Emerging roles of Galectin-3 in diabetes and diabetes complications: A snapshot
Rev Endocr Metab Disord. 2022 Jan 27. doi: 10.1007/s11154-021-09704-7. Online ahead of print.ABSTRACTGalectin-3 is a member of the galectin family, widely expressed in immune cells and plays a role mainly in inflammation, autoimmunity, apoptosis, and chemotaxis. We summarized the roles of Galectin-3 in diabetes and its complications, as well as the underlying mechanisms. Clinical research has determined that the circulating level of Galectin-3 is closely related to diabetes and its complications, thus it is promising to use Galectin-3 as a predictor and biomarker for those diseases. Galectin-3 also may be considered as an ...
Source: ENDOCR REV - January 27, 2022 Category: Endocrinology Authors: Yanhua Li Tian Li Zhiguang Zhou Yang Xiao Source Type: research

Appetitive interoception, the hippocampus and western-style diet
Rev Endocr Metab Disord. 2022 Jan 24. doi: 10.1007/s11154-021-09698-2. Online ahead of print.ABSTRACTObesity, Type 2 diabetes and other metabolic disorders continue to pose serious challenges to human health and well-being. An important source of these challenges is the overconsumption of saturated fats and sugar, main staples of what has been called the Western-style diet (WD). The current paper describes a theoretical model and supporting evidence that links intake of a WD to interference with a specific brain substrate that underlies processing of interoceptive signals of hunger and satiety. We review findings from rats...
Source: ENDOCR REV - January 24, 2022 Category: Endocrinology Authors: Terry L Davidson Richard J Stevenson Source Type: research

Pasireotide-a novel somatostatin receptor ligand after 20  years of use
Rev Endocr Metab Disord. 2022 Jan 24. doi: 10.1007/s11154-022-09710-3. Online ahead of print.ABSTRACTPasireotide, a novel multireceptor-targeted somatostatin receptor ligand (SRL) is characterized by a higher affinity to somatostatin receptor type 5 than type 2, unlike first-generation SRLs. Because of the broader binding profile, pasireotide has been suggested to have a greater clinical efficacy in acromegaly than first-generation SRLs and to be efficacious in Cushing's disease. The consequence of this binding profile is the increased blood glucose level in some patients. This results from the inhibition of both insulin s...
Source: ENDOCR REV - January 24, 2022 Category: Endocrinology Authors: Marek Bolanowski Marcin Ka łużny Przemys ław Witek Aleksandra Jawiarczyk-Przyby łowska Source Type: research

Appetitive interoception, the hippocampus and western-style diet
Rev Endocr Metab Disord. 2022 Jan 24. doi: 10.1007/s11154-021-09698-2. Online ahead of print.ABSTRACTObesity, Type 2 diabetes and other metabolic disorders continue to pose serious challenges to human health and well-being. An important source of these challenges is the overconsumption of saturated fats and sugar, main staples of what has been called the Western-style diet (WD). The current paper describes a theoretical model and supporting evidence that links intake of a WD to interference with a specific brain substrate that underlies processing of interoceptive signals of hunger and satiety. We review findings from rats...
Source: ENDOCR REV - January 24, 2022 Category: Endocrinology Authors: Terry L Davidson Richard J Stevenson Source Type: research

Pasireotide-a novel somatostatin receptor ligand after 20  years of use
Rev Endocr Metab Disord. 2022 Jan 24. doi: 10.1007/s11154-022-09710-3. Online ahead of print.ABSTRACTPasireotide, a novel multireceptor-targeted somatostatin receptor ligand (SRL) is characterized by a higher affinity to somatostatin receptor type 5 than type 2, unlike first-generation SRLs. Because of the broader binding profile, pasireotide has been suggested to have a greater clinical efficacy in acromegaly than first-generation SRLs and to be efficacious in Cushing's disease. The consequence of this binding profile is the increased blood glucose level in some patients. This results from the inhibition of both insulin s...
Source: ENDOCR REV - January 24, 2022 Category: Endocrinology Authors: Marek Bolanowski Marcin Ka łużny Przemys ław Witek Aleksandra Jawiarczyk-Przyby łowska Source Type: research

Appetitive interoception, the hippocampus and western-style diet
Rev Endocr Metab Disord. 2022 Jan 24. doi: 10.1007/s11154-021-09698-2. Online ahead of print.ABSTRACTObesity, Type 2 diabetes and other metabolic disorders continue to pose serious challenges to human health and well-being. An important source of these challenges is the overconsumption of saturated fats and sugar, main staples of what has been called the Western-style diet (WD). The current paper describes a theoretical model and supporting evidence that links intake of a WD to interference with a specific brain substrate that underlies processing of interoceptive signals of hunger and satiety. We review findings from rats...
Source: ENDOCR REV - January 24, 2022 Category: Endocrinology Authors: Terry L Davidson Richard J Stevenson Source Type: research

