Entecavir-associated thrombocytopenia
Int J Immunopathol Pharmacol. 2021 Jan-Dec;35:20587384211059676. doi: 10.1177/20587384211059676.ABSTRACTEntecavir (ETV) is widely used in the treatment of hepatitis B, but there are only a few reports about entecavir-associated thrombocytopenia, and it is considered as an immediate response and inappropriate to continue the treatment with other nucleoside analogues. Now, we report the third case, and this case was delayed response and we switched to treatment with tenofovir (TDF). There was a 66-year-old female who was infected with hepatitis B virus (HBV). Her platelet count decreased from 111*109/L to 3*109/L and was pro...
Source: International Journal of Immunopathology and Pharmacology - November 26, 2021 Category: Allergy & Immunology Authors: Yi Yu Hao Feng Source Type: research

Oral booster probiotic bifidobacteria in SARS-COV-2 patients
This study aims to evaluate the role of oral probiotic Bifidobacterium on moderate/severe SARS-CoV-2 inpatients. In this single-center study, we analyzed data of 44 moderate/severe inpatients with diagnosed COVID-19 in Istanbul Maltepe University Medical Faculty Hospital, 2020 from 1 November 2020 to 15 December 2020. Clinical and medication features were compared and analyzed between patients with or without probiotic. In result, 19 of the 44 patients (43.18%) who were administrated with oral booster-single strain probiotic were discharged with the median inpatient day of 7.6 days which were significantly shorter than tho...
Source: International Journal of Immunopathology and Pharmacology - November 25, 2021 Category: Allergy & Immunology Authors: H üseyin S Bozkurt Ömer Bilen Source Type: research

The correlation between lipoprotein associated phospholipase A < sub > 2 < /sub > and central overweight status
This study is aimed to investigate whether Lp-PLA2 was associated with an overweight status.METHODS: This was a cross-sectional study that enrolled 3760 Chinese adults (age, 18-50 years) who underwent medical examination department of Xiamen Chang-Gung Hospital (XCGH) from 2018 to 2020. To explore the distribution of overweight classifications in the Chinese population, we evaluated the correlation of the overweight status with Lp-PLA2, after correcting for possible influencing factors.RESULTS: The Lp-PLA2 level was greater in male than in female subjects (p
Source: International Journal of Immunopathology and Pharmacology - November 19, 2021 Category: Allergy & Immunology Authors: Yi-Hsuan Chen Wen-Cheng Li Yi-Chuan Chen Wei-Chung Yeh Wei Yu Hsiung Ying Hung Xiong-Xue Jie Jau-Yuan Chen Source Type: research

The correlation between lipoprotein associated phospholipase A < sub > 2 < /sub > and central overweight status
This study is aimed to investigate whether Lp-PLA2 was associated with an overweight status.METHODS: This was a cross-sectional study that enrolled 3760 Chinese adults (age, 18-50 years) who underwent medical examination department of Xiamen Chang-Gung Hospital (XCGH) from 2018 to 2020. To explore the distribution of overweight classifications in the Chinese population, we evaluated the correlation of the overweight status with Lp-PLA2, after correcting for possible influencing factors.RESULTS: The Lp-PLA2 level was greater in male than in female subjects (p
Source: International Journal of Immunopathology and Pharmacology - November 19, 2021 Category: Allergy & Immunology Authors: Yi-Hsuan Chen Wen-Cheng Li Yi-Chuan Chen Wei-Chung Yeh Wei Yu Hsiung Ying Hung Xiong-Xue Jie Jau-Yuan Chen Source Type: research

The role of the sphingosine axis in immune regulation: A dichotomy in the anti-inflammatory effects between sphingosine kinase 1 and sphingosine kinase 2-dependent pathways
Conclusions: Early administration of SphK1 inhibitor in a murine model of immune-mediated hepatitis alleviated liver damage and inflammation with a statistically significant reduction in IFN-γ levels. The data support a dichotomy in the anti-inflammatory effects of SphK1 and SphK2, and suggests that isoenzyme-directed therapies can improve the effect of targeting these pathways.PMID:34789044 | DOI:10.1177/20587384211053274 (Source: International Journal of Immunopathology and Pharmacology)
Source: International Journal of Immunopathology and Pharmacology - November 18, 2021 Category: Allergy & Immunology Authors: Yuval Ishay Dvorah Rotnemer-Golinkin Yaron Ilan Source Type: research

