A Longitudinal Study of White Matter Development in Relation to Changes in Autism Severity Across Early Childhood
Cross-sectional diffusion-weighted MRI studies suggest that young autistic children have alterations in white matter structure that differ from older autistic individuals. However, it is unclear if these differences result from atypical neurodevelopment or sampling differences between young and older cohorts. Furthermore, the relationship between altered white matter development and longitudinal changes in autism symptoms is unknown. (Source: Biological Psychiatry)
Source: Biological Psychiatry - October 29, 2020 Category: Psychiatry Authors: Derek Sayre Andrews, Joshua K. Lee, Danielle Jenine Harvey, Einat Waizbard-Bartov, Marjorie Solomon, Sally J. Rogers, Christine Wu Nordahl, David G. Amaral Tags: Archival Report Source Type: research

Persistently elevated mTORC1-S6 kinase 1 disrupts DARPP-32-dependent D1 dopamine receptor signaling and behaviors
The serine-threonine kinase mammalian target of rapamycin complex 1 (mTORC1) is essential for normal cell function but is aberrantly activated in brain in both genetic-developmental and sporadic diseases and is associated with a spectrum of neuropsychiatric symptoms. The underlying molecular mechanisms of cognitive and neuropsychiatric symptoms remain controversial. (Source: Biological Psychiatry)
Source: Biological Psychiatry - October 27, 2020 Category: Psychiatry Authors: Raozhou Lin, Lisa N. Learman, Chan-Hyun Na, Santosh Renuse, Kevin T. Chen, Po Yu Chen, Gum-Hwa Lee, Bo Xiao, Susan M. Resnick, Juan C. Troncoso, Karen K. Szumlinski, David J. Linden, Joo-Min Park, Alena Savonenko, Akhilesh Pandey, Paul F. Worley Tags: Priority Communication Source Type: research

Dietary quality and dietary inflammatory potential during pregnancy and offspring emotional and behavioral symptoms in childhood: an individual participant data meta-analysis of four European cohorts
The impact of maternal diet during pregnancy on child neurodevelopment is of public health and clinical relevance. We evaluated associations of dietary quality (based on Dietary Approaches to Stop Hypertension (DASH) score) and dietary inflammatory potential (based on energy-adjusted Dietary Inflammatory Index (E-DII) score) during pregnancy with offspring emotional and behavioral symptoms at 7-10 years of age. (Source: Biological Psychiatry)
Source: Biological Psychiatry - October 23, 2020 Category: Psychiatry Authors: Kinga Polanska, Pawel Kaluzny, Adrien M. Aubert, Jonathan Y. Bernard, Liesbeth Duijts, Hanan El Marroun, Wojciech Hanke, James R. H ébert, Barbara Heude, Agnieszka Jankowska, Giulia Mancano, Sara M. Mensink-Bout, Caroline Relton, Nitin Shivappa, Matthew Tags: Archival Report Source Type: research

Cord Serum Cytokines at Birth and Children's Anxiety/Depression Trajectories from 3 to 8 Years: The EDEN Mother-Child Cohort
The objectives of the study were to describe the network of cord serum cytokines at birth and test whether they are associated with subsequent anxiety/depression symptom trajectories in offspring. (Source: Biological Psychiatry)
Source: Biological Psychiatry - October 23, 2020 Category: Psychiatry Authors: C édric Galera, Susana Barbosa, Ophélie Collet, Olfa Khalfallah, Bruno Aouizerate, Anne-Laure Sutter-Dalley, Muriel Koehl, Lucile Capuron, Judith Van der Waerden, Maria Melchior, Sylvana Côté, Barbara Heude, Nicolas Glaichenhaus, Laetitia Davidovic, E Tags: Archival Report Source Type: research

Computational Analysis of Multidimensional Behavioral Alterations After Chronic Social Defeat Stress
The study of depression in humans depends on animal models that attempt to mimic specific features of the human syndrome. Most studies focus on one or a few behavioral domains, with time and practical considerations prohibiting a comprehensive evaluation. While machine-learning has enabled unbiased analysis of behavior in animals, this has not yet been applied to animal models of psychiatric disease. (Source: Biological Psychiatry)
Source: Biological Psychiatry - October 23, 2020 Category: Psychiatry Authors: Zachary S. Lorsch, Alberto Ambesi-Impiombato, Rebecca Zenowich, Irene Morganstern, Emer Leahy, Mukesh Bansal, Eric J. Nestler, Taleen Hanania Tags: Archival Report Source Type: research