Pasireotide-a novel somatostatin receptor ligand after 20  years of use
Rev Endocr Metab Disord. 2022 Jan 24. doi: 10.1007/s11154-022-09710-3. Online ahead of print.ABSTRACTPasireotide, a novel multireceptor-targeted somatostatin receptor ligand (SRL) is characterized by a higher affinity to somatostatin receptor type 5 than type 2, unlike first-generation SRLs. Because of the broader binding profile, pasireotide has been suggested to have a greater clinical efficacy in acromegaly than first-generation SRLs and to be efficacious in Cushing's disease. The consequence of this binding profile is the increased blood glucose level in some patients. This results from the inhibition of both insulin s...
Source: ENDOCR REV - January 24, 2022 Category: Endocrinology Authors: Marek Bolanowski Marcin Ka łużny Przemys ław Witek Aleksandra Jawiarczyk-Przyby łowska Source Type: research

A systematic review of multimodal clinical biomarkers in the management of thyroid eye disease
Rev Endocr Metab Disord. 2022 Jan 23. doi: 10.1007/s11154-021-09702-9. Online ahead of print.ABSTRACTThyroid Eye Disease (TED) is an autoimmune disease that affects the extraocular muscles and periorbital fat. It most commonly occurs with Graves' Disease (GD) as an extrathyroidal manifestation, hence, it is also sometimes used interchangeably with Graves' Ophthalmopathy (GO). Well-known autoimmune markers for GD include thyroid stimulating hormone (TSH) receptor antibodies (TSH-R-Ab) which contribute to hyperthyroidism and ocular signs. Currently, apart from radiological investigations, detection of TED is based on clinica...
Source: ENDOCR REV - January 23, 2022 Category: Endocrinology Authors: Stephanie Hiu Ling Poon Janice Jing-Chee Cheung Kendrick Co Shih Yau Kei Chan Source Type: research

Mechanisms linking obesity and its metabolic comorbidities with cerebral grey and white matter changes
Rev Endocr Metab Disord. 2022 Jan 21. doi: 10.1007/s11154-021-09706-5. Online ahead of print.ABSTRACTObesity is a preventable risk factor for cerebrovascular disorders and it is associated with cerebral grey and white matter changes. Specifically, individuals with obesity show diminished grey matter volume and thickness, which seems to be more prominent among fronto-temporal regions in the brain. At the same time, obesity is associated with lower microstructural white matter integrity, and it has been found to precede increases in white matter hyperintensity load. To date, however, it is unclear whether these findings can ...
Source: ENDOCR REV - January 21, 2022 Category: Endocrinology Authors: Isabel Garc ía-García Andr éanne Michaud Mar ía Ángeles Jurado Alain Dagher Filip Morys Source Type: research

Mechanisms linking obesity and its metabolic comorbidities with cerebral grey and white matter changes
Rev Endocr Metab Disord. 2022 Jan 21. doi: 10.1007/s11154-021-09706-5. Online ahead of print.ABSTRACTObesity is a preventable risk factor for cerebrovascular disorders and it is associated with cerebral grey and white matter changes. Specifically, individuals with obesity show diminished grey matter volume and thickness, which seems to be more prominent among fronto-temporal regions in the brain. At the same time, obesity is associated with lower microstructural white matter integrity, and it has been found to precede increases in white matter hyperintensity load. To date, however, it is unclear whether these findings can ...
Source: ENDOCR REV - January 21, 2022 Category: Endocrinology Authors: Isabel Garc ía-García Andr éanne Michaud Mar ía Ángeles Jurado Alain Dagher Filip Morys Source Type: research

Mechanisms linking obesity and its metabolic comorbidities with cerebral grey and white matter changes
Rev Endocr Metab Disord. 2022 Jan 21. doi: 10.1007/s11154-021-09706-5. Online ahead of print.ABSTRACTObesity is a preventable risk factor for cerebrovascular disorders and it is associated with cerebral grey and white matter changes. Specifically, individuals with obesity show diminished grey matter volume and thickness, which seems to be more prominent among fronto-temporal regions in the brain. At the same time, obesity is associated with lower microstructural white matter integrity, and it has been found to precede increases in white matter hyperintensity load. To date, however, it is unclear whether these findings can ...
Source: ENDOCR REV - January 21, 2022 Category: Endocrinology Authors: Isabel Garc ía-García Andr éanne Michaud Mar ía Ángeles Jurado Alain Dagher Filip Morys Source Type: research

The endocrine adipose organ
Rev Endocr Metab Disord. 2022 Jan 19:1-4. doi: 10.1007/s11154-022-09709-w. Online ahead of print.NO ABSTRACTPMID:35048260 | PMC:PMC8769372 | DOI:10.1007/s11154-022-09709-w (Source: ENDOCR REV)
Source: ENDOCR REV - January 20, 2022 Category: Endocrinology Authors: Saverio Cinti Source Type: research

