Effects of Maternal Prenatal Stress on the Fetal Brain and Hope for the Prevention of Psychopathology
Understanding the effects of prenatal stress on brain development and later psychopathology offers the possibility of prevention. Few psychiatric disorders can be cured; most at best can be ameliorated. But some, at least, may be stopped from developing in the first place. Animal studies have shown for more than 50 years that prenatal stress can alter the neurodevelopment of the offspring. Research in humans in the last 20 years has shown that prenatal stress can increase the risk for a range of emotional, behavioral, and cognitive problems in children and adults. (Source: Biological Psychiatry)
Source: Biological Psychiatry - February 18, 2020 Category: Psychiatry Authors: Vivette Glover Tags: Commentary Source Type: research

Next Stop for Fatty Acid Amide Hydrolase Inhibitors, the Clinic?
When a group of young cannabis smokers were asked to explain why they used the drug, “relieving nervousness” and “getting along in the world” were among the most frequent answers (1). Coping with the stress of daily life is not the only subjective motivation for using cannabis but it is probably a major one. Indeed, there have long been hints that its intoxicating constituen t, Δ9-tetrahydrocannabinol (THC), might alleviate certain forms of anxiety. In a small, double-blind, placebo-controlled trial conducted almost 40 years ago, treatment with a low oral dose of the THC analogue nabilone (Ces...
Source: Biological Psychiatry - February 18, 2020 Category: Psychiatry Authors: Daniele Piomelli Tags: Commentary Source Type: research

Advances in Mapping the Startle Eye-Blink Response Onto Neural Circuits
Cross-species translational research allows us to further knowledge regarding the biological mechanisms underlying psychiatric symptoms (1,2). In neuroscience, such research can bridge the precise probing of neural circuits in animal models with the less invasive work performed in humans using neuroimaging, with the goal of mapping human emotions to neural functioning. Affective modulation measured with startle is a prime example of a translational paradigm that can be measured across human and nonhuman species using the eye-blink startle response measured with facial electromyography (EMG) in humans or whole-body startle ...
Source: Biological Psychiatry - February 18, 2020 Category: Psychiatry Authors: Antonia N. Kaczkurkin Tags: Early Career Investigator Commentary Source Type: research

In This Issue
Volume 87, Number 6, March 15, 2020 (Source: Biological Psychiatry)
Source: Biological Psychiatry - February 18, 2020 Category: Psychiatry Tags: In This Issue Source Type: research

The Complex Role of Nociceptin Signaling in Stress: Clarity Through Neuroimaging?
Shortly after it became the first orphan G protein –coupled receptor successfully cloned, the eponymously named nociceptin opioid peptide/orphaninFQ receptor (NOPR) and its endogenous ligand (N/OFQ) were speculated to mediate behaviors beyond nociception (1). Given the high levels of expression of N/OFQ and NOPR in hypothalamic, limbic, and monoam inergic structures across the mammalian brain (2,3), focus quickly turned toward the investigation of how this novel opioidergic system regulated stress and affective behaviors, such as anxiety and depression. (Source: Biological Psychiatry)
Source: Biological Psychiatry - February 18, 2020 Category: Psychiatry Authors: Sean C. Piantadosi, Diego A. Pizzagalli, Michael R. Bruchas Tags: Commentary Source Type: research

Editorial Board Page
(Source: Biological Psychiatry)
Source: Biological Psychiatry - February 18, 2020 Category: Psychiatry Source Type: research

Subscribers Page
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Source: Biological Psychiatry - February 18, 2020 Category: Psychiatry Source Type: research

Table of Contents
(Source: Biological Psychiatry)
Source: Biological Psychiatry - February 18, 2020 Category: Psychiatry Source Type: research

Guide for Authors
(Source: Biological Psychiatry)
Source: Biological Psychiatry - February 18, 2020 Category: Psychiatry Source Type: research

