Survival prediction in patients with gynecological cancer irradiated for brain metastases
Acta Oncol. 2024 Apr 21;63:206-212. doi: 10.2340/1651-226X.2023.34899.ABSTRACTBACKGROUND AND PURPOSE: This large population-based, retrospective, single-center study aimed to identify prognostic factors in patients with brain metastases (BM) from gynecological cancers.MATERIAL AND METHODS: One hundred and forty four patients with BM from gynecological cancer treated with radiotherapy (RT) were identified. Primary cancer diagnosis, age, performance status, number of BM, presence of extracranial disease, and type of BM treatment were assessed. Overall survival (OS) was calculated using the Kaplan-Meier method and the Cox pro...
Source: Acta Oncologica - April 22, 2024 Category: Cancer & Oncology Authors: Silje Skjelsvik Os Kjersti Skipar Eva Skovlund Ivar Hompland Taran Paulsen Hellebust Marianne Gr ønlie Guren Kristina Lindemann Esten S øndrol Nakken Source Type: research
A comparison study of dynamic [18F]Alfatide II imaging and [11C]MET in orthotopic rat models of glioblastoma
Conclusion[18F]Alfatide II demonstrates potential in imaging tumor-associated neovascularization in the context of glioblastoma multiforme (GBM), suggesting its utility as a tool for further exploration in neovascular characterization. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 22, 2024 Category: Cancer & Oncology Source Type: research
Imaging findings of children with PTEN-related hamartoma tumor syndrome: a 20-year multicentric pediatric cohort
ConclusionBrain abnormalities, benign non-vascular soft tissue abnormalities, and vascular anomalies are commonly seen in children and adolescents with PTEN-related hamartoma tumor syndrome. However, malignancies involving the thyroid gland are not uncommon. Familiarity with the phenotype of PTEN-related hamartoma tumor syndrome in the pediatric population can improve diagnosis and prompt appropriate clinical surveillance of abnormal findings that warrant further management.Graphical abstract (Source: Pediatric Radiology)
Source: Pediatric Radiology - April 22, 2024 Category: Radiology Source Type: research
Impact of concurrent antibody –drug conjugates and radiotherapy on symptomatic radiation necrosis in breast cancer patients with brain metastases: a multicenter retrospective study
ConclusionsThis study suggests that concurrent ADC and radiotherapy are associated with a higher risk of SRN in HER2-positive breast cancer patients. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 22, 2024 Category: Cancer & Oncology Source Type: research
Cancers, Vol. 16, Pages 1594: Endovascular Applications for the Management of High-Grade Gliomas in the Modern Era
Aziz-Sultan
Joshua D. Bernstock
High-grade gliomas (HGGs) have a poor prognosis and are difficult to treat. This review examines the evolving landscape of endovascular therapies for HGGs. Recent advances in endovascular catheter technology and delivery methods allow for super-selective intra-arterial cerebral infusion (SSIACI) with increasing precision. This treatment modality may offer the ability to deliver anti-tumoral therapies directly to tumor regions while minimizing systemic toxicity. However, challenges persist, including blood–brain barrier (BBB) penetration, hemodynamic complexities, and drug...
Source: Cancers - April 22, 2024 Category: Cancer & Oncology Authors: Ari D. Kappel Rohan Jha Saibaba Guggilapu William J. Smith Abdullah H. Feroze Adam A. Dmytriw Juan Vicenty-Padilla Rodolfo E. Alcedo Guardia Florian A. Gessler Nirav J. Patel Rose Du Alfred P. See Pier Paolo Peruzzi Mohammad A. Aziz-Sultan Joshua D. Berns Tags: Review Source Type: research
Radio-anatomical evaluation of clinical and radiomic profile of multi-parametric magnetic resonance imaging of de novo glioblastoma multiforme
CONCLUSION: The current study takes a third-party database and reduces physician bias from interfering with study findings. Further prospective and retrospective studies are needed to provide conclusive data.PMID:38644430 | DOI:10.1186/s43046-024-00217-3 (Source: J Egypt Natl Canc In...)
Source: J Egypt Natl Canc In... - April 21, 2024 Category: Cancer & Oncology Authors: H Shafeeq Ahmed Trupti Devaraj Maanini Singhvi T Arul Dasan Priya Ranganath Source Type: research
Radio-anatomical evaluation of clinical and radiomic profile of multi-parametric magnetic resonance imaging of de novo glioblastoma multiforme
CONCLUSION: The current study takes a third-party database and reduces physician bias from interfering with study findings. Further prospective and retrospective studies are needed to provide conclusive data.PMID:38644430 | DOI:10.1186/s43046-024-00217-3 (Source: J Egypt Natl Canc In...)
Source: J Egypt Natl Canc In... - April 21, 2024 Category: Cancer & Oncology Authors: H Shafeeq Ahmed Trupti Devaraj Maanini Singhvi T Arul Dasan Priya Ranganath Source Type: research
Radio-anatomical evaluation of clinical and radiomic profile of multi-parametric magnetic resonance imaging of de novo glioblastoma multiforme
CONCLUSION: The current study takes a third-party database and reduces physician bias from interfering with study findings. Further prospective and retrospective studies are needed to provide conclusive data.PMID:38644430 | DOI:10.1186/s43046-024-00217-3 (Source: J Egypt Natl Canc In...)
Source: J Egypt Natl Canc In... - April 21, 2024 Category: Cancer & Oncology Authors: H Shafeeq Ahmed Trupti Devaraj Maanini Singhvi T Arul Dasan Priya Ranganath Source Type: research
Psychoneuroimmunology in multiple myeloma and autologous hematopoietic stem cell transplant: Opportunities for research among patients and caregivers
Brain Behav Immun. 2024 Apr 19:S0889-1591(24)00366-0. doi: 10.1016/j.bbi.2024.04.019. Online ahead of print.ABSTRACTMultiple myeloma (MM) is an incurable cancer and is the leading indication for autologous hematopoietic stem cell transplantation (HSCT). To be eligible for HSCT, a patient must have a caregiver, as caregivers play a central role in HSCT preparation and recovery. MM patients remain on treatment indefinitely, and thus patients and their caregivers face long-term challenges including the intensity of HSCT and perpetual therapy after transplant. Importantly, both patients and their caregivers show heightened dep...
Source: Brain, Behavior, and Immunity - April 21, 2024 Category: Neurology Authors: Lisa M Christian Janice K Kiecolt-Glaser Steve W Cole Christin E Burd Annelise A Madison Stephanie J Wilson Ashley E Rosko Source Type: research
Radio-anatomical evaluation of clinical and radiomic profile of multi-parametric magnetic resonance imaging of de novo glioblastoma multiforme
CONCLUSION: The current study takes a third-party database and reduces physician bias from interfering with study findings. Further prospective and retrospective studies are needed to provide conclusive data.PMID:38644430 | DOI:10.1186/s43046-024-00217-3 (Source: J Egypt Natl Canc In...)
Source: J Egypt Natl Canc In... - April 21, 2024 Category: Cancer & Oncology Authors: H Shafeeq Ahmed Trupti Devaraj Maanini Singhvi T Arul Dasan Priya Ranganath Source Type: research
Psychoneuroimmunology in multiple myeloma and autologous hematopoietic stem cell transplant: Opportunities for research among patients and caregivers
Brain Behav Immun. 2024 Apr 19:S0889-1591(24)00366-0. doi: 10.1016/j.bbi.2024.04.019. Online ahead of print.ABSTRACTMultiple myeloma (MM) is an incurable cancer and is the leading indication for autologous hematopoietic stem cell transplantation (HSCT). To be eligible for HSCT, a patient must have a caregiver, as caregivers play a central role in HSCT preparation and recovery. MM patients remain on treatment indefinitely, and thus patients and their caregivers face long-term challenges including the intensity of HSCT and perpetual therapy after transplant. Importantly, both patients and their caregivers show heightened dep...
