Sexually dimorphic effect of H-ferritin genetic manipulation on survival and tumor microenvironment in a mouse model of glioblastoma

ConclusionGenetic manipulation ofFth1 which leads to reduced systemic levels of FTH1 protein had a sexually dimorphic impact on survival.Fth1 heterozygosity significantly worsened survival in females but did not affect survival in male GBMs. Furthermore, the genetic manipulation ofFth1 significantly affected tumor infiltration of T-cells, CD8  + T cells, fibroblasts, and mast cells in a sexually dimorphic manner. These results demonstrate a role for FTH1 and presumably iron status in establishing the tumor cellular landscape that ultimately impacts survival and further reveals a sex bias that may inform the population studies showing a sex effect on the prevalence of brain tumors.
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research