The β-secretase BACE1 in Alzheimer’s disease
The β-site amyloid precursor protein cleaving enzyme 1 (BACE1), was initially cloned and characterized in 1999. It is required for the generation of all monomeric forms of Aβ, including Aβ42, which aggregates into bioactive conformational species and likely initiates toxicity in Alzheimer’s disease (AD). BACE1 concentrations and rates of activity are increased in AD brains and body fluids, thus supporting the hypothesis that BACE1 may drive AD progression. Therefore, BACE1 is a prime drug target for slowing down Aβ production in early AD. (Source: Biological Psychiatry)
Source: Biological Psychiatry - February 13, 2020 Category: Psychiatry Authors: Harald Hampel, Robert Vassar, Bart De Strooper, John Hardy, Michael Willem, Neeraj Singh, John Zhou, Riqiang Yan, Eugeen Vanmechelen, Ann De Vos, Robert Nistic ò, Massimo Corbo, Bruno Pietro Imbimbo, Johannes Streffer, Iryna Voytyuk, Maarten Timmers, Ami Tags: Review Source Type: research

Markers of Psychosis Risk in the General Population
The categorical approach to defining schizophrenia spectrum disorders requires meeting established criteria. To advance early identification and intervention in young people the field has progressed to studying help-seeking individuals who are at clinical high risk based on subthreshold psychosis spectrum symptoms, and criteria have been articulated for qualifying individuals as at-risk. A broader dimensional examination of psychosis has been applied to population- based studies on non-help seekers. (Source: Biological Psychiatry)
Source: Biological Psychiatry - February 13, 2020 Category: Psychiatry Authors: Jerome H. Taylor, Monica E. Calkins, Raquel E. Gur Tags: Review Source Type: research

Modeling Individual Differences in Brain Development
Within the field of developmental cognitive neuroscience there is an increasing interest in studying individual differences in human brain development in order to predict mental health outcomes. So far, however, most longitudinal neuroimaging studies focus on group-level estimates. In this review, we highlight longitudinal neuroimaging studies that have moved beyond group-level estimates to illustrate the heterogeneity in patterns of brain development. We provide practical methodological recommendations on how longitudinal neuroimaging datasets can be used to understand heterogeneity in human brain development. (Source: Biological Psychiatry)
Source: Biological Psychiatry - February 10, 2020 Category: Psychiatry Authors: Andrik I. Becht, Kathryn L. Mills Tags: Review Source Type: research

Tripping Over the Same Stone
Recently, in a large, 6-year follow-up controlled study, Ab é et al. (1) found abnormal cortical thinning between study time points in subjects with bipolar disorder (BD). Moreover, they found that subjects who were being treated with lithium seemed to be “protected” from some of these anatomical changes. These findings are in line with those of other studies, which also support a neuroprogressive mechanism for BD and neuroprotective effects for lithium (2). This would seem to be both good news (we all hope that lithium’s neuroprotective effects operate at the clinical level) and bad news (BD ...
Source: Biological Psychiatry - February 7, 2020 Category: Psychiatry Authors: Sergio A. Strejilevich, Danilo Quiroz Tags: Correspondence Source Type: research

Reply to: Tripping Over the Same Stone
Commenting on our longitudinal study of brain structural changes in bipolar disorder (BD) (1), Strejilevich and Quiroz (2) raised the important issue of potential effects of medication use. Certain drugs may affect brain structure. Therefore, we controlled for current medication use at follow-up and baseline. These analyses did not indicate that our findings were confounded by antipsychotic drug use. (Source: Biological Psychiatry)
Source: Biological Psychiatry - February 7, 2020 Category: Psychiatry Authors: Christoph Ab é, Benny Liberg, Predrag Petrovic, Martin Ingvar, Mikael Landén Tags: Correspondence Source Type: research

Schizophrenia and Epigenetic Aging Biomarkers: Increased Mortality, Reduced Cancer Risk, and Unique Clozapine Effects
This study tested the hypothesis that altered aging in SZ manifests in these other clocks. (Source: Biological Psychiatry)
Source: Biological Psychiatry - February 7, 2020 Category: Psychiatry Authors: Albert T. Higgins-Chen, Marco P. Boks, Christiaan H. Vinkers, Ren é S. Kahn, Morgan E. Levine Tags: Archival Report Source Type: research

