A novel prognostic model based on pretreatment serum albumin and ECOG PS for primary CNS lymphoma: an international, multi-center study
ConclusionsThe novel two-factor prognostic model based on albumin and ECOG  PS we propose represents a simple but significant prognostic tool for assessing newly diagnosed patients with PCNSL. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - May 26, 2023 Category: Cancer & Oncology Source Type: research

Low expression of Ki-67/MIB-1 labeling index in IDH wild type glioblastoma predicts prolonged survival independently by MGMT methylation status
ConclusionsAmong other studies focused on Ki-67/MIB-1-LI, this is the first observational study showing a positive correlation between OS of IDHwt GBM patients and Ki-67/MIB-1-LI that we propose as a new predictive marker in this subtype of GBM. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - May 25, 2023 Category: Cancer & Oncology Source Type: research

Outcomes of systemic bevacizumab in radiation-induced optic neuropathy, case series
ConclusionSystemic bevacizumab may stabilize vision in some patients with RION, though the limitations of our study do not allow us to draw this conclusion definitively. Therefore, the risks and potential benefits of using IV bevacizumab should be considered in each individual case. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - May 25, 2023 Category: Cancer & Oncology Source Type: research

Letter to the editor: neurocognitive functioning after Gamma Knife and LINAC stereotactic radiosurgery in patients with brain metastases
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - May 25, 2023 Category: Cancer & Oncology Source Type: research

Contemporary care for brain metastasis patients: multidisciplinary approaches and the role of prospective national registries
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - May 25, 2023 Category: Cancer & Oncology Source Type: research

Clinical outcomes and safety of large or giant vestibular schwannoma in older patients undergoing microsurgery: a matched cohort study
ConclusionsFor older patients ( ≥ 60 years) with symptomatic, large or giant -VSs, microsurgery is the only effective method to prolong lifespan, alleviate clinical symptoms and cure the tumor. However, radical resection of VSs may result in a decreased preservation rate of facial-acoustic nerve function and an increased posto perative complication incidence. Therefore, subtotal resection followed by stereotactic radiotherapy should be recommended. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - May 24, 2023 Category: Cancer & Oncology Source Type: research

Journal of Neuro Oncology: Diagnostic and therapeutic implications of IDH mutations in gliomas following the 2021 World Health Organization classification of CNS tumors
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - May 22, 2023 Category: Cancer & Oncology Source Type: research

Publisher ’s Note
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - May 22, 2023 Category: Cancer & Oncology Source Type: research

Palliative care referral across the disease trajectory in high-grade glioma
ConclusionA minority of HGG patients ever received PCC, which primarily occurred in the inpatient setting, and nearly half during the end-of-life phase. Thus, only about one in ten patients in the entire cohort potentially received the benefits of earlier PCC despite earlier referral having an association with longer survival. Further studies should elucidate barriers and facilitators to early PCC in HGG. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - May 20, 2023 Category: Cancer & Oncology Source Type: research

Large language model artificial intelligence: the current state and future of ChatGPT in neuro-oncology publishing
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - May 20, 2023 Category: Cancer & Oncology Source Type: research

Caspase-3 in glioma indicates an unfavorable prognosis by involving surrounding angiogenesis and tumor cell repopulation
ConclusionThis study innovatively identified an unfavorable prognostic role of caspase-3 in glioma. The pro-angiogenic and repopulation-prompting effects of caspase-3/COX-2 signaling may explain its unfavorable prognostic role and offer novel insights into therapy sensitization and curative effect prediction of glioma. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - May 17, 2023 Category: Cancer & Oncology Source Type: research

Postoperative course of cerebrospinal fluid diversion in the setting of leptomeningeal disease: a systematic review, meta-analysis, and meta-regression with an illustrative case
ConclusionAlthough CSF diversion in the setting of LMD can improve hydrocephalus symptoms in the majority of patients, there is a non-negligible proportion that will require shunt revision. Postoperatively, the prognosis of LMD remains poor irrespective of shunt type, and despite possible biases within the current literature, the expected median overall survival after index surgery is a matter of months. These findings support CSF diversion as an effective palliative procedure when considering symptoms and quality of life. Further research is required to understand how postoperative expectations can be managed to respect t...
Source: Journal of Neuro-Oncology - May 16, 2023 Category: Cancer & Oncology Source Type: research

Class I HDAC inhibitor entinostat synergizes with PLK1 inhibitors in MYC-amplified medulloblastoma cells
ConclusionThe combination of entinostat and PLK1i showed synergistic interaction in vitro, but not in vivo. Therefore, further screening of blood –brain barrier penetrating PLK1i is warranted to determine the true potential of the combination as no on-target activity was observed after PLK1i volasertib treatment in vivo. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - May 15, 2023 Category: Cancer & Oncology Source Type: research

Volumetric response and pattern of failure of histone altered high grade glioma in adults following management with radiation therapy
ConclusionH3K27M-mutant gliomas are highly responsive to radiotherapy but exhibit high propensity for subsequent leptomeningeal and subependymal spread. H3G34R-mutant tumours exhibit lesser early volumetric response to radiotherapy and propensity for distant in-brain failure. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - May 15, 2023 Category: Cancer & Oncology Source Type: research

Sonodynamic therapy and magnetic resonance-guided focused ultrasound: new therapeutic strategy in glioblastoma
AbstractGlioblastoma (GB) is one of the most aggressive and difficult-to-treat brain tumors, with a poor prognosis and limited treatment options. In recent years, sonodynamic therapy (SDT) and magnetic resonance focused ultrasound (MRgFUS) have emerged as promising approaches for the treatment of GB. SDT uses ultrasound waves in combination with a sonosensitizer to selectively damage cancer cells, while MRgFUS delivers high-intensity ultrasound waves to precisely target tumor tissue and disrupt the blood –brain barrier to enhance drug delivery. In this review, we explore the potential of SDT as a novel therapeutic strate...
Source: Journal of Neuro-Oncology - May 14, 2023 Category: Cancer & Oncology Source Type: research