Conferone, a coumarin from < em > Ferula flabelliloba < /em > , induced toxic effects on adult T-cell leukemia/lymphoma cells
CONCLUSION: Obtained findings indicated that conferone induced considerable cytotoxic effects on MT-2 cells in a time- and dose-dependent manner. In addition, accumulation of cells in the sub-G1 phase of the cell cycle was detected upon conferone administration. Moreover, conferone reduced the expression of CDK6, c-MYC, CFLIPL, and NF-κB (Rel-A) in MT-2 cells. Accordingly, conferone could be considered as a potent agent against ATL, although complementary investigations are required to define more precisely its mechanism of action.PMID:37688389 | PMC:PMC10493046 | DOI:10.1177/03946320231197592 (Source: International Journ...
Source: International Journal of Immunopathology and Pharmacology - September 9, 2023 Category: Allergy & Immunology Authors: Houshang Rafatpanah Marziyeh Golizadeh Maryam Mahdifar Shakiba Mahdavi Mehrdad Iranshahi Fatemeh B Rassouli Source Type: research

Conferone, a coumarin from < em > Ferula flabelliloba < /em > , induced toxic effects on adult T-cell leukemia/lymphoma cells
CONCLUSION: Obtained findings indicated that conferone induced considerable cytotoxic effects on MT-2 cells in a time- and dose-dependent manner. In addition, accumulation of cells in the sub-G1 phase of the cell cycle was detected upon conferone administration. Moreover, conferone reduced the expression of CDK6, c-MYC, CFLIPL, and NF-κB (Rel-A) in MT-2 cells. Accordingly, conferone could be considered as a potent agent against ATL, although complementary investigations are required to define more precisely its mechanism of action.PMID:37688389 | DOI:10.1177/03946320231197592 (Source: International Journal of Immunopathol...
Source: International Journal of Immunopathology and Pharmacology - September 9, 2023 Category: Allergy & Immunology Authors: Houshang Rafatpanah Marziyeh Golizadeh Maryam Mahdifar Shakiba Mahdavi Mehrdad Iranshahi Fatemeh B Rassouli Source Type: research

Association of Guillain-Barr é syndrome following COVID-19 vaccination
Conclusion: This review highlights the diverse and clinically relevant associations between COVID-19 vaccination and GBS. The findings underscore the importance of conducting further studies to explore the causative links in this correlation and gain a better understanding of the relationship.PMID:37681361 | DOI:10.1177/03946320231199349 (Source: International Journal of Immunopathology and Pharmacology)
Source: International Journal of Immunopathology and Pharmacology - September 8, 2023 Category: Allergy & Immunology Authors: Selia Chowdhury Samia Chowdhury Source Type: research

Ischemia reperfusion myocardium injuries in type 2 diabetic rats: Effects of ketamine and insulin on LC3-II and mTOR expression
Conclusion: The findings of the study suggest that ketamine combined with insulin administration remarkably protects I/R-induced myocardial injury in rats with T2DM by reducing the dysregulation of autophagy.PMID:37643354 | PMC:PMC10467302 | DOI:10.1177/03946320231196450 (Source: International Journal of Immunopathology and Pharmacology)
Source: International Journal of Immunopathology and Pharmacology - August 29, 2023 Category: Allergy & Immunology Authors: Zhiguo Tao Rongmu Lin Rui Zhang Peng He Chengwen Lei Yuanhai Li Source Type: research

Ischemia reperfusion myocardium injuries in type 2 diabetic rats: Effects of ketamine and insulin on LC3-II and mTOR expression
Conclusion: The findings of the study suggest that ketamine combined with insulin administration remarkably protects I/R-induced myocardial injury in rats with T2DM by reducing the dysregulation of autophagy.PMID:37643354 | DOI:10.1177/03946320231196450 (Source: International Journal of Immunopathology and Pharmacology)
Source: International Journal of Immunopathology and Pharmacology - August 29, 2023 Category: Allergy & Immunology Authors: Zhiguo Tao Rongmu Lin Rui Zhang Peng He Chengwen Lei Yuanhai Li Source Type: research

Evaluation of inflammatory cytokines in drug-na ïve major depressive disorder: A systematic review and meta-analysis
Conclusion: The present study findings suggest the upregulated level of peripheral TNF-α but not CRP, INF-γ, and MCP-1 involve in depression. The elevated inflammatory cytokines confirmed the inflammatory state of depression. Therefore, inflammatory cytokines might serve as potential risk assessment markers in MDD.PMID:37625799 | DOI:10.1177/03946320231198828 (Source: International Journal of Immunopathology and Pharmacology)
Source: International Journal of Immunopathology and Pharmacology - August 25, 2023 Category: Allergy & Immunology Authors: Md Rabiul Islam Md Sohan Sohel Daria Abdullah Al Masud Maizbha Uddin Ahmed Arpita Roy Mohammad Shahriar Source Type: research