Genome-wide association analysis of Parkinson ’s disease and schizophrenia reveals shared genetic architecture and identifies novel risk loci
Parkinson ’s disease (PD) and schizophrenia (SCZ) are heritable brain disorders that both involve dysregulation of the dopaminergic system. Epidemiological studies have reported potential comorbidity between the disorders, and movement disturbances are common in SCZ patients before treatment with antipsycho tic drugs. Despite this, little is known about shared genetic etiology between the disorders. (Source: Biological Psychiatry)
Source: Biological Psychiatry - February 7, 2020 Category: Psychiatry Authors: Olav B. Smeland, Alexey Shadrin, Shahram Bahrami, Iris Broce, Martin Tesli, Oleksandr Frei, Katrine V. Wirgenes, Kevin S. O ’Connell, Florian Krull, Francesco Bettella, Nils Eiel Steen, Leo Sugrue, Yunpeng Wang, Per Svenningsson, Manu Sharma, Lasse Pihl Tags: Archival Report Source Type: research

Glutamate and Dysconnection in the Salience Network: Neurochemical, Effective-connectivity, and Computational Evidence in Schizophrenia
Functional dysconnection in schizophrenia is underwritten by a pathophysiology of the glutamate neurotransmission that affects the excitation-inhibition balance in key nodes of the salience network. Physiologically, this is manifest as aberrant effective connectivity in intrinsic connections involving inhibitory interneurons. In computational terms, this produces a pathology of evidence accumulation and ensuing inference in the brain. Finally, the pathophysiology and aberrant inference would partially account for the psychopathology of schizophrenia as measured in terms of symptoms and signs. (Source: Biological Psychiatry)
Source: Biological Psychiatry - February 5, 2020 Category: Psychiatry Authors: Roberto Limongi, Peter Jeon, Michael Mackinley, Tushar Das, Kara Dempster, Jean Th éberge, Robert Bartha, Dickson Wong, Lena Palaniyappan Tags: Archival Report Source Type: research

Amyloid and tau pathology associations with personality traits, neuropsychiatric symptoms and cognitive lifestyle in the preclinical phases of sporadic and autosomal dominant Alzheimer ’s disease
Major prevention trials for Alzheimer ’s disease (AD) are now focusing on multi-domain lifestyle interventions. However, the exact combination of behavioral factors related to AD pathology remains unclear. In two cohorts of cognitively unimpaired individuals at risk of AD, we examined which combinations of personality traits, neuropsy chiatric symptoms, and cognitive lifestyle (years of education or lifetime cognitive activity) related to the pathological hallmarks of AD, amyloid-beta and tau deposits. (Source: Biological Psychiatry)
Source: Biological Psychiatry - February 5, 2020 Category: Psychiatry Authors: Alexa Pichet Binette, Étienne Vachon-Presseau, John Morris, Randall Bateman, Tammie Benzinger, D. Louis Collins, Judes Poirier, John C.S. Breitner, Sylvia Villeneuve, Dominantly Inherited Alzheimer Network (DIAN), the PREVENT-AD Research Group Tags: Archival Report Source Type: research

Developing Predictive Biomarkers Goes Alongside Diagnostic Biotypes in Major Depressive Disorder
Major depressive disorder is the most common psychiatric disorder and is a leading cause of disease burden worldwide. Pharmacological and psychological therapies are considered first-line treatments. However, at least one third of patients fail to achieve remission despite a full course of pharmacological or psychological therapy, and persistent symptoms are associated with a higher risk of chronicity and recurrence (1,2). Clinical guidelines offer treatment recommendations based on empirical clinical trials, yet it is not possible to predict the efficacy of any treatment at the individual level. (Source: Biological Psychiatry)
Source: Biological Psychiatry - February 4, 2020 Category: Psychiatry Authors: Cynthia H.Y. Fu Tags: Commentary Source Type: research

