Evidence for an intra-tumoral microbiome in pituitary neuroendocrine tumors with different clinical phenotypes
ConclusionIn summary, we provide an evidence for the existence of intra-tumoral bacteria in PitNET. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - May 4, 2023 Category: Cancer & Oncology Source Type: research

Genome-wide profiling of patient-derived glioblastoma stem-like cells reveals recurrent genetic and transcriptomic signatures associated with brain tumors
ConclusionThe availability of a large set of fully molecularly characterized GCSs represents a valuable public resource to support the advancement of precision oncology for the treatment of GBM. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - May 4, 2023 Category: Cancer & Oncology Source Type: research

A novel CDK4/6 inhibitor combined with irradiation demonstrates potent anti-tumor efficacy in diffuse midline glioma
ConclusionCollectively, YF-PRJ8-1011 is a novel, safe, and selective CDK4/6 inhibitor for DMG treatment. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - May 3, 2023 Category: Cancer & Oncology Source Type: research

Breast cancer brain metastases localization and risk of hydrocephalus: a single institution experience
ConclusionBrain metastases in patients with breast cancer occurred more often along midline structures of the brain, which we believe may be associated with the increased estrogen activity in these structures. This finding is important for physicians who treat patients with metastatic breast cancer given the higher possibility of developing obstructive hydrocephalus. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - May 2, 2023 Category: Cancer & Oncology Source Type: research

Treatment of hydrocephalus following posterior fossa tumor resection: a multicenter collaboration from the Hydrocephalus Clinical Research Network
ConclusionsETV and VPS offer similar overall success rates for PFBT-related postoperative hydrocephalus. ETV failure occurs earlier, while susceptibility to VPS failure persists beyond 5  years. Tumor histology and grade may be considered when selecting the optimal means of CSF diversion. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - May 2, 2023 Category: Cancer & Oncology Source Type: research