GSE227631 MYC promotes aggressive growth and metastasis of a WNT-medulloblastoma mouse model
Contributors : Timothy Phoenix ; Rachel HartleySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMedulloblastoma (MB), the most common malignant pediatric brain tumor, comprises of four molecularly and clinically distinct subgroups (termed WNT, SHH, Group3, and Group4). Prognosis varies based on genetic and pathological features associated with each molecular subgroup. WNT-MB, considered low-risk, are rarely metastatic and contain activating mutations in CTNNB1; Group3-MB, commonly classified as high-risk, are frequently metastatic and can contain genomic alterations resulting in elev...
Source: GEO: Gene Expression Omnibus - April 30, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Advanced AI-driven approach for enhanced brain tumor detection from MRI images utilizing EfficientNetB2 with equalization and homomorphic filtering
Brain tumors pose a significant medical challenge necessitating precise detection and diagnosis, especially in Magnetic resonance imaging(MRI). Current methodologies reliant on traditional image processing and... (Source: BMC Medical Informatics and Decision Making)
Source: BMC Medical Informatics and Decision Making - April 30, 2024 Category: Information Technology Authors: A. M. J. Zubair Rahman, Muskan Gupta, S. Aarathi, T. R. Mahesh, V. Vinoth Kumar, S. Yogesh Kumaran and Suresh Guluwadi Tags: Research Source Type: research
Glioma hexokinase 3 positively correlates with malignancy and macrophage infiltration
ConclusionsThis is the first comprehensive research to figure out the relationship between HK3 and TME characteristics in gliomas. HK3 is positively associated with macrophage infiltration and can induce the immunosuppressive TME and malignant phenotype of gliomas. (Source: Metabolic Brain Disease)
Source: Metabolic Brain Disease - April 30, 2024 Category: Neurology Source Type: research
Leveraging radiomics and machine learning to differentiate radiation necrosis from recurrence in patients with brain metastases
ConclusionsRadiomics with ML may assist the diagnostic ability of distinguishing RN from tumor recurrence after SRS. Further work is needed to validate this in a larger multi-institutional cohort and prospectively evaluate it ’s utility in patient care. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 30, 2024 Category: Cancer & Oncology Source Type: research
LOXL1-AS1 contributes to metastasis in sonic-hedgehog medulloblastoma by promoting cancer stem-like phenotypes
Medulloblastomas (MBs) are one of the most common malignant brain tumor types in children. MB prognosis, despite improvement in recent years, still depends on clinical and biological risk factors. Metastasis i... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - April 30, 2024 Category: Cancer & Oncology Authors: Anh Duy Do, Kuo-Sheng Wu, Shing-Shung Chu, Le Hien Giang, Yu-Ling Lin, Che-Chang Chang, Tai-Tong Wong, Chia-Ling Hsieh and Shian-Ying Sung Tags: Research Source Type: research
Sensors, Vol. 24, Pages 2865: Biosensor-Enhanced Organ-on-a-Chip Models for Investigating Glioblastoma Tumor Microenvironment Dynamics
ng Tian
Glioblastoma, an aggressive primary brain tumor, poses a significant challenge owing to its dynamic and intricate tumor microenvironment. This review investigates the innovative integration of biosensor-enhanced organ-on-a-chip (OOC) models as a novel strategy for an in-depth exploration of glioblastoma tumor microenvironment dynamics. In recent years, the transformative approach of incorporating biosensors into OOC platforms has enabled real-time monitoring and analysis of cellular behaviors within a controlled microenvironment. Conventional in vitro and in vivo models exhibit inherent limitations in accuratel...
