The Scope of Practice of an Outpatient Pediatric Palliative Care Oncology Clinic
1. Describe the spectrum of provider-reported pediatric palliative care domains discussed and managed during pediatric palliative care - oncology clinic visits and how these differ across initial and follow-up visits.2. Compare the differences in palliative care domains addressed and managed in visits with pediatric patients with brain tumors versus solid tumors vs leukemia/lymphoma. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Hee Su Park, Nicholas DeGroote, Anna Lange, Dio Kavalieratos, Katharine E. Brock Source Type: research
Use of Progestogen Tied to Higher Chance of Benign Brain Tumor
Many people worldwide use progestogen-based hormonal contraception or hormone replacement therapy to manage menopause symptoms. Previous research has linked a handful of high-dose progestogens —cyproterone acetate, nomegestrol acetate, and chlormadinone acetate—with increased risk of meningiomas, a common type of brain tumor that is generally noncancerous. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 19, 2024 Category: General Medicine Source Type: research
Comment in reply to Chen et al. Journal of Neuro-Oncology (2023) 165:535 –545 “Focused ultrasound combined with radiotherapy for malignant brain tumor: a preclinical and clinical study”
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 19, 2024 Category: Cancer & Oncology Source Type: research
Short-term predictors of stereotactic radiosurgery outcome for untreated single non-small cell lung cancer brain metastases: a restrospective cohort study
AbstractStereotactic radiosurgery (SRS) is an option for brain metastases (BM) not eligible for surgical resection, however, predictors of SRS outcomes are poorly known. The aim of this study is to investigate predictors of SRS outcome in patients with BM secondary to non-small cell lung cancer (NSCLC). The secondary objective is to analyze the value of volumetric criteria in identifying BM progression. This retrospective cohort study included patients>18 years of age with a single untreated BM secondary to NSCLC. Demographic, clinical, and radiological data were assessed. The primary outcome was treatment failure, defi...
Source: Neurosurgical Review - April 19, 2024 Category: Neurosurgery Source Type: research
The role of annexins in central nervous system development and disease
AbstractAnnexins, a group of Ca2+-dependent phospholipid-binding proteins, exert diverse roles in neuronal development, normal central nervous system (CNS) functioning, neurological disorders, and CNS tumors. This paper reviews the roles of individual annexins (A1-A13) in these contexts. Annexins possess unique structural and functional features, such as Ca2+-dependent binding to phospholipids, participating in membrane organization, and modulating cell signaling. They are implicated in various CNS processes, including endocytosis, exocytosis, and stabilization of plasma membranes. Annexins exhibit dynamic roles in neurona...
Source: Journal of Molecular Medicine - April 19, 2024 Category: Molecular Biology Source Type: research
Cancers, Vol. 16, Pages 1576: Focused Ultrasound-Enhanced Liquid Biopsy: A Promising Diagnostic Tool for Brain Tumor Patients
In conclusion, FUS-BBBO-enhanced liquid biopsy using stable cavitation shows diagnostic potential for primary brain tumors. Further research is imperative before integrating FUS-BBBO for liquid biopsy enhancement into clinical practice. (Source: Cancers)
Source: Cancers - April 19, 2024 Category: Cancer & Oncology Authors: Akke Bakker Anna E. Ixkes Hema Venugopal Mario G. Ries Nathalie S. M. Lak Filip Y. F. L. de Vos Dannis G. van Vuurden Tom J. Snijders Tags: Systematic Review Source Type: research
Cancers, Vol. 16, Pages 1566: Advancements in Image-Based Models for High-Grade Gliomas Might Be Accelerated
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The first half of 2022 saw the publication of several major research advances in image-based models and artificial intelligence applications to optimize treatment strategies for high-grade gliomas, the deadliest brain tumors. We review them and discuss the barriers that delay their entry into clinical practice; particularly, the small sample size and the heterogeneity of the study designs and methodologies used. We will also write about the poor and late palliation that patients suffering from high-grade glioma can count on at the end of life, as well as the current legislative instruments, with particular reference ...
Source: Cancers - April 19, 2024 Category: Cancer & Oncology Authors: Guido Frosina Tags: Review Source Type: research
The role of [18 F]FDOPA PET as an adjunct to conventional MRI in the diagnosis of aggressive glial lesions
ConclusionDynamic [18 F]FDOPA PET provides a similar diagnostic accuracy as contrast enhancement in MRI to identify the aggressiveness of suspected glial lesions at diagnosis. Both methods, however, are complementary and [18 F]FDOPA PET may be a useful additional tool in equivocal cases. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 19, 2024 Category: Nuclear Medicine Source Type: research
Adaptive cascaded transformer U-Net for MRI brain tumor segmentation
Phys Med Biol. 2024 Apr 18. doi: 10.1088/1361-6560/ad4081. Online ahead of print.ABSTRACTOBJECTIVE: Brain tumor segmentation on magnetic resonance imaging (MRI) plays an important role in assisting the diagnosis and treatment of cancer patients. Recently, cascaded U-Net models have achieved excellent performance via conducting coarse-to-fine segmentation of MRI brain tumors. However, they still suffer from obvious global and local differences among various brain tumors, which are difficult to solve with conventional convolutions.APPROACH: To address the issue, this work proposes a novel Adaptive Cascaded Transformer U-Net ...