The endocrine adipose organ
Rev Endocr Metab Disord. 2022 Jan 19. doi: 10.1007/s11154-022-09709-w. Online ahead of print.NO ABSTRACTPMID:35048260 | DOI:10.1007/s11154-022-09709-w (Source: ENDOCR REV)
Source: ENDOCR REV - January 20, 2022 Category: Endocrinology Authors: Saverio Cinti Source Type: research

The efficacy and safety of cinacalcet in primary hyperparathyroidism: a systematic review and meta-analysis of randomized controlled trials and cohort studies
Rev Endocr Metab Disord. 2022 Jan 18. doi: 10.1007/s11154-021-09694-6. Online ahead of print.ABSTRACTCinacalcet, a positive allosteric modulator of the calcium sensing receptor (CaSR) reduces parathyroid hormone (PTH) secretion by increasing the sensitivity of the CaSR on parathyroid cells. We conducted a systematic review and meta-analysis on the safety and efficacy of cinacalcet in Primary Hyperparathyroidism (PHPT). MEDLINE, Embase, BIOSIS, and the Cochrane Library were searched for published articles (from database inception to Sept 2020). All double-blind RCTs and cohort studies that reported data on the efficacy and ...
Source: ENDOCR REV - January 18, 2022 Category: Endocrinology Authors: Manju Chandran John P Bilezikian Joel Lau Reshma Rajeev Samantha Peiling Yang Miny Samuel Rajeev Parameswaran Source Type: research

A clinical update on Gestational Diabetes Mellitus
Endocr Rev. 2022 Jan 18:bnac003. doi: 10.1210/endrev/bnac003. Online ahead of print.ABSTRACTGestational diabetes mellitus (GDM) traditionally refers to abnormal glucose tolerance with onset or first recognition during pregnancy (1). GDM has long been associated with obstetric and neonatal complications primarily relating to higher infant birthweight and is increasingly recognised as a risk factor for future maternal and offspring cardiometabolic disease. The prevalence of GDM continues to rise internationally due to epidemiological factors including the increase in background rates of obesity in women of reproductive age a...
Source: ENDOCR REV - January 18, 2022 Category: Endocrinology Authors: Arianne Sweeting Jencia Wong Helen R Murphy Glynis P Ross Source Type: research

The efficacy and safety of cinacalcet in primary hyperparathyroidism: a systematic review and meta-analysis of randomized controlled trials and cohort studies
Rev Endocr Metab Disord. 2022 Jan 18. doi: 10.1007/s11154-021-09694-6. Online ahead of print.ABSTRACTCinacalcet, a positive allosteric modulator of the calcium sensing receptor (CaSR) reduces parathyroid hormone (PTH) secretion by increasing the sensitivity of the CaSR on parathyroid cells. We conducted a systematic review and meta-analysis on the safety and efficacy of cinacalcet in Primary Hyperparathyroidism (PHPT). MEDLINE, Embase, BIOSIS, and the Cochrane Library were searched for published articles (from database inception to Sept 2020). All double-blind RCTs and cohort studies that reported data on the efficacy and ...
Source: ENDOCR REV - January 18, 2022 Category: Endocrinology Authors: Manju Chandran John P Bilezikian Joel Lau Reshma Rajeev Samantha Peiling Yang Miny Samuel Rajeev Parameswaran Source Type: research

A clinical update on Gestational Diabetes Mellitus
Endocr Rev. 2022 Jan 18:bnac003. doi: 10.1210/endrev/bnac003. Online ahead of print.ABSTRACTGestational diabetes mellitus (GDM) traditionally refers to abnormal glucose tolerance with onset or first recognition during pregnancy (1). GDM has long been associated with obstetric and neonatal complications primarily relating to higher infant birthweight and is increasingly recognised as a risk factor for future maternal and offspring cardiometabolic disease. The prevalence of GDM continues to rise internationally due to epidemiological factors including the increase in background rates of obesity in women of reproductive age a...
Source: ENDOCR REV - January 18, 2022 Category: Endocrinology Authors: Arianne Sweeting Jencia Wong Helen R Murphy Glynis P Ross Source Type: research

Role of anatomical location, cellular phenotype and perfusion of adipose tissue in intermediary metabolism: A narrative review
Rev Endocr Metab Disord. 2022 Jan 15. doi: 10.1007/s11154-021-09708-3. Online ahead of print.ABSTRACTIt is well-established that adipose tissue accumulation is associated with insulin resistance through multiple mechanisms. One major metabolic link is the classical Randle cycle: enhanced release of free fatty acids (FFA) from hydrolysis of adipose tissue triglycerides impedes insulin-mediated glucose uptake in muscle tissues. Less well studied are the different routes of this communication. First, white adipose tissue depots may be regionally distant from muscle (i.e., gluteal fat and diaphragm muscle) or contiguous to mus...
Source: ENDOCR REV - January 15, 2022 Category: Endocrinology Authors: Stefania Camastra Ele Ferrannini Source Type: research

