Risk of developing glioblastoma following non-CNS primary cancer: a SEER analysis between 2000 and 2018

ConclusionPatients with a history of prior non-CNS malignancy are at an overall increased risk of developing SPGBM relative to the incidence of developing GBM in the general population. However, the incidence of SPGBM after prior non-CNS malignancy varies by primary tumor location, with some non-CNS malignancies demonstrating either increased or decreased predisposition for SPGBM depending on tumor origin. These findings merit future investigation into whether these relationships represent treatment effects or a previously unknown shared predisposition for glioblastoma and non-CNS malignancy.
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research