Source: Sensors - April 30, 2024 Category: Biotechnology Authors: Gayathree Thenuwara Bilal Javed Baljit Singh Furong Tian Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1752: Drivers Underlying Metastasis and Relapse in Medulloblastoma and Targeting Strategies
wartling
Medulloblastomas comprise a molecularly diverse set of malignant pediatric brain tumors in which patients are stratified according to different prognostic risk groups that span from very good to very poor. Metastasis at diagnosis is most often a marker of poor prognosis and the relapse incidence is higher in these children. Medulloblastoma relapse is almost always fatal and recurring cells have, apart from resistance to standard of care, acquired genetic and epigenetic changes that correlate with an increased dormancy state, cell state reprogramming and immune escape. Here, we review means to carefully study m...
Source: Cancers - April 30, 2024 Category: Cancer & Oncology Authors: Karl O. Holmberg Anna Borgenvik Miao Zhao G éraldine Giraud Fredrik J. Swartling Tags: Review Source Type: research
367. Effect of Neuregulin1 in Brain Microvascular Endothelial Cells Stimulated With Tumor Necrosis Alpha (TNF- α): A Possible Protective Role in Blood Brain Barrier Injury
Traumatic brain injury (TBI), caused by exposure to explosions is common among returning war Veterans that have suffered trauma during their deployment. Neuroinflammation is a key feature after TBI characterized by increased pro- and anti-inflammatory cytokines, disruption of blood-brain-barrier (BBB) permeability, resulting in many neuropsychiatric diseases. Perturbation of BBB is pivotal in TBI as dysfunctional barrier allows inflammatory cells trafficking resulting in impairment of neurovascular unit. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Sudhiranjan Gupta, Christina Hejl, William Stewart, Rakeshwar Guleria Source Type: research
Roles of TRPM channels in glioma
Cancer Biol Ther. 2024 Dec 31;25(1):2338955. doi: 10.1080/15384047.2024.2338955. Epub 2024 Apr 29.ABSTRACTGliomas are the most common type of primary brain tumor. Despite advances in treatment, it remains one of the most aggressive and deadly tumor of the central nervous system (CNS). Gliomas are characterized by high malignancy, heterogeneity, invasiveness, and high resistance to radiotherapy and chemotherapy. It is urgent to find potential new molecular targets for glioma. The TRPM channels consist of TRPM1-TPRM8 and play a role in many cellular functions, including proliferation, migration, invasion, angiogenesis, etc. ...
Source: Cancer Biology and Therapy - April 29, 2024 Category: Cancer & Oncology Authors: Zhigang Chen Han Xie Jun Liu JiaJia Zhao Ruixiang Huang Yufei Xiang Haoyuan Wu Dasheng Tian Erbao Bian Zhang Xiong Source Type: research
How Does the Number of Brain Metastases Correlate With Normal Brain Exposure in Single-Isocenter Multitarget Multifraction Stereotactic Radiosurgery
CONCLUSIONS: Based on clinical SRT plans, our study provides information on correlations between normal brain exposure and the number and total volume of targets. As SRT becomes more greatly used for patients with increasingly extensive brain metastases, more clinical data on outcomes and toxicities is necessary to better define the normal brain dose constraints for high-exposure cases and to optimize the SRT management for those patients.PMID:38681891 | PMC:PMC11047183 | DOI:10.1016/j.adro.2024.101499 (Source: Adv Data)
Source: Adv Data - April 29, 2024 Category: Epidemiology Authors: Dandan Zheng Jihyung Yoon Hyunuk Jung Olga Maria Dona Lemus Lang Gou Yuwei Zhou Kenneth Y Usuki Sara Hardy Michael T Milano Source Type: research
A phase I dose-escalation study of pulsatile afatinib in patients with recurrent or progressive brain cancer
