Vitamin D, infections and immunity
Rev Endocr Metab Disord. 2021 Jul 29:1-13. doi: 10.1007/s11154-021-09679-5. Online ahead of print.ABSTRACTVitamin D, best known for its role in skeletal health, has emerged as a key regulator of innate immune responses to microbial threat. In immune cells such as macrophages, expression of CYP27B1, the 25-hydroxyvitamin D 1α-hydroxylase, is induced by immune-specific inputs, leading to local production of hormonal 1,25-dihydroxyvitamin D (1,25D) at sites of infection, which in turn directly induces the expression of genes encoding antimicrobial peptides. Vitamin D signaling is active upstream and downstream of patter...
Source: ENDOCR REV - July 29, 2021 Category: Endocrinology Authors: Aiten Ismailova John H White Source Type: research

Vitamin D, infections and immunity
Rev Endocr Metab Disord. 2021 Jul 29:1-13. doi: 10.1007/s11154-021-09679-5. Online ahead of print.ABSTRACTVitamin D, best known for its role in skeletal health, has emerged as a key regulator of innate immune responses to microbial threat. In immune cells such as macrophages, expression of CYP27B1, the 25-hydroxyvitamin D 1α-hydroxylase, is induced by immune-specific inputs, leading to local production of hormonal 1,25-dihydroxyvitamin D (1,25D) at sites of infection, which in turn directly induces the expression of genes encoding antimicrobial peptides. Vitamin D signaling is active upstream and downstream of patter...
Source: ENDOCR REV - July 29, 2021 Category: Endocrinology Authors: Aiten Ismailova John H White Source Type: research

Mechanisms and management of drug-induced hyperkalemia in kidney transplant patients
Rev Endocr Metab Disord. 2021 Jul 22. doi: 10.1007/s11154-021-09677-7. Online ahead of print.ABSTRACTHyperkalemia is a common and potentially life-threatening complication following kidney transplantation that can be caused by a composite of factors such as medications, delayed graft function, and possibly potassium intake. Managing hyperkalemia after kidney transplantation is associated with increased morbidity and healthcare costs, and can be a cause of multiple hospital admissions and barriers to patient discharge. Medications used routinely after kidney transplantation are considered the most frequent culprit for post-...
Source: ENDOCR REV - July 22, 2021 Category: Endocrinology Authors: John G Rizk Jose G Lazo David Quan Steven Gabardi Youssef Rizk Elani Streja Csaba P Kovesdy Kamyar Kalantar-Zadeh Source Type: research

Mechanisms and management of drug-induced hyperkalemia in kidney transplant patients
Rev Endocr Metab Disord. 2021 Jul 22. doi: 10.1007/s11154-021-09677-7. Online ahead of print.ABSTRACTHyperkalemia is a common and potentially life-threatening complication following kidney transplantation that can be caused by a composite of factors such as medications, delayed graft function, and possibly potassium intake. Managing hyperkalemia after kidney transplantation is associated with increased morbidity and healthcare costs, and can be a cause of multiple hospital admissions and barriers to patient discharge. Medications used routinely after kidney transplantation are considered the most frequent culprit for post-...
Source: ENDOCR REV - July 22, 2021 Category: Endocrinology Authors: John G Rizk Jose G Lazo David Quan Steven Gabardi Youssef Rizk Elani Streja Csaba P Kovesdy Kamyar Kalantar-Zadeh Source Type: research

Mechanisms and management of drug-induced hyperkalemia in kidney transplant patients
Rev Endocr Metab Disord. 2021 Jul 22. doi: 10.1007/s11154-021-09677-7. Online ahead of print.ABSTRACTHyperkalemia is a common and potentially life-threatening complication following kidney transplantation that can be caused by a composite of factors such as medications, delayed graft function, and possibly potassium intake. Managing hyperkalemia after kidney transplantation is associated with increased morbidity and healthcare costs, and can be a cause of multiple hospital admissions and barriers to patient discharge. Medications used routinely after kidney transplantation are considered the most frequent culprit for post-...
Source: ENDOCR REV - July 22, 2021 Category: Endocrinology Authors: John G Rizk Jose G Lazo David Quan Steven Gabardi Youssef Rizk Elani Streja Csaba P Kovesdy Kamyar Kalantar-Zadeh Source Type: research

Mechanisms and management of drug-induced hyperkalemia in kidney transplant patients
Rev Endocr Metab Disord. 2021 Jul 22. doi: 10.1007/s11154-021-09677-7. Online ahead of print.ABSTRACTHyperkalemia is a common and potentially life-threatening complication following kidney transplantation that can be caused by a composite of factors such as medications, delayed graft function, and possibly potassium intake. Managing hyperkalemia after kidney transplantation is associated with increased morbidity and healthcare costs, and can be a cause of multiple hospital admissions and barriers to patient discharge. Medications used routinely after kidney transplantation are considered the most frequent culprit for post-...
Source: ENDOCR REV - July 22, 2021 Category: Endocrinology Authors: John G Rizk Jose G Lazo David Quan Steven Gabardi Youssef Rizk Elani Streja Csaba P Kovesdy Kamyar Kalantar-Zadeh Source Type: research