Esketamine for Postpartum Suicidality
We report the first case of rapid life-saving improvement in postpartum depression (PPD) with severe suicidal ideation/attempt following the introduction of esketamine injections after failing to achieve a response with antidepressants. (Source: Biological Psychiatry)
Source: Biological Psychiatry - October 22, 2020 Category: Psychiatry Authors: Catarina Machado, Acioly L.T. Lacerda, Rodrigo A. Bressan, Cristiano Noto Tags: Correspondence Source Type: research

Astrocytic Activation to Restore Goal-Directed Behaviors
When we are first learning how to drive a car, every action we perform is carefully planned and executed. We might have to remind ourselves “I’m approaching a stop sign, so I need to release my foot from the gas and gently push the brake,” or “I’m merging into the next lane, so I need to make sure I look in my blind spot.” As we repeatedly perform these actions and gain experience navigating our automobile across different s ituations and environments, these behaviors become automatic. For better or worse, we no longer have to consciously remind ourselves to remove our foot from the gas ...
Source: Biological Psychiatry - October 19, 2020 Category: Psychiatry Authors: Stephanie M. Groman Tags: Commentary Source Type: research

“Coding” Is Not Enough: The Role of Long “Noncoding” RNA for Cocaine Addiction
Cocaine exposure causes long-lasting and persistent molecular changes in the brain, particularly in areas that play an important role in reward, such as the striatum and the nucleus accumbens (ventral striatum) where molecular memory is formed. These molecular adaptations, some rightly viewed as maladaptations, mostly result from gene expression changes caused by alterations of transcription factors and/or epigenetic regulations through chromatin modification (1). Posttranscriptional gene regulation also contributes because microRNAs (miRNAs) have been reported to function as molecular regulators that control actions of co...
Source: Biological Psychiatry - October 19, 2020 Category: Psychiatry Authors: Yonwoo Jung Tags: Early Career Investigator Commentary Source Type: research

Designing Neuroimaging Studies to Help Inform the Clinical Treatment of Addiction
Positron emission tomography (PET) provides a unique window into the neurochemistry underlying addiction. Using PET, the field has been able to study neurotransmitter –receptor interactions in living individuals with drug use disorders in brain regions innervated by dopamine (DA). PET studies have consistently identified DA dysfunction in the striatum in drug and alcohol use disorders. There are lower levels of striatal D2/3 receptors (D2/3Rs) in individuals wi th cocaine, alcohol, tobacco, cannabis, stimulant, and heroin use disorders compared with nonusing individuals. (Source: Biological Psychiatry)
Source: Biological Psychiatry - October 19, 2020 Category: Psychiatry Authors: Yasmin Zakiniaeiz, Kelly P. Cosgrove Tags: Commentary Source Type: research

A Mechanism of Cocaine Addiction Susceptibility Through D2 Receptor –Mediated Regulation of Nucleus Accumbens Cholinergic Interneurons
People with addiction differ from casual drug users by their uncontrollable drug intake despite the adverse consequences associated with drug use. The compulsive drug-seeking and drug-taking behaviors that define addiction are also observed in rodent models that were first established almost 2 decades ago. Studies have shown that there is a percentage of individuals in human and rodent populations that are susceptible to drug use while others are resilient (1,2). Susceptibility to developing any substance use disorder is influenced by genetic and epigenetic variation along with psychosocial factors. (Source: Biological Psychiatry)
Source: Biological Psychiatry - October 19, 2020 Category: Psychiatry Authors: Robert G. Lewis, Emiliana Borrelli Tags: Commentary Source Type: research

In This Issue
Volume 88, Number 10, November 15, 2020 (Source: Biological Psychiatry)
Source: Biological Psychiatry - October 19, 2020 Category: Psychiatry Tags: In This Issue Source Type: research

Editorial Board Page
(Source: Biological Psychiatry)
Source: Biological Psychiatry - October 19, 2020 Category: Psychiatry Source Type: research

Subscribers Page
(Source: Biological Psychiatry)
Source: Biological Psychiatry - October 19, 2020 Category: Psychiatry Source Type: research

Table of Contents
(Source: Biological Psychiatry)
Source: Biological Psychiatry - October 19, 2020 Category: Psychiatry Source Type: research

