A Case of Gallbladder Cancer with Trousseau Syndrome Successfully Treated Using Radical Resection
We describe the first case of a successfully treated gallbladder adenocarcinoma accompanied by Trousseau syndrome. A 66-year-old woman presented with right hemiplegia. Magnetic resonance imaging identified multiple cerebral infarctions. Her serum carbohydrate antigen 19-9 and D-dimer levels were markedly elevated, and a gallbladder tumor was detected via abdominal computed tomography. Venous ultrasonography of the lower limbs revealed a deep venous thrombus in the right peroneal vein. These findings suggested that the brain infarctions were likely caused by Trousseau syndrome associated with her gallbladder cancer. Radical...
Source: Acta Medica Okayama - April 30, 2024 Category: General Medicine Authors: Akari Masunaga Motoyasu Tabuchi Shinya Sakamoto Rika Yoshimatsu Manabu Matsumoto Jun Iwata Takehiro Okabayashi Source Type: research
PL-hMSC and CH-hMSC derived soluble factors inhibit proliferation but improve hGBM cell migration by activating TGF- β and inhibiting Wnt signaling
Biosci Rep. 2024 Apr 30:BSR20231964. doi: 10.1042/BSR20231964. Online ahead of print.ABSTRACTGlioblastoma multiforme (GBM) is one of the most common and aggressive brain tumors. GBM resists most chemotherapeutic agents, resulting in a high mortality rate in patients. Human mesenchymal stem cells (hMSCs), which are parts of the cancer stroma, have been shown to be involved in the development and progression of GBM. However, different sources of hMSCs might affect GBM cells differently. In the present study, we established hMSCs from placenta(PL-hMSC) and chorion (CH-hMSC) to study the effects of their released soluble facto...
Source: Bioscience Reports - April 30, 2024 Category: Biomedical Science Authors: Tanawat Uthanaphun Sirikul Manochantr Chairat Tantrawatpan Duangrat Tantikanlayaporn Pakpoom Kheolamai Source Type: research
A Case of Gallbladder Cancer with Trousseau Syndrome Successfully Treated Using Radical Resection
We describe the first case of a successfully treated gallbladder adenocarcinoma accompanied by Trousseau syndrome. A 66-year-old woman presented with right hemiplegia. Magnetic resonance imaging identified multiple cerebral infarctions. Her serum carbohydrate antigen 19-9 and D-dimer levels were markedly elevated, and a gallbladder tumor was detected via abdominal computed tomography. Venous ultrasonography of the lower limbs revealed a deep venous thrombus in the right peroneal vein. These findings suggested that the brain infarctions were likely caused by Trousseau syndrome associated with her gallbladder cancer. Radical...
Source: Acta Med Okayama - April 30, 2024 Category: Universities & Medical Training Authors: Akari Masunaga Motoyasu Tabuchi Shinya Sakamoto Rika Yoshimatsu Manabu Matsumoto Jun Iwata Takehiro Okabayashi Source Type: research
Anti-viral Effects of Pavetta indica Methanolic Extract and Acyclovir on Behavioral and Biochemical Parameters in Streptozotocin-induced Alzheimer's Disease in Rats
CONCLUSION: In a dose-dependent manner, acyclovir and Pavetta indica methanolic extract treatments abrogated the streptozotocin-induced behavioral and neurological abnormalities in rats. The potential therapeutic effects of PIME and acyclovir administration in intracerebroventricular-streptozotocin-treated rats may be attributed to its potential antiviral, antioxidant, and anti-inflammatory effects. The current study suggests that Pavetta indica methanolic extract and acyclovir are promising therapeutic targets against Alzheimer's disease.PMID:38685761 | DOI:10.2174/0118715303273145240110100341 (Source: Endocrine, Metaboli...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 30, 2024 Category: Endocrinology Authors: Deepak Kumar Govind Singh None Tarun Meenakshi Dhanawat Sumeet Gupta Mohamed A Morsy Anroop B Nair Asmaa I Matouk Source Type: research
Anti-viral Effects of Pavetta indica Methanolic Extract and Acyclovir on Behavioral and Biochemical Parameters in Streptozotocin-induced Alzheimer's Disease in Rats