Transcranial Magnetic Stimulation Parameter Space: Wide Open for Exploration
Major depressive disorder remains a disabling disease, and one third of patients do not experience significant reductions in their symptoms with currently available treatments. Repetitive transcranial magnetic stimulation (rTMS) is an important treatment option for these patients; however, the optimal stimulation parameters for the treatment of depression are still unknown. Thus, studies that compare experimental stimulation parameters to those commonly used in the clinical setting —such as the study by Li et al. (Source: Biological Psychiatry)
Source: Biological Psychiatry - February 4, 2020 Category: Psychiatry Authors: Brandon S. Bentzley, Nolan R. Williams Tags: Commentary Source Type: research

Can a Predictive Processing Framework Improve the Specification of Negative Bias in Depression?
Our understanding of the psychological mechanisms underpinning depression was transformed by Aaron Beck ’s 1979 cognitive model (1). Beck conceptualized the role of negative self-beliefs or schemata in depression, driving negative biases in information processing, and thereby maintaining the diverse symptoms seen in the disorder. These ideas have remained influential to this day. This model formed t he basis for the development of psychological treatments such as cognitive behavioral therapy and shaped subsequent research and work in this area. (Source: Biological Psychiatry)
Source: Biological Psychiatry - February 4, 2020 Category: Psychiatry Authors: Catherine J. Harmer, Michael Browning Tags: Commentary Source Type: research

Increasing Diversity in Science: It  Begins With All of Us
“The mission of Biological Psychiatry is to publish impactful scientific communications. To further that mission, we promote diversity in all aspects of the publication process, including authorship, reviewing, and editing. Our diversity efforts aim to increase participation among individuals of u nderrepresented racial, ethnic, and gender identities; from underrepresented countries or disadvantaged backgrounds; and those with disabilities. For further information, see [this Editorial].” (Source: Biological Psychiatry)
Source: Biological Psychiatry - February 4, 2020 Category: Psychiatry Authors: Ellen Leibenluft Tags: Editorial Source Type: research

In This Issue
Volume 87, Number 5, March 1, 2020 (Source: Biological Psychiatry)
Source: Biological Psychiatry - February 4, 2020 Category: Psychiatry Tags: In This Issue Source Type: research

Editorial Board Page
(Source: Biological Psychiatry)
Source: Biological Psychiatry - February 4, 2020 Category: Psychiatry Source Type: research

Subscribers Page
(Source: Biological Psychiatry)
Source: Biological Psychiatry - February 4, 2020 Category: Psychiatry Source Type: research

Table of Contents
(Source: Biological Psychiatry)
Source: Biological Psychiatry - February 4, 2020 Category: Psychiatry Source Type: research

Guide for Authors
(Source: Biological Psychiatry)
Source: Biological Psychiatry - February 4, 2020 Category: Psychiatry Source Type: research

A physiological instability displayed in hippocampal neurons derived from lithium non-responsive bipolar disorder patients
We recently reported a hyperexcitability phenotype displayed in dentate gyrus (DG) granule neurons derived from bipolar disorder (BD) patients (1, 2) and also a hyperexcitability that appeared only in CA3 pyramidal hippocampal neurons that were derived from BD patients who responded to lithium treatment (LR) but not from BD patients who were lithium non-responders (NR) (3). (Source: Biological Psychiatry)
Source: Biological Psychiatry - February 4, 2020 Category: Psychiatry Authors: Shani Stern, Anindita Sarkar, Dekel Galor, Tchelet Stern, Arianna Mei, Yam Stern, Ana P.D. Mendes, Lynne Randolph-Moore, Guy Rouleau, Anne Bang, Renata Santos, Martin Alda, Maria C. Marchetto, Fred H. Gage Tags: Archival Report Source Type: research

Disentangling heterogeneity in Alzheimer ’s disease and related dementias using data-driven methods
Brain aging is a complex process that includes atrophy, vascular injury, and a variety of age-associated neurodegenerative pathologies, together determining an individual ’s course of cognitive decline. While Alzheimer's disease and related neurodegenerative dementias (ADRD) contribute to the heterogeneity of brain aging, these conditions themselves are also heterogeneous in their clinical presentation, progression and pattern of neural injury. We reviewed studies that leveraged data-driven approaches to examining heterogeneity in ADRD, with a principal focus on neuroimaging studies exploring subtypes of regional neu...
Source: Biological Psychiatry - January 30, 2020 Category: Psychiatry Authors: Mohamad Habes, Michel J. Grothe, Birkan Tunc, Corey McMillan, David A. Wolk, Christos Davatzikos Tags: Review Source Type: research

