Pediatric neurosurgical medulloblastoma outcomes in La Paz, Bolivia: How a Lower Middle-Income Country (LMIC) institution in South America compares to the United States
ConclusionsPediatric neurosurgical medulloblastoma outcomes at the Children ’s Hospital of La Paz, Bolivia are significantly inferior to that of a generalized US experience. Future research is required to identify institution- and country-specific initiatives to improve discrepancies between institutions in LMICs in South America compared to HICs. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 2, 2024 Category: Cancer & Oncology Source Type: research
Perioperative psychological distress in patients with intracranial tumors; a single center study
ConclusionDistress levels were high across the entire cohort which indicated a high need for psychological support. Motor deficits and poor post-operative neurological performance were significantly associated with DT values above 6. Distress levels showed little peri-operative variation. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 2, 2024 Category: Cancer & Oncology Source Type: research
Sex differences in adverse events in Medicare individuals ≥ 66 years of age post glioblastoma treatment
ConclusionsSex differences for individuals, 66 years and older, diagnosed with GB exist in treatment received and adverse events developed across different treatment modalities. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 2, 2024 Category: Cancer & Oncology Source Type: research
Elevating the findings by substituting in “ISarcoPRM”
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 2, 2024 Category: Cancer & Oncology Source Type: research
Maximal cardiopulmonary exercise testing in glioblastoma patients undergoing chemotherapy: assessment of feasibility, safety, and physical fitness status
ConclusionMax. CPET in this well-defined population proved feasible and safe. GBM patients exhibit reduced cardiorespiratory fitness, indicating the need for tailored exercise to enhance health and quality of life. CPET could be essential in establishing precise exercise guidelines. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 1, 2024 Category: Cancer & Oncology Source Type: research
Loss of methylthioadenosine phosphorylase immunoreactivity correlates with poor prognosis and elevated uptake of 11C-methionine in IDH-mutant astrocytoma
ConclusionOur study revealed that the loss of MTAP expression correlates with poor prognosis and an elevated T/N ratio of11C-methionine uptake in astrocytoma, IDH-mutant. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 1, 2024 Category: Cancer & Oncology Source Type: research
Machine learning-based pathomics signature of histology slides as a novel prognostic indicator in primary central nervous system lymphoma
ConclusionAs a novel, non-invasive, and convenient approach, the newly developed pathomics signature is a powerful predictor of OS and PFS in PCNSL and might be a potential predictive indicator for therapeutic response. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 1, 2024 Category: Cancer & Oncology Source Type: research
Hypofractionated re-irradiation with bevacizumab for relapsed chemorefractory glioblastoma after prior high dose radiotherapy: a feasible option for patients with large-volume relapse
ConclusionPatients with recurrent glioblastoma who have been previously treated with 60 Gy radiotherapy have a meaningful survival benefit from large volume re-irradiation which is well tolerated. ReRT should not be ignored as a salvage treatment option in patients with chemorefractory progressive disease. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 29, 2024 Category: Cancer & Oncology Source Type: research
A new updated prognostic index for patients with brain metastases (BMs) treated with palliative whole brain radiotherapy (WBRT) in the era of precision oncology. METASNCore project
ConclusionsMETASNCore items are associated with OS and they could be useful to select palliative pts to receive WBRT. More studies are necessary to corroborate our findings. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 27, 2024 Category: Cancer & Oncology Source Type: research
A systematic review of extraneural meningioma metastasis: timing, evolution and outlook
ConclusionMetastatic meningioma appears to be associated with more positive prognosis than other brain tumor types with extra-neural metastasis or metastasis in general. This is particularly true for cases arising from a WHO grade 1 meningioma. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 26, 2024 Category: Cancer & Oncology Source Type: research
Utility of molecular markers in predicting local control specific to lung cancer spine metastases treated with stereotactic body radiotherapy
ConclusionWe report a significant association of PD-L1 ≥ 50% status on improved LC rates from spine SBRT in NSCLC patients. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 25, 2024 Category: Cancer & Oncology Source Type: research
Adjuvant re-irradiation vs. no early re-irradiation of resected recurrent glioblastoma: pooled comparative cohort analysis from two tertiary centers
ConclusionFactors such as MGMT promoter methylation status and treatment interval play crucial roles in determining patient outcomes after second surgery. Personalized treatment strategies should consider these factors to optimize the management of rGBM. Prospective research is needed to define the value of re-RT after second surgery and to inform decision making in this situation. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 23, 2024 Category: Cancer & Oncology Source Type: research
Letter to the editor: Dexamethasone and overall survival and progression free survival in patients with newly diagnosed glioblastoma: a meta-analysis
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 22, 2024 Category: Cancer & Oncology Source Type: research
Correction to: Targeted immunotherapy for glioblastoma involving whole tumor-derived autologous cells in the upfront setting after craniotomy
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 22, 2024 Category: Cancer & Oncology Source Type: research
Palliative care for in-patient malignant glioma patients in Germany
ConclusionDespite the poor prognosis and complex symptomatology associated with malignant gliomas, only a small proportion of affected patients received advanced palliative care. Specifically, only about 10% of hospitalized patients with malignant gliomas, and approximately 40% of those who succumb to the disease in hospital settings, were afforded complex or specialized palliative care. This discrepancy underscores an urgent need to expand palliative care access for this patient demographic. Additionally, it highlights the importance of further research to identify and address the barriers preventing wider implementation ...
Source: Journal of Neuro-Oncology - March 20, 2024 Category: Cancer & Oncology Source Type: research