Benefits of prescribing low-dose digoxin in atrial fibrillation
Int J Immunopathol Pharmacol. 2021 Jan-Dec;35:20587384211051955. doi: 10.1177/20587384211051955.ABSTRACTINTRODUCTION: The role of digoxin (cardiac glycoside) in controlling the heart rate (HR) for the treatment of atrial fibrillation (AF) patients has not been explored in depth.METHODS: To contribute to the limited data, our team conducted retrospective analysis of the clinical records of 1444 AF patients. We divided the AF patients into two groups, wherein group 1 patients were treated with beta-blockers (BB), low-dose digoxin, and an anticoagulant (vitamin K antagonist/factor-IIa inhibitor/factor-Xa inhibitor), and group...
Source: International Journal of Immunopathology and Pharmacology - November 2, 2021 Category: Allergy & Immunology Authors: Ciprian Ilie Rosca Nilima Rajpal Kundnani Anca Tudor Maria-Silvia Rosca Violeta-Ariana Nicoras Gabriela Otiman Elena Ciurariu Alin Ionescu Morariu Stelian Abhinav Sharma Claudia Borza Daniel Florin Lighezan Source Type: research

Benefits of prescribing low-dose digoxin in atrial fibrillation
Int J Immunopathol Pharmacol. 2021 Jan-Dec;35:20587384211051955. doi: 10.1177/20587384211051955.ABSTRACTINTRODUCTION: The role of digoxin (cardiac glycoside) in controlling the heart rate (HR) for the treatment of atrial fibrillation (AF) patients has not been explored in depth.METHODS: To contribute to the limited data, our team conducted retrospective analysis of the clinical records of 1444 AF patients. We divided the AF patients into two groups, wherein group 1 patients were treated with beta-blockers (BB), low-dose digoxin, and an anticoagulant (vitamin K antagonist/factor-IIa inhibitor/factor-Xa inhibitor), and group...
Source: International Journal of Immunopathology and Pharmacology - November 2, 2021 Category: Allergy & Immunology Authors: Ciprian Ilie Rosca Nilima Rajpal Kundnani Anca Tudor Maria-Silvia Rosca Violeta-Ariana Nicoras Gabriela Otiman Elena Ciurariu Alin Ionescu Morariu Stelian Abhinav Sharma Claudia Borza Daniel Florin Lighezan Source Type: research

Curative role of mesenchymal stromal cells in chronic pancreatitis: Modulation of MAPK and TGF- β1/SMAD factors
CONCLUSION: our results further bring to light the promise of cell transplant therapy for chronic pancreatitis.PMID:34696610 | PMC:PMC8552371 | DOI:10.1177/20587384211054036 (Source: International Journal of Immunopathology and Pharmacology)
Source: International Journal of Immunopathology and Pharmacology - October 26, 2021 Category: Allergy & Immunology Authors: Hager S Taha Enas M Moustafa Fatma Sm Moawed Marwa Ga Hegazy Source Type: research

Curative role of mesenchymal stromal cells in chronic pancreatitis: Modulation of MAPK and TGF- β1/SMAD factors
CONCLUSION: our results further bring to light the promise of cell transplant therapy for chronic pancreatitis.PMID:34696610 | DOI:10.1177/20587384211054036 (Source: International Journal of Immunopathology and Pharmacology)
Source: International Journal of Immunopathology and Pharmacology - October 26, 2021 Category: Allergy & Immunology Authors: Hager S Taha Enas M Moustafa Fatma Sm Moawed Marwa Ga Hegazy Source Type: research

The bioinformatics analysis of quercetin in octagonal lotus for the screening of breast cancer MYC, CXCL10, CXCL11, and E2F1
CONCLUSION: This study initially screened the key active ingredients of star aniseed lotus and analyzed key genes and several essential pathways. Traditional Chinese medicine is expected to provide new evidence and research ideas to prevent and treat breast cancer.PMID:34693792 | PMC:PMC8544779 | DOI:10.1177/20587384211040903 (Source: International Journal of Immunopathology and Pharmacology)
Source: International Journal of Immunopathology and Pharmacology - October 25, 2021 Category: Allergy & Immunology Authors: Yuexing Ma Zirong Peng Rongbin Pan Zhixin Zhu Xiaoqi Meng Huiming Hu Xin Qiao Xuening Huang Mengyu Hou Source Type: research

