Stereotactic radiosurgery for large vestibular schwannomas: 2.5 cm and beyond
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 17, 2023 Category: Cancer & Oncology Source Type: research
Is reduced-dose whole-brain radiotherapy also feasible in primary CNS lymphoma for curative or salvage purpose?
ConclusionReduced-dose WBRT in curative and salvage treatments for PCNSL had no significant negative effect on the intracranial disease control rate or survival. Therefore, without impaired efficacy, use of reduced-dose WBRT appears promising for reduction of neurotoxicity. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 14, 2023 Category: Cancer & Oncology Source Type: research
The outcome of central nervous system hemangioblastomas in Von Hippel-Lindau (VHL) disease treated with belzutifan: a single-institution retrospective experience
ConclusionBelzutifan appears to be an effective and safe treatment for CNS hemangioblastoma in VHL patients. Further clinical trials to assess the long-term effectiveness of the medication are required. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 13, 2023 Category: Cancer & Oncology Source Type: research
Postoperative stereotactic radiosurgery for intracranial solitary fibrous tumors: systematic review and pooled quantitative analysis
ConclusionsSRS is a safe and effective treatment for intracranial SFTs. In the setting of measurable disease, our pooled data suggests a potential dose response of improving LTC with increasing SRS margin dose. Our improved understanding of the aggressive biology of SFTs and the tolerated adjuvant SRS parameters supports potentially earlier use of SRS in the postoperative treatment paradigm for intracranial SFTs. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 13, 2023 Category: Cancer & Oncology Source Type: research
Safety of microneurosurgical interventions for superficial and deep-seated brain metastases: single-center cohort study of 637 consecutive cases
ConclusionsModern microneurosurgical resection can be considered an excellent option in the management of BM in terms of safety, as the overall rate of major AEs are very rare even in eloquent and deep-seated lesions. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 10, 2023 Category: Cancer & Oncology Source Type: research
Clinical outcomes of stereotactic biopsy on children with pontine diffuse midline glioma
ConclusionIn our series, stereotactic pontine DMG biopsies did not carry any permanent deficit or complication and yielded diagnostic tissue in all patients. Similar post-operative course was observed in both robot-assisted and frameless stereotactic approaches. There was no significant difference in survival based on mutation status or clinical trial enrollment. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 9, 2023 Category: Cancer & Oncology Source Type: research
Incidence, management, and outcome of incidental meningioma: what has happened in 10 years?
ConclusionsDespite the same number of unique patients undergoing brain scans in the time periods, there was a trend towards more patients diagnosed with an incidental asymptomatic meningioma in the more recent years. This difference may be attributed to more contrast enhanced scans and more scans among the elderly but needs to be further studied. Patients in the cohort from 2018 to 2019 more often had non-metastatic cancer, with their cause of scan screening for metastases. There was no significant difference in management decision at diagnosis, but within 3 years of follow up significantly more patients in the latter coho...
Source: Journal of Neuro-Oncology - November 8, 2023 Category: Cancer & Oncology Source Type: research
Correction to: Impact of boost sequence in concurrent chemo-radiotherapy on newly diagnosed IDH-wildtype glioblastoma multiforme
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 8, 2023 Category: Cancer & Oncology Source Type: research
Enhanced sensitivity of electrocorticography during awake craniotomy using a novel circular grid electrode
ConclusionWe demonstrate higher sensitivity in detecting ictal and interictal activity on ECoG during awake craniotomy with a novel circular grid compared to strip electrode, likely due to better spatial sampling during ECoG. We also found association between PFEDs and intraoperative seizures. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 7, 2023 Category: Cancer & Oncology Source Type: research
Correction to: Undetected pseudoprogressions in the CeTeG/NOA-09 trial: hints from postprogression survival and MRI analyses
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 3, 2023 Category: Cancer & Oncology Source Type: research
Qualitative MR features to identify non-enhancing tumors within glioblastoma ’s T2-FLAIR hyperintense lesions
ConclusionThe current investigation demonstrated that qualitative assessments of glioblastoma ’s MRI might help identify nCET in T2/FLAIR high-intensity lesions. The novel nCET score is expected to aid in expanding treatment targets within the T2/FLAIR high-intensity lesions.Graphical abstract (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 2, 2023 Category: Cancer & Oncology Source Type: research
Predictors for delayed awakening in adult glioma patients receiving awake craniotomy under monitored anesthesia care
ConclusionOur retrospective analysis of patients receiving monitored anesthesia care for awake craniotomy revealed that delayed awakening after propofol discontinuation occurred more often in patients with IDH1 wild-type tumors and repeated craniotomies. Also, delayed awakening was associated with somnolence during functional mapping and a lower gross total resection rate. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 2, 2023 Category: Cancer & Oncology Source Type: research
Focused ultrasound for brain metastases: an update on global clinical trials
ConclusionFurther work is required to establish FUS as a standard therapy for BMs. FUS has the potential to transform brain tumor treatment, particularly when combined with immunotherapy and targeted therapy as a non-invasive alternative to surgery and radiation therapy. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - November 1, 2023 Category: Cancer & Oncology Source Type: research
Decreased eukaryotic initiation factors expression upon temozolomide treatment —potential novel implications for eIFs in glioma therapy
ConclusionOur study provides novel insights into chemotherapeutic effects on eIF regulation in gliomas and suggests that eIFs are interesting candidates for future research to improve glioma therapy. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 31, 2023 Category: Cancer & Oncology Source Type: research
Identification of health-related quality of life profiles among long-term survivors of primary central nervous system tumors
ConclusionsIn the poor PCNST LTS HRQOL class, an overwhelming majority faced significant physical challenges, and the good HRQOL class experienced mood-related disturbance but limited physical challenges. These HRQOL profiles can be used to guide survivorship programs and tailored interventions. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 30, 2023 Category: Cancer & Oncology Source Type: research