Guide for Authors
Biological Psychiatry is the official journal of the Society of Biological Psychiatry. The Journal rapidly publishes reports of novel results on a broad range of topics related to the pathophysiology and treatment of major neuropsychiatric disorders. Both basic and clinical neuroscience contributions are encouraged, particularly those addressing genetic and environmental risk factors, neural circuitry and neurochemistry, and important new therapeutic approaches. (Source: Biological Psychiatry)
Source: Biological Psychiatry - October 19, 2020 Category: Psychiatry Source Type: research

Introducing a new journal, Biological Psychiatry: Global Open Science
The editors of the Society of Biological Psychiatry journals are thrilled to introduce Biological Psychiatry: Global Open Science (BP:GOS), a new sibling journal for Biological Psychiatry (BP) and Biological Psychiatry: Cognitive Neuroscience and Neuroimaging (BP:CNNI). (Source: Biological Psychiatry)
Source: Biological Psychiatry - October 12, 2020 Category: Psychiatry Authors: John H. Krystal, Deanna M. Barch, Cameron S. Carter Tags: Editorial Source Type: research

An adolescent sensitive period for threat responding: impacts of stress and sex
Anxiety and fear-related disorders peak in prevalence during adolescence, a window of rapid behavioral development and neural remodeling. However, understanding of the development of threat responding and the underlying neural circuits remains limited. Preclinical models of threat conditioning and extinction have provided an unparalleled glimpse into the developing brain. In this review we discuss mouse and rat studies on the development of threat response regulation with a focus on the adolescent period. (Source: Biological Psychiatry)
Source: Biological Psychiatry - October 9, 2020 Category: Psychiatry Authors: Danielle M. Gerhard, Heidi C. Meyer, Francis S. Lee Tags: Review Source Type: research

Plasma and Fecal Metabolite Profiles in Autism Spectrum Disorder
Autism Spectrum Disorder (ASD) is a neurodevelopmental condition with hallmark behavioral manifestations including impaired social communication and restricted repetitive behavior. In addition, many affected individuals display metabolic imbalances, immune dysregulation, gastrointestinal (GI) dysfunction, and altered gut microbiome compositions. (Source: Biological Psychiatry)
Source: Biological Psychiatry - October 9, 2020 Category: Psychiatry Authors: Brittany D. Needham, Mark D. Adame, Gloria Serena, Destanie R. Rose, Gregory M. Preston, Mary C. Conrad, A. Stewart Campbell, David H. Donabedian, Alessio Fasano, Paul Ashwood, Sarkis K. Mazmanian Tags: Archival Report Source Type: research

Pleiotropy and Cross-Disorder Genetics Among Psychiatric Disorders
Genome-wide analyses of common and rare genetic variation have documented the heritability of major psychiatric disorders, established their highly polygenic genetic architecture, and identified hundreds of contributing variants. In recent years, these studies have illuminated another key feature of the genetic basis of psychiatric disorders: the important role and pervasive nature of pleiotropy. It is now clear that a substantial fraction of genetic influences on psychopathology transcend clinical diagnostic boundaries. (Source: Biological Psychiatry)
Source: Biological Psychiatry - October 9, 2020 Category: Psychiatry Authors: Phil H. Lee, Yen-Chen A. Feng, Jordan W. Smoller Tags: Review Source Type: research

Understanding the Emergence of Social Anxiety in Children with Behavioral Inhibition
Behavioral Inhibition (BI) is a temperament characterized in early childhood by distress to novelty and avoidance of unfamiliar people and is one of the best known risk factors for the development of social anxiety. However, nearly 60% of children with BI do not go on to meet criteria for social anxiety disorder. In this review we present an approach to understanding differential developmental trajectories among children with BI. We review research using laboratory-based tasks which isolate specific attention processes that enhance versus mitigate risk for social anxiety among behaviorally inhibited children and studies th...
Source: Biological Psychiatry - October 9, 2020 Category: Psychiatry Authors: Nathan A. Fox, George A. Buzzell, Santiago Morales, Emilio A. Valadez, McLennon Wilson, Heather A. Henderson Tags: Review Source Type: research