Source: Physics in Medicine and Biology - April 18, 2024 Category: Physics Authors: Bonian Chen Qiule Sun Yutong Han Bin Liu Jianxin Zhang Qiang Zhang Source Type: research
UBE2C enhances temozolomide resistance by regulating the expression of p53 to induce aerobic glycolysis in glioma
In this study, we explore the role of UBE2C in regulating temozolomide (TMZ) resistance in glioma and investigate the underlying mechanisms involved. Twenty normal brain tissues and 100 glioma tissues from 50 TMZ-resistant patients and 50 TMZ-sensitive patients are included in this study. TMZ-resistant cell lines are constructed to explore the role of UBE2C in regulating glioma cell viability and TMZ resistance. Our results show that both the mRNA and protein levels of UBE2C are significantly elevated in the brain tissues of glioma patients, especially in those of TMZ-resistant patients. Consistently, UBE2C expression is m...
Source: Acta Biochimica et Biophysica Sinica - April 18, 2024 Category: Biochemistry Authors: Kun Zhou Dexin Wang Xiaolin Du Xia Feng Xiaoxi Zhu Cheng Wang Source Type: research
The role of [18 F]FDOPA PET as an adjunct to conventional MRI in the diagnosis of aggressive glial lesions
CONCLUSION: Dynamic [18 F]FDOPA PET provides a similar diagnostic accuracy as contrast enhancement in MRI to identify the aggressiveness of suspected glial lesions at diagnosis. Both methods, however, are complementary and [18 F]FDOPA PET may be a useful additional tool in equivocal cases.PMID:38637354 | DOI:10.1007/s00259-024-06720-y (Source: Molecular Medicine)
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Adeline Zinsz Celso Pouget Fabien Rech Luc Taillandier Marie Blonski Samir Amlal Laetitia Imbert Timoth ée Zaragori Antoine Verger Source Type: research
Vascular mimicry as a facilitator of melanoma brain metastasis
Cell Mol Life Sci. 2024 Apr 18;81(1):188. doi: 10.1007/s00018-024-05217-z.ABSTRACTMelanoma has the highest propensity among solid tumors to metastasize to the brain. Melanoma brain metastases (MBM) are a leading cause of death in melanoma and affect 40-60% of patients with late-stage disease. Therefore, uncovering the molecular mechanisms behind MBM is necessary to enhance therapeutic interventions. Vascular mimicry (VM) is a form of neovascularization linked to invasion, increased risk of metastasis, and poor prognosis in many tumor types, but its significance in MBM remains poorly understood. We found that VM density is ...
Source: Cellular and Molecular Life Sciences : CMLS - April 18, 2024 Category: Cytology Authors: Olivia K Provance Victor O Oria Thuy T Tran Jasmine I Caulfield Christopher R Zito Adam Aguirre-Ducler Kurt A Schalper Harriet M Kluger Lucia B Jilaveanu Source Type: research
GBM Immunotherapy: Macrophage Impacts
CONCLUSION: This review provides a comprehensive overview of the latest research on the nature of TAMs and the development of therapeutic strategies targeting TAMs, focusing on the variety of macrophage properties, being modulated, as well as molecular targets.PMID:38634572 | DOI:10.1080/08820139.2024.2337022 (Source: Immunological Investigations)
Source: Immunological Investigations - April 18, 2024 Category: Allergy & Immunology Authors: Nina Loginova Denis Aniskin Peter Timashev Ilya Ulasov Rajesh Kumar Kharwar Source Type: research
The RAS oncogene in brain tumors and the involvement of let-7 microRNA
Mol Biol Rep. 2024 Apr 18;51(1):531. doi: 10.1007/s11033-024-09439-z.ABSTRACTRAS oncogenes are master regulator genes in many cancers. In general, RAS-driven cancers have an oncogenic RAS mutation that promotes disease progression (colon, lung, pancreas). In contrast, brain tumors are not necessarily RAS-driven cancers because RAS mutations are rarely observed. In particular, glioblastomas (the most lethal brain tumor) do not appear to have dominant genetic mutations that are suitable for targeted therapy. Standard treatment for most brain tumors continues to focus on maximal surgical resection, radiotherapy and chemothera...
Source: Molecular Biology Reports - April 18, 2024 Category: Molecular Biology Authors: Samantha Messina Source Type: research
Single administration of a psychedelic [(R)-DOI] influences coping strategies to an escapable social stress
Neuropharmacology. 2024 Apr 16;252:109949. doi: 10.1016/j.neuropharm.2024.109949. Online ahead of print.ABSTRACTPsychedelic compounds have potentially rapid, long-lasting anxiolytic, antidepressive and anti-inflammatory effects. We investigated whether the psychedelic compound (R)-2,5-dimethoxy-4-iodoamphetamine [(R)-DOI], a selective 5-HT2A receptor partial agonist, decreases stress-related behavior in male mice exposed to repeated social aggression. Additionally, we explored the likelihood that these behavioral changes are related to anti-inflammatory properties of [(R)-DOI]. Animals were subjected to the Stress Alternat...
Source: Neuropharmacology - April 18, 2024 Category: Drugs & Pharmacology Authors: Kevin T Krupp Jazmine D W Yaeger Leighton J Ledesma Miyuraj Harishchandra Hikkaduwa Withanage J J Gale Chase B Howe Trevor J Allen Monica Sathyanesan Samuel S Newton Cliff H Summers Source Type: research