Role of anatomical location, cellular phenotype and perfusion of adipose tissue in intermediary metabolism: A narrative review
Rev Endocr Metab Disord. 2022 Jan 15. doi: 10.1007/s11154-021-09708-3. Online ahead of print.ABSTRACTIt is well-established that adipose tissue accumulation is associated with insulin resistance through multiple mechanisms. One major metabolic link is the classical Randle cycle: enhanced release of free fatty acids (FFA) from hydrolysis of adipose tissue triglycerides impedes insulin-mediated glucose uptake in muscle tissues. Less well studied are the different routes of this communication. First, white adipose tissue depots may be regionally distant from muscle (i.e., gluteal fat and diaphragm muscle) or contiguous to mus...
Source: ENDOCR REV - January 15, 2022 Category: Endocrinology Authors: Stefania Camastra Ele Ferrannini Source Type: research

Role of anatomical location, cellular phenotype and perfusion of adipose tissue in intermediary metabolism: A narrative review
Rev Endocr Metab Disord. 2022 Jan 15. doi: 10.1007/s11154-021-09708-3. Online ahead of print.ABSTRACTIt is well-established that adipose tissue accumulation is associated with insulin resistance through multiple mechanisms. One major metabolic link is the classical Randle cycle: enhanced release of free fatty acids (FFA) from hydrolysis of adipose tissue triglycerides impedes insulin-mediated glucose uptake in muscle tissues. Less well studied are the different routes of this communication. First, white adipose tissue depots may be regionally distant from muscle (i.e., gluteal fat and diaphragm muscle) or contiguous to mus...
Source: ENDOCR REV - January 15, 2022 Category: Endocrinology Authors: Stefania Camastra Ele Ferrannini Source Type: research

Deconstructing a Syndrome: Genomic Insights into PCOS Causal Mechanisms and Classification
Endocr Rev. 2022 Jan 13:bnac001. doi: 10.1210/endrev/bnac001. Online ahead of print.ABSTRACTPolycystic ovary syndrome (PCOS) is among the most common disorders of reproductive-age women, affecting up to 15% worldwide, depending on the diagnostic criteria. PCOS is characterized by a constellation of interrelated reproductive abnormalities including disordered gonadotropin secretion, increased androgen production, chronic anovulation, and polycystic ovarian morphology. It is frequently associated with insulin resistance and obesity. These reproductive and metabolic derangements cause major morbidities across the lifespan, in...
Source: ENDOCR REV - January 13, 2022 Category: Endocrinology Authors: Matthew Dapas Andrea Dunaif Source Type: research

Deconstructing a Syndrome: Genomic Insights into PCOS Causal Mechanisms and Classification
Endocr Rev. 2022 Jan 13:bnac001. doi: 10.1210/endrev/bnac001. Online ahead of print.ABSTRACTPolycystic ovary syndrome (PCOS) is among the most common disorders of reproductive-age women, affecting up to 15% worldwide, depending on the diagnostic criteria. PCOS is characterized by a constellation of interrelated reproductive abnormalities including disordered gonadotropin secretion, increased androgen production, chronic anovulation, and polycystic ovarian morphology. It is frequently associated with insulin resistance and obesity. These reproductive and metabolic derangements cause major morbidities across the lifespan, in...
Source: ENDOCR REV - January 13, 2022 Category: Endocrinology Authors: Matthew Dapas Andrea Dunaif Source Type: research

Semaglutide, a glucagon like peptide-1 receptor agonist with cardiovascular benefits for management of type 2 diabetes
Rev Endocr Metab Disord. 2022 Jan 7:1-19. doi: 10.1007/s11154-021-09699-1. Online ahead of print.ABSTRACTSemaglutide, a glucagon like peptide-1 (GLP-1) receptor agonist, is available as monotherapy in both subcutaneous as well as oral dosage form (first approved oral GLP-1 receptor agonist). It has been approved as a second line treatment option for better glycaemic control in type 2 diabetes and currently under scrutiny for anti-obesity purpose. Semaglutide has been proved to be safe in adults and elderly patients with renal or hepatic disorders demanding no dose modification. Cardiovascular (CV) outcome trials establishe...
Source: ENDOCR REV - January 7, 2022 Category: Endocrinology Authors: Manoj Kumar Mahapatra Muthukumar Karuppasamy Biswa Mohan Sahoo Source Type: research