CONCLUSION: In a dose-dependent manner, acyclovir and Pavetta indica methanolic extract treatments abrogated the streptozotocin-induced behavioral and neurological abnormalities in rats. The potential therapeutic effects of PIME and acyclovir administration in intracerebroventricular-streptozotocin-treated rats may be attributed to its potential antiviral, antioxidant, and anti-inflammatory effects. The current study suggests that Pavetta indica methanolic extract and acyclovir are promising therapeutic targets against Alzheimer's disease.PMID:38685761 | DOI:10.2174/0118715303273145240110100341 (Source: Herpes)
Source: Herpes - April 30, 2024 Category: Infectious Diseases Authors: Deepak Kumar Govind Singh None Tarun Meenakshi Dhanawat Sumeet Gupta Mohamed A Morsy Anroop B Nair Asmaa I Matouk Source Type: research
An Optimization Numerical Spiking Neural Membrane System with Adaptive Multi-Mutation Operators for Brain Tumor Segmentation
Int J Neural Syst. 2024 Apr 30:2450036. doi: 10.1142/S0129065724500369. Online ahead of print.ABSTRACTMagnetic Resonance Imaging (MRI) is an important diagnostic technique for brain tumors due to its ability to generate images without tissue damage or skull artifacts. Therefore, MRI images are widely used to achieve the segmentation of brain tumors. This paper is the first attempt to discuss the use of optimization spiking neural P systems to improve the threshold segmentation of brain tumor images. To be specific, a threshold segmentation approach based on optimization numerical spiking neural P systems with adaptive mult...
Source: International Journal of Neural Systems - April 30, 2024 Category: Neurology Authors: Jianping Dong Gexiang Zhang Yangheng Hu Yijin Wu Haina Rong Source Type: research
A review on potential heterocycles for the treatment of glioblastoma targeting receptor tyrosine kinases
Oncol Res. 2024 Apr 23;32(5):849-875. doi: 10.32604/or.2024.047042. eCollection 2024.ABSTRACTGlioblastoma, the most aggressive form of brain tumor, poses significant challenges in terms of treatment success and patient survival. Current treatment modalities for glioblastoma include radiation therapy, surgical intervention, and chemotherapy. Unfortunately, the median survival rate remains dishearteningly low at 12-15 months. One of the major obstacles in treating glioblastoma is the recurrence of tumors, making chemotherapy the primary approach for secondary glioma patients. However, the efficacy of drugs is hampered by the...
Source: Oncology Research - April 30, 2024 Category: Cancer & Oncology Authors: Nilam Bhusare Maushmi Kumar Source Type: research
Targeting brain tumors with innovative nanocarriers: bridging the gap through the blood-brain barrier
CONCLUSION: This review also provides deep insights into recent advancements in nanocarrier-based formulations and technologies for GBM management. Elucidation of various scientific advances in conjunction with encouraging findings concerning the future perspectives and challenges of nanocarriers for effective brain tumor management has also been discussed.PMID:38686045 | PMC:PMC11056000 | DOI:10.32604/or.2024.047278 (Source: Oncology Research)
Source: Oncology Research - April 30, 2024 Category: Cancer & Oncology Authors: Karan Wadhwa Payal Chauhan Shobhit Kumar Rakesh Pahwa Ravinder Verma Rajat Goyal Govind Singh Archana Sharma Neha Rao Deepak Kaushik Source Type: research
Clinical role of NDRG2-based methylation status on survival pattern of glioblastoma
CONCLUSION: Current findings highlight the importance of studying DNA methylation of NDRG2 as a key factor to understand the role of epigenetic alterations in GBM.PMID:38686946 | DOI:10.1177/03946320241250294 (Source: International Journal of Immunopathology and Pharmacology)
Source: International Journal of Immunopathology and Pharmacology - April 30, 2024 Category: Allergy & Immunology Authors: Menha Swellam Mohamed K Khalifa Amira M Nageeb Lobna Ezz El-Arab Manal El-Mahdy Khaled El-Bahy Magda Sayed Mahmoud Source Type: research
A novel immune cell signature for predicting glioblastoma after radiotherapy prognosis and guiding therapy
Conclusion: The immune cell signature, comprising SDC-1, PLAUR, FN1, and CXCL13, holds promise as a predictive tool for assessing glioblastoma prognosis following radiotherapy. This signature also offers valuable guidance for tailoring treatment strategies, emphasizing its potential clinical relevance in improving patient outcomes.PMID:38687369 | DOI:10.1177/03946320241249395 (Source: International Journal of Immunopathology and Pharmacology)
