Monocyte to eosinophil ratio as a diagnostic biomarker for overlap syndrome and predictor of disease exacerbation
Conclusion: The monocyte to eosinophil ratio (MER) was independent predictors of OS among exacerbated COPD patients and had a very good prognostic utility for predicting the next exacerbation episodes. Long term follow up is recommended to evaluate the severity of exacerbations and the effect of complications of OS on the morbidity and mortality of these patients.PMID:37977558 | PMC:PMC10657538 | DOI:10.1177/03946320231216321 (Source: International Journal of Immunopathology and Pharmacology)
Source: International Journal of Immunopathology and Pharmacology - November 17, 2023 Category: Allergy & Immunology Authors: Asmaa Ali Ahmed Samir Abdelhafiz Mai M Saleh Heba Salem Mohammed A Rakha Seham Ezzat Source Type: research

Bibliometric and visual analyses of trends in the field of T cell exhaustion research: Findings from 2000 to 2022
CONCLUSION: These findings highlight the importance of collaborations among institutions and nations in order to further propel novel studies of T cell exhaustion. Efforts to unravel the signal transduction and transcriptional mechanisms underlying the onset of T cell exhaustion were also identified as an emerging hotspot in this field. Ultimately, these results support the pivotal status of T cell exhaustion research as a key direction for immunotherapeutic research and development efforts in the coming years.PMID:37975658 | PMC:PMC10656813 | DOI:10.1177/03946320231215219 (Source: International Journal of Immunopathology and Pharmacology)
Source: International Journal of Immunopathology and Pharmacology - November 17, 2023 Category: Allergy & Immunology Authors: Ziling Liu Huan Wan Yao Tan Deshuang Li Jianguo Huang Chuanhe Zhang Fangyuan Liu Bo Qin Source Type: research

Steroid initiation timing and outcome of coronavirus disease 2019 patients: A multicenter, retrospective, observational study
Conclusion: The analysis included 3692 patients (men, 64.1%; median age, 68 years). Unadjusted comparisons of mortality groups showed significant differences in demographic and clinical characteristics; patients with early dexamethasone initiation had more risk factors for severe disease and significantly higher mortality than did patients with delayed initiation (13.3% vs 7.9%, p < .001). No significant differences were found in intubation rates or duration, length of hospitalization, or time from intubation to death. Multivariate analyses showed significant differences from symptom onset to steroid administration, wit...
Source: International Journal of Immunopathology and Pharmacology - November 17, 2023 Category: Allergy & Immunology Authors: Ryu Sugimoto Tsuneaki Kenzaka Ayako Mikami Nobuaki Matsunaga Takayuki Akiyama Norio Ohmagari Hogara Nishisaki Source Type: research

Monocyte to eosinophil ratio as a diagnostic biomarker for overlap syndrome and predictor of disease exacerbation
Conclusion: The monocyte to eosinophil ratio (MER) was independent predictors of OS among exacerbated COPD patients and had a very good prognostic utility for predicting the next exacerbation episodes. Long term follow up is recommended to evaluate the severity of exacerbations and the effect of complications of OS on the morbidity and mortality of these patients.PMID:37977558 | PMC:PMC10657538 | DOI:10.1177/03946320231216321 (Source: International Journal of Immunopathology and Pharmacology)
Source: International Journal of Immunopathology and Pharmacology - November 17, 2023 Category: Allergy & Immunology Authors: Asmaa Ali Ahmed Samir Abdelhafiz Mai M Saleh Heba Salem Mohammed A Rakha Seham Ezzat Source Type: research

Bibliometric and visual analyses of trends in the field of T cell exhaustion research: Findings from 2000 to 2022
CONCLUSION: These findings highlight the importance of collaborations among institutions and nations in order to further propel novel studies of T cell exhaustion. Efforts to unravel the signal transduction and transcriptional mechanisms underlying the onset of T cell exhaustion were also identified as an emerging hotspot in this field. Ultimately, these results support the pivotal status of T cell exhaustion research as a key direction for immunotherapeutic research and development efforts in the coming years.PMID:37975658 | DOI:10.1177/03946320231215219 (Source: International Journal of Immunopathology and Pharmacology)
Source: International Journal of Immunopathology and Pharmacology - November 17, 2023 Category: Allergy & Immunology Authors: Ziling Liu Huan Wan Yao Tan Deshuang Li Jianguo Huang Chuanhe Zhang Fangyuan Liu Bo Qin Source Type: research

Steroid initiation timing and outcome of coronavirus disease 2019 patients: A multicenter, retrospective, observational study
Conclusion: The analysis included 3692 patients (men, 64.1%; median age, 68 years). Unadjusted comparisons of mortality groups showed significant differences in demographic and clinical characteristics; patients with early dexamethasone initiation had more risk factors for severe disease and significantly higher mortality than did patients with delayed initiation (13.3% vs 7.9%, p < .001). No significant differences were found in intubation rates or duration, length of hospitalization, or time from intubation to death. Multivariate analyses showed significant differences from symptom onset to steroid administration, wit...
Source: International Journal of Immunopathology and Pharmacology - November 17, 2023 Category: Allergy & Immunology Authors: Ryu Sugimoto Tsuneaki Kenzaka Ayako Mikami Nobuaki Matsunaga Takayuki Akiyama Norio Ohmagari Hogara Nishisaki Source Type: research

