Gamma knife radiosurgery for clival metastasis: case series and systematic review
ConclusionClival metastasis is rare and associated with poor prognosis. GKRS is a safe, effective treatment for clival metastasis. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 10, 2024 Category: Cancer & Oncology Source Type: research

Correction to: Focused ultrasound combined with radiotherapy for malignant brain tumor: a preclinical and clinical study
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 10, 2024 Category: Cancer & Oncology Source Type: research

Profile of miRNAs in small extracellular vesicles released from glioblastoma cells treated by boron neutron capture therapy
ConclusionThese miRNA after BNCT may proceed tumors, modulate radiation resistance, or inhibit invasion and affect the prognosis of glioma. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 10, 2024 Category: Cancer & Oncology Source Type: research

Assessment of multimodal treatment options in recurrent and persistent acromegaly: a systematic review and meta-analysis
ConclusionsThe management of persistent and recurrent acromegaly optimally requires a multimodal approach. In different scenarios of refractory acromegaly based on previous treatment, secondary treatments may vary in terms of remission rate and complications. Medical agents provide considerable effectiveness as a second-line therapy for recurrent or persistent disease. In selected cases, however, reoperation still provides an opportunity for cure or freedom from medications. The findings of this study may help clinicians to prioritize varying options involved in this multifaceted decision-making process. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 8, 2024 Category: Cancer & Oncology Source Type: research

Intraoperative magnetic resonance imaging in glioma surgery: a single-center experience
ConclusionIn this study, the convenience provided by the high-field MRI device was explored and proven both in reducing the tumor burden, increasing the PFS, and providing the surgeon with a maximal resection in the first operation. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 3, 2024 Category: Cancer & Oncology Source Type: research

Repurposing mebendazole against triple-negative breast cancer CNS metastasis
ConclusionsWe demonstrated that MBZ is a safe and effective oral agent in an animal model of TNBC CNS metastasis. Our findings are concordant with previous efforts involving MBZ and CNS pathology and support the drug ’s potential utility to slow down leptomeningeal spread. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 2, 2024 Category: Cancer & Oncology Source Type: research

Comparative analysis of the spatial distribution of brain metastases across several primary cancers using machine learning and deep learning models
ConclusionsIn summary, our results support accurate multiclass ML classification regarding brain metastases distribution. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 2, 2024 Category: Cancer & Oncology Source Type: research

Real-world cost- effectiveness analysis: Tumor Treating Fields for newly diagnosed glioblastoma in China
ConclusionsThis cost-effectiveness analysis affirms that incorporating TTFields into TMZ treatment proves to be cost-effective, given a threshold three times the Chinese per capita GDP. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 2, 2024 Category: Cancer & Oncology Source Type: research

Pediatric neurosurgical medulloblastoma outcomes in La Paz, Bolivia: How a Lower Middle-Income Country (LMIC) institution in South America compares to the United States
ConclusionsPediatric neurosurgical medulloblastoma outcomes at the Children ’s Hospital of La Paz, Bolivia are significantly inferior to that of a generalized US experience. Future research is required to identify institution- and country-specific initiatives to improve discrepancies between institutions in LMICs in South America compared to HICs. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 2, 2024 Category: Cancer & Oncology Source Type: research

Perioperative psychological distress in patients with intracranial tumors; a single center study
ConclusionDistress levels were high across the entire cohort which indicated a high need for psychological support. Motor deficits and poor post-operative neurological performance were significantly associated with DT values above 6. Distress levels showed little peri-operative variation. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 2, 2024 Category: Cancer & Oncology Source Type: research

Sex differences in adverse events in Medicare individuals  ≥ 66 years of age post glioblastoma treatment
ConclusionsSex differences for individuals, 66 years and older, diagnosed with GB exist in treatment received and adverse events developed across different treatment modalities. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 2, 2024 Category: Cancer & Oncology Source Type: research

Elevating the findings by substituting in “ISarcoPRM”
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 2, 2024 Category: Cancer & Oncology Source Type: research

Maximal cardiopulmonary exercise testing in glioblastoma patients undergoing chemotherapy: assessment of feasibility, safety, and physical fitness status
ConclusionMax. CPET in this well-defined population proved feasible and safe. GBM patients exhibit reduced cardiorespiratory fitness, indicating the need for tailored exercise to enhance health and quality of life. CPET could be essential in establishing precise exercise guidelines. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 1, 2024 Category: Cancer & Oncology Source Type: research

Loss of methylthioadenosine phosphorylase immunoreactivity correlates with poor prognosis and elevated uptake of 11C-methionine in IDH-mutant astrocytoma
ConclusionOur study revealed that the loss of MTAP expression correlates with poor prognosis and an elevated T/N ratio of11C-methionine uptake in astrocytoma, IDH-mutant. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 1, 2024 Category: Cancer & Oncology Source Type: research

Machine learning-based pathomics signature of histology slides as a novel prognostic indicator in primary central nervous system lymphoma
ConclusionAs a novel, non-invasive, and convenient approach, the newly developed pathomics signature is a powerful predictor of OS and PFS in PCNSL and might be a potential predictive indicator for therapeutic response. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 1, 2024 Category: Cancer & Oncology Source Type: research