Shared Versus Disorder-Specific Brain Morphometric Features of Major Psychiatric Disorders in Adulthood
There have been challenges in determining shared versus disorder-specific neural markers of psychiatric illness (1). Specifically, studies must be designed with large sample sizes of individuals with heterogeneity in clinical diagnoses and symptoms. Such large-scale studies must also account for the age ranges inherent in these designs and control for features of healthy physiologic aging. Lastly, human studies have been limited by cost, access to scanners with shared acquisition features, and data sharing practices. (Source: Biological Psychiatry)
Source: Biological Psychiatry - October 5, 2020 Category: Psychiatry Authors: Kristen L. Eckstrand Tags: Early Career Investigator Commentary Source Type: research

Circuit-Based Interventions for the Treatment of Behaviors Relevant to Schizophrenia
Aberrant hippocampal structure and function has been implicated in a variety of psychiatric disorders; however, the specific hippocampal circuits contributing to discrete symptom domains have not been extensively evaluated. The hippocampus has long been associated with the consolidation of declarative memory where dysfunction leads to amnesia (1); however, it is also intimately associated with emotion and stress responsivity where aberrant activity is associated with disorders such as schizophrenia and depression (2,3). (Source: Biological Psychiatry)
Source: Biological Psychiatry - October 5, 2020 Category: Psychiatry Authors: Daniel J. Lodge Tags: Commentary Source Type: research

Challenges Associated With Neuropharmacological Challenge Studies
In the current issue of Biological Psychiatry, Strube et  al. (1) present a large-scale neuropharmacological challenge study in healthy individuals testing two candidate neurotransmitter–neuroreceptor mechanisms posited to underlie probabilistic reasoning deficits in actively psychotic schizophrenia patients: 1) deficient glutamatergic NMDA receptor (N MDAR) neurotransmission and 2) excessive dopaminergic D2 receptor (D2R) neurotransmission. Research on delusions in schizophrenia has implicated impairments in probabilistic reasoning. (Source: Biological Psychiatry)
Source: Biological Psychiatry - October 5, 2020 Category: Psychiatry Authors: Daniel H. Mathalon Tags: Commentary Source Type: research

Alterations in the Endocannabinoid System in Schizophrenia
The notion linking psychosis outcomes with exposure to exogenous cannabinoids, including cannabis, Δ9-tetrahydrocannabinol, and synthetic cannabinoids, is well recognized. More recently, an endogenous hypothesis has been proposed according to which the endocannabinoid (eCB) system may be altered in psychosis. The extent to which the endogenous and exogenous cannabinoid hypotheses are related is not understood. (Source: Biological Psychiatry)
Source: Biological Psychiatry - October 5, 2020 Category: Psychiatry Authors: Mohini Ranganathan, Deepak Cyril D ’Souza Tags: Commentary Source Type: research

In This Issue
Volume 88, Number 9, November 1, 2020 (Source: Biological Psychiatry)
Source: Biological Psychiatry - October 5, 2020 Category: Psychiatry Tags: In This Issue Source Type: research

Editorial Board Page
(Source: Biological Psychiatry)
Source: Biological Psychiatry - October 5, 2020 Category: Psychiatry Source Type: research

Subscribers Page
(Source: Biological Psychiatry)
Source: Biological Psychiatry - October 5, 2020 Category: Psychiatry Source Type: research

Table of Contents
(Source: Biological Psychiatry)
Source: Biological Psychiatry - October 5, 2020 Category: Psychiatry Source Type: research

Guide for Authors
Biological Psychiatry is the official journal of the Society of Biological Psychiatry. The Journal rapidly publishes reports of novel results on a broad range of topics related to the pathophysiology and treatment of major neuropsychiatric disorders. Both basic and clinical neuroscience contributions are encouraged, particularly those addressing genetic and environmental risk factors, neural circuitry and neurochemistry, and important new therapeutic approaches. (Source: Biological Psychiatry)
Source: Biological Psychiatry - October 5, 2020 Category: Psychiatry Source Type: research

Sex differences in nociceptor translatomes contribute to divergent prostaglandin signaling in male and female mice
We examined the transcript ome and translatome of the mouse DRG with the goal of identifying sex differences. (Source: Biological Psychiatry)
Source: Biological Psychiatry - October 3, 2020 Category: Psychiatry Authors: Diana Tavares-Ferreira, Pradipta R. Ray, Ishwarya Sankaranarayanan, Galo L. Mejia, Andi Wangzhou, Stephanie Shiers, Ruta Uttarkar, Salim Megat, Paulino Barragan-Iglesias, Gregory Dussor, Armen N. Akopian, Theodore J. Price Tags: Archival Report Source Type: research