Mechanisms and management of drug-induced hyperkalemia in kidney transplant patients
Rev Endocr Metab Disord. 2021 Jul 22. doi: 10.1007/s11154-021-09677-7. Online ahead of print.ABSTRACTHyperkalemia is a common and potentially life-threatening complication following kidney transplantation that can be caused by a composite of factors such as medications, delayed graft function, and possibly potassium intake. Managing hyperkalemia after kidney transplantation is associated with increased morbidity and healthcare costs, and can be a cause of multiple hospital admissions and barriers to patient discharge. Medications used routinely after kidney transplantation are considered the most frequent culprit for post-...
Source: ENDOCR REV - July 22, 2021 Category: Endocrinology Authors: John G Rizk Jose G Lazo David Quan Steven Gabardi Youssef Rizk Elani Streja Csaba P Kovesdy Kamyar Kalantar-Zadeh Source Type: research

Mechanisms and management of drug-induced hyperkalemia in kidney transplant patients
Rev Endocr Metab Disord. 2021 Jul 22. doi: 10.1007/s11154-021-09677-7. Online ahead of print.ABSTRACTHyperkalemia is a common and potentially life-threatening complication following kidney transplantation that can be caused by a composite of factors such as medications, delayed graft function, and possibly potassium intake. Managing hyperkalemia after kidney transplantation is associated with increased morbidity and healthcare costs, and can be a cause of multiple hospital admissions and barriers to patient discharge. Medications used routinely after kidney transplantation are considered the most frequent culprit for post-...
Source: ENDOCR REV - July 22, 2021 Category: Endocrinology Authors: John G Rizk Jose G Lazo David Quan Steven Gabardi Youssef Rizk Elani Streja Csaba P Kovesdy Kamyar Kalantar-Zadeh Source Type: research

Shifts in gut microbiota and their metabolites induced by bariatric surgery. Impact of factors shaping gut microbiota on bariatric surgery outcomes
Rev Endocr Metab Disord. 2021 Jul 21. doi: 10.1007/s11154-021-09676-8. Online ahead of print.ABSTRACTEvidence suggests that bariatric surgery alters gut microbiota, although its impact at compositional and functional level is not well described. In this review, the most relevant findings, mainly described in Roux-en-Y gastric bypass and sleeve gastrectomy, are outlined. Although the number of studies has increased in the last years, conclusive assertions cannot be elaborated. An issue to address is to know the influence of these alterations on host metabolism and the contribution of gut microbiota derived metabolites. New ...
Source: ENDOCR REV - July 21, 2021 Category: Endocrinology Authors: Carolina Guti érrez-Repiso Isabel Moreno-Indias Francisco J Tinahones Source Type: research

Shifts in gut microbiota and their metabolites induced by bariatric surgery. Impact of factors shaping gut microbiota on bariatric surgery outcomes
Rev Endocr Metab Disord. 2021 Jul 21. doi: 10.1007/s11154-021-09676-8. Online ahead of print.ABSTRACTEvidence suggests that bariatric surgery alters gut microbiota, although its impact at compositional and functional level is not well described. In this review, the most relevant findings, mainly described in Roux-en-Y gastric bypass and sleeve gastrectomy, are outlined. Although the number of studies has increased in the last years, conclusive assertions cannot be elaborated. An issue to address is to know the influence of these alterations on host metabolism and the contribution of gut microbiota derived metabolites. New ...
Source: ENDOCR REV - July 21, 2021 Category: Endocrinology Authors: Carolina Guti érrez-Repiso Isabel Moreno-Indias Francisco J Tinahones Source Type: research

Repurposing sodium-glucose co-transporter 2 inhibitors (SGLT2i) for cancer treatment - A Review
Rev Endocr Metab Disord. 2021 Jul 17. doi: 10.1007/s11154-021-09675-9. Online ahead of print.ABSTRACTDeveloped as an antidiabetic drug, recent evidence suggests that several sodium-glucose co-transporter 2 inhibitors (SGLT2i), especially canagliflozin and dapagliflozin, may exhibit in vitro and in vivo anticancer activities in selected cancer types, including an inhibition of tumor growth and induction of cell death. When used in combination with chemotherapy or radiotherapy, SGLT2i may offer possible synergistic effects in enhancing their treatment efficacy while alleviating associated side effects. Potential mechanisms i...
Source: ENDOCR REV - July 17, 2021 Category: Endocrinology Authors: Kristy T K Lau Lui Ng Jason W H Wong Herbert H F Loong Wendy W L Chan Chi Ho Lee Carlos K H Wong Source Type: research

Insulin: a hundred year-old discovery with a fascinating history
We present here a historical perspective on the concepts and ideas regarding the physiopathology of the disease, on the progressive focus on the pancreas, in particular on the islets discovered by Langerhans in 1869, leading to the iconic experiment of Minkowski and von Mering in 1889 showing that pancreatectomy in a dog induced polyuria and diabetes mellitus. Subsequently, multiple investigators searched for the active substance of the pancreas and some managed to produce extracts that lowered blood glucose and decreased polyuria in pancreatectomized dogs, but were too toxic to be administered to patients. The breakthroug...
Source: ENDOCR REV - July 17, 2021 Category: Endocrinology Authors: William Rost ène Pierre De Meyts Source Type: research

