Advances in glioblastoma multiforme: Integrating therapy and pathology perspectives
In conclusion, our efforts offer hope for enhanced outcomes and improved quality of life for GBM patients through alkaloid-based therapies. By integrating insights from pathology and therapeutic perspectives, we underscore the significance of a comprehensive approach in addressing this devastating disease.PMID:38653089 | DOI:10.1016/j.prp.2024.155285 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - April 23, 2024 Category: Pathology Authors: Seyed Hossein Shahcheraghi Maliheh Alimardani Malihe Lotfi Marzieh Lotfi Vladimir N Uversky Stephanie Tamdem Guetchueng Sushesh Shrivastsa Palakurthi Nitin B Charbe Altijana Hromi ć-Jahjefendić Alaa A A Aljabali Manoj M Gadewar Sumira Malik Rohit Goyal Source Type: research
Diagnostic and therapeutic use of oral micronized progesterone in endocrinology
Rev Endocr Metab Disord. 2024 Apr 23. doi: 10.1007/s11154-024-09882-0. Online ahead of print.ABSTRACTProgesterone is a natural steroid hormone, while progestins are synthetic molecules. In the female reproductive system, progesterone contributes to the control of luteinizing hormone and follicle-stimulating hormone secretion and their pulsatility, via its receptors on the kisspeptin, neurokinin B, and dynorphin neurons in the hypothalamus. Progesterone together with estradiol controls the cyclic changes of proliferation and decidualization of the endometrium; exerts anti-mitogenic actions on endometrial epithelial cells; r...
Source: ENDOCR REV - April 23, 2024 Category: Endocrinology Authors: Eleni Memi Polina Pavli Papagianni Maria Nikolaos Vrachnis George Mastorakos Source Type: research
Identification of core genes of craniopharyngioma angiogenesis based on single-cell nuclear transcriptome sequencing
This study aimed to explore the core genes of craniopharyngioma angiogenesis for targeted vascular therapy based on single-cell nuclear transcriptome sequencing. For single-cell nuclear transcriptome sequencing, we collected six samples from the tumor center and adjacent hypothalamic tumor tissues from three patients with craniopharyngioma, as well as four normal brain tissues based on Gene Expression Omnibus. We screened genes with differential up-regulation between vascular endothelial cells of craniopharyngioma and those of normal brain tissues, performed GO and KEGG analysis, constructed the protein-protein interaction...
Source: Mol Biol Cell - April 23, 2024 Category: Molecular Biology Authors: Jinshi Zhang Lin Xu Jiye Ye Chunming Xu Bowen Wu Jie Wu Tao Hong Source Type: research
Relationship between brain tumors and intracranial aneurysms: a systematic review
CONCLUSION: There is a lack of evidence to affirm that the existence of brain neoplasm plays a role in the formation and rupture of intracranial aneurysms. Additionally, there is insufficient evidence to confirm a greater prevalence of intracranial aneurysms in individuals with brain tumors. The association of these two disorders does not appear to worsen patient outcome. Prognosis depends on tumor pathology for malignant cases and on subarachnoid hemorrhage in patients with ruptured aneurysms.PMID:38650567 | DOI:10.5137/1019-5149.JTN.43614-23.4 (Source: Turkish Neurosurgery)
Source: Turkish Neurosurgery - April 23, 2024 Category: Neurosurgery Authors: Pedro Henrique Mouty Rabello N ícollas Nunes Rabelo Jo ão Paulo Telles Eberval Gadelha Figueiredo Source Type: research
Molecular biology and novel therapeutics for IDH mutant gliomas: The new era of IDH inhibitors
Biochim Biophys Acta Rev Cancer. 2024 Apr 21:189102. doi: 10.1016/j.bbcan.2024.189102. Online ahead of print.ABSTRACTGliomas with Isocitrate dehydrogenase (IDH) mutation represent a discrete category of primary brain tumors with distinct and unique characteristics, behaviors, and clinical disease outcomes. IDH mutations lead to aberrant high-level production of the oncometabolite D-2-hydroxyglutarate (D-2HG), which act as a competitive inhibitor of enzymes regulating epigenetics, signaling pathways, metabolism, and various other processes. This review summarizes the significance of IDH mutations, resulting upregulation of ...
