The role of cytoreductive surgery in multifocal/multicentric glioblastomas
ConclusionResective surgery in mGBM is associated with better survival. This benefit seems to relate prominently to an increased number of patients being able to tolerate effective adjuvant therapies after tumor resections. In addition, cytoreductive surgery may have a survival impact per se. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 12, 2023 Category: Cancer & Oncology Source Type: research

The state of art of awake craniotomy in Latin American countries: a scoping review
ConclusionImproved accessibility to resources, infrastructure, and adequate instrumentation is crucial for wider AC availability in Latin America. Despite disparities, AC implementation with proper training and teamwork yields favorable outcomes in resource-limited centers. Efforts should focus on addressing challenges and promoting equitable access to this valuable surgical technique in the region. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 12, 2023 Category: Cancer & Oncology Source Type: research

The prognostic power of [11C]methionine PET in IDH-wildtype diffuse gliomas with lower-grade histological features: venturing beyond WHO classification
ConclusionMET PET is useful for the prognostic stratification of patients with IDH-wt glial neoplasms with histological LGGs features. Considering their huge biological heterogeneity, the combination of MET PET and molecular analyses may help to improve the prognostic accuracy in these diffuse gliomas subset and influence therapeutic choices accordingly. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 11, 2023 Category: Cancer & Oncology Source Type: research

EGFR-mutated non-small lung cancer brain metastases and radiosurgery outcomes with a focus on leptomeningeal disease
ConclusionThe study shows that current-generation targeted therapy for EGFR-mutated NSCLC patients may prevent the development and progression of LMD, leading to improved survival outcomes. Nevertheless, LMD is associated with poor outcomes and neurologic death, making innovative strategies to treat LMD essential. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 10, 2023 Category: Cancer & Oncology Source Type: research

Dynamic contrast-enhanced MRI radiomics model predicts epidermal growth factor receptor amplification in glioblastoma, IDH-wildtype
ConclusionThe DCE MRI-based radiomics model that predictsEGFR amplification in glioblastoma,IDH wildtype, was developed and validated. The MRI-based radiomics model using the Ktrans map has higher AUROC than conventional MRI. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 10, 2023 Category: Cancer & Oncology Source Type: research

Decision system for extent of resection in WHO grade 3 gliomas: a Chinese Glioma Genome Atlas database analysis
ConclusionsExtensive resection benefits only a proportion of patients with WHO grade 3 IDH-mutant gliomas. Younger patients with astrocytomas had survival benefits from extensive resection. In addition to clinical characteristics (especially age), molecular pathology impacted prognosis in patients with gliomas. Our findings provide guiding information to neurosurgeons while planning surgeries. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 5, 2023 Category: Cancer & Oncology Source Type: research

Predicting survival in glioblastoma with multimodal neuroimaging and machine learning
ConclusionWe demonstrate that machine learning can accurately classify survival in GBM patients based on multimodal neuroimaging before any surgical or medical intervention. These results were achieved without information regarding presentation symptoms, treatments, postsurgical outcomes, or tumor genomic information. Our results suggest GBMs have a global effect on the brain ’s structural and functional organization, which is predictive of survival. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 5, 2023 Category: Cancer & Oncology Source Type: research

Intracranial intraoperative radiotherapy (IORT): evaluation of electrocorticography and peri-operative seizure risk
ConclusionsIORT is an option for delivery of definitive radiation in surgically resected brain tumors without increasing the peri-operative or long-term risk of seizure. ECoG data during the delivery of radiation fail to demonstrate any electrophysiological changes in response to ionizing radiation. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 5, 2023 Category: Cancer & Oncology Source Type: research

Neuropsychological impairment in primary malignant brain tumor patients with awake craniotomy: a hospital-based registration study
ConclusionIn awake craniotomy, patients with left-sided brain tumors had worse cognitive function than those with right-sided tumors in terms of global function, language, and attention. 77% of patients with right-sided tumors had neuropsychological impairment. Therefore, a comprehensive neuropsychological evaluation and awake craniotomy are necessary for patients with brain tumors. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 5, 2023 Category: Cancer & Oncology Source Type: research

Letter to the editor: outcome of glioblastoma patients after intensive care unit admission with invasive mechanical ventilation: a multicenter analysis
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 5, 2023 Category: Cancer & Oncology Source Type: research

Long-term treatment outcomes of temozolomide-based chemoradiation in patients with adult-type diffuse IDH-mutant grade 2 astrocytoma
ConclusionsTMZ-based chemoradiation is associated with survival benefit in patients with grade 2 IDH-mutant astrocytoma. For this group of patients, chemoradiation can be deferred until time of progression in younger patients receiving extensive resection, while early treatment should be recommended in high-risk patients. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 4, 2023 Category: Cancer & Oncology Source Type: research

Management of chordoma and chondrosarcoma with definitive dose-escalated single-fraction spine stereotactic radiosurgery
ConclusionDefinitive dose-escalated SSRS to 24  Gy in 1 fraction appears to be a safe and effective treatment for achieving durable local control in chordoma or chondrosarcoma involving the spine, and may hold particular importance as a low-morbidity alternative to surgery in selected cases. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 4, 2023 Category: Cancer & Oncology Source Type: research

Is it advisable to perform radiosurgery for EGFR-TKI-controlled brain metastases? A retrospective study of the role of radiosurgery in lung cancer treatment
ConclusionsWhile upfront TKI alone proved highly effective in BM control, this study also demonstrated the outcomes of SRS when implemented concurrently with TKI or as salvage therapy for TKI-uncontrolled BMs. This study also presents a strategy of the precise timing and targeting of SRS to lesions in progression. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 1, 2023 Category: Cancer & Oncology Source Type: research

Durable tumor regression and restoration of neurologic function after treatment with anti-PD-1 in patients with functionally unresectable cutaneous squamous cell carcinoma with perineural spread into the cavernous sinus
ConclusionAdministration of anti-PD-1 to patients with CSCC with perineural spread into the cavernous sinus can generate durable anti-tumor regressions and restore CN function, while sparing the morbidity associated with surgical resection and/or radiotherapy. Our findings add to emerging literature supporting this treatment approach for this patient population. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 1, 2023 Category: Cancer & Oncology Source Type: research

Cerebrospinal fluid exosomal protein alterations via proteomic analysis of NSCLC with leptomeningeal carcinomatosis
ConclusionWe investigated the application of label free and PRM based proteomics to detect key proteins related to LC. FN1 may serve as potential indicator to classify LC and NSCLC. Extracellular matrix (ECM) and epithelial-mesenchymal transition (EMT) are important in the process of LC. These data is promising for early prediction and diagnosis of LC. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 1, 2023 Category: Cancer & Oncology Source Type: research