Repurposing sodium-glucose co-transporter 2 inhibitors (SGLT2i) for cancer treatment - A Review
Rev Endocr Metab Disord. 2021 Jul 17. doi: 10.1007/s11154-021-09675-9. Online ahead of print.ABSTRACTDeveloped as an antidiabetic drug, recent evidence suggests that several sodium-glucose co-transporter 2 inhibitors (SGLT2i), especially canagliflozin and dapagliflozin, may exhibit in vitro and in vivo anticancer activities in selected cancer types, including an inhibition of tumor growth and induction of cell death. When used in combination with chemotherapy or radiotherapy, SGLT2i may offer possible synergistic effects in enhancing their treatment efficacy while alleviating associated side effects. Potential mechanisms i...
Source: ENDOCR REV - July 17, 2021 Category: Endocrinology Authors: Kristy T K Lau Lui Ng Jason W H Wong Herbert H F Loong Wendy W L Chan Chi Ho Lee Carlos K H Wong Source Type: research

Insulin: a hundred year-old discovery with a fascinating history
We present here a historical perspective on the concepts and ideas regarding the physiopathology of the disease, on the progressive focus on the pancreas, in particular on the islets discovered by Langerhans in 1869, leading to the iconic experiment of Minkowski and von Mering in 1889 showing that pancreatectomy in a dog induced polyuria and diabetes mellitus. Subsequently, multiple investigators searched for the active substance of the pancreas and some managed to produce extracts that lowered blood glucose and decreased polyuria in pancreatectomized dogs, but were too toxic to be administered to patients. The breakthroug...
Source: ENDOCR REV - July 17, 2021 Category: Endocrinology Authors: William Rost ène Pierre De Meyts Source Type: research

Repurposing sodium-glucose co-transporter 2 inhibitors (SGLT2i) for cancer treatment - A Review
Rev Endocr Metab Disord. 2021 Jul 17. doi: 10.1007/s11154-021-09675-9. Online ahead of print.ABSTRACTDeveloped as an antidiabetic drug, recent evidence suggests that several sodium-glucose co-transporter 2 inhibitors (SGLT2i), especially canagliflozin and dapagliflozin, may exhibit in vitro and in vivo anticancer activities in selected cancer types, including an inhibition of tumor growth and induction of cell death. When used in combination with chemotherapy or radiotherapy, SGLT2i may offer possible synergistic effects in enhancing their treatment efficacy while alleviating associated side effects. Potential mechanisms i...
Source: ENDOCR REV - July 17, 2021 Category: Endocrinology Authors: Kristy T K Lau Lui Ng Jason W H Wong Herbert H F Loong Wendy W L Chan Chi Ho Lee Carlos K H Wong Source Type: research

Insulin: a hundred year-old discovery with a fascinating history
We present here a historical perspective on the concepts and ideas regarding the physiopathology of the disease, on the progressive focus on the pancreas, in particular on the islets discovered by Langerhans in 1869, leading to the iconic experiment of Minkowski and von Mering in 1889 showing that pancreatectomy in a dog induced polyuria and diabetes mellitus. Subsequently, multiple investigators searched for the active substance of the pancreas and some managed to produce extracts that lowered blood glucose and decreased polyuria in pancreatectomized dogs, but were too toxic to be administered to patients. The breakthroug...
Source: ENDOCR REV - July 17, 2021 Category: Endocrinology Authors: William Rost ène Pierre De Meyts Source Type: research

Repurposing sodium-glucose co-transporter 2 inhibitors (SGLT2i) for cancer treatment - A Review
Rev Endocr Metab Disord. 2021 Jul 17. doi: 10.1007/s11154-021-09675-9. Online ahead of print.ABSTRACTDeveloped as an antidiabetic drug, recent evidence suggests that several sodium-glucose co-transporter 2 inhibitors (SGLT2i), especially canagliflozin and dapagliflozin, may exhibit in vitro and in vivo anticancer activities in selected cancer types, including an inhibition of tumor growth and induction of cell death. When used in combination with chemotherapy or radiotherapy, SGLT2i may offer possible synergistic effects in enhancing their treatment efficacy while alleviating associated side effects. Potential mechanisms i...
Source: ENDOCR REV - July 17, 2021 Category: Endocrinology Authors: Kristy T K Lau Lui Ng Jason W H Wong Herbert H F Loong Wendy W L Chan Chi Ho Lee Carlos K H Wong Source Type: research

Insulin: a hundred year-old discovery with a fascinating history
We present here a historical perspective on the concepts and ideas regarding the physiopathology of the disease, on the progressive focus on the pancreas, in particular on the islets discovered by Langerhans in 1869, leading to the iconic experiment of Minkowski and von Mering in 1889 showing that pancreatectomy in a dog induced polyuria and diabetes mellitus. Subsequently, multiple investigators searched for the active substance of the pancreas and some managed to produce extracts that lowered blood glucose and decreased polyuria in pancreatectomized dogs, but were too toxic to be administered to patients. The breakthroug...
Source: ENDOCR REV - July 17, 2021 Category: Endocrinology Authors: William Rost ène Pierre De Meyts Source Type: research

Endocrine risk factors for COVID-19: Endogenous and exogenous glucocorticoid excess
Rev Endocr Metab Disord. 2021 Jul 9:1-18. doi: 10.1007/s11154-021-09670-0. Online ahead of print.ABSTRACTPatients with endogenous or exogenous glucocorticoid (GC) excess exhibit a range of side effects, including an increased risk of infections. Via both mechanism, immune impairments and cardiometabolic concomitant diseases, patients with GC excess could be at increased risk for COVID-19. The impact on incidence and outcome of a SARS-CoV-2 infection in this population are not yet completely clear. This review aims to compile the data available to date and to discuss the existing literature on this topic. Further we highlig...
Source: ENDOCR REV - July 9, 2021 Category: Endocrinology Authors: Frederick Vogel Martin Reincke Source Type: research

