Cancers, Vol. 16, Pages 1660: Temporal Muscle Thickness Compared to Functional Scales as a Prognostic Parameter in Patients with Brain Metastases
ian F. Freyschlag
Metastases are the most frequent intracranial malignant tumors in adults. While Karnofsky Performance Status (KPS) and Clinical Frailty Scale (CFS) are known to have significant impact on overall survival (OS), temporal muscle thickness (TMT) has been postulated to be a promising new parameter to estimate prognosis. Patients who received a resection of one to three brain metastases in our institution were included. Temporal muscle thickness was measured in preoperative MRI scans according to a standardized protocol. In 199 patients, the mean TMT was 7.5 mm (95CI 7.3–7.7) and the mean OS ...
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: Julia Klingenschmid Aleksandrs Krigers Daniel Pinggera Johannes Kerschbaumer Nadine Pichler Victoria Sch ön Matthias Demetz Astrid E. Grams Claudius Thom é Christian F. Freyschlag Tags: Article Source Type: research
Survival outcomes after using charged particle radiotherapy as a treatment modality for gliomas: A systematic review and meta-analysis
Charged particle therapy is an emerging radiation treatment for a number of tumors; however, more research is needed to determine its safety and efficacy when treating intra-axial brain tumors (commonly known as gliomas). The overall survival of patients treated with charged particle radiation versus those receiving photon therapy were compared in this systematic review and meta-analysis. (Source: Journal of Medical Imaging and Radiation Sciences)
Source: Journal of Medical Imaging and Radiation Sciences - April 25, 2024 Category: Radiology Authors: Bareq S. Al-Lami, Baqer S. Al-Lami, Yasir S. Al-Lami Tags: Review Article Source Type: research
Randomized self-controlled study comparing open-face vs. closed immobilization masks in fractionated cranial radiotherapy
Radiotherapy is an essential part in the management of primary and metastatic brain tumors. To ensure safe and reproducible delivery of radiotherapy, accurate patient positioning and immobilization is required. The standard-of-care immobilization for fractionated brain irradiation, as for head-and-neck cancer, is an individually made thermoplastic mask which is closed around the patient ’s face. Closed masks provide stability, accuracy and reproducibility of each treatment fraction [1,2,3]. The inter- and intrafraction accuracy described by setup and head motion uncertainties for intracranial radiotherapy are reportedly ...
Source: Radiotherapy and Oncology - April 25, 2024 Category: Radiology Authors: Mich èle Keane, Nienke Weitkamp, Indira Madani, Jonathan Day, Riccardo Dal Bello, Mariangela Zamburlini, Antonia Schiess, Amanda Moreira, Sophie Perryck, Katja Tomuschat, Marilyn Spencer, Stephanie Tanadini-Lang, Matthias Guckenberger, Michelle Brown Tags: Original Article Source Type: research
Correction to: A bis-boron boramino acid PET tracer for brain tumor diagnosis
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 24, 2024 Category: Nuclear Medicine Source Type: research
Inhibition of autophagy antagonizes breast cancer brain metastogenesis and augments the anticancer activity of lapatinib
Clin Transl Med. 2024 Apr;14(4):e1662. doi: 10.1002/ctm2.1662.NO ABSTRACTPMID:38658768 | DOI:10.1002/ctm2.1662 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 24, 2024 Category: Cancer & Oncology Authors: Steffan T Nawrocki Claudia M Espitia Maria Janina Carrera Espinoza Trace M Jones Madison E Gamble Sruthi Sureshkumar Mengyang Chang Wei Wang Jennifer S Carew Source Type: research
Inhibition of autophagy antagonizes breast cancer brain metastogenesis and augments the anticancer activity of lapatinib
Clin Transl Med. 2024 Apr;14(4):e1662. doi: 10.1002/ctm2.1662.NO ABSTRACTPMID:38658768 | DOI:10.1002/ctm2.1662 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 24, 2024 Category: Cancer & Oncology Authors: Steffan T Nawrocki Claudia M Espitia Maria Janina Carrera Espinoza Trace M Jones Madison E Gamble Sruthi Sureshkumar Mengyang Chang Wei Wang Jennifer S Carew Source Type: research
GMAlignNet: multi-scale lightweight brain tumor image segmentation with enhanced semantic information consistency
Phys Med Biol. 2024 Apr 24. doi: 10.1088/1361-6560/ad4301. Online ahead of print.ABSTRACTAlthough the U-shaped architecture, represented by UNet, has become a major network model for brain tumor segmentation, the repeated convolution and sampling operations can easily lead to the loss of crucial information. Additionally, directly fusing features from different levels without distinction can easily result in feature misalignment, affecting segmentation accuracy. On the other hand, traditional convolutional blocks used for feature extraction cannot capture the abundant multi-scale information present in brain tumor images. ...
