Mini-colon and brain ‘organoids’ shed light on cancer and other diseases
Nature, Published online: 24 April 2024; doi:10.1038/d41586-024-01199-xTiny 3D structures made from human stem cells sometimes offer insights that animal models cannot. (Source: Nature AOP)
Source: Nature AOP - April 24, 2024 Category: Research Authors: Sara Reardon Source Type: research
Neurologic Dysphagia
This article aims to review the major categories of neurologic dysphagia, to outline specific findings and special considerations for each population, and to acknowledge the importance of integrating each patient ’s medical prognosis, goals of care, and developmental stage into a multidisciplinary treatment plan. (Source: Otolaryngologic clinics of North America)
Source: Otolaryngologic clinics of North America - April 24, 2024 Category: ENT & OMF Authors: Jillian Nyswonger Sugg, Janet Waimin Lee Source Type: research
Mini-colon and brain 'organoids' shed light on cancer and other diseases
Nature, Published online: 24 April 2024; doi:10.1038/d41586-024-01199-xTiny 3D structures made from human stem cells sometimes offer insights that animal models cannot. (Source: Nature AOP)
Source: Nature AOP - April 24, 2024 Category: Research Authors: Sara Reardon Source Type: research
Cancers, Vol. 16, Pages 1637: Pentraxin 3: A Main Driver of Inflammation and Immune System Dysfunction in the Tumor Microenvironment of Glioblastoma
Paola Capra
Brain tumors are a heterogeneous group of brain neoplasms that are highly prevalent in individuals of all ages worldwide. Within this pathological framework, the most prevalent and aggressive type of primary brain tumor is glioblastoma (GB), a subtype of glioma that falls within the IV-grade astrocytoma group. The death rate for patients with GB remains high, occurring within a few months after diagnosis, even with the gold-standard therapies now available, such as surgery, radiation, or a pharmaceutical approach with Temozolomide. For this reason, it is crucial to continue looking for cutting-edge therape...
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: Sarah Adriana Scuderi Alessio Ardizzone Ayomide Eniola Salako Giuseppe Pant ò Fabiola De Luca Emanuela Esposito Anna Paola Capra Tags: Review Source Type: research
Genes, Vol. 15, Pages 535: Preservation of 5-Hydroxymethylcytosine Levels in LRIG1 across Genomic DNA and Cell-Free DNA in Glioma Patients
In this study, our aim was to identify cfDNA biomarkers by investigating genes that displayed significant differences between glioma patients and their corresponding controls. To accomplish this, we utilized publicly available data from the Gene Expression Omnibus, focusing on 5-hydroxymethylcytosine (5hmC) profiles in both cfDNA and genomic DNA (gDNA) from glioma patients and healthy individuals. The intersection of gene lists derived from these comparative analyses unveiled LRIG1 and ZNF703 as the two genes with elevated 5hmC levels in both the cfDNA of glioma patients and gDNA of glioma tissue compared to their respecti...