Inborn errors of metabolism: Lessons from iPSC models
Rev Endocr Metab Disord. 2021 Jul 9. doi: 10.1007/s11154-021-09671-z. Online ahead of print.ABSTRACTThe possibility of reprogramming human somatic cells to pluripotency has opened unprecedented opportunities for creating genuinely human experimental models of disease. Inborn errors of metabolism (IEMs) constitute a greatly heterogeneous class of diseases that appear, in principle, especially suited to be modeled by iPSC-based technology. Indeed, dozens of IEMs have already been modeled to some extent using patient-specific iPSCs. Here, we review the advantages and disadvantages of iPSC-based disease modeling in the context...
Source: ENDOCR REV - July 9, 2021 Category: Endocrinology Authors: Rub én Escribá Raquel Ferrer-Lorente Ángel Raya Source Type: research

Endocrine risk factors for COVID-19: Endogenous and exogenous glucocorticoid excess
Rev Endocr Metab Disord. 2021 Jul 9:1-18. doi: 10.1007/s11154-021-09670-0. Online ahead of print.ABSTRACTPatients with endogenous or exogenous glucocorticoid (GC) excess exhibit a range of side effects, including an increased risk of infections. Via both mechanism, immune impairments and cardiometabolic concomitant diseases, patients with GC excess could be at increased risk for COVID-19. The impact on incidence and outcome of a SARS-CoV-2 infection in this population are not yet completely clear. This review aims to compile the data available to date and to discuss the existing literature on this topic. Further we highlig...
Source: ENDOCR REV - July 9, 2021 Category: Endocrinology Authors: Frederick Vogel Martin Reincke Source Type: research

Inborn errors of metabolism: Lessons from iPSC models
Rev Endocr Metab Disord. 2021 Jul 9. doi: 10.1007/s11154-021-09671-z. Online ahead of print.ABSTRACTThe possibility of reprogramming human somatic cells to pluripotency has opened unprecedented opportunities for creating genuinely human experimental models of disease. Inborn errors of metabolism (IEMs) constitute a greatly heterogeneous class of diseases that appear, in principle, especially suited to be modeled by iPSC-based technology. Indeed, dozens of IEMs have already been modeled to some extent using patient-specific iPSCs. Here, we review the advantages and disadvantages of iPSC-based disease modeling in the context...
Source: ENDOCR REV - July 9, 2021 Category: Endocrinology Authors: Rub én Escribá Raquel Ferrer-Lorente Ángel Raya Source Type: research

Endocrine risk factors for COVID-19: Endogenous and exogenous glucocorticoid excess
Rev Endocr Metab Disord. 2021 Jul 9:1-18. doi: 10.1007/s11154-021-09670-0. Online ahead of print.ABSTRACTPatients with endogenous or exogenous glucocorticoid (GC) excess exhibit a range of side effects, including an increased risk of infections. Via both mechanism, immune impairments and cardiometabolic concomitant diseases, patients with GC excess could be at increased risk for COVID-19. The impact on incidence and outcome of a SARS-CoV-2 infection in this population are not yet completely clear. This review aims to compile the data available to date and to discuss the existing literature on this topic. Further we highlig...
Source: ENDOCR REV - July 9, 2021 Category: Endocrinology Authors: Frederick Vogel Martin Reincke Source Type: research

Inborn errors of metabolism: Lessons from iPSC models
Rev Endocr Metab Disord. 2021 Jul 9. doi: 10.1007/s11154-021-09671-z. Online ahead of print.ABSTRACTThe possibility of reprogramming human somatic cells to pluripotency has opened unprecedented opportunities for creating genuinely human experimental models of disease. Inborn errors of metabolism (IEMs) constitute a greatly heterogeneous class of diseases that appear, in principle, especially suited to be modeled by iPSC-based technology. Indeed, dozens of IEMs have already been modeled to some extent using patient-specific iPSCs. Here, we review the advantages and disadvantages of iPSC-based disease modeling in the context...
Source: ENDOCR REV - July 9, 2021 Category: Endocrinology Authors: Rub én Escribá Raquel Ferrer-Lorente Ángel Raya Source Type: research

Endocrine risk factors for COVID-19: Endogenous and exogenous glucocorticoid excess
Rev Endocr Metab Disord. 2021 Jul 9:1-18. doi: 10.1007/s11154-021-09670-0. Online ahead of print.ABSTRACTPatients with endogenous or exogenous glucocorticoid (GC) excess exhibit a range of side effects, including an increased risk of infections. Via both mechanism, immune impairments and cardiometabolic concomitant diseases, patients with GC excess could be at increased risk for COVID-19. The impact on incidence and outcome of a SARS-CoV-2 infection in this population are not yet completely clear. This review aims to compile the data available to date and to discuss the existing literature on this topic. Further we highlig...
Source: ENDOCR REV - July 9, 2021 Category: Endocrinology Authors: Frederick Vogel Martin Reincke Source Type: research