"Large-scale genomics: a paradigm shift in psychiatry? ”
“It was the best of times, it was the worst of times…” Charles Dickens, A Tale of Two Cities. (Source: Biological Psychiatry)
Source: Biological Psychiatry - January 30, 2020 Category: Psychiatry Authors: Michael J. Owen, Michael C. O ’Donovan Tags: Commentary Source Type: research

2-Arachidonoylglycerol Modulation of Anxiety and Stress Adaptation: from grass roots to novel therapeutics
Over the past decade there has been a surge of interest in the development of endocannabinoid (eCB)-based therapeutic approaches for the treatment of diverse neuropsychiatric conditions. Although initial preclinical and clinical development efforts focused on pharmacological inhibition of fatty-acid amide hydrolase to elevate levels of the eCB anandamide, more recent efforts have focused on inhibition of monoacylglycerol lipase (MAGL) to enhance signaling of the most abundant and efficacious eCB ligand, 2-arachidonoylglycerol (2-AG). (Source: Biological Psychiatry)
Source: Biological Psychiatry - January 29, 2020 Category: Psychiatry Authors: Gaurav Bedse, Mathew N. Hill, Sachin Patel Tags: Review Source Type: research

Causes and Consequences of Diagnostic Heterogeneity in Depression: Paths to Discovering Novel Biological Depression Subtypes
Depression is a highly heterogeneous syndrome that bears only modest correlations with its biological substrates, motivating a renewed interest in rethinking our approach to diagnosing depression for research purposes and new efforts to discover subtypes of depression anchored in biology. Here, we review the major causes of diagnostic heterogeneity in depression, with consideration of both clinical symptoms and behaviors (symptomatology, trajectory of depressive episodes) and biology (genetics, sexually dimorphic factors). (Source: Biological Psychiatry)
Source: Biological Psychiatry - January 28, 2020 Category: Psychiatry Authors: Charles J. Lynch, Faith M. Gunning, Conor Liston Tags: Review Source Type: research

Appropriate use of bifactor analysis in psychopathology research: Appreciating benefits and limitations
Co-occurrence of psychiatric disorders is well-documented. Recent quantitative efforts have moved toward an understanding of this phenomenon, with the ‘general psychopathology’ or p-factor model emerging as the most prominent characterization. Over the past decade, bifactor model analysis has become increasingly popular as a statistical approach to describe common/shared and unique elements in psychopathology. However, recent work has highligh ted potential problems with common approaches to evaluating and interpreting bifactor models. (Source: Biological Psychiatry)
Source: Biological Psychiatry - January 28, 2020 Category: Psychiatry Authors: Marina A. Bornovalova, Alexandria M. Choate, Haya Fatimah, Karl J. Petersen, Brenton M. Wiernik Tags: Review Source Type: research

Depression heterogeneity and its biological underpinnings: towards immuno-metabolic depression
Epidemiological evidence indicates dysregulated homeostatic biological pathways in depressed patients, such as increased inflammation and disrupted energy-regulating neuroendocrine signaling (e.g. leptin, insulin). Alterations in these biological pathways may explain the considerable comorbidity between depression and cardiometabolic conditions (e.g. obesity, metabolic syndrome, diabetes) and represent a promising target for intervention. This review will describe how immuno-metabolic dysregulations vary as a function of depression heterogeneity by illustrating that such biological dysregulations: 1) map more consistently ...
Source: Biological Psychiatry - January 28, 2020 Category: Psychiatry Authors: Yuri Milaneschi, Femke Lamers, Michael Berk, Brenda WJH. Penninx Tags: Review Source Type: research