Source: International Journal of Immunopathology and Pharmacology - April 30, 2024 Category: Allergy & Immunology Authors: Rong Huang Xiaoxu Lu Xueming Sun Hui Wu Source Type: research
Shared and Specific Neural Correlates of Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorder: A Meta-Analysis of 243 Task-Based Functional MRI Studies
CONCLUSIONS: Although ASD and ADHD showed both shared and disorder-specific standardized neural activations, disorder-specific activations were more prominent than shared ones. Functional brain differences between ADHD and ASD are more likely to reflect diagnosis-related pathophysiology than bias from the selection of specific neuropsychological tasks.PMID:38685858 | DOI:10.1176/appi.ajp.20230270 (Source: Cancer Control)
Source: Cancer Control - April 30, 2024 Category: Cancer & Oncology Authors: Hiroki Tamon Junya Fujino Takashi Itahashi Lennart Frahm Valeria Parlatini Yuta Y Aoki Francisco Xavier Castellanos Simon B Eickhoff Samuele Cortese Source Type: research
BPTF promotes glioma development through USP34-mediated de-ubiquitination of FOXC1
In conclusion, the BPTF/FOXC1 axis was identified as a key promotor in glioma development and may be a potential target in the inhibition of glioma development.PMID:38686761 | DOI:10.14670/HH-18-748 (Source: Histology and Histopathology)
Source: Histology and Histopathology - April 30, 2024 Category: Cytology Authors: Yanling Pan Feng Yuan Zhiren Lin Yijie Li Source Type: research
Anti-viral Effects of Pavetta indica Methanolic Extract and Acyclovir on Behavioral and Biochemical Parameters in Streptozotocin-induced Alzheimer's Disease in Rats
CONCLUSION: In a dose-dependent manner, acyclovir and Pavetta indica methanolic extract treatments abrogated the streptozotocin-induced behavioral and neurological abnormalities in rats. The potential therapeutic effects of PIME and acyclovir administration in intracerebroventricular-streptozotocin-treated rats may be attributed to its potential antiviral, antioxidant, and anti-inflammatory effects. The current study suggests that Pavetta indica methanolic extract and acyclovir are promising therapeutic targets against Alzheimer's disease.PMID:38685761 | DOI:10.2174/0118715303273145240110100341 (Source: Endocrine, Metaboli...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 30, 2024 Category: Drugs & Pharmacology Authors: Deepak Kumar Govind Singh None Tarun Meenakshi Dhanawat Sumeet Gupta Mohamed A Morsy Anroop B Nair Asmaa I Matouk Source Type: research
Development and validation of a nomogram to predict leptomeningeal metastases in lung adenocarcinoma: Cervical lymph node metastasis is an important association factor
ConclusionsWe created a user-friendly nomogram to predict LMs in advanced lung cancer patients, which could help guide treatment decisions and reduce unnecessary lumbar punctures. (Source: Cancer Medicine)
Source: Cancer Medicine - April 30, 2024 Category: Cancer & Oncology Authors: Xiaoyu Hua,
Weifeng Feng,
Minting Ye,
Mingyao Lai,
Xiaojun Yu,
Mengnan Sun,
Juan Li,
Ruyu Ai,
Yanlin He,
Linbo Cai,
Changzheng Shi,
Xiangning Liu Tags: RESEARCH ARTICLE Source Type: research
Investigation of the effects of thiazole compounds on thioredoxin reductase 1 (TrxR1), glutathione S ‐transferase (GST), and glutathione reductase (GR) targeted human brain glioblastoma cancer (U‐87 MG)
AbstractCancer is a fatal disease that kills thousands of people worldwide. Despite the information produced by research on cancer treatment, applications in cancer treatment are limited. Therefore, scientists ’ efforts to develop more effective treatment approaches continue. In the study, we aimed to determine the anticancer potential of amino thiazole compounds on human glioblastoma (U-87 MG) and human dermal fibroblast (HDFa) cells and their inhibition effects on enzymes that cause multidrug resistan ce in cancer cells. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide cell viability test was performed ...
Source: Biotechnology and Applied Biochemistry - April 30, 2024 Category: Biochemistry Authors: I şıl Nihan Korkmaz Tags: ORIGINAL ARTICLE Source Type: research