Prepubertal environmental enrichment prevents dopamine dysregulation and hippocampal hyperactivity in MAM schizophrenia model rats.
Schizophrenia (SCZ) is a neurodevelopmental disorder with a progressive, prolonged course. Early prevention for SCZ is promising, but overall lacks support from preclinical evidence. Previous studies have tested environmental enrichment (EE) in certain models of SCZ and discovered a broadly beneficial effect in preventing behavioral abnormalities relevant, yet not specific, to the disorder. Nonetheless, whether EE can prevent dopamine (DA) dysregulation, a hallmark of psychosis and SCZ, had not been tested (Source: Biological Psychiatry)
Source: Biological Psychiatry - October 3, 2020 Category: Psychiatry Authors: Xiyu Zhu, Anthony A. Grace Tags: Archival Report Source Type: research

Parsing the Functional Impact of Non-Coding Genetic Variants in the Brain Epigenome
The heritability of common psychiatric disorders has motivated global efforts to identify risk-associated genetic variants and elucidate molecular pathways connecting DNA sequence to disease-associated brain dysfunction. The over-representation of risk variants among gene-regulatory instead of protein-coding loci, however, poses a unique challenge in discerning which among the many thousands of variants identified contribute functionally to disease etiology. Defined broadly, psychiatric epigenomics seeks to understand the effects of disease-associated genetic variation on functional readouts of chromatin in an effort to pr...
Source: Biological Psychiatry - October 2, 2020 Category: Psychiatry Authors: Samuel K. Powell, Callan O ’Shea, Kristen J. Brennand, Schahram Akbarian Tags: Review Source Type: research

Intrinsic connectivity patterns of task-defined brain networks allow individual prediction of cognitive symptom dimension of schizophrenia and are linked to molecular architecture
Despite the marked inter-individual variability in the clinical presentation of schizophrenia, it remains unclear the extent to which individual dimensions of psychopathology relate to the functional variability in brain networks among patients. Here, we address this question using network-based predictive modeling of individual psychopathology along four data-driven symptom dimensions. Follow-up analyses assess the molecular underpinnings of predictive networks by relating them to neurotransmitter-receptor distribution patterns. (Source: Biological Psychiatry)
Source: Biological Psychiatry - October 2, 2020 Category: Psychiatry Authors: Ji Chen, Veronika I. M üller, Juergen Dukart, Felix Hoffstaedter, Justin T. Baker, Avram J. Holmes, Deniz Vatansever, Thomas Nickl-Jockschat, Xiaojin Liu, Birgit Derntl, Lydia Kogler, Renaud Jardri, Oliver Gruber, André Aleman, Iris E. Sommer, Simon B. Tags: Archival Report Source Type: research

Deep Brain Stimulation of the Subthalamic, Accumbens, or Caudate Nuclei for Patients With Severe Obsessive-Compulsive Disorder: A Randomized Crossover Controlled Study
For over 10 years, electrical stimulation within the limbic corticosubcortical network has been evaluated for treating patients with severe obsessive-compulsive disorder (OCD) (1). High-frequency deep brain stimulation (DBS) of various targets has been tested, including the anteromedial part of the subthalamic nucleus (amSTN), nucleus accumbens (NAc), ventral capsule/ventral striatum, anterior limb of the internal capsule, bed nucleus of the stria terminalis, and inferior thalamic peduncle (1). So far, published data do not support superiority of any particular target, with a mean decrease of 45% in OCD severity for whiche...
Source: Biological Psychiatry - October 1, 2020 Category: Psychiatry Authors: Marie-Laure Welter, Joao Flores Alves Dos Santos, Anne-Helene Clair, Brian Lau, Hassimiou Mamadou Diallo, Sara Fernandez-Vidal, Hayat Belaid, Antoine Pelissolo, Philippe Domenech, Carine Karachi, Luc Mallet Tags: Correspondence Source Type: research