Don ’t Blame the Tools: Clinical Neuroscience and the Quest to Link Brain With Behavior
As the old saying goes, bad workers blame their tools for their failures. But what is a clinical neuroscientist to do when bumping up against the limits of the tools and techniques available to study the human brain and human behavior? The effort to link brain and behavior is fundamental to the field of biological psychiatry, but our ability to create those linkages is constrained by the tools and techniques available to study brain and behavior in humans. What we can measure, and the brain –behavior links we can identify, are indeed defined by the tools we use and their inherent limits (in terms of the features they...
Source: Biological Psychiatry - January 22, 2020 Category: Psychiatry Authors: Sarah H. Lisanby Tags: Commentary Source Type: research

Transforming Psychiatry Through Novel Neuroscience: Computational and Developmental Frameworks Guided by Research Domain Criteria
Mental and substance use disorders account for more than 7% of the global burden of disease and are the leading cause of disability in young people (1,2). In terms of lost productivity, the cumulative disability due to depression alone exacts an annual cost of $201 billion in the United States (3). The toll on young people is especially alarming; in the United States, the suicide rate among 15- to 24-year-olds has tripled since the 1950s (4). This alarming situation has created an escalating sense of urgency for innovations in clinical neuroscience. (Source: Biological Psychiatry)
Source: Biological Psychiatry - January 22, 2020 Category: Psychiatry Authors: Leanne M. Williams Tags: Commentary Source Type: research

Getting Below the Surface of Behavioral Symptoms in Psychiatry
Computational psychiatry has emerged in recent years as a potentially powerful new way of analyzing behavioral or clinical symptoms (1 –5). Traditionally, behavior has been quantified by reaction time, response accuracy, or another easily measurable parameter of performance on a test task. Computationally, behavior is quantified by learning rate, response bias, or some other parameter of the underlying cognitive processes driving measurable task performance. (Source: Biological Psychiatry)
Source: Biological Psychiatry - January 22, 2020 Category: Psychiatry Authors: Edward Bullmore Tags: Commentary Source Type: research

Innovations in Clinical Neuroscience: Tools, Techniques, and Transformative Frameworks
The field of biological psychiatry is in the early part of a catalytic period for discovery. The purpose of the 2019 Society of Biological Psychiatry (SOBP) annual meeting was to provide an interactive platform for learning and discovery. The meeting program focused on innovative and transformative frameworks for understanding psychiatric illnesses, with presentations about enhanced and newly emerging tools for measurement and intervention. Within these frameworks and with these tools are illustrated techniques and experimental designs that can enhance our understanding of psychiatric illness and elucidate the biological p...
Source: Biological Psychiatry - January 22, 2020 Category: Psychiatry Authors: Scott A. Langenecker, Mary L. Phillips Tags: Commentary Source Type: research

In This Issue
Volume 87, Number 4, February 15, 2020 (Source: Biological Psychiatry)
Source: Biological Psychiatry - January 22, 2020 Category: Psychiatry Tags: In This Issue Source Type: research

Editorial Board Page
(Source: Biological Psychiatry)
Source: Biological Psychiatry - January 22, 2020 Category: Psychiatry Source Type: research

Subscribers Page
(Source: Biological Psychiatry)
Source: Biological Psychiatry - January 22, 2020 Category: Psychiatry Source Type: research

Table of Contents
(Source: Biological Psychiatry)
Source: Biological Psychiatry - January 22, 2020 Category: Psychiatry Source Type: research

Guide for Authors
(Source: Biological Psychiatry)
Source: Biological Psychiatry - January 22, 2020 Category: Psychiatry Source Type: research

Dual effect of 5-HT1B/1D receptors on dopamine neurons in ventral tegmental area: implication for the functional switch after chronic cocaine exposure
5-HT1B/1D receptor (5-HT1B/1DR) agonists undergo an abstinence-induced “switch” in their effects on cocaine-related behaviors, which may involve changes in modulation of dopamine (DA) neurons in the ventral tegmental area (VTA). However, it is unclear how 5-HT1B/1DRs affect VTA DA neuronal function, and whether modulation of these neurons mediates the abstinence-in duced switch after chronic cocaine exposure. (Source: Biological Psychiatry)
Source: Biological Psychiatry - January 22, 2020 Category: Psychiatry Authors: Ming Gao, Taleen S. Der-Ghazarian, Shuangtao Li, Shenfeng Qiu, Janet L. Neisewander, Jie Wu Tags: Archival Report Source Type: research