Source: Physics in Medicine and Biology - April 24, 2024 Category: Physics Authors: Jianli Song Xiaoqi Lu Yu Gu Source Type: research
Profiles, diagnostic process, and patterns of care of patients with stage III non-small cell lung cancer: A French national study
CONCLUSIONS: Diagnostic procedures and treatment modalities in French medical centers generally align with clinical guidelines for stage III NSCLC, except for invasive staging that was less commonly performed than expected.PMID:38657298 | DOI:10.1016/j.resmer.2024.101087 (Source: Respiratory Care)
Source: Respiratory Care - April 24, 2024 Category: Respiratory Medicine Authors: Jean-Bernard Auliac Laurent Greillier Etienne Martin Pierre-Emmanuel Falcoz Pierre Boisselier Sabine Ano Marc Lefran çois Alexis Cortot Source Type: research
Inhibition of autophagy antagonizes breast cancer brain metastogenesis and augments the anticancer activity of lapatinib
Clin Transl Med. 2024 Apr;14(4):e1662. doi: 10.1002/ctm2.1662.NO ABSTRACTPMID:38658768 | DOI:10.1002/ctm2.1662 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 24, 2024 Category: Cancer & Oncology Authors: Steffan T Nawrocki Claudia M Espitia Maria Janina Carrera Espinoza Trace M Jones Madison E Gamble Sruthi Sureshkumar Mengyang Chang Wei Wang Jennifer S Carew Source Type: research
Profiles, diagnostic process, and patterns of care of patients with stage III non-small cell lung cancer: A French national study
CONCLUSIONS: Diagnostic procedures and treatment modalities in French medical centers generally align with clinical guidelines for stage III NSCLC, except for invasive staging that was less commonly performed than expected.PMID:38657298 | DOI:10.1016/j.resmer.2024.101087 (Source: Cell Research)
Source: Cell Research - April 24, 2024 Category: Cytology Authors: Jean-Bernard Auliac Laurent Greillier Etienne Martin Pierre-Emmanuel Falcoz Pierre Boisselier Sabine Ano Marc Lefran çois Alexis Cortot Source Type: research
GSE249459 Cancer-stromal cell interactions in breast cancer brain metastases induce glycocalyx-mediated resistance to HER2-targeting therapies [ATAC-seq]
Contributors : Kornelia Polyak ; Marie-Anne Goyette ; Laura StevensSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensIn a 3D coculture with stroma cells derived from breast cancer patients ’ brain metastasis, HER2+ breast cancer cells were protected from HER2-targeted therapies, particularly the EGFR/HER2 small molecule inhibitor neratinib. To get insight into how this protection arises, ATAC-seq on coculture cells with or without neratinib as performed. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
GSE249573 Cancer-stromal cell interactions in breast cancer brain metastases induce glycocalyx-mediated resistance to HER2-targeting therapies [RNA-seq]
Contributors : Kornelia Polyak ; Marie-Anne Goyette ; Laura StevensSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn a 3D coculture with stroma cells derived from breast cancer patients ’ brain metastasis, HER2+ breast cancer cells were protected from HER2-targeted therapies, particularly the EGFR/HER2 small molecule inhibitor neratinib. To get insight into how this protection arises, a Synthetic Notch (SynNotch) reporter model allowed to study the effect of direct contact betwee n stroma and cancer cells. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE249574 Cancer-stromal cell interactions in breast cancer brain metastases induce glycocalyx-mediated resistance to HER2-targeting therapies
Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE237390 Loss of Kmt2c or Kmt2d drives brain metastasis via KDM6A-dependent upregulation of MMP3 [ChIP-seq]
Contributors : Marco Seehawer ; Li Zheqi ; Jun Nishida ; Pierre Foidart ; Andrew Reiter ; Ernesto Rojas ; Marie-Anne Goyette ; Paloma Cejas ; Seth Goldman ; Karen Adelman ; Henry Long ; Malvina Papanastasiou ; Kornelia PolyakSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusHistone lysine methyltransferases KMT2C and KMT2D are among the most commonly mutated genes in the highly metastatic TNBC subtype of breast cancer. However, it is not known if mutations of either of these genes similarly effect epigenomic and transcriptomic landscape or if a specific downst...
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research
GSE237287 Loss of Kmt2c or Kmt2d drives brain metastasis via KDM6A-dependent upregulation of MMP3 [RNA-seq]
Contributors : Marco Seehawer ; Li Zheqi ; Jun Nishida ; Pierre Foidart ; Andrew Reiter ; Ernesto Rojas ; Marie-Anne Goyette ; Paloma Cejas ; Seth Goldman ; Karen Adelman ; Henry Long ; Malvina Papanastasiou ; Kornelia PolyakSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHistone lysine methyltransferases KMT2C and KMT2D are among the most commonly mutated genes in the highly metastatic TNBC subtype of breast cancer. However, it is not known if mutations of either of these genes similarly effect epigenomic and transcriptomic landscape or if a specific downstream target mi...
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