Semaglutide, a glucagon like peptide-1 receptor agonist with cardiovascular benefits for management of type 2 diabetes
Rev Endocr Metab Disord. 2022 Jan 7:1-19. doi: 10.1007/s11154-021-09699-1. Online ahead of print.ABSTRACTSemaglutide, a glucagon like peptide-1 (GLP-1) receptor agonist, is available as monotherapy in both subcutaneous as well as oral dosage form (first approved oral GLP-1 receptor agonist). It has been approved as a second line treatment option for better glycaemic control in type 2 diabetes and currently under scrutiny for anti-obesity purpose. Semaglutide has been proved to be safe in adults and elderly patients with renal or hepatic disorders demanding no dose modification. Cardiovascular (CV) outcome trials establishe...
Source: ENDOCR REV - January 7, 2022 Category: Endocrinology Authors: Manoj Kumar Mahapatra Muthukumar Karuppasamy Biswa Mohan Sahoo Source Type: research

Semaglutide, a glucagon like peptide-1 receptor agonist with cardiovascular benefits for management of type 2 diabetes
Rev Endocr Metab Disord. 2022 Jan 7:1-19. doi: 10.1007/s11154-021-09699-1. Online ahead of print.ABSTRACTSemaglutide, a glucagon like peptide-1 (GLP-1) receptor agonist, is available as monotherapy in both subcutaneous as well as oral dosage form (first approved oral GLP-1 receptor agonist). It has been approved as a second line treatment option for better glycaemic control in type 2 diabetes and currently under scrutiny for anti-obesity purpose. Semaglutide has been proved to be safe in adults and elderly patients with renal or hepatic disorders demanding no dose modification. Cardiovascular (CV) outcome trials establishe...
Source: ENDOCR REV - January 7, 2022 Category: Endocrinology Authors: Manoj Kumar Mahapatra Muthukumar Karuppasamy Biswa Mohan Sahoo Source Type: research

Semaglutide, a glucagon like peptide-1 receptor agonist with cardiovascular benefits for management of type 2 diabetes
Rev Endocr Metab Disord. 2022 Jan 7:1-19. doi: 10.1007/s11154-021-09699-1. Online ahead of print.ABSTRACTSemaglutide, a glucagon like peptide-1 (GLP-1) receptor agonist, is available as monotherapy in both subcutaneous as well as oral dosage form (first approved oral GLP-1 receptor agonist). It has been approved as a second line treatment option for better glycaemic control in type 2 diabetes and currently under scrutiny for anti-obesity purpose. Semaglutide has been proved to be safe in adults and elderly patients with renal or hepatic disorders demanding no dose modification. Cardiovascular (CV) outcome trials establishe...
Source: ENDOCR REV - January 7, 2022 Category: Endocrinology Authors: Manoj Kumar Mahapatra Muthukumar Karuppasamy Biswa Mohan Sahoo Source Type: research

Interactions between emotions and eating behaviors: Main issues, neuroimaging contributions, and innovative preventive or corrective strategies
Rev Endocr Metab Disord. 2022 Jan 4. doi: 10.1007/s11154-021-09700-x. Online ahead of print.ABSTRACTEmotional eating is commonly defined as the tendency to (over)eat in response to emotion. Insofar as it involves the (over)consumption of high-calorie palatable foods, emotional eating is a maladaptive behavior that can lead to eating disorders, and ultimately to metabolic disorders and obesity. Emotional eating is associated with eating disorder subtypes and with abnormalities in emotion processing at a behavioral level. However, not enough is known about the neural pathways involved in both emotion processing and food inta...
Source: ENDOCR REV - January 5, 2022 Category: Endocrinology Authors: Ambre Godet Alexandra Fortier Elise Bannier Nicolas Coquery David Val-Laillet Source Type: research

Association of vitamin D status with COVID-19 and its severity : Vitamin D and COVID-19: a narrative review
Rev Endocr Metab Disord. 2022 Jan 4:1-21. doi: 10.1007/s11154-021-09705-6. Online ahead of print.ABSTRACTVitamin D is associated with biological activities of the innate and adaptive immune systems, as well as inflammation. In observational studies, an inverse relationship has been found between serum 25-hydroxyvitamin D (25(OH)D) concentrations and the risk or severity of coronavirus disease 2019 (COVID-19). Several mechanisms have been proposed for the role of vitamin D in COVID-19, including modulation of immune and inflammatory responses, regulation of the renin-angiotensin-aldosterone system, and involvement in glucos...
Source: ENDOCR REV - January 4, 2022 Category: Endocrinology Authors: Jae Hyun Bae Hun Jee Choe Michael F Holick Soo Lim Source Type: research

Stem cells and organs-on-chips: new promising technologies for human infertility treatment
Endocr Rev. 2021 Dec 30:bnab047. doi: 10.1210/endrev/bnab047. Online ahead of print.ABSTRACTHaving biological children remains an unattainable dream for most couples with reproductive failure or gonadal dysgenesis. The combination of stem cells with gene editing technology and organ-on-a-chip models provides unique opportunity for infertile patients with impaired gametogenesis caused by congenital disorders in sex development or cancer survivors. But, how will these technologies overcome human infertility? This review discusses the regenerative mechanisms, applications and advantages of different types of stem cells for re...
Source: ENDOCR REV - December 30, 2021 Category: Endocrinology Authors: Eisa Tahmasbpour Marzouni Andrew Henrik Sinclair Catharyn Stern Elena Jane Tucker Source Type: research