Gene expression in patient-derived neural progenitors implicates WNT5A signaling in the etiology of schizophrenia
In this study we use Cultured Neural progenitor cells derived from Olfactory Neuroepithelium (CNON) as a genetically unaltered cellular model to elucidate the neurodevelopmental aspects of schizophrenia. (Source: Biological Psychiatry)
Source: Biological Psychiatry - January 21, 2020 Category: Psychiatry Authors: Oleg V. Evgrafov, Chris Armoskus, Bozena B. Wrobel, Valeria N. Spitsyna, Tade Souaiaia, Jennifer S. Herstein, Christopher P. Walker, Joseph D. Nguyen, Adrian Camarena, Jonathan R. Weitz, Jae Mun ‘Hugo’ Kim, Edder Lopez Duarte, Kai Wang, George M. Simp Tags: Archival Report Source Type: research

Shared Transcriptional Signatures in Major Depressive Disorder and Mouse Chronic Stress Models
Most of our knowledge of the biological basis of major depressive disorder (MDD) is derived from studies of chronic stress models in rodents. While these models capture certain aspects of the behavioral and neuroendocrine features of MDD, the extent to which they reproduce the molecular pathology of the human syndrome remains unknown. (Source: Biological Psychiatry)
Source: Biological Psychiatry - January 21, 2020 Category: Psychiatry Authors: Joseph R. Scarpa, Mena Fatma, Yong-Hwee E. Loh, Said Romaric Traore, Theo Stefan, Ting Huei Chen, Eric J. Nestler, Benoit Labont é Tags: Archival Report Source Type: research

Maternal effects as causes of risk for obsessive-compulsive disorder
While genetic variation has a known impact on the risk for obsessive ‐compulsive disorder (OCD), there is also evidence that there are maternal components to this risk. Here, we partition sources of variation, namely direct genetic and maternal genetic effects, on risk for OCD. (Source: Biological Psychiatry)
Source: Biological Psychiatry - January 21, 2020 Category: Psychiatry Authors: Behrang Mahjani, Lambertus Klei, Christina M. Hultman, Henrik Larsson, Bernie Devlin, Joseph D. Buxbaum, Sven Sandin, Dorothy E. Grice Tags: Archival Report Source Type: research

Aberrant cortical ensembles and schizophrenia-like sensory phenotypes in setd1a mice.
A breakdown of synchrony within neuronal ensembles leading to destabilization of network “attractors” could be a defining aspect of neuropsychiatric diseases like schizophrenia (SZ), representing a common downstream convergence point for the diverse etiological pathways associated with the disease. Using a mouse genetic model, here we demonstrate how altered ensembles are associated with pathological sensory cortical processing phenotypes resulting from loss of function mutations in the setd1a gene, a recently identified rare risk genotype with very high penetrance for SZ. (Source: Biological Psychiatry)
Source: Biological Psychiatry - January 16, 2020 Category: Psychiatry Authors: Jordan P. Hamm, Yuriy Shymkiv, Jun Mukai, Joseph A. Gogos, Rafael Yuste Tags: Priority Communication Source Type: research

Psilocybin induces time-dependent changes in global functional connectivity
The use of Psilocybin in scientific and experimental clinical contexts has triggered renewed interest in the mechanism of action of psychedelics. However, its time-dependent systems-level neurobiology remains sparsely investigated in humans. (Source: Biological Psychiatry)
Source: Biological Psychiatry - January 13, 2020 Category: Psychiatry Authors: Katrin H. Preller, Patricia Duerler, Joshua B. Burt, Jie Lisa Ji, Brendan Adkinson, Philipp St ämpfli, Erich Seifritz, Grega Repovs, John H. Krