Incidence and imaging characteristics of difficult to detect retrospectively identified brain metastases in patients receiving repeat courses of stereotactic radiosurgery
ConclusionRadiographic evidence of brain metastases requiring future treatment was occasionally present on brain MRIs from prior SRS treatments. Most RIMs were + DC, and some subsequent SRS courses treated only + DC RIMs. These findings suggest enhanced BM detection might enable earlier treatment and reduce the need for additional SRS. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 10, 2024 Category: Cancer & Oncology Source Type: research
The importance of considering competing risks in recurrence analysis of intracranial meningioma
ConclusionThe importance of considering competing events in recurrence risk analysis is poorly recognized as only 6% of the studies we surveyed employed Aalen-Johansen analyses. Consequently, most of the previous literature has overestimated the risk of recurrence. The overestimation was negligible for studies involving low-grade lesions in younger individuals; however, overestimation might have been substantial for studies on high-grade lesions. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 10, 2024 Category: Cancer & Oncology Source Type: research
Repeat surgery of recurrent glioma for molecularly informed treatment in the age of precision oncology: A risk –benefit analysis
ConclusionSurgery for recurrent glioma provides relevant molecular diagnostic information with a direct consequence for targeted therapy under a reasonable risk of postoperative complications. With satisfactory postoperative survival it can therefore complement a multi-modal glioma therapy approach. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 9, 2024 Category: Cancer & Oncology Source Type: research
Treatment outcome of IDH1/2 wildtype CNS WHO grade 4 glioma histologically diagnosed as WHO grade II or III astrocytomas
ConclusionsWHO grade 2 and 3 IDH1/2 wt astrocytomas, treated according to the same treatment protocols, have a similar OS. Age, extent of resection, and strong EGFR expression were the most important treatment related prognostic factors. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 7, 2024 Category: Cancer & Oncology Source Type: research
Converging survival trends in non-small cell lung cancer patients with and without brain metastasis receiving state-of-the-art treatment
ConclusionThe results imply that the presence of BM has no impact on the prognosis of NSCLC. The practice of excluding NSCLC patients with BM from clinical trials warrants reconsideration. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 7, 2024 Category: Cancer & Oncology Source Type: research
A systematic review of the impact of brain tumours on risk of motor vehicle crashes
ConclusionLimited data exists regarding driving behaviour and MVC incidence in brain tumour patients. Existing guidelines inadequately address neurocognitive complexities in this group. Future studies evaluating real-world data is required to inform development of more applicable driving guidelines.Systematic review registration numberPROSPERO 2023 CRD42023434608. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 6, 2024 Category: Cancer & Oncology Source Type: research
Whole-exome sequencing reveals genetic variants that may play a role in neurocytomas
AbstractObjectivesNeurocytomas (NCs) are rare intracranial tumors that can often be surgically resected. However, disease course is unpredictable in many patients and medical therapies are lacking. We have used whole exome sequencing to explore the molecular etiology for neurocytoma and assist in target identification to develop novel therapeutic interventions.MethodsWe used whole exome sequencing (WES) to compare the molecular landscape of 21 primary& recurrent NCs to five normal cerebellar control samples. WES data was analyzed using the Qiagen Clinical Insight program, variants of interest (VOI) were interrogated us...
Source: Journal of Neuro-Oncology - February 6, 2024 Category: Cancer & Oncology Source Type: research
Adverse radiation effect versus tumor progression following stereotactic radiosurgery for brain metastases: Implications of radiologic uncertainty
ConclusionsRU resolution took > 6 months in > 25% of cases. RU may lead to suboptimal outcomes and symptom burden. Improved characterization of post-SRS RU is needed. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 5, 2024 Category: Cancer & Oncology Source Type: research
Clinical outcomes of melanoma brain metastases treated with nivolumab and ipilimumab alone versus nivolumab and ipilimumab with stereotactic radiosurgery
ConclusionIn our analysis, patients who received SRS with nivolumab and ipilimumab had superior LC without increased risk of toxicity or compromised immunotherapy treatment completion despite the SRS cohort having higher rates of prior immunotherapy. Further prospective study of combination nivolumab and ipilimumab with SRS is warranted. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 3, 2024 Category: Cancer & Oncology Source Type: research
Utility of contrast-enhanced MRI radiomics features combined with clinical indicators for predicting induction chemotherapy response in primary central nervous system lymphoma
ConclusionsOur prediction model, which combines radiomics signatures from CE-MRI with serum IL-2R, can effectively stratify patients with PCNSL before high-dose methotrexate (HD-MTX) -based chemotherapy. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 3, 2024 Category: Cancer & Oncology Source Type: research
The relationship between pathological brain activity and functional network connectivity in glioma patients
ConclusionOur results indicate that pathological activity and connectivity co-localize in a complex manner in glioma. This insight is relevant to our understanding of disease progression and cognitive symptomatology. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 3, 2024 Category: Cancer & Oncology Source Type: research
Evaluating contouring accuracy and dosimetry impact of current MRI-guided adaptive radiation therapy for brain metastases: a retrospective study
ConclusionsThe accuracy of online target contouring was unsatisfactory for the current MRI-guided online adaptive FSRT. Small lesions had poor visibility on 1.5 T non-contrast-enhanced MR-Linac images. Contour inaccuracies caused a one-third drop in prescription dose coverage for the target volume. Future studies should explore the feasibility of contrast agent administration during daily treatment in MRI-guided online adaptive FSRT procedures. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 1, 2024 Category: Cancer & Oncology Source Type: research
Two is better than one: longitudinal detection and volumetric evaluation of brain metastases after Stereotactic Radiosurgery with a deep learning pipeline
ConclusionAutomated detection and volumetric quantification of brain metastases following SRS have the potential to enhance the assessment of treatment response and alleviate the clinician workload. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - February 1, 2024 Category: Cancer & Oncology Source Type: research
An exploratory prospective phase II study of preoperative neoadjuvant bevacizumab and temozolomide for newly diagnosed glioblastoma
ConclusionPreoperative Bev and TMZ is safe as long as the instructions are followed. The strategy might be useful for GB in some patients, not only reducing tumor burden, but also improving patient KPS preoperatively.Trial Registration Number: UMIN000025579, jRCT1031180233https://jrct.niph.go.jp/latest-detail/jRCT1031180233. Registration Date: Jan. 16, 2017 (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - January 31, 2024 Category: Cancer & Oncology Source Type: research
Intrathecal chemotherapy for leptomeningeal disease in high-grade gliomas: a systematic review
ConclusionLMD continues to be an uncommon complication associated with HGG with a poor prognosis. This article provides an overview of the presently available literature on IT chemotherapy for LMD secondary to HGG, and their respective treatment protocols with overall survival attributes. Additional research is warranted to ascertain how to maximize the potential efficacy of IT chemotherapy as a treatment option. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - January 31, 2024 Category: Cancer & Oncology Source Type: research
