Treatment outcomes of single-fraction stereotactic radiosurgery for adenoid cystic carcinoma: a case series of 55 patients
ConclusionSRS provided a high rate of local tumor control, but marginal failure was frequent. Integrating SRS with added EBRT exhibits potential for enhancing local and local/marginal tumor control, particularly in recurrent cases. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - January 5, 2024 Category: Cancer & Oncology Source Type: research

Bevacizumab and gamma knife radiosurgery for first-recurrence glioblastoma
ConclusionThis study demonstrates that the combined use of bevacizumab with concurrent stereotactic radiosurgery can have improve survival in patients with rGBM. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - January 4, 2024 Category: Cancer & Oncology Source Type: research

The utility of arterial spin labeling imaging for predicting prognosis after a recurrence of high-grade glioma in patients under bevacizumab treatment
ConclusionThe ASL-derived rCBF values of recurrent lesions may serve as an effective imaging biomarker for prognosis in HGG patients undergoing BVZ therapy. Low rCBF values may indicate that BVZ efficacy is sustainable, which will influence BVZ treatment strategies in HGG patients. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - January 2, 2024 Category: Cancer & Oncology Source Type: research

Comparative evaluation of 11C-methionine and 18F-fluorodeoxyglucose positron emission tomography for distinguishing between primary central nervous system lymphoma and isocitrate dehydrogenase-wildtype glioblastoma
ConclusionMET PET could detect both PCNSL and IDH-wildtype glioblastoma, but unlike FDG PET, it could not distinguish between these two major malignant brain tumors. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - December 31, 2023 Category: Cancer & Oncology Source Type: research

Rapid detection of mutations in CSF-cfTNA with the Genexus Integrated Sequencer
ConclusionIn summary, our results indicate that CSF-cfTNA analysis with the Genexus-OPA can provide clinically relevant information in patients with brain metastases with short TAT. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - December 30, 2023 Category: Cancer & Oncology Source Type: research

A combined analysis of two prospective randomised studies exploring the impact of extended post-radiation temozolomide on survival outcomes in newly diagnosed glioblastoma
ConclusionFor glioblastoma patients, extending post-radiation temozolomide from 6 to 12  months is well tolerated but does not improve 6mPFS. We could not identify any subset that benefitted from extended treatment. Six months should remain standard-of-care. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - December 28, 2023 Category: Cancer & Oncology Source Type: research

Long-term outcomes of stereotactic radiosurgery for intracranial schwannoma in neurofibromatosis type 2: a genetic analysis perspective
ConclusionSRS achieved excellent PFR for NF2-associated intracranial schwannomas in the mild (group 2A) and moderate (group 2B) groups. SRS necessitates careful consideration for the severe group (group 3), especially in cases with NF2 truncating mutation exons 2 –13. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - December 27, 2023 Category: Cancer & Oncology Source Type: research

Dexamethasone and overall survival and progression free survival in patients with newly diagnosed glioblastoma: a meta-analysis
ConclusionDexamethasone appeared to be associated with poor survival outcomes of glioblastoma patients. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - December 27, 2023 Category: Cancer & Oncology Source Type: research

Exploring MGMT methylation-driven structural connectivity changes in insular gliomas: a tractography and graph theoretical analysis
ConclusionOur findings highlight a significant, hemisphere-specific correlation between MGMT promoter methylation and structural connectivity in insular gliomas. This study provides new insights into the genetic influence on glioma pathology, which could inform targeted therapeutic strategies. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - December 27, 2023 Category: Cancer & Oncology Source Type: research

Treatment evaluation by volumetric segmentation in pediatric optic pathway glioma: evaluation of the effect of bevacizumab on intra-tumor components
ConclusionTreatment with BVZ of progressive pediatric OPGs leads to a decrease of both total tumor volume and cystic volume for the majority of OPGs with emphasis on the first three months. NF1 and KIAA1549-BRAF fusion related OPGs showed a different (early) treatment effect regarding the tumor enhancing component on MRI, which did not correlate with tumor volume changes. Future research is necessary to further evaluate these findings and its relevance to clinical outcome parameters. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - December 27, 2023 Category: Cancer & Oncology Source Type: research

The development of a combined clinico-radiomics model for predicting post-operative recurrence in atypical meningiomas: a multicenter study
ConclusionsThe present study established a radiomics signature and a clinico-radiomics model with a favorable performance in predicting tumor recurrence for atypical meningiomas. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - December 26, 2023 Category: Cancer & Oncology Source Type: research

Automated identification and quantification of metastatic brain tumors and perilesional edema based on a deep learning neural network
ConclusionThis paper introduces a deep learning model for the automated segmentation and quantification of brain metastatic tumors and perilesional edema trained using only T1cWI and T2WI. This technique could facilitate further research on metastatic tumors and perilesional edema as well as other intracranial lesions. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - December 22, 2023 Category: Cancer & Oncology Source Type: research

Oncogene-induced senescence in meningiomas —an immunohistochemical study
ConclusionOur findings suggest the senescence activation in meningiomas grade 2 as a potential mechanism for the restraining of tumour growth and give hope for applying of promising senolytic therapy. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - December 20, 2023 Category: Cancer & Oncology Source Type: research

MGMT promoter methylation in 1p19q-intact gliomas
ConclusionsThis ancillary analysis supports conclusions from the CATNON trial for adjuvant TMZ as standard-of-care for anaplastic astrocytomas (IDH-mutant and 1p19q-intact), irrespective ofMGMT status. Determining the optimal strategy for diffuse gliomas that are IDH-wildtype will be particularly important.MGMT promoter methylation should be considered as a stratification factor in future clinical trials for these patients. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - December 20, 2023 Category: Cancer & Oncology Source Type: research

Clinical course of ventriculoperitoneal shunting for hydrocephalus following glioblastoma surgery: a systematic review and meta-analysis
ConclusionsOf the limited proportion of glioblastoma patients requiring VPS surgery for hydrocephalus after index surgery, 78% patients are expected to show symptom improvement, and 24% can expect to undergo revision surgery. An individualized approach to each patient is required to optimize both index glioblastoma and VPS surgeries to account for anatomy and goals of care given the poor prognosis of this tumor overall. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - December 19, 2023 Category: Cancer & Oncology Source Type: research