Validation of a methylation-based signature for subventricular zone involvement in glioblastoma
ConclusionHerein, we validated the specific epigenetic signature in GBM in the vicinity of the SVZ and highlighted the importance of methylation of a part of the LRBA/MAB21L2 gene locus. Whether SVZM can replace MRI-based SVZ assignment as a prognostic and diagnostic tool will require prospective studies of large, homogeneous cohorts. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 20, 2024 Category: Cancer & Oncology Source Type: research
Radio-pathomic maps of glioblastoma identify phenotypes of non-enhancing tumor infiltration associated with bevacizumab treatment response
ConclusionPatients with a hypocellular tumor front identified by radio-pathomic maps showed improved treatment efficacy when treated with bevacizumab, and reducing hypocellular volumes over the course of treatment may indicate treatment response. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 19, 2024 Category: Cancer & Oncology Source Type: research
Leptomeningeal carcinomatosis and brain metastases in gastroesophageal carcinoma: a real-world analysis of clinical and pathologic characteristics and outcomes
ConclusionHER2 expression were enriched in patients with BrM, while it is uncommon in LMC. Patients treated with surgery followed by radiation had an improved OS in BrM and WBRT benefited patients with LMC. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 19, 2024 Category: Cancer & Oncology Source Type: research
The risk and burden of thromboembolic and hemorrhagic events in patients with malignant gliomas receiving bevacizumab
ConclusionIn order to stratify the risk for developing ICH before the initiation of bevacizumab, we recommend to assess for the presence of cerebral macrobleeding as it is associated with ICH development. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 19, 2024 Category: Cancer & Oncology Source Type: research
Imaging as an early biomarker to predict sensitivity to everolimus for progressive NF2-related vestibular schwannoma
ConclusionsVolumetric imaging at 3 months can serve as an early biomarker to predict long-term sensitivity to everolimus treatment. Everolimus may represent a safe treatment option to decrease the growth of NF2-related VS in patients who have stable hearing and neurological condition. TRN: NCT01345136 (April 29, 2011). (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 19, 2024 Category: Cancer & Oncology Source Type: research
Ki-67 labeling index predicts tumor progression patterns and survival in patients with atypical meningiomas following stereotactic radiosurgery
ConclusionPatients with high Ki-67 LI showed significantly more tumor progression and tumor-related death. Ki-67 LI might offer valuable predictive insights for the post-SRS management of atypical meningiomas. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 18, 2024 Category: Cancer & Oncology Source Type: research
Effect of Pneumocystis jirovecii pneumonia prophylaxis on hematologic toxicity in patients receiving chemoradiation for primary brain tumors
ConclusionThese findings suggest that the type of PJP prophylaxis does not significantly affect the risk for hematologic toxicity in brain tumor patients receiving radiation and temozolomide. Additional studies are merited to evaluate the higher rate of neutropenia in patients on TMP/SMX observed in this study. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 16, 2024 Category: Cancer & Oncology Source Type: research
The development of a custom RNA-sequencing panel for the identification of predictive and diagnostic biomarkers in glioma
ConclusionsTOP2-RNA is a highly sensitive assay for detecting fusion genes, exon skipping, and aberrant gene expression. Alterations in targetable driver genes were identified in more than 50% of glioblastoma. Molecular profiling by TOP2-RNA provides ample predictive, prognostic, and diagnostic biomarkers that may not be identified by conventional assays and, therefore, is expected to increase treatment options for individual patients with glioma. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 16, 2024 Category: Cancer & Oncology Source Type: research
Stereotactic radiosurgery and bevacizumab for recurrent glioblastoma
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 16, 2024 Category: Cancer & Oncology Source Type: research
Stereotactic radiosurgery for intracranial adenoid cystic carcinoma
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 16, 2024 Category: Cancer & Oncology Source Type: research
Predictive role of intracranial PD-L1 expression in a real-world cohort of NSCLC patients treated with immune checkpoint inhibition following brain metastasis resection
ConclusionOur study highlights the potential role of intracranial PD-L1 TPS in NSCLC, which could be used to predict ICI response in cases where extracranial tissue is not available for PD-L1 assessment as well as to specifically predict intracranial response. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 15, 2024 Category: Cancer & Oncology Source Type: research
Correction to: CDKN2A/B deletion in IDH-mutant astrocytomas: An evaluation by Fluorescence in-situ hybridization
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 15, 2024 Category: Cancer & Oncology Source Type: research
The role of spine stereotactic radiosurgery for patients with breast cancer metastases
ConclusionsSpinal radiosurgery is a safe and highly effective long-term treatment modality for metastases to the spine that originate from breast cancer. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 14, 2024 Category: Cancer & Oncology Source Type: research
Imaging predictors of 4q12 amplified and RB1 mutated glioblastoma IDH-wildtype
ConclusionsPatients with glioblastoma IDH-wildtype harboring 4q12 amplification rarely have restricting DWI patterns compared to their wildtype counterparts, in which this DWI pattern is present in ~ 50% of patients. This suggests that some phenotypic imaging characteristics can be identified among molecular subtypes of IDH-wildtype glioblastoma. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 13, 2024 Category: Cancer & Oncology Source Type: research
Repeated surgical resections for management of high-grade glioma and its impact on quality of life
ConclusionsThese results suggest that repeated resection is a viable strategy in certain cases for management of HGG recurrence, with similar impact on QoL as observed in patients undergoing first time surgery. These encouraging outcomes provide useful insight to guide treatment strategies and patient and clinician decision making to optimize surgical and functional outcomes. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 13, 2024 Category: Cancer & Oncology Source Type: research