Source: Brain, Behavior, and Immunity - April 21, 2024 Category: Neurology Authors: Lisa M Christian Janice K Kiecolt-Glaser Steve W Cole Christin E Burd Annelise A Madison Stephanie J Wilson Ashley E Rosko Source Type: research
Radio-anatomical evaluation of clinical and radiomic profile of multi-parametric magnetic resonance imaging of de novo glioblastoma multiforme
CONCLUSION: The current study takes a third-party database and reduces physician bias from interfering with study findings. Further prospective and retrospective studies are needed to provide conclusive data.PMID:38644430 | DOI:10.1186/s43046-024-00217-3 (Source: J Egypt Natl Canc In...)
Source: J Egypt Natl Canc In... - April 21, 2024 Category: Cancer & Oncology Authors: H Shafeeq Ahmed Trupti Devaraj Maanini Singhvi T Arul Dasan Priya Ranganath Source Type: research
Effect of metformin in hypothalamic astrocytes from an immunocompromised mice model
Biochimie. 2024 Apr 18:S0300-9084(24)00080-4. doi: 10.1016/j.biochi.2024.04.005. Online ahead of print.ABSTRACTAstrocytes are glial cells that play key roles in neuroinflammation, which is a common feature in diabetic encephalopathy and aging process. Metformin is an antidiabetic compound that shows neuroprotective properties, including in inflammatory models, but astroglial signaling pathways involved are still poorly known. Interferons α/β are cytokines that participate in antiviral responses and the lack of their signaling increases susceptible to viral infections. Here, we investigated the effects of metformin on ast...
Source: Biochimie - April 20, 2024 Category: Biochemistry Authors: Larissa Daniele Bobermin Daniele Schauren da Costa Aline Daniel Moreira de Moraes Vanessa Fernanda da Silva Giancarlo Tomazzoni de Oliveira Patr ícia Sesterheim Ana Carolina Tramontina Luiz Augusto Basso Guilhian Leipnitz Andr é Quincozes-Santos Carlos- Source Type: research
Effect of metformin in hypothalamic astrocytes from an immunocompromised mice model
Biochimie. 2024 Apr 18:S0300-9084(24)00080-4. doi: 10.1016/j.biochi.2024.04.005. Online ahead of print.ABSTRACTAstrocytes are glial cells that play key roles in neuroinflammation, which is a common feature in diabetic encephalopathy and aging process. Metformin is an antidiabetic compound that shows neuroprotective properties, including in inflammatory models, but astroglial signaling pathways involved are still poorly known. Interferons α/β are cytokines that participate in antiviral responses and the lack of their signaling increases susceptible to viral infections. Here, we investigated the effects of metformin on ast...
Source: Biochimie - April 20, 2024 Category: Biochemistry Authors: Larissa Daniele Bobermin Daniele Schauren da Costa Aline Daniel Moreira de Moraes Vanessa Fernanda da Silva Giancarlo Tomazzoni de Oliveira Patr ícia Sesterheim Ana Carolina Tramontina Luiz Augusto Basso Guilhian Leipnitz Andr é Quincozes-Santos Carlos- Source Type: research
Multi-omics technologies and molecular biomarkers in brain tumor-related epilepsy
CONCLUSIONS: Based on the synthesized information, this review provided new research perspectives and insights into the early diagnosis, etiological factors, and personalized treatment of BTRE.PMID:38641945 | PMC:PMC11031674 | DOI:10.1111/cns.14717 (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - April 20, 2024 Category: Neuroscience Authors: Yaoqiang Du Rusong Li Danqing Fu Biqin Zhang Ailin Cui Yutian Shao Zeyu Lai Rongrong Chen Bingyu Chen Zhen Wang Wei Zhang Lisheng Chu Source Type: research