Monocyte to eosinophil ratio as a diagnostic biomarker for overlap syndrome and predictor of disease exacerbation
Conclusion: The monocyte to eosinophil ratio (MER) was independent predictors of OS among exacerbated COPD patients and had a very good prognostic utility for predicting the next exacerbation episodes. Long term follow up is recommended to evaluate the severity of exacerbations and the effect of complications of OS on the morbidity and mortality of these patients.PMID:37977558 | DOI:10.1177/03946320231216321 (Source: International Journal of Immunopathology and Pharmacology)
Source: International Journal of Immunopathology and Pharmacology - November 17, 2023 Category: Allergy & Immunology Authors: Asmaa Ali Ahmed Samir Abdelhafiz Mai M Saleh Heba Salem Mohammed A Rakha Seham Ezzat Source Type: research

Correlation analysis between cytokines' profile, autoimmune antibodies and the duration of type 1 diabetes: A case control study in a specialized children's centre in Riyadh
CONCLUSION: Autoantibodies remained positive at high levels in our patients over a 3-year duration of the disease and correlated with specific cytokines. The clear correlations with disease duration and profile of specific cytokines could be targets for future therapeutic interventions.PMID:37953627 | PMC:PMC10644762 | DOI:10.1177/03946320231209821 (Source: International Journal of Immunopathology and Pharmacology)
Source: International Journal of Immunopathology and Pharmacology - November 13, 2023 Category: Allergy & Immunology Authors: Mohammed Al-Dubayee Amir Babiker Abdulaziz Alkewaibeen Abdulrahman Alkhalifah Tammam Alanazi Maysa Nogoud Anas Alotaibi Faisal Alotaibi Firas Almetairi Mohammed A Alrowaily Emad Masuadi Amre Nasr Source Type: research

Correlation analysis between cytokines' profile, autoimmune antibodies and the duration of type 1 diabetes: A case control study in a specialized children's centre in Riyadh
CONCLUSION: Autoantibodies remained positive at high levels in our patients over a 3-year duration of the disease and correlated with specific cytokines. The clear correlations with disease duration and profile of specific cytokines could be targets for future therapeutic interventions.PMID:37953627 | DOI:10.1177/03946320231209821 (Source: International Journal of Immunopathology and Pharmacology)
Source: International Journal of Immunopathology and Pharmacology - November 13, 2023 Category: Allergy & Immunology Authors: Mohammed Al-Dubayee Amir Babiker Abdulaziz Alkewaibeen Abdulrahman Alkhalifah Tammam Alanazi Maysa Nogoud Anas Alotaibi Faisal Alotaibi Firas Almetairi Mohammed A Alrowaily Emad Masuadi Amre Nasr Source Type: research

Renal venous malformation misdiagnosed as carcinoma: A report of one case and the review of literature
Int J Immunopathol Pharmacol. 2023 Jan-Dec;37:3946320231214117. doi: 10.1177/03946320231214117.ABSTRACTThe present study reports the clinical data of a patient with renal venous malformation misdiagnosed as carcinoma. CT revealed hematocele in the left renal pelvis and ureter. CTU: the left renal pelvis and calyces showed a slightly high density shadow, a size of about 2.6 cm*1.5 cm, and mild-to-moderate enhancement was found at the edge of the lesion. Enhanced MR showed that irregular mass abnormal signal was observed in the lower calyx of the left kidney and the lesions were cast, with short T1 and slightly long T2 signa...
Source: International Journal of Immunopathology and Pharmacology - November 9, 2023 Category: Allergy & Immunology Authors: Xinchun Zhang Ning Wang Bingkui Yang Source Type: research

Identification and development of TP53 mutation-associated Long non-coding RNAs signature for optimized prognosis assessment and treatment selection in hepatocellular carcinoma
CONCLUSION: The present study aimed to identify and validate LncRNAs associated with TP53 mutations. We constructed a prognostic model that can predict chemosensitivity and response to ICB therapy in HCC patients. This novel approach sheds light on the role of LncRNAs in TP53 mutation and provides valuable resources for analyzing patient prognosis and treatment selection.PMID:37942552 | PMC:PMC10637161 | DOI:10.1177/03946320231211795 (Source: International Journal of Immunopathology and Pharmacology)
Source: International Journal of Immunopathology and Pharmacology - November 9, 2023 Category: Allergy & Immunology Authors: Chenghao Chu Daoli Liu Duofa Wang Shuangjiu Hu Yongwei Zhang Source Type: research

Renal venous malformation misdiagnosed as carcinoma: A report of one case and the review of literature
Int J Immunopathol Pharmacol. 2023 Jan-Dec;37:3946320231214117. doi: 10.1177/03946320231214117.ABSTRACTThe present study reports the clinical data of a patient with renal venous malformation misdiagnosed as carcinoma. CT revealed hematocele in the left renal pelvis and ureter. CTU: the left renal pelvis and calyces showed a slightly high density shadow, a size of about 2.6 cm*1.5 cm, and mild-to-moderate enhancement was found at the edge of the lesion. Enhanced MR showed that irregular mass abnormal signal was observed in the lower calyx of the left kidney and the lesions were cast, with short T1 and slightly long T2 signa...
Source: International Journal of Immunopathology and Pharmacology - November 9, 2023 Category: Allergy & Immunology Authors: Xinchun Zhang Ning Wang Bingkui Yang Source Type: research