Source: Genes - April 24, 2024 Category: Genetics & Stem Cells Authors: Da ša Jevšinek Skok Luka Bolha Nina Hauptman Tags: Brief Report Source Type: research
Relationship between brain tumors and intracranial aneurysms: a systematic review
CONCLUSION: There is a lack of evidence to affirm that the existence of brain neoplasm plays a role in the formation and rupture of intracranial aneurysms. Additionally, there is insufficient evidence to confirm a greater prevalence of intracranial aneurysms in individuals with brain tumors. The association of these two disorders does not appear to worsen patient outcome. Prognosis depends on tumor pathology for malignant cases and on subarachnoid hemorrhage in patients with ruptured aneurysms.PMID:38650567 | DOI:10.5137/1019-5149.JTN.43614-23.4 (Source: Turkish Neurosurgery)
Source: Turkish Neurosurgery - April 23, 2024 Category: Neurosurgery Authors: Pedro Henrique Mouty Rabello N ícollas Nunes Rabelo Jo ão Paulo Telles Eberval Gadelha Figueiredo Source Type: research
Relationship between brain tumors and intracranial aneurysms: a systematic review
CONCLUSION: There is a lack of evidence to affirm that the existence of brain neoplasm plays a role in the formation and rupture of intracranial aneurysms. Additionally, there is insufficient evidence to confirm a greater prevalence of intracranial aneurysms in individuals with brain tumors. The association of these two disorders does not appear to worsen patient outcome. Prognosis depends on tumor pathology for malignant cases and on subarachnoid hemorrhage in patients with ruptured aneurysms.PMID:38650567 | DOI:10.5137/1019-5149.JTN.43614-23.4 (Source: Turkish Neurosurgery)
Source: Turkish Neurosurgery - April 23, 2024 Category: Neurosurgery Authors: Pedro Henrique Mouty Rabello N ícollas Nunes Rabelo Jo ão Paulo Telles Eberval Gadelha Figueiredo Source Type: research
Relationship between brain tumors and intracranial aneurysms: a systematic review
CONCLUSION: There is a lack of evidence to affirm that the existence of brain neoplasm plays a role in the formation and rupture of intracranial aneurysms. Additionally, there is insufficient evidence to confirm a greater prevalence of intracranial aneurysms in individuals with brain tumors. The association of these two disorders does not appear to worsen patient outcome. Prognosis depends on tumor pathology for malignant cases and on subarachnoid hemorrhage in patients with ruptured aneurysms.PMID:38650567 | DOI:10.5137/1019-5149.JTN.43614-23.4 (Source: Turkish Neurosurgery)
Source: Turkish Neurosurgery - April 23, 2024 Category: Neurosurgery Authors: Pedro Henrique Mouty Rabello N ícollas Nunes Rabelo Jo ão Paulo Telles Eberval Gadelha Figueiredo Source Type: research
Identification of core genes of craniopharyngioma angiogenesis based on single-cell nuclear transcriptome sequencing
This study aimed to explore the core genes of craniopharyngioma angiogenesis for targeted vascular therapy based on single-cell nuclear transcriptome sequencing. For single-cell nuclear transcriptome sequencing, we collected six samples from the tumor center and adjacent hypothalamic tumor tissues from three patients with craniopharyngioma, as well as four normal brain tissues based on Gene Expression Omnibus. We screened genes with differential up-regulation between vascular endothelial cells of craniopharyngioma and those of normal brain tissues, performed GO and KEGG analysis, constructed the protein-protein interaction...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Jinshi Zhang Lin Xu Jiye Ye Chunming Xu Bowen Wu Jie Wu Tao Hong Source Type: research
Relationship between brain tumors and intracranial aneurysms: a systematic review
CONCLUSION: There is a lack of evidence to affirm that the existence of brain neoplasm plays a role in the formation and rupture of intracranial aneurysms. Additionally, there is insufficient evidence to confirm a greater prevalence of intracranial aneurysms in individuals with brain tumors. The association of these two disorders does not appear to worsen patient outcome. Prognosis depends on tumor pathology for malignant cases and on subarachnoid hemorrhage in patients with ruptured aneurysms.PMID:38650567 | DOI:10.5137/1019-5149.JTN.43614-23.4 (Source: Turkish Neurosurgery)
Source: Turkish Neurosurgery - April 23, 2024 Category: Neurosurgery Authors: Pedro Henrique Mouty Rabello N ícollas Nunes Rabelo Jo ão Paulo Telles Eberval Gadelha Figueiredo Source Type: research
Identification of core genes of craniopharyngioma angiogenesis based on single-cell nuclear transcriptome sequencing
This study aimed to explore the core genes of craniopharyngioma angiogenesis for targeted vascular therapy based on single-cell nuclear transcriptome sequencing. For single-cell nuclear transcriptome sequencing, we collected six samples from the tumor center and adjacent hypothalamic tumor tissues from three patients with craniopharyngioma, as well as four normal brain tissues based on Gene Expression Omnibus. We screened genes with differential up-regulation between vascular endothelial cells of craniopharyngioma and those of normal brain tissues, performed GO and KEGG analysis, constructed the protein-protein interaction...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Jinshi Zhang Lin Xu Jiye Ye Chunming Xu Bowen Wu Jie Wu Tao Hong Source Type: research
Diagnostic and therapeutic use of oral micronized progesterone in endocrinology
Rev Endocr Metab Disord. 2024 Apr 23. doi: 10.1007/s11154-024-09882-0. Online ahead of print.ABSTRACTProgesterone is a natural steroid hormone, while progestins are synthetic molecules. In the female reproductive system, progesterone contributes to the control of luteinizing hormone and follicle-stimulating hormone secretion and their pulsatility, via its receptors on the kisspeptin, neurokinin B, and dynorphin neurons in the hypothalamus. Progesterone together with estradiol controls the cyclic changes of proliferation and decidualization of the endometrium; exerts anti-mitogenic actions on endometrial epithelial cells; r...