The bioinformatics analysis of quercetin in octagonal lotus for the screening of breast cancer MYC, CXCL10, CXCL11, and E2F1
CONCLUSION: This study initially screened the key active ingredients of star aniseed lotus and analyzed key genes and several essential pathways. Traditional Chinese medicine is expected to provide new evidence and research ideas to prevent and treat breast cancer.PMID:34693792 | DOI:10.1177/20587384211040903 (Source: International Journal of Immunopathology and Pharmacology)
Source: International Journal of Immunopathology and Pharmacology - October 25, 2021 Category: Allergy & Immunology Authors: Yuexing Ma Zirong Peng Rongbin Pan Zhixin Zhu Xiaoqi Meng Huiming Hu Xin Qiao Xuening Huang Mengyu Hou Source Type: research

The 30th birthday of chronic ulcerative stomatitis: A systematic review
CONCLUSION: Dermatologists should suspect CUS in chronic steroid-unresponsive erosive/ulcerative stomatitis. In these cases, to diagnose CUS, the presence of stratified epithelium-specific antinuclear antibodies (SES-ANA) should be investigated through immunofluorescence. Once diagnosed, CUS can be treated with antimalarials, which are an effective treatment contrarily to corticosteroids.PMID:34666534 | PMC:PMC8532222 | DOI:10.1177/20587384211052437 (Source: International Journal of Immunopathology and Pharmacology)
Source: International Journal of Immunopathology and Pharmacology - October 20, 2021 Category: Allergy & Immunology Authors: Astrid Herzum Martina Burlando Emanuele Cozzani Aurora Parodi Source Type: research

The 30th birthday of chronic ulcerative stomatitis: A systematic review
CONCLUSION: Dermatologists should suspect CUS in chronic steroid-unresponsive erosive/ulcerative stomatitis. In these cases, to diagnose CUS, the presence of stratified epithelium-specific antinuclear antibodies (SES-ANA) should be investigated through immunofluorescence. Once diagnosed, CUS can be treated with antimalarials, which are an effective treatment contrarily to corticosteroids.PMID:34666534 | DOI:10.1177/20587384211052437 (Source: International Journal of Immunopathology and Pharmacology)
Source: International Journal of Immunopathology and Pharmacology - October 20, 2021 Category: Allergy & Immunology Authors: Astrid Herzum Martina Burlando Emanuele Cozzani Aurora Parodi Source Type: research

Thrombo-inflammatory biomarkers to predict sepsis outcome
CONCLUSION: PAI-1 and suPAR were significant predictors of hospital mortality among sepsis patients. The sample size was relatively small, which may have decreased the statistical power of the results of the present study. Hence, additional studies with large sample sizes are required for further validation of the present results.PMID:34647483 | PMC:PMC8521754 | DOI:10.1177/20587384211048561 (Source: International Journal of Immunopathology and Pharmacology)
Source: International Journal of Immunopathology and Pharmacology - October 14, 2021 Category: Allergy & Immunology Authors: Alaa Efat Sabry Abdallah Shoeib Ayman F Arafa Ashraf Abdelraof Dawod Mohamad A Abd ElHafez Essam A Abd ElMohsen Hany F Eladly Reda A Ibrahim Aly Elkholy Source Type: research

Thrombo-inflammatory biomarkers to predict sepsis outcome
CONCLUSION: PAI-1 and suPAR were significant predictors of hospital mortality among sepsis patients. The sample size was relatively small, which may have decreased the statistical power of the results of the present study. Hence, additional studies with large sample sizes are required for further validation of the present results.PMID:34647483 | DOI:10.1177/20587384211048561 (Source: International Journal of Immunopathology and Pharmacology)
Source: International Journal of Immunopathology and Pharmacology - October 14, 2021 Category: Allergy & Immunology Authors: Alaa Efat Sabry Abdallah Shoeib Ayman F Arafa Ashraf Abdelraof Dawod Mohamad A Abd ElHafez Essam A Abd ElMohsen Hany F Eladly Reda A Ibrahim Aly Elkholy Source Type: research

A review: Antibody-dependent enhancement in COVID-19: The not so friendly side of antibodies
Int J Immunopathol Pharmacol. 2021 Jan-Dec;35:20587384211050199. doi: 10.1177/20587384211050199.ABSTRACTThe coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), represents an unprecedented global public health emergency with economic and social consequences. One of the main concerns in the development of vaccines is the antibody-dependent enhancement phenomenon, better known as ADE. In this review, we provide an overview of SARS-CoV-2 infection as well as the immune response generated by the host. On the bases of this principle, we also describe what is known...
Source: International Journal of Immunopathology and Pharmacology - October 11, 2021 Category: Allergy & Immunology Authors: Gabriela Athziri S ánchez-Zuno M ónica Guadalupe Matuz-Flores Guillermo Gonz ález-Estevez Ferdinando Nicoletti Francisco Javier Turrubiates-Hern ández Katia Mangano Jos é Francisco Muñoz-Valle Source Type: research

Steroids plus antiviral agents are more effective than steroids alone in the treatment of severe Bell's palsy patients over 40 years of age
CONCLUSION: Combination therapy with steroids and antiviral agents resulted in significantly higher favorable recovery rates than steroids alone in severe Bell's palsy patients. Combination therapy was particularly more effective than steroids alone in patients aged ≥40 years and in patients without hypertension and diabetes.PMID:34633253 | PMC:PMC8511921 | DOI:10.1177/20587384211042124 (Source: International Journal of Immunopathology and Pharmacology)
Source: International Journal of Immunopathology and Pharmacology - October 11, 2021 Category: Allergy & Immunology Authors: Yong Kim Jeon Gang Doo Jinmann Chon Jong Ha Lee Junyang Jung Jae Min Lee Sang Hoon Kim Seung Geun Yeo Source Type: research

A review: Antibody-dependent enhancement in COVID-19: The not so friendly side of antibodies
Int J Immunopathol Pharmacol. 2021 Jan-Dec;35:20587384211050199. doi: 10.1177/20587384211050199.ABSTRACTThe coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), represents an unprecedented global public health emergency with economic and social consequences. One of the main concerns in the development of vaccines is the antibody-dependent enhancement phenomenon, better known as ADE. In this review, we provide an overview of SARS-CoV-2 infection as well as the immune response generated by the host. On the bases of this principle, we also describe what is known...
Source: International Journal of Immunopathology and Pharmacology - October 11, 2021 Category: Allergy & Immunology Authors: Gabriela Athziri S ánchez-Zuno M ónica Guadalupe Matuz-Flores Guillermo Gonz ález-Estevez Ferdinando Nicoletti Francisco Javier Turrubiates-Hern ández Katia Mangano Jos é Francisco Muñoz-Valle Source Type: research

Steroids plus antiviral agents are more effective than steroids alone in the treatment of severe Bell's palsy patients over 40 years of age
CONCLUSION: Combination therapy with steroids and antiviral agents resulted in significantly higher favorable recovery rates than steroids alone in severe Bell's palsy patients. Combination therapy was particularly more effective than steroids alone in patients aged ≥40 years and in patients without hypertension and diabetes.PMID:34633253 | DOI:10.1177/20587384211042124 (Source: International Journal of Immunopathology and Pharmacology)
Source: International Journal of Immunopathology and Pharmacology - October 11, 2021 Category: Allergy & Immunology Authors: Yong Kim Jeon Gang Doo Jinmann Chon Jong Ha Lee Junyang Jung Jae Min Lee Sang Hoon Kim Seung Geun Yeo Source Type: research

A review: Antibody-dependent enhancement in COVID-19: The not so friendly side of antibodies
Int J Immunopathol Pharmacol. 2021 Jan-Dec;35:20587384211050199. doi: 10.1177/20587384211050199.ABSTRACTThe coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), represents an unprecedented global public health emergency with economic and social consequences. One of the main concerns in the development of vaccines is the antibody-dependent enhancement phenomenon, better known as ADE. In this review, we provide an overview of SARS-CoV-2 infection as well as the immune response generated by the host. On the bases of this principle, we also describe what is known...
Source: International Journal of Immunopathology and Pharmacology - October 11, 2021 Category: Allergy & Immunology Authors: Gabriela Athziri S ánchez-Zuno M ónica Guadalupe Matuz-Flores Guillermo Gonz ález-Estevez Ferdinando Nicoletti Francisco Javier Turrubiates-Hern ández Katia Mangano Jos é Francisco Muñoz-Valle Source Type: research