Stem cells and organs-on-chips: new promising technologies for human infertility treatment
Endocr Rev. 2021 Dec 30:bnab047. doi: 10.1210/endrev/bnab047. Online ahead of print.ABSTRACTHaving biological children remains an unattainable dream for most couples with reproductive failure or gonadal dysgenesis. The combination of stem cells with gene editing technology and organ-on-a-chip models provides unique opportunity for infertile patients with impaired gametogenesis caused by congenital disorders in sex development or cancer survivors. But, how will these technologies overcome human infertility? This review discusses the regenerative mechanisms, applications and advantages of different types of stem cells for re...
Source: ENDOCR REV - December 30, 2021 Category: Endocrinology Authors: Eisa Tahmasbpour Marzouni Andrew Henrik Sinclair Catharyn Stern Elena Jane Tucker Source Type: research

Stem cells and organs-on-chips: new promising technologies for human infertility treatment
Endocr Rev. 2021 Dec 30:bnab047. doi: 10.1210/endrev/bnab047. Online ahead of print.ABSTRACTHaving biological children remains an unattainable dream for most couples with reproductive failure or gonadal dysgenesis. The combination of stem cells with gene editing technology and organ-on-a-chip models provides unique opportunity for infertile patients with impaired gametogenesis caused by congenital disorders in sex development or cancer survivors. But, how will these technologies overcome human infertility? This review discusses the regenerative mechanisms, applications and advantages of different types of stem cells for re...
Source: ENDOCR REV - December 30, 2021 Category: Endocrinology Authors: Eisa Tahmasbpour Marzouni Andrew Henrik Sinclair Catharyn Stern Elena Jane Tucker Source Type: research

Stem cells and organs-on-chips: new promising technologies for human infertility treatment
Endocr Rev. 2021 Dec 30:bnab047. doi: 10.1210/endrev/bnab047. Online ahead of print.ABSTRACTHaving biological children remains an unattainable dream for most couples with reproductive failure or gonadal dysgenesis. The combination of stem cells with gene editing technology and organ-on-a-chip models provides unique opportunity for infertile patients with impaired gametogenesis caused by congenital disorders in sex development or cancer survivors. But, how will these technologies overcome human infertility? This review discusses the regenerative mechanisms, applications and advantages of different types of stem cells for re...
Source: ENDOCR REV - December 30, 2021 Category: Endocrinology Authors: Eisa Tahmasbpour Marzouni Andrew Henrik Sinclair Catharyn Stern Elena Jane Tucker Source Type: research

Hypothalamic-Pituitary and Other Endocrine Surveillance Among Childhood Cancer Survivors
Endocr Rev. 2021 Nov 20:bnab040. doi: 10.1210/endrev/bnab040. Online ahead of print.ABSTRACTEndocrine disorders in survivors of childhood, adolescent, and young adult (CAYA) cancers are associated with substantial adverse physical and psychosocial effects. To improve appropriate and timely endocrine screening and referral to a specialist, the International Late Effects of Childhood Cancer Guideline Harmonization Group (IGHG) aims to develop evidence and expert consensus-based guidelines for healthcare providers that harmonize recommendations for surveillance of endocrine disorders in CAYA cancer survivors. Existing IGHG su...
Source: ENDOCR REV - December 28, 2021 Category: Endocrinology Authors: Laura van Iersel Renee L Mulder Christian Denzer Laurie E Cohen Helen A Spoudeas Lillian R Meacham Elaine Sugden Antoinette Y N Schouten-van Meeteren Eelco W Hoving Roger J Packer Gregory T Armstrong Sogol Mostoufi-Moab Aline M Stades Dannis van Vuurden G Source Type: research

Hypothalamic-Pituitary and Other Endocrine Surveillance Among Childhood Cancer Survivors
Endocr Rev. 2021 Nov 20:bnab040. doi: 10.1210/endrev/bnab040. Online ahead of print.ABSTRACTEndocrine disorders in survivors of childhood, adolescent, and young adult (CAYA) cancers are associated with substantial adverse physical and psychosocial effects. To improve appropriate and timely endocrine screening and referral to a specialist, the International Late Effects of Childhood Cancer Guideline Harmonization Group (IGHG) aims to develop evidence and expert consensus-based guidelines for healthcare providers that harmonize recommendations for surveillance of endocrine disorders in CAYA cancer survivors. Existing IGHG su...
Source: ENDOCR REV - December 28, 2021 Category: Endocrinology Authors: Laura van Iersel Renee L Mulder Christian Denzer Laurie E Cohen Helen A Spoudeas Lillian R Meacham Elaine Sugden Antoinette Y N Schouten-van Meeteren Eelco W Hoving Roger J Packer Gregory T Armstrong Sogol Mostoufi-Moab Aline M Stades Dannis van Vuurden G Source Type: research