Source: ENDOCR REV - April 23, 2024 Category: Endocrinology Authors: Eleni Memi Polina Pavli Papagianni Maria Nikolaos Vrachnis George Mastorakos Source Type: research
Relationship between brain tumors and intracranial aneurysms: a systematic review
CONCLUSION: There is a lack of evidence to affirm that the existence of brain neoplasm plays a role in the formation and rupture of intracranial aneurysms. Additionally, there is insufficient evidence to confirm a greater prevalence of intracranial aneurysms in individuals with brain tumors. The association of these two disorders does not appear to worsen patient outcome. Prognosis depends on tumor pathology for malignant cases and on subarachnoid hemorrhage in patients with ruptured aneurysms.PMID:38650567 | DOI:10.5137/1019-5149.JTN.43614-23.4 (Source: Turkish Neurosurgery)
Source: Turkish Neurosurgery - April 23, 2024 Category: Neurosurgery Authors: Pedro Henrique Mouty Rabello N ícollas Nunes Rabelo Jo ão Paulo Telles Eberval Gadelha Figueiredo Source Type: research
Molecular biology and novel therapeutics for IDH mutant gliomas: The new era of IDH inhibitors
Biochim Biophys Acta Rev Cancer. 2024 Apr 21:189102. doi: 10.1016/j.bbcan.2024.189102. Online ahead of print.ABSTRACTGliomas with Isocitrate dehydrogenase (IDH) mutation represent a discrete category of primary brain tumors with distinct and unique characteristics, behaviors, and clinical disease outcomes. IDH mutations lead to aberrant high-level production of the oncometabolite D-2-hydroxyglutarate (D-2HG), which act as a competitive inhibitor of enzymes regulating epigenetics, signaling pathways, metabolism, and various other processes. This review summarizes the significance of IDH mutations, resulting upregulation of ...
Source: Biochimica et Biophysica Acta - April 23, 2024 Category: Biochemistry Authors: Yosuke Kitagawa Ami Kobayashi Daniel P Cahill Hiroaki Wakimoto Shota Tanaka Source Type: research
Identification of core genes of craniopharyngioma angiogenesis based on single-cell nuclear transcriptome sequencing
This study aimed to explore the core genes of craniopharyngioma angiogenesis for targeted vascular therapy based on single-cell nuclear transcriptome sequencing. For single-cell nuclear transcriptome sequencing, we collected six samples from the tumor center and adjacent hypothalamic tumor tissues from three patients with craniopharyngioma, as well as four normal brain tissues based on Gene Expression Omnibus. We screened genes with differential up-regulation between vascular endothelial cells of craniopharyngioma and those of normal brain tissues, performed GO and KEGG analysis, constructed the protein-protein interaction...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Jinshi Zhang Lin Xu Jiye Ye Chunming Xu Bowen Wu Jie Wu Tao Hong Source Type: research