Source: Biochimica et Biophysica Acta - April 23, 2024 Category: Biochemistry Authors: Yosuke Kitagawa Ami Kobayashi Daniel P Cahill Hiroaki Wakimoto Shota Tanaka Source Type: research
Advances in glioblastoma multiforme: Integrating therapy and pathology perspectives
In conclusion, our efforts offer hope for enhanced outcomes and improved quality of life for GBM patients through alkaloid-based therapies. By integrating insights from pathology and therapeutic perspectives, we underscore the significance of a comprehensive approach in addressing this devastating disease.PMID:38653089 | DOI:10.1016/j.prp.2024.155285 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - April 23, 2024 Category: Pathology Authors: Seyed Hossein Shahcheraghi Maliheh Alimardani Malihe Lotfi Marzieh Lotfi Vladimir N Uversky Stephanie Tamdem Guetchueng Sushesh Shrivastsa Palakurthi Nitin B Charbe Altijana Hromi ć-Jahjefendić Alaa A A Aljabali Manoj M Gadewar Sumira Malik Rohit Goyal Source Type: research
Identification of core genes of craniopharyngioma angiogenesis based on single-cell nuclear transcriptome sequencing
This study aimed to explore the core genes of craniopharyngioma angiogenesis for targeted vascular therapy based on single-cell nuclear transcriptome sequencing. For single-cell nuclear transcriptome sequencing, we collected six samples from the tumor center and adjacent hypothalamic tumor tissues from three patients with craniopharyngioma, as well as four normal brain tissues based on Gene Expression Omnibus. We screened genes with differential up-regulation between vascular endothelial cells of craniopharyngioma and those of normal brain tissues, performed GO and KEGG analysis, constructed the protein-protein interaction...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Jinshi Zhang Lin Xu Jiye Ye Chunming Xu Bowen Wu Jie Wu Tao Hong Source Type: research
Diagnostic and therapeutic use of oral micronized progesterone in endocrinology
Rev Endocr Metab Disord. 2024 Apr 23. doi: 10.1007/s11154-024-09882-0. Online ahead of print.ABSTRACTProgesterone is a natural steroid hormone, while progestins are synthetic molecules. In the female reproductive system, progesterone contributes to the control of luteinizing hormone and follicle-stimulating hormone secretion and their pulsatility, via its receptors on the kisspeptin, neurokinin B, and dynorphin neurons in the hypothalamus. Progesterone together with estradiol controls the cyclic changes of proliferation and decidualization of the endometrium; exerts anti-mitogenic actions on endometrial epithelial cells; r...
Source: ENDOCR REV - April 23, 2024 Category: Endocrinology Authors: Eleni Memi Polina Pavli Papagianni Maria Nikolaos Vrachnis George Mastorakos Source Type: research
Diagnostic and therapeutic use of oral micronized progesterone in endocrinology
Rev Endocr Metab Disord. 2024 Apr 23. doi: 10.1007/s11154-024-09882-0. Online ahead of print.ABSTRACTProgesterone is a natural steroid hormone, while progestins are synthetic molecules. In the female reproductive system, progesterone contributes to the control of luteinizing hormone and follicle-stimulating hormone secretion and their pulsatility, via its receptors on the kisspeptin, neurokinin B, and dynorphin neurons in the hypothalamus. Progesterone together with estradiol controls the cyclic changes of proliferation and decidualization of the endometrium; exerts anti-mitogenic actions on endometrial epithelial cells; r...
