10, 2024 Category: Cancer & Oncology Source Type: research