BME-SIG Lecture with Molly Schoichet
Drug discovery in cancer typically involves screening cells grown on 2-dimensional, hard plastic dishes; however, since human tissue is neither 2D nor plastic, this environment does not sufficiently emulate human disease. To overcome this limitation, we designed materials (i.e., hydrogels) for 3-dimensional cell culture with the goal of screening cells in an environment that mimics that of native tissue. With 3D cell culture, we gain an understanding of both cell invasion and cell viability, thereby providing insights that are inherently limited with traditional 2D cell culture. To achieve a suitable environment, we synthe...
Source: Videocast - All Events - April 24, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Neural-immune Interactions in Cognitive Impairment Following Cancer Therapy or COVID
Michelle Monje is a leading neuroscientist and neuro-oncologist who is advancing our understanding of postnatal brain development and translating her findings into promising therapies for pediatric brain tumors. She has made seminal contributions to elucidating the phenomena of " chemobrain, " a debilitating side effect of chemotherapy which include symptoms such as memory lapses, slowed thinking, and mental fog. Her COVID-themed seminar will be focused on her recent studies into the similarities between the chemobrain phenomena and the short- and long-term neurological effects of COVID. See https://med.stanford.edu/profil...
Source: Videocast - All Events - September 26, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
July 2021 Clinical Case Vid. 1
Video 1. Axial (horizontal) T2 MRI of the brain at presentation showing filling of the IAC with tumor and loss of
cerebrospinal fluid signal in IAC. (Source: The Hearing Journal - Video)
Source: The Hearing Journal - Video - July 7, 2021 Category: Audiology Source Type: video
Aug 2020 Clinical Case Vid. 6
Video 6. Sagittal (vertical parallel to ear) T1-weighted postcontrast MRI of the brain showing the tumor in the sagittal plane. (Source: The Hearing Journal - Video)
Source: The Hearing Journal - Video - August 5, 2020 Category: Audiology Source Type: video
June 2020 Clinical Case Vid. 2
Video 2. Axial (horizontal) T1 MPR MRI of the brain (1 mm slices) taken six months prior to presentation
showing an unclear image in the area of the tumor. (Source: The Hearing Journal - Video)
Source: The Hearing Journal - Video - June 6, 2020 Category: Audiology Source Type: video
The Case for BK Polyomavirus as a Cause of Bladder Cancer
NCI ’ s Center for Cancer Research (CCR) Grand Rounds
Dr. Buck ’ s lab studies polyomaviruses. A great majority of healthy adults chronically shed
polyomavirus virions in their urine and from the surface of their skin. Although these lifelong infections generally aren't known to cause symptoms in healthy individuals, under conditions of immune impairment polyomaviruses can cause disease. For example, BK polyomavirus (BKV) causes kidney and bladder damage in organ transplant patients, while its close relative JCV causes a lethal brain disease in patients on immunosuppressive therapies and in individuals suffering from ...
Source: Videocast - All Events - March 2, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
NCI-CONNECT & BTTC Annual Meeting Tumor Board
Neuro-oncology tumor board for brain and CNS tumors.Air date: 4/7/2020 8:30:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - February 24, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
Cellular Therapy Targeting Malignant Brain Tumors
CCR Grand Rounds
Duane A. Mitchell, M.D., Ph.D. is Co-Director of the Preston A. Wells Jr. Center for Brain Tumor Therapy and Director of the UF Brain Tumor Immunotherapy Program. He is the Phyllis Kottler Friedman Professor in the Department of Neurosurgery and the State of Florida Endowed Cancer Research Chair at the University of Florida College of Medicine.
Dr. Mitchell graduated from Rutgers College in New Brunswick, New Jersey with a bachelor ’ s degree in biology before receiving his medical degree and doctorate degree in immunology from Duke University in Durham, North Carolina in 2001. He completed post-graduate...
Source: Videocast - All Events - February 24, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
The Peter Pan Syndrome: Oncohistones Stall Development in Pediatric Cancers
CCR Grand Rounds
Dr. Jabado ’ s research focuses on elucidating genetic signatures of pediatric astrocytomas and examining how they compare to adults. These are deadly brain tumors that originate in the brain and include glioblastomas (GBM, the highest grade of astrocytomas), which are one of the deadliest cancers in humans. Her group uncovered that pediatric high-grade astrocytomas (HGA) are molecularly and genetically distinct from adult tumors. They also identified a new molecular mechanism driving pediatric HGA, namely recurrent somatic driver mutations in the tail of histone 3 variants (H3.3 and H3.1). These mutatio...
Source: Videocast - All Events - October 21, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Using light to treat cancer and schizophrenia? It  s in-gene-ious.
Using tiny photonic implants, researchers have wirelessly controlled a gene in lab-grown brain tissue -- an initial step that could one day lead to new cancer treatments and ways to prevent and treat certain mental disorders.This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - July 26, 2019 Category: Science Source Type: video
Stampede supercomputer (Image 4)
The Stampede supercomputer, located at the University of Texas at Austin's Texas Advanced Computing Center, has already enabled research teams to predict where and when earthquakes may strike, how much sea levels could rise and how fast brain tumors grow.
More about this ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - April 8, 2019 Category: Science Source Type: video
Mass spectrometry imaging applications to support clinical decision making
Proteomics Interest Group
Mass spectrometry provides multiple options for the direct characterization of tissue to support surgical decision-making, and provides significant insight in the development of drugs targeting tumors of the central nervous system (CNS). Using an array of mass spectrometry (MS) applications, we rapidly analyze specific tumor markers ranging from small metabolites to proteins from surgical tissue for rapid diagnosis and surgical guidance. Using similar clinical protocols, we visualize drug and metabolites penetration in brain tumor tissue and correlate with tumor heterogeneity and response to suppo...
Source: Videocast - All Events - January 3, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