Inborn errors of metabolism: Lessons from iPSC models
Rev Endocr Metab Disord. 2021 Jul 9. doi: 10.1007/s11154-021-09671-z. Online ahead of print.ABSTRACTThe possibility of reprogramming human somatic cells to pluripotency has opened unprecedented opportunities for creating genuinely human experimental models of disease. Inborn errors of metabolism (IEMs) constitute a greatly heterogeneous class of diseases that appear, in principle, especially suited to be modeled by iPSC-based technology. Indeed, dozens of IEMs have already been modeled to some extent using patient-specific iPSCs. Here, we review the advantages and disadvantages of iPSC-based disease modeling in the context...
Source: ENDOCR REV - July 9, 2021 Category: Endocrinology Authors: Rub én Escribá Raquel Ferrer-Lorente Ángel Raya Source Type: research

Endocrine risk factors for COVID-19: Endogenous and exogenous glucocorticoid excess
Rev Endocr Metab Disord. 2021 Jul 9:1-18. doi: 10.1007/s11154-021-09670-0. Online ahead of print.ABSTRACTPatients with endogenous or exogenous glucocorticoid (GC) excess exhibit a range of side effects, including an increased risk of infections. Via both mechanism, immune impairments and cardiometabolic concomitant diseases, patients with GC excess could be at increased risk for COVID-19. The impact on incidence and outcome of a SARS-CoV-2 infection in this population are not yet completely clear. This review aims to compile the data available to date and to discuss the existing literature on this topic. Further we highlig...
Source: ENDOCR REV - July 9, 2021 Category: Endocrinology Authors: Frederick Vogel Martin Reincke Source Type: research

Inborn errors of metabolism: Lessons from iPSC models
Rev Endocr Metab Disord. 2021 Jul 9. doi: 10.1007/s11154-021-09671-z. Online ahead of print.ABSTRACTThe possibility of reprogramming human somatic cells to pluripotency has opened unprecedented opportunities for creating genuinely human experimental models of disease. Inborn errors of metabolism (IEMs) constitute a greatly heterogeneous class of diseases that appear, in principle, especially suited to be modeled by iPSC-based technology. Indeed, dozens of IEMs have already been modeled to some extent using patient-specific iPSCs. Here, we review the advantages and disadvantages of iPSC-based disease modeling in the context...
Source: ENDOCR REV - July 9, 2021 Category: Endocrinology Authors: Rub én Escribá Raquel Ferrer-Lorente Ángel Raya Source Type: research

Lessons from bariatric surgery: Can increased GLP-1 enhance vascular repair during cardiometabolic-based chronic disease?
Rev Endocr Metab Disord. 2021 Jul 6. doi: 10.1007/s11154-021-09669-7. Online ahead of print.ABSTRACTType 2 diabetes (T2D) and obesity represent entangled pandemics that accelerate the development of cardiovascular disease (CVD). Given the immense burden of CVD in society, non-invasive prevention and treatment strategies to promote cardiovascular health are desperately needed. During T2D and obesity, chronic dysglycemia and abnormal adiposity result in systemic oxidative stress and inflammation that deplete the vascular regenerative cell reservoir in the bone marrow that impairs blood vessel repair and exacerbates the penet...
Source: ENDOCR REV - July 6, 2021 Category: Endocrinology Authors: Ehab Bakbak Daniella C Terenzi Justin Z Trac Hwee Teoh Adrian Quan Stephen A Glazer Ori D Rotstein Mohammed Al-Omran Subodh Verma David A Hess Source Type: research

Lessons from bariatric surgery: Can increased GLP-1 enhance vascular repair during cardiometabolic-based chronic disease?
Rev Endocr Metab Disord. 2021 Jul 6. doi: 10.1007/s11154-021-09669-7. Online ahead of print.ABSTRACTType 2 diabetes (T2D) and obesity represent entangled pandemics that accelerate the development of cardiovascular disease (CVD). Given the immense burden of CVD in society, non-invasive prevention and treatment strategies to promote cardiovascular health are desperately needed. During T2D and obesity, chronic dysglycemia and abnormal adiposity result in systemic oxidative stress and inflammation that deplete the vascular regenerative cell reservoir in the bone marrow that impairs blood vessel repair and exacerbates the penet...
Source: ENDOCR REV - July 6, 2021 Category: Endocrinology Authors: Ehab Bakbak Daniella C Terenzi Justin Z Trac Hwee Teoh Adrian Quan Stephen A Glazer Ori D Rotstein Mohammed Al-Omran Subodh Verma David A Hess Source Type: research

Lessons from bariatric surgery: Can increased GLP-1 enhance vascular repair during cardiometabolic-based chronic disease?
Rev Endocr Metab Disord. 2021 Jul 6. doi: 10.1007/s11154-021-09669-7. Online ahead of print.ABSTRACTType 2 diabetes (T2D) and obesity represent entangled pandemics that accelerate the development of cardiovascular disease (CVD). Given the immense burden of CVD in society, non-invasive prevention and treatment strategies to promote cardiovascular health are desperately needed. During T2D and obesity, chronic dysglycemia and abnormal adiposity result in systemic oxidative stress and inflammation that deplete the vascular regenerative cell reservoir in the bone marrow that impairs blood vessel repair and exacerbates the penet...
Source: ENDOCR REV - July 6, 2021 Category: Endocrinology Authors: Ehab Bakbak Daniella C Terenzi Justin Z Trac Hwee Teoh Adrian Quan Stephen A Glazer Ori D Rotstein Mohammed Al-Omran Subodh Verma David A Hess Source Type: research

Functional ACE2 deficiency leading to angiotensin imbalance in the pathophysiology of COVID-19
Rev Endocr Metab Disord. 2021 Jul 1:1-20. doi: 10.1007/s11154-021-09663-z. Online ahead of print.ABSTRACTSARS-CoV-2, the virus responsible for COVID-19, uses angiotensin converting enzyme 2 (ACE2) as its primary cell-surface receptor. ACE2 is a key enzyme in the counter-regulatory pathway of the broader renin-angiotensin system (RAS) that has been implicated in a broad array of human pathology. The RAS is composed of two competing pathways that work in opposition to each other: the "conventional" arm involving angiotensin converting enzyme (ACE) generating angiotensin-2 and the more recently identified ACE2 pathw...
Source: ENDOCR REV - July 1, 2021 Category: Endocrinology Authors: Joshua R Cook John Ausiello Source Type: research

Metabolic responses of light and taste receptors - unexpected actions of GPCRs in adipocytes
Rev Endocr Metab Disord. 2021 Jul 1. doi: 10.1007/s11154-021-09667-9. Online ahead of print.ABSTRACTThe G-protein-coupled receptor (GPCR) superfamily includes sensory receptors that can detect and respond to taste and light. Recent investigations have identified key metabolic roles for such receptors in tissues considered 'non-sensory' such as adipose tissue. The major functions of white and brown adipose tissues include energy storage/release and thermogenesis, respectively. These processes are tightly controlled by GPCR pathways that serve to maintain energy homeostasis. Opsins 3 and 4 are GPCRs activated by blue light a...
Source: ENDOCR REV - July 1, 2021 Category: Endocrinology Authors: Onyinye Nuella Ekechukwu Mark Christian Source Type: research

Functional ACE2 deficiency leading to angiotensin imbalance in the pathophysiology of COVID-19
Rev Endocr Metab Disord. 2021 Jul 1:1-20. doi: 10.1007/s11154-021-09663-z. Online ahead of print.ABSTRACTSARS-CoV-2, the virus responsible for COVID-19, uses angiotensin converting enzyme 2 (ACE2) as its primary cell-surface receptor. ACE2 is a key enzyme in the counter-regulatory pathway of the broader renin-angiotensin system (RAS) that has been implicated in a broad array of human pathology. The RAS is composed of two competing pathways that work in opposition to each other: the "conventional" arm involving angiotensin converting enzyme (ACE) generating angiotensin-2 and the more recently identified ACE2 pathw...
Source: ENDOCR REV - July 1, 2021 Category: Endocrinology Authors: Joshua R Cook John Ausiello Source Type: research

Metabolic responses of light and taste receptors - unexpected actions of GPCRs in adipocytes
Rev Endocr Metab Disord. 2021 Jul 1. doi: 10.1007/s11154-021-09667-9. Online ahead of print.ABSTRACTThe G-protein-coupled receptor (GPCR) superfamily includes sensory receptors that can detect and respond to taste and light. Recent investigations have identified key metabolic roles for such receptors in tissues considered 'non-sensory' such as adipose tissue. The major functions of white and brown adipose tissues include energy storage/release and thermogenesis, respectively. These processes are tightly controlled by GPCR pathways that serve to maintain energy homeostasis. Opsins 3 and 4 are GPCRs activated by blue light a...
Source: ENDOCR REV - July 1, 2021 Category: Endocrinology Authors: Onyinye Nuella Ekechukwu Mark Christian Source Type: research

Functional ACE2 deficiency leading to angiotensin imbalance in the pathophysiology of COVID-19
Rev Endocr Metab Disord. 2021 Jul 1:1-20. doi: 10.1007/s11154-021-09663-z. Online ahead of print.ABSTRACTSARS-CoV-2, the virus responsible for COVID-19, uses angiotensin converting enzyme 2 (ACE2) as its primary cell-surface receptor. ACE2 is a key enzyme in the counter-regulatory pathway of the broader renin-angiotensin system (RAS) that has been implicated in a broad array of human pathology. The RAS is composed of two competing pathways that work in opposition to each other: the "conventional" arm involving angiotensin converting enzyme (ACE) generating angiotensin-2 and the more recently identified ACE2 pathw...
Source: ENDOCR REV - July 1, 2021 Category: Endocrinology Authors: Joshua R Cook John Ausiello Source Type: research

Metabolic responses of light and taste receptors - unexpected actions of GPCRs in adipocytes
Rev Endocr Metab Disord. 2021 Jul 1. doi: 10.1007/s11154-021-09667-9. Online ahead of print.ABSTRACTThe G-protein-coupled receptor (GPCR) superfamily includes sensory receptors that can detect and respond to taste and light. Recent investigations have identified key metabolic roles for such receptors in tissues considered 'non-sensory' such as adipose tissue. The major functions of white and brown adipose tissues include energy storage/release and thermogenesis, respectively. These processes are tightly controlled by GPCR pathways that serve to maintain energy homeostasis. Opsins 3 and 4 are GPCRs activated by blue light a...
Source: ENDOCR REV - July 1, 2021 Category: Endocrinology Authors: Onyinye Nuella Ekechukwu Mark Christian Source Type: research