Attachment style moderates polygenic risk for posttraumatic stress in United States military veterans: Results from the National Health and Resilience in Veterans Study
Polygenic risk scores (PRS) derived from genome-wide association studies (GWAS) of posttraumatic stress disorder (PTSD) may inform risk for this disorder. To date, however, no known study has examined whether social environmental factors such as attachment style may moderate the relation between PRS and PTSD. (Source: Biological Psychiatry)
Source: Biological Psychiatry - September 29, 2020 Category: Psychiatry Authors: Amanda J.F. Tamman, Frank R. Wendt, Gita A. Pathak, John H. Krystal, Janitza L. Montalvo-Ortiz, Steven M. Southwick, Lauren M. Sippel, Joel Gelernter, Renato Polimanti, Robert H. Pietrzak Tags: Archival Report Source Type: research

The Influence of Cannabis and Nicotine Co-Use on Neuromaturation – A Systematic Review of Adolescent and Young Adult Studies
Accumulating evidence suggests that the use of cannabis and nicotine and tobacco-related products (NTPs) during the adolescent years has harmful effects on the developing brain. Yet, few studies have focused on the developing brain as it relates to the co-administration of cannabis and NTPs, despite the high prevalence rates of co-use in adolescence. The review aimed to synthesize the existing literature on the neurocognitive, structural, and functional outcomes associated with cannabis and NTP co-use. (Source: Biological Psychiatry)
Source: Biological Psychiatry - September 27, 2020 Category: Psychiatry Authors: Margie Hernandez Mejia, Natasha E. Wade, Rachel Baca, Vanessa G. Diaz, Joanna Jacobus Tags: Review Source Type: research

Functional genomics identify a regulatory risk variation rs4420550 in the 16p11.2 schizophrenia-associated locus
Genome-wide association studies (GWAS) have reported hundreds of genomic loci associated with schizophrenia, yet identifying the functional risk variations is a key step in elucidating the underlying mechanisms. (Source: Biological Psychiatry)
Source: Biological Psychiatry - September 21, 2020 Category: Psychiatry Authors: Hong Chang, Xin Cai, Hui-Juan Li, Wei-Peng Liu, Li-Juan Zhao, Chu-Yi Zhang, Jun-Yang Wang, Jie-Wei Liu, Xiao-Lei Ma, Lu Wang, Yong-Gang Yao, Xiong-Jian Luo, Ming Li, Xiao Xiao Tags: Archival Report Source Type: research

Erratum
to: “Major Depressive Disorder Is Associated With Differential Expression of Innate Immune and Neutrophil-Related Gene Networks in Peripheral Blood: A Quantitative Review of Whole-Genome Transcriptional Data From Case-Control Studies,” by Wittenberg et al. (Biol Psychiatry 2020; 88:625–637); http s://doi.org/10.1016/j.biopsych.2020.05.006. (Source: Biological Psychiatry)
Source: Biological Psychiatry - September 21, 2020 Category: Psychiatry Tags: Erratum Source Type: research

The Many Avenues Leading to Adult Neurogenesis Adaptations
Adult hippocampal neurogenesis (AHN) is a phenomenon by which the brain responds to biological and environmental clues by producing new neurons in selected brain regions of adult mammals, including humans (1,2). There has been an ongoing debate regarding the presence of AHN in humans and about the role that adult-born neurons might have in cognition and behavior (3). Functions related to AHN are dependent not just on neurogenesis per se, but on the ability of newborn neurons to survive, differentiate, and integrate in the dentate gyrus (DG) circuit. (Source: Biological Psychiatry)
Source: Biological Psychiatry - September 21, 2020 Category: Psychiatry Authors: Maura Boldrini Tags: Commentary Source Type: research

Central Amygdala Discovery Efforts in Primates Reveals New Clues on Anxious Temperament
Our brains are built to consider and reflect on the unknown. These adaptive features protect us from potential threats in dynamic and complex environments, but they can also lead us to perseverate on perceived threats and fear an unknown future. Ranging across a spectrum from adaptive to maladaptive, anxious and fearful behavior exists in many animal species. In an effort to develop new therapeutics and understand the etiology of anxiety-related conditions, such as anxiety disorders, obsessive-compulsive disorder, panic disorder, and posttraumatic stress disorder, research using laboratory animal models has focused on the ...
Source: Biological Psychiatry - September 21, 2020 Category: Psychiatry Authors: J. Andrew Hardaway Tags: Early Career Investigator Commentary Source Type: research

