Residual diffusion-weighted imaging hyperintense signal in primary central nervous system lymphoma can predict early recurrence
ConclusionA residual DWI hyperintense signal at the end of treatment was statistically associated with shorter PFS. Among patients who achieved CR/CRu evaluated based on postcontrast T1WI, DWI could be a valuable additional sequence to predict the early recurrence of PCNSL. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 13, 2023 Category: Cancer & Oncology Source Type: research
Targeting TNFAIP2 induces immunogenic cell death and sensitizes glioblastoma multiforme to anti-PD-1 therapy
ConclusionsTNFAIP2 knockdown induces ICD by downregulating TNFAIP2 in GBM. In addition, TNFAIP2 knockdown sensitized glioma to anti-PD-1 therapy. Hence, targeting TNFAIP2 alone or in combination with anti-PD-1 therapy may be a potential strategy for GBM treatment through ICD. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 11, 2023 Category: Cancer & Oncology Source Type: research
Pachymeningeal disease: a systematic review and metanalysis
ConclusionWhile PMD has a superior prognosis to LMD, it is nevertheless a critical oncologic event associated with significant mortality and remains poorly recognized. PMD is predominantly observed in patients with controlled systemic disease status and infratentorial location. Future treatment strategies should focus on reducing surgical seeding and sterilizing surgical cavities. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 10, 2023 Category: Cancer & Oncology Source Type: research
Intraoperative or postoperative stereotactic radiotherapy for brain metastases: time to systemic treatment onset and other patient-relevant outcomes
ConclusionIORT for BMs results in faster completion of interdisciplinary treatment when compared to adjuvant SRT, without increasing corticosteroid intake or prolonging in-hospital times. A randomised phase III trial will determine the clinical effects of shorter TTNT. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 9, 2023 Category: Cancer & Oncology Source Type: research
Letter to the editor: the impact of systemic treatment on brain metastases should be considered in clinical outcome analysis
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 9, 2023 Category: Cancer & Oncology Source Type: research
Sexually dimorphic effect of H-ferritin genetic manipulation on survival and tumor microenvironment in a mouse model of glioblastoma
ConclusionGenetic manipulation ofFth1 which leads to reduced systemic levels of FTH1 protein had a sexually dimorphic impact on survival.Fth1 heterozygosity significantly worsened survival in females but did not affect survival in male GBMs. Furthermore, the genetic manipulation ofFth1 significantly affected tumor infiltration of T-cells, CD8 + T cells, fibroblasts, and mast cells in a sexually dimorphic manner. These results demonstrate a role for FTH1 and presumably iron status in establishing the tumor cellular landscape that ultimately impacts survival and further reveals a sex bias that may inform the population ...
Source: Journal of Neuro-Oncology - October 9, 2023 Category: Cancer & Oncology Source Type: research
Patterns and predictors of anxiety and depression symptom trajectories in patients diagnosed with primary brain tumors
ConclusionspPBTs commonly experience elevated symptoms of anxiety and depression that may fluctuate in clinically meaningful manners throughout the disease. Routine screening for elevated symptoms is needed to capture clinically meaningful changes and identify factors affecting symptoms to intervene on. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 7, 2023 Category: Cancer & Oncology Source Type: research
The impact of changes in gadolinium-enhancement on disease progression in children with neurofibromatosis type 1-associated optic pathway glioma: a retrospective analysis
ConclusionIncreased gadolinium-enhancement independent of a concurrent increase in tumor size on MRI should not be used as a marker of NF1-OPG progression and does not appear to be associated with visual decline or initiation of chemotherapy. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 7, 2023 Category: Cancer & Oncology Source Type: research
Risk of developing glioblastoma following non-CNS primary cancer: a SEER analysis between 2000 and 2018
ConclusionPatients with a history of prior non-CNS malignancy are at an overall increased risk of developing SPGBM relative to the incidence of developing GBM in the general population. However, the incidence of SPGBM after prior non-CNS malignancy varies by primary tumor location, with some non-CNS malignancies demonstrating either increased or decreased predisposition for SPGBM depending on tumor origin. These findings merit future investigation into whether these relationships represent treatment effects or a previously unknown shared predisposition for glioblastoma and non-CNS malignancy. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 4, 2023 Category: Cancer & Oncology Source Type: research
Class I HDAC inhibition reduces DNA damage repair capacity of MYC-amplified medulloblastoma cells
ConclusionOur study identifies the combination of entinostat with olaparib as a new potential therapeutic approach forMYC-driven Group 3 MB. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 3, 2023 Category: Cancer & Oncology Source Type: research
RAI-measured frailty predicts non-home discharge following metastatic brain tumor resection: national inpatient sample analysis of 20,185 patients
ConclusionIncreasing RAI-measured frailty status is significantly associated with increased complication rates, eLOS, NHD, and mortality following MBTR. Preoperative frailty assessment using the RAI may aid in preoperative surgical planning and risk stratification for patient selection. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 3, 2023 Category: Cancer & Oncology Source Type: research
The proneural subtype is not associated with survival benefit from bevacizumab in newly diagnosed glioblastoma: a secondary analysis of the GLARIUS trial
ConclusionIn contrast to AVAglio, glioblastoma gene expression subgroups were not associated with a differential OS benefit from first-line bevacizumab in the GLARIUS trial. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 3, 2023 Category: Cancer & Oncology Source Type: research
Supramaximal resection based on en-bloc technique reduces tumor burden and prolongs survival in primary supratentorial lobar glioblastoma
ConclusionsApplying en-bloc technique and achieving SMR, which could reduce tumor burden and did not increase additional complications, both had remarkedly positive effects on clinical outcomes in patients with primary supratentorial lobar glioblastomas. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 2, 2023 Category: Cancer & Oncology Source Type: research
Age and sex disparities in Latin-American adults with gliomas: a systematic review and meta-analysis
ConclusionOur study found mean ages of glioma and glioblastoma were 6 and 10 years lower than those reported in the CBTRUS. Our study suggests disparities in the age and sex distribution of gliomas in Latin America compared to other regions.PROSPERO registration numberCRD42021274423. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 29, 2023 Category: Cancer & Oncology Source Type: research
Treatment outcomes for response-based radiotherapy in children and adolescents with central nervous system germinoma: a prospective study
ConclusionGood prognosis was still achieved after reducing dose and extent of radiation for the patients who achieved complete response (CR) after induction chemotherapy or pathological CR after second-look surgery. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 28, 2023 Category: Cancer & Oncology Source Type: research