Functional ACE2 deficiency leading to angiotensin imbalance in the pathophysiology of COVID-19
Rev Endocr Metab Disord. 2021 Jul 1:1-20. doi: 10.1007/s11154-021-09663-z. Online ahead of print.ABSTRACTSARS-CoV-2, the virus responsible for COVID-19, uses angiotensin converting enzyme 2 (ACE2) as its primary cell-surface receptor. ACE2 is a key enzyme in the counter-regulatory pathway of the broader renin-angiotensin system (RAS) that has been implicated in a broad array of human pathology. The RAS is composed of two competing pathways that work in opposition to each other: the "conventional" arm involving angiotensin converting enzyme (ACE) generating angiotensin-2 and the more recently identified ACE2 pathw...
Source: ENDOCR REV - July 1, 2021 Category: Endocrinology Authors: Joshua R Cook John Ausiello Source Type: research

Metabolic responses of light and taste receptors - unexpected actions of GPCRs in adipocytes
Rev Endocr Metab Disord. 2021 Jul 1. doi: 10.1007/s11154-021-09667-9. Online ahead of print.ABSTRACTThe G-protein-coupled receptor (GPCR) superfamily includes sensory receptors that can detect and respond to taste and light. Recent investigations have identified key metabolic roles for such receptors in tissues considered 'non-sensory' such as adipose tissue. The major functions of white and brown adipose tissues include energy storage/release and thermogenesis, respectively. These processes are tightly controlled by GPCR pathways that serve to maintain energy homeostasis. Opsins 3 and 4 are GPCRs activated by blue light a...
Source: ENDOCR REV - July 1, 2021 Category: Endocrinology Authors: Onyinye Nuella Ekechukwu Mark Christian Source Type: research

Functional ACE2 deficiency leading to angiotensin imbalance in the pathophysiology of COVID-19
Rev Endocr Metab Disord. 2021 Jul 1:1-20. doi: 10.1007/s11154-021-09663-z. Online ahead of print.ABSTRACTSARS-CoV-2, the virus responsible for COVID-19, uses angiotensin converting enzyme 2 (ACE2) as its primary cell-surface receptor. ACE2 is a key enzyme in the counter-regulatory pathway of the broader renin-angiotensin system (RAS) that has been implicated in a broad array of human pathology. The RAS is composed of two competing pathways that work in opposition to each other: the "conventional" arm involving angiotensin converting enzyme (ACE) generating angiotensin-2 and the more recently identified ACE2 pathw...
Source: ENDOCR REV - July 1, 2021 Category: Endocrinology Authors: Joshua R Cook John Ausiello Source Type: research

Metabolic responses of light and taste receptors - unexpected actions of GPCRs in adipocytes
Rev Endocr Metab Disord. 2021 Jul 1. doi: 10.1007/s11154-021-09667-9. Online ahead of print.ABSTRACTThe G-protein-coupled receptor (GPCR) superfamily includes sensory receptors that can detect and respond to taste and light. Recent investigations have identified key metabolic roles for such receptors in tissues considered 'non-sensory' such as adipose tissue. The major functions of white and brown adipose tissues include energy storage/release and thermogenesis, respectively. These processes are tightly controlled by GPCR pathways that serve to maintain energy homeostasis. Opsins 3 and 4 are GPCRs activated by blue light a...
Source: ENDOCR REV - July 1, 2021 Category: Endocrinology Authors: Onyinye Nuella Ekechukwu Mark Christian Source Type: research

The β Cell in Diabetes: Integrating Biomarkers with Functional Measures
Endocr Rev. 2021 Jun 28:bnab021. doi: 10.1210/endrev/bnab021. Online ahead of print.ABSTRACTThe pathogenesis of hyperglycemia observed in most forms of diabetes is intimately tied to the islet β cell. Impairments in propeptide processing and secretory function along with the loss of these vital cells is demonstrable not only in those in whom the diagnosis is established, but typically also in individuals who are at increased risk of developing the disease. Biomarkers are used to inform on the state of a biological process, pathological condition or response to an intervention and are increasingly being used for predic...
Source: ENDOCR REV - June 28, 2021 Category: Endocrinology Authors: Steven E Kahn Yi-Chun Chen Nathalie Esser Austin J Taylor Dani ël H van Raalte Sakeneh Zraika C Bruce Verchere Source Type: research

The β Cell in Diabetes: Integrating Biomarkers with Functional Measures
Endocr Rev. 2021 Jun 28:bnab021. doi: 10.1210/endrev/bnab021. Online ahead of print.ABSTRACTThe pathogenesis of hyperglycemia observed in most forms of diabetes is intimately tied to the islet β cell. Impairments in propeptide processing and secretory function along with the loss of these vital cells is demonstrable not only in those in whom the diagnosis is established, but typically also in individuals who are at increased risk of developing the disease. Biomarkers are used to inform on the state of a biological process, pathological condition or response to an intervention and are increasingly being used for predic...
Source: ENDOCR REV - June 28, 2021 Category: Endocrinology Authors: Steven E Kahn Yi-Chun Chen Nathalie Esser Austin J Taylor Dani ël H van Raalte Sakeneh Zraika C Bruce Verchere Source Type: research

The β Cell in Diabetes: Integrating Biomarkers with Functional Measures
Endocr Rev. 2021 Jun 28:bnab021. doi: 10.1210/endrev/bnab021. Online ahead of print.ABSTRACTThe pathogenesis of hyperglycemia observed in most forms of diabetes is intimately tied to the islet β cell. Impairments in propeptide processing and secretory function along with the loss of these vital cells is demonstrable not only in those in whom the diagnosis is established, but typically also in individuals who are at increased risk of developing the disease. Biomarkers are used to inform on the state of a biological process, pathological condition or response to an intervention and are increasingly being used for predic...
Source: ENDOCR REV - June 28, 2021 Category: Endocrinology Authors: Steven E Kahn Yi-Chun Chen Nathalie Esser Austin J Taylor Dani ël H van Raalte Sakeneh Zraika C Bruce Verchere Source Type: research

Therapeutic potentials of agonist and antagonist of adenosine receptors in type 2 diabetes
Rev Endocr Metab Disord. 2021 Jun 24. doi: 10.1007/s11154-021-09668-8. Online ahead of print.ABSTRACTType 2 diabetes has been a global health challenge over the decades and is among the leading causes of death. Several treatment approaches have been developed, but more effective and new therapies are still needed. The role of adenosine in glucose and lipid homeostasis has offered a different therapeutic approach. Adenosine mediates its physiological role through the activation of adenosine receptors. These adenosine receptors have been implicated in glucose and lipid homeostasis. The ability of agonists and antagonists of ...
Source: ENDOCR REV - June 24, 2021 Category: Endocrinology Authors: Olakunle Sanni G Terre'Blanche Source Type: research

Therapeutic potentials of agonist and antagonist of adenosine receptors in type 2 diabetes
Rev Endocr Metab Disord. 2021 Jun 24. doi: 10.1007/s11154-021-09668-8. Online ahead of print.ABSTRACTType 2 diabetes has been a global health challenge over the decades and is among the leading causes of death. Several treatment approaches have been developed, but more effective and new therapies are still needed. The role of adenosine in glucose and lipid homeostasis has offered a different therapeutic approach. Adenosine mediates its physiological role through the activation of adenosine receptors. These adenosine receptors have been implicated in glucose and lipid homeostasis. The ability of agonists and antagonists of ...
Source: ENDOCR REV - June 24, 2021 Category: Endocrinology Authors: Olakunle Sanni G Terre'Blanche Source Type: research

Therapeutic potentials of agonist and antagonist of adenosine receptors in type 2 diabetes
Rev Endocr Metab Disord. 2021 Jun 24. doi: 10.1007/s11154-021-09668-8. Online ahead of print.ABSTRACTType 2 diabetes has been a global health challenge over the decades and is among the leading causes of death. Several treatment approaches have been developed, but more effective and new therapies are still needed. The role of adenosine in glucose and lipid homeostasis has offered a different therapeutic approach. Adenosine mediates its physiological role through the activation of adenosine receptors. These adenosine receptors have been implicated in glucose and lipid homeostasis. The ability of agonists and antagonists of ...
Source: ENDOCR REV - June 24, 2021 Category: Endocrinology Authors: Olakunle Sanni G Terre'Blanche Source Type: research

Therapeutic potentials of agonist and antagonist of adenosine receptors in type 2 diabetes
Rev Endocr Metab Disord. 2021 Jun 24. doi: 10.1007/s11154-021-09668-8. Online ahead of print.ABSTRACTType 2 diabetes has been a global health challenge over the decades and is among the leading causes of death. Several treatment approaches have been developed, but more effective and new therapies are still needed. The role of adenosine in glucose and lipid homeostasis has offered a different therapeutic approach. Adenosine mediates its physiological role through the activation of adenosine receptors. These adenosine receptors have been implicated in glucose and lipid homeostasis. The ability of agonists and antagonists of ...
Source: ENDOCR REV - June 24, 2021 Category: Endocrinology Authors: Olakunle Sanni G Terre'Blanche Source Type: research

A systematic review of resting-state functional connectivity in obesity: Refining current neurobiological frameworks and methodological considerations moving forward
Rev Endocr Metab Disord. 2021 Jun 23. doi: 10.1007/s11154-021-09665-x. Online ahead of print.ABSTRACTObesity is the second most common cause of preventable morbidity worldwide. Resting-state functional magnetic resonance imaging (fMRI) has been used extensively to characterise altered communication between brain regions in individuals with obesity, though findings from this research have not yet been systematically evaluated within the context of prominent neurobiological frameworks. This systematic review aggregated resting-state fMRI findings in individuals with obesity and evaluated the contribution of these findings to...
Source: ENDOCR REV - June 23, 2021 Category: Endocrinology Authors: Nicholas Parsons Trevor Steward Rebecca Clohesy Hannes Almgren Leonie Duehlmeyer Source Type: research

A systematic review of resting-state functional connectivity in obesity: Refining current neurobiological frameworks and methodological considerations moving forward
Rev Endocr Metab Disord. 2021 Jun 23. doi: 10.1007/s11154-021-09665-x. Online ahead of print.ABSTRACTObesity is the second most common cause of preventable morbidity worldwide. Resting-state functional magnetic resonance imaging (fMRI) has been used extensively to characterise altered communication between brain regions in individuals with obesity, though findings from this research have not yet been systematically evaluated within the context of prominent neurobiological frameworks. This systematic review aggregated resting-state fMRI findings in individuals with obesity and evaluated the contribution of these findings to...
Source: ENDOCR REV - June 23, 2021 Category: Endocrinology Authors: Nicholas Parsons Trevor Steward Rebecca Clohesy Hannes Almgren Leonie Duehlmeyer Source Type: research