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: Eleni Memi Polina Pavli Papagianni Maria Nikolaos Vrachnis George Mastorakos Source Type: research
Genomic landscape of glioblastoma without IDH somatic mutation in 42 cases: a comprehensive analysis using RNA sequencing data
ConclusionRNA sequencing is a promising approach for genotyping glioblastomas because it provides comprehensive information on gene expression and is relatively cost-effective. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 23, 2024 Category: Cancer & Oncology Source Type: research
Diagnostic and therapeutic use of oral micronized progesterone in endocrinology
AbstractProgesterone is a natural steroid hormone, while progestins are synthetic molecules. In the female reproductive system,progesterone contributes to the control ofluteinizing hormone andfollicle-stimulating hormone secretion and their pulsatility,via itsreceptors on thekisspeptin,neurokinin B, anddynorphin neurons in the hypothalamus.Progesterone together withestradiol controls the cyclic changes of proliferation and decidualization of the endometrium; exerts anti-mitogenic actions on endometrial epithelial cells; regulates normal menstrual bleeding; contributes to fertilization and pregnancy maintenance; participate...
Source: Reviews in Endocrine and Metabolic Disorders - April 23, 2024 Category: Endocrinology Source Type: research
Clinical management of TP53 mosaic variants found on germline genetic testing
Diagnosis of Li-Fraumeni syndrome (LFS) is based on personal and/or family cancer history[1 –4] of core cancers including: breast cancer (BC), soft tissue/bone sarcoma, brain tumors, and adrenal cortical carcinoma[5]. In Classic LFS, patients have cancer at early ages (50% cancer risk by age 30) and high risk for multiple cancers over the lifespan[6]. Recently, a spectrum of LFS has been proposed incorporating broader clinical phenotypes[7]. (Source: Cancer Genetics and Cytogenetics)
Source: Cancer Genetics and Cytogenetics - April 23, 2024 Category: Genetics & Stem Cells Authors: Abigail Ward, Dana Farengo-Clark, Danielle B. McKenna, Anton Safonov, Madeline Good, Anh Le, Lisa Kessler, Payal D. Shah, Angela R. Bradbury, Susan M. Domchek, Katherine L. Nathanson, Jacquelyn Powers, Kara N. Maxwell Source Type: research
Genes, Vol. 15, Pages 529: SNP and Structural Study of the Notch Superfamily Provides Insights and Novel Pharmacological Targets against the CADASIL Syndrome and Neurodegenerative Diseases
In this study, an in silico analysis of polymorphisms and mutations in human Notch family members that lead to neurodegenerative diseases was performed in order to investigate the correlations among Notch family proteins and neurodegenerative diseases. Particular emphasis was placed on the study of mutations in the Notch3 protein and the structure analysis of the mutant Notch3 protein that leads to the manifestation of the CADASIL syndrome in order to spot possible conserved mutations and interpret the effect of these mutations in the Notch3 protein structure. Conserved mutations of cysteine residues may be candidate pharm...
Source: Genes - April 23, 2024 Category: Genetics & Stem Cells Authors: Louis Papageorgiou Lefteria Papa Eleni Papakonstantinou Antonia Mataragka Konstantina Dragoumani Dimitrios Chaniotis Apostolos Beloukas Costas Iliopoulos Erik Bongcam-Rudloff George P. Chrousos Sofia Kossida Elias Eliopoulos Dimitrios Vlachakis Tags: Article Source Type: research
Intraoperative radiotherapy combined with spinal stabilization surgery —a novel treatment strategy for spinal metastases based on a first single-center experiences
Conclusion50 kV photon IORT for SM and consecutive unstable spine needing surgical intervention is safe and feasible and can be a promising technique in selected cases. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 23, 2024 Category: Cancer & Oncology Source Type: research
Immunotherapy for Brain Tumors: Where We Have Been, and Where Do We Go From Here?
Opinion statementImmunotherapy for glioblastoma (GBM) remains an intensive area of investigation. Given the seismic impact of cancer immunotherapy across a range of malignancies, there is optimism that harnessing the power of immunity will influence GBM as well. However, despite several phase 3 studies, there are still no FDA-approved immunotherapies for GBM. Importantly, the field has learned a great deal from the randomized studies to date. Today, we are continuing to better understand the disease-specific features of the microenvironment in GBM —as well as the exploitable antigenic characteristic of the tumor cells th...
Source: Current Treatment Options in Oncology - April 23, 2024 Category: Cancer & Oncology Source Type: research