Computational approaches to predicting treatment response to obesity using neuroimaging
Rev Endocr Metab Disord. 2021 Dec 23. doi: 10.1007/s11154-021-09701-w. Online ahead of print.ABSTRACTObesity is a worldwide disease associated with multiple severe adverse consequences and comorbid conditions. While an increased body weight is the defining feature in obesity, etiologies, clinical phenotypes and treatment responses vary between patients. These variations can be observed within individual treatment options which comprise lifestyle interventions, pharmacological treatment, and bariatric surgery. Bariatric surgery can be regarded as the most effective treatment method. However, long-term weight regain is compa...
Source: ENDOCR REV - December 24, 2021 Category: Endocrinology Authors: Leonard Kozarzewski Lukas Maurer Anja M ähler Joachim Spranger Martin Weygandt Source Type: research

Computational approaches to predicting treatment response to obesity using neuroimaging
Rev Endocr Metab Disord. 2021 Dec 23. doi: 10.1007/s11154-021-09701-w. Online ahead of print.ABSTRACTObesity is a worldwide disease associated with multiple severe adverse consequences and comorbid conditions. While an increased body weight is the defining feature in obesity, etiologies, clinical phenotypes and treatment responses vary between patients. These variations can be observed within individual treatment options which comprise lifestyle interventions, pharmacological treatment, and bariatric surgery. Bariatric surgery can be regarded as the most effective treatment method. However, long-term weight regain is compa...
Source: ENDOCR REV - December 24, 2021 Category: Endocrinology Authors: Leonard Kozarzewski Lukas Maurer Anja M ähler Joachim Spranger Martin Weygandt Source Type: research

Computational approaches to predicting treatment response to obesity using neuroimaging
Rev Endocr Metab Disord. 2021 Dec 23. doi: 10.1007/s11154-021-09701-w. Online ahead of print.ABSTRACTObesity is a worldwide disease associated with multiple severe adverse consequences and comorbid conditions. While an increased body weight is the defining feature in obesity, etiologies, clinical phenotypes and treatment responses vary between patients. These variations can be observed within individual treatment options which comprise lifestyle interventions, pharmacological treatment, and bariatric surgery. Bariatric surgery can be regarded as the most effective treatment method. However, long-term weight regain is compa...
Source: ENDOCR REV - December 24, 2021 Category: Endocrinology Authors: Leonard Kozarzewski Lukas Maurer Anja M ähler Joachim Spranger Martin Weygandt Source Type: research

Computational approaches to predicting treatment response to obesity using neuroimaging
Rev Endocr Metab Disord. 2021 Dec 23. doi: 10.1007/s11154-021-09701-w. Online ahead of print.ABSTRACTObesity is a worldwide disease associated with multiple severe adverse consequences and comorbid conditions. While an increased body weight is the defining feature in obesity, etiologies, clinical phenotypes and treatment responses vary between patients. These variations can be observed within individual treatment options which comprise lifestyle interventions, pharmacological treatment, and bariatric surgery. Bariatric surgery can be regarded as the most effective treatment method. However, long-term weight regain is compa...
Source: ENDOCR REV - December 24, 2021 Category: Endocrinology Authors: Leonard Kozarzewski Lukas Maurer Anja M ähler Joachim Spranger Martin Weygandt Source Type: research

Vitamin D: Dosing, levels, form, and route of administration: Does one approach fit all?
Rev Endocr Metab Disord. 2021 Dec 23:1-18. doi: 10.1007/s11154-021-09693-7. Online ahead of print.ABSTRACTThe 4th International Conference on Controversies in Vitamin D was held as a virtual meeting in September, 2020, gathering together leading international scientific and medical experts in vitamin D. Since vitamin D has a crucial role in skeletal and extra-skeletal systems, the aim of the Conference was to discuss improved management of vitamin D dosing, therapeutic levels and form or route of administration in the general population and in different clinical conditions. A tailored approach, based on the specific mechan...
Source: ENDOCR REV - December 23, 2021 Category: Endocrinology Authors: John P Bilezikian Anna Maria Formenti Robert A Adler Neil Binkley Roger Bouillon Marise Lazaretti-Castro Claudio Marcocci Nicola Napoli Rene Rizzoli Andrea Giustina Source Type: research

Novel insights into adipose tissue heterogeneity
Rev Endocr Metab Disord. 2021 Dec 21. doi: 10.1007/s11154-021-09703-8. Online ahead of print.ABSTRACTWhen normalized to volume, adipose tissue is comprised mainly of large lipid metabolizing and storing cells called adipocytes. Strikingly, the numerical representation of non-adipocytes, composed of a wide variety of cell types found in the so-called stromal vascular fraction (SVF), outnumber adipocytes by far. Besides its function in energy storage, adipose tissue has emerged as a versatile organ that regulates systemic metabolism and has therefore constituted an attractive target for the treatment of metabolic diseases. R...
Source: ENDOCR REV - December 22, 2021 Category: Endocrinology Authors: Tongtong Wang Anand Kumar Sharma Christian Wolfrum Source Type: research

Novel insights into adipose tissue heterogeneity
Rev Endocr Metab Disord. 2021 Dec 21. doi: 10.1007/s11154-021-09703-8. Online ahead of print.ABSTRACTWhen normalized to volume, adipose tissue is comprised mainly of large lipid metabolizing and storing cells called adipocytes. Strikingly, the numerical representation of non-adipocytes, composed of a wide variety of cell types found in the so-called stromal vascular fraction (SVF), outnumber adipocytes by far. Besides its function in energy storage, adipose tissue has emerged as a versatile organ that regulates systemic metabolism and has therefore constituted an attractive target for the treatment of metabolic diseases. R...
Source: ENDOCR REV - December 22, 2021 Category: Endocrinology Authors: Tongtong Wang Anand Kumar Sharma Christian Wolfrum Source Type: research

Erratum to: Personalized Management of Pheochromocytoma and Paraganglioma
Endocr Rev. 2021 Dec 14:bnab044. doi: 10.1210/endrev/bnab044. Online ahead of print.NO ABSTRACTPMID:34904637 | DOI:10.1210/endrev/bnab044 (Source: ENDOCR REV)
Source: ENDOCR REV - December 14, 2021 Category: Endocrinology Source Type: research

Corrigendum to: Personalized Management of Pheochromocytoma and Paraganglioma
Endocr Rev. 2021 Dec 14:bnab045. doi: 10.1210/endrev/bnab045. Online ahead of print.NO ABSTRACTPMID:34904662 | DOI:10.1210/endrev/bnab045 (Source: ENDOCR REV)
Source: ENDOCR REV - December 14, 2021 Category: Endocrinology Source Type: research

Erratum to: Personalized Management of Pheochromocytoma and Paraganglioma
Endocr Rev. 2021 Dec 14:bnab044. doi: 10.1210/endrev/bnab044. Online ahead of print.NO ABSTRACTPMID:34904637 | DOI:10.1210/endrev/bnab044 (Source: ENDOCR REV)
Source: ENDOCR REV - December 14, 2021 Category: Endocrinology Source Type: research

Corrigendum to: Personalized Management of Pheochromocytoma and Paraganglioma
Endocr Rev. 2021 Dec 14:bnab045. doi: 10.1210/endrev/bnab045. Online ahead of print.NO ABSTRACTPMID:34904662 | DOI:10.1210/endrev/bnab045 (Source: ENDOCR REV)
Source: ENDOCR REV - December 14, 2021 Category: Endocrinology Source Type: research

Erratum to: Personalized Management of Pheochromocytoma and Paraganglioma
Endocr Rev. 2021 Dec 14:bnab044. doi: 10.1210/endrev/bnab044. Online ahead of print.NO ABSTRACTPMID:34904637 | DOI:10.1210/endrev/bnab044 (Source: ENDOCR REV)
Source: ENDOCR REV - December 14, 2021 Category: Endocrinology Source Type: research

Corrigendum to: Personalized Management of Pheochromocytoma and Paraganglioma
Endocr Rev. 2021 Dec 14:bnab045. doi: 10.1210/endrev/bnab045. Online ahead of print.NO ABSTRACTPMID:34904662 | DOI:10.1210/endrev/bnab045 (Source: ENDOCR REV)
Source: ENDOCR REV - December 14, 2021 Category: Endocrinology Source Type: research

Erratum to: Personalized Management of Pheochromocytoma and Paraganglioma
Endocr Rev. 2021 Dec 14:bnab044. doi: 10.1210/endrev/bnab044. Online ahead of print.NO ABSTRACTPMID:34904637 | DOI:10.1210/endrev/bnab044 (Source: ENDOCR REV)
Source: ENDOCR REV - December 14, 2021 Category: Endocrinology Source Type: research

Corrigendum to: Personalized Management of Pheochromocytoma and Paraganglioma
Endocr Rev. 2021 Dec 14:bnab045. doi: 10.1210/endrev/bnab045. Online ahead of print.NO ABSTRACTPMID:34904662 | DOI:10.1210/endrev/bnab045 (Source: ENDOCR REV)
Source: ENDOCR REV - December 14, 2021 Category: Endocrinology Source Type: research

Erratum to: Personalized Management of Pheochromocytoma and Paraganglioma
Endocr Rev. 2021 Dec 14:bnab044. doi: 10.1210/endrev/bnab044. Online ahead of print.NO ABSTRACTPMID:34904637 | DOI:10.1210/endrev/bnab044 (Source: ENDOCR REV)
Source: ENDOCR REV - December 14, 2021 Category: Endocrinology Source Type: research