The Scope of Practice of an Outpatient Pediatric Palliative Care Oncology Clinic
1. Describe the spectrum of provider-reported pediatric palliative care domains discussed and managed during pediatric palliative care - oncology clinic visits and how these differ across initial and follow-up visits.2. Compare the differences in palliative care domains addressed and managed in visits with pediatric patients with brain tumors versus solid tumors vs leukemia/lymphoma. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Hee Su Park, Nicholas DeGroote, Anna Lange, Dio Kavalieratos, Katharine E. Brock Source Type: research
Cancers, Vol. 16, Pages 1576: Focused Ultrasound-Enhanced Liquid Biopsy: A Promising Diagnostic Tool for Brain Tumor Patients
In conclusion, FUS-BBBO-enhanced liquid biopsy using stable cavitation shows diagnostic potential for primary brain tumors. Further research is imperative before integrating FUS-BBBO for liquid biopsy enhancement into clinical practice. (Source: Cancers)
Source: Cancers - April 19, 2024 Category: Cancer & Oncology Authors: Akke Bakker Anna E. Ixkes Hema Venugopal Mario G. Ries Nathalie S. M. Lak Filip Y. F. L. de Vos Dannis G. van Vuurden Tom J. Snijders Tags: Systematic Review Source Type: research
Cancers, Vol. 16, Pages 1566: Advancements in Image-Based Models for High-Grade Gliomas Might Be Accelerated
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The first half of 2022 saw the publication of several major research advances in image-based models and artificial intelligence applications to optimize treatment strategies for high-grade gliomas, the deadliest brain tumors. We review them and discuss the barriers that delay their entry into clinical practice; particularly, the small sample size and the heterogeneity of the study designs and methodologies used. We will also write about the poor and late palliation that patients suffering from high-grade glioma can count on at the end of life, as well as the current legislative instruments, with particular reference ...
Source: Cancers - April 19, 2024 Category: Cancer & Oncology Authors: Guido Frosina Tags: Review Source Type: research
The role of [18 F]FDOPA PET as an adjunct to conventional MRI in the diagnosis of aggressive glial lesions
ConclusionDynamic [18 F]FDOPA PET provides a similar diagnostic accuracy as contrast enhancement in MRI to identify the aggressiveness of suspected glial lesions at diagnosis. Both methods, however, are complementary and [18 F]FDOPA PET may be a useful additional tool in equivocal cases. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 19, 2024 Category: Nuclear Medicine Source Type: research
PRMT6-mediated transcriptional activation of ythdf2 promotes glioblastoma migration, invasion, and emt via the wnt- β-catenin pathway
CONCLUSIONS: Our results demonstrate the PRMT6-YTHDF2-Wnt-β-Catenin axis promotes GBM migration, invasion, and EMT in vitro and in vivo, potentially serving as a therapeutic target for GBM.PMID:38637831 | DOI:10.1186/s13046-024-03038-3 (Source: Cell Research)
Source: Cell Research - April 18, 2024 Category: Cytology Authors: Peng Yu Tutu Xu Wenmeng Ma Xiang Fang Yue Bao Chengran Xu Jinhai Huang Yongqing Sun Guangyu Li Source Type: research
Deuterium metabolic imaging differentiates glioblastoma metabolic subtypes and detects early response to chemoradiotherapy
Cancer Res. 2024 Apr 18. doi: 10.1158/0008-5472.CAN-23-2552. Online ahead of print.ABSTRACTMetabolic subtypes of glioblastoma have different prognoses and responses to treatment. Deuterium metabolic imaging with 2H-labeled substrates is a potential approach to stratify patients into metabolic subtypes for targeted treatment. Here, we used 2H magnetic resonance spectroscopy (MRS) and spectroscopic imaging (MRSI) measurements of [6,6'-2H2]glucose metabolism to identify metabolic subtypes and their responses to chemoradiotherapy in patient-derived glioblastoma xenografts in vivo. The metabolism of patient-derived cells was fi...
Source: Cell Research - April 18, 2024 Category: Cytology Authors: Jacob Chen Ming Low Jianbo Cao Friederike Hesse Alan J Wright Anastasia Tsyben Islam Alshamleh Richard Mair Kevin M Brindle Source Type: research
Vascular mimicry as a facilitator of melanoma brain metastasis
Cell Mol Life Sci. 2024 Apr 18;81(1):188. doi: 10.1007/s00018-024-05217-z.ABSTRACTMelanoma has the highest propensity among solid tumors to metastasize to the brain. Melanoma brain metastases (MBM) are a leading cause of death in melanoma and affect 40-60% of patients with late-stage disease. Therefore, uncovering the molecular mechanisms behind MBM is necessary to enhance therapeutic interventions. Vascular mimicry (VM) is a form of neovascularization linked to invasion, increased risk of metastasis, and poor prognosis in many tumor types, but its significance in MBM remains poorly understood. We found that VM density is ...