CONCLUSIONS: Afatinib taken orally was safe and well-tolerated up to 280 mg every 7 days in brain cancer patients.PMID:38680990 | PMC:PMC11046985 | DOI:10.1093/noajnl/vdae049 (Source: Adv Data)
Source: Adv Data - April 29, 2024 Category: Epidemiology Authors: Tiffany M Juarez Jaya M Gill Annie Heng Jose A Carrillo Naveed Wagle Natsuko Nomura Minhdan Nguyen Judy Truong Lucia Dobrawa Walavan Sivakumar Garni Barkhoudarian Daniel F Kelly Santosh Kesari Source Type: research
[11C]-methionine positron emission tomography in the evaluation of pediatric low-grade gliomas
CONCLUSIONS: Our study shows that [11C]-MET-PET reliably characterizes new and previously treated pLGGs. Our study also shows that quantitative parameters tend to decrease with treatment, and differences may exist between various pLGG types.PMID:38680989 | PMC:PMC11055465 | DOI:10.1093/noajnl/vdae056 (Source: Adv Data)
Source: Adv Data - April 29, 2024 Category: Epidemiology Authors: Emily Y Kim Amy L Vavere Scott E Snyder Jason Chiang Yimei Li Tushar Patni Ibrahim Qaddoumi Thomas E Merchant Giles W Robinson Joseph L Holtrop Barry L Shulkin Asim K Bag Source Type: research
Unique genomic alterations in the circulating tumor DNA of patients with solid tumors brain metastases
CONCLUSIONS: This study illustrates the feasibility of detecting alterations from ctDNA among patients with BrMs. A higher frequency of actionable mutations was observed in ctDNA in patients with BrMs. Additional studies comparing ctDNA and alterations in BrMs tissue are needed to determine if ctDNA can be considered a surrogate to support treatment decisions.PMID:38680992 | PMC:PMC11046982 | DOI:10.1093/noajnl/vdae052 (Source: Adv Data)
Source: Adv Data - April 29, 2024 Category: Epidemiology Authors: Laura Alder Gloria Broadwater Michelle Green Amanda E D Van Swearingen Eric S Lipp Jeffrey Melson Clarke Carey K Anders Sarah Sammons Source Type: research
Enhanced therapeutic efficacy for glioblastoma immunotherapy with an oncolytic herpes simplex virus armed with anti-PD-1 antibody and IL-12
In this study, we developed a new generation of oncolytic herpes simplex virus C5252 by deletion of a 15-kb internal repeat region and both copies of γ34.5 genes. Additionally, C5252 was armed with anti-programmed cell death protein 1 antibody and interleukin-12 to enhance its therapeutic efficacy for glioblastoma immune-virotherapy. In vitro and in vivo experiments demonstrate that C5252 has a remarkable safety profile and potent anti-tumor activity against glioblastoma. Mechanistic studies demonstrated that C5252 specifically induces cell apoptosis by caspase-3/7 activation via downregulating ciliary neurotrophic factor...
Source: Herpes - April 29, 2024 Category: Infectious Diseases Authors: Lei Wang Xusha Zhou Xiaoqing Chen Yuanyuan Liu Yue Huang Yuan Cheng Peigen Ren Jing Zhao Grace Guoying Zhou Source Type: research
Roles of TRPM channels in glioma
Cancer Biol Ther. 2024 Dec 31;25(1):2338955. doi: 10.1080/15384047.2024.2338955. Epub 2024 Apr 29.ABSTRACTGliomas are the most common type of primary brain tumor. Despite advances in treatment, it remains one of the most aggressive and deadly tumor of the central nervous system (CNS). Gliomas are characterized by high malignancy, heterogeneity, invasiveness, and high resistance to radiotherapy and chemotherapy. It is urgent to find potential new molecular targets for glioma. The TRPM channels consist of TRPM1-TPRM8 and play a role in many cellular functions, including proliferation, migration, invasion, angiogenesis, etc. ...
Source: Cancer Biology and Therapy - April 29, 2024 Category: Cancer & Oncology Authors: Zhigang Chen Han Xie Jun Liu JiaJia Zhao Ruixiang Huang Yufei Xiang Haoyuan Wu Dasheng Tian Erbao Bian Zhang Xiong Source Type: research