Searching for Genomic Biomarkers for Major Depressive Disorder in Peripheral Immune Cells
Challenges to the diagnosis and treatment of patients with psychiatric disorders have long been acknowledged in the field. In recent years, efforts have been made to identify genomic biomarkers for psychiatric disorders. A link between immune function and major depressive disorder (MDD) has been suggested for decades (1), but the identification of differentially expressed genes (DEGs) that underlie immune function as biomarkers for MDD has been more recent. Hundreds of DEGs have been reported for transcriptome-wide association studies (TWASs) of MDD. (Source: Biological Psychiatry)
Source: Biological Psychiatry - September 21, 2020 Category: Psychiatry Authors: Ke Xu, Bradley E. Aouizerat Tags: Commentary Source Type: research

Microglial Activation and Response to Anti-inflammatory Treatment in Major Depressive Disorder: Another Piece in the Inflammation –Mood Disorders Puzzle
There is good news and bad news when it comes to our understanding of inflammation in the pathogenesis and treatment of major depressive disorder (MDD). The bad news is that, like the dexamethasone suppression test or the efficacy of antidepressants before it, inflammation is oversold as an answer to the mystery of depression and its treatment. The good news is that an unusually replicable set of findings (for psychiatry) increasingly paints a consistent picture of the ways in which inflammation is of value in understanding MDD. (Source: Biological Psychiatry)
Source: Biological Psychiatry - September 21, 2020 Category: Psychiatry Authors: Charles L. Raison Tags: Commentary Source Type: research

In This Issue
Volume 88, Number 8, October 15, 2020 (Source: Biological Psychiatry)
Source: Biological Psychiatry - September 21, 2020 Category: Psychiatry Tags: In This Issue Source Type: research

Editorial Board Page
(Source: Biological Psychiatry)
Source: Biological Psychiatry - September 21, 2020 Category: Psychiatry Source Type: research

Subscribers Page
(Source: Biological Psychiatry)
Source: Biological Psychiatry - September 21, 2020 Category: Psychiatry Source Type: research

Table of Contents
(Source: Biological Psychiatry)
Source: Biological Psychiatry - September 21, 2020 Category: Psychiatry Source Type: research

Guide for Authors
Biological Psychiatry is the official journal of the Society of Biological Psychiatry. The Journal rapidly publishes reports of novel results on a broad range of topics related to the pathophysiology and treatment of major neuropsychiatric disorders. Both basic and clinical neuroscience contributions are encouraged, particularly those addressing genetic and environmental risk factors, neural circuitry and neurochemistry, and important new therapeutic approaches. (Source: Biological Psychiatry)
Source: Biological Psychiatry - September 21, 2020 Category: Psychiatry Source Type: research

Association of Tourette syndrome and chronic tic disorder with subsequent risk of alcohol- or drug-related disorders, criminal convictions, and death: a population-based family study
It remains unclear if individuals with Tourette syndrome (TS) or chronic tic disorder (CTD) have an elevated risk of subsequent substance misuse. (Source: Biological Psychiatry)
Source: Biological Psychiatry - September 20, 2020 Category: Psychiatry Authors: Suvi Virtanen, Anna Sidorchuk, Lorena Fern ández de la Cruz, Gustaf Brander, Paul Lichtenstein, Antti Latvala, David Mataix-Cols Tags: Archival Report Source Type: research

Associations between maternal lifetime stress and placental mitochondrial DNA mutations in an urban multi-ethnic cohort
Disrupted placental functioning due to stress can have lifelong implications. Cumulative stress and trauma are likely to have lasting impacts on maternal physiological functioning and offspring development resulting in increased risk for later life complex disorders for which racial disparities exist. (Source: Biological Psychiatry)
Source: Biological Psychiatry - September 17, 2020 Category: Psychiatry Authors: Kelly J. Brunst, Li Zhang, Xiang Zhang, Andrea A. Baccarelli, Tessa Bloomquist, Rosalind J. Wright Tags: Archival Report Source Type: research

Navigating the social environment in adolescence: The role of social brain development
Successful navigation of the social environment is dependent on a number of social cognitive processes, including mentalising and resistance to peer influence. These processes continue to develop during adolescence, a time of significant social change, and are underpinned by regions of the social brain that continue to mature structurally and functionally into adulthood. In this review, we describe how mentalising, peer influence and emotion regulation capacities develop to aid the navigation of the social environment during adolescence. (Source: Biological Psychiatry)
Source: Biological Psychiatry - September 15, 2020 Category: Psychiatry Authors: Jack L. Andrews, Saz Ahmed, Sarah-Jayne Blakemore Tags: Review Source Type: research