Source: Cellular and Molecular Life Sciences : CMLS - April 18, 2024 Category: Cytology Authors: Olivia K Provance Victor O Oria Thuy T Tran Jasmine I Caulfield Christopher R Zito Adam Aguirre-Ducler Kurt A Schalper Harriet M Kluger Lucia B Jilaveanu Source Type: research
The role of [18 F]FDOPA PET as an adjunct to conventional MRI in the diagnosis of aggressive glial lesions
CONCLUSION: Dynamic [18 F]FDOPA PET provides a similar diagnostic accuracy as contrast enhancement in MRI to identify the aggressiveness of suspected glial lesions at diagnosis. Both methods, however, are complementary and [18 F]FDOPA PET may be a useful additional tool in equivocal cases.PMID:38637354 | DOI:10.1007/s00259-024-06720-y (Source: Molecular Medicine)
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Adeline Zinsz Celso Pouget Fabien Rech Luc Taillandier Marie Blonski Samir Amlal Laetitia Imbert Timoth ée Zaragori Antoine Verger Source Type: research
Association Between < sup > 18 < /sup > F-FDG PET Activity and HER2 Status in Breast Cancer Brain Metastases
CONCLUSION: The SUVmax ratio may help to identify the HER2 status of breast cancer brain metastases, if validated prospectively.PMID:38633284 | PMC:PMC11018722 | DOI:10.1007/s13139-024-00843-8 (Source: Molecular Medicine)
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Jonathan R Young Julie A Ressler Joanne E Mortimer Daniel Schmolze Mariko Fitzgibbons Bihong T Chen Source Type: research
UBE2C enhances temozolomide resistance by regulating the expression of p53 to induce aerobic glycolysis in glioma
In this study, we explore the role of UBE2C in regulating temozolomide (TMZ) resistance in glioma and investigate the underlying mechanisms involved. Twenty normal brain tissues and 100 glioma tissues from 50 TMZ-resistant patients and 50 TMZ-sensitive patients are included in this study. TMZ-resistant cell lines are constructed to explore the role of UBE2C in regulating glioma cell viability and TMZ resistance. Our results show that both the mRNA and protein levels of UBE2C are significantly elevated in the brain tissues of glioma patients, especially in those of TMZ-resistant patients. Consistently, UBE2C expression is m...
Source: Acta Biochimica et Biophysica Sinica - April 18, 2024 Category: Biochemistry Authors: Kun Zhou Dexin Wang Xiaolin Du Xia Feng Xiaoxi Zhu Cheng Wang Source Type: research
GBM Immunotherapy: Macrophage Impacts
CONCLUSION: This review provides a comprehensive overview of the latest research on the nature of TAMs and the development of therapeutic strategies targeting TAMs, focusing on the variety of macrophage properties, being modulated, as well as molecular targets.PMID:38634572 | DOI:10.1080/08820139.2024.2337022 (Source: Immunological Investigations)
Source: Immunological Investigations - April 18, 2024 Category: Allergy & Immunology Authors: Nina Loginova Denis Aniskin Peter Timashev Ilya Ulasov Rajesh Kumar Kharwar Source Type: research
Effects of dependent care theory-based post-surgical home care intervention on self-care, symptoms, and caregiver burden in patients with primary brain tumor and their caregivers: a randomized controlled trial
ConclusionDependent care theory-based post-surgical home care intervention increased patients ’ self-care and reduced symptoms and their effects. It also reduced the caregiver burden. Dependent care theory can guide the nursing practices of nurses who provide institutional and/or home care services to patients with chronic diseases and their caregivers.Trial RegistrationNCT05328739 on April 14, 2022 (retrospectively registered). (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - April 18, 2024 Category: Cancer & Oncology Source Type: research
PRMT6-mediated transcriptional activation of ythdf2 promotes glioblastoma migration, invasion, and emt via the wnt –β-catenin pathway
Protein arginine methyltransferase 6 (PRMT6) plays a crucial role in various pathophysiological processes and diseases. Glioblastoma (GBM; WHO Grade 4 glioma) is the most common and lethal primary brain tumor ... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - April 18, 2024 Category: Cancer & Oncology Authors: Peng Yu, Tutu Xu, Wenmeng Ma, Xiang Fang, Yue Bao, Chengran Xu, Jinhai Huang, Yongqing Sun and Guangyu Li Tags: Research Source Type: research
Survival Analysis of Patients Undergoing Intraoperative Contrast-enhanced Ultrasound in the Surgical Treatment of Malignant Glioma
ConclusionICEUS facilitates the identification of residual tumors. Age and ICEUS are prognostic factors for malignant glioma surgery, and use of ICEUS offers a better prognosis for patients with malignant glioma. (Source: Journal of Huazhong University of Science and Technology -- Medical Sciences --)
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - April 18, 2024 Category: Research Source Type: research
Cancers, Vol. 16, Pages 1543: Predicting Isocitrate Dehydrogenase Status in Non-Contrast-Enhanced Adult-Type Astrocytic Tumors Using Diffusion Tensor Imaging and 11C-Methionine, 11C-Choline, and 18F-Fluorodeoxyglucose PET
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Tsuyoshi Izumo
We aimed to differentiate the isocitrate dehydrogenase (IDH) status among non-enhanced astrocytic tumors using preoperative MRI and PET. We analyzed 82 patients with non-contrast-enhanced, diffuse, supratentorial astrocytic tumors (IDH mutant [IDH-mut], 55 patients; IDH-wildtype [IDH-wt], 27 patients) who underwent MRI and PET between May 2012 and December 2022. We calculated the fractional anisotropy (FA) and mean diffusivity (MD) values using diffusion tensor imaging. We evaluated the tumor/normal brain uptake (T/N) ratios using 11C-methionine, 11C-choline, and 18F-fluorodeoxyglucose PET; extracte...
Source: Cancers - April 18, 2024 Category: Cancer & Oncology Authors: Shoji Yasuda Hirohito Yano Yuka Ikegame Soko Ikuta Takashi Maruyama Morio Kumagai Yoshihiro Muragaki Toru Iwama Jun Shinoda Tsuyoshi Izumo Tags: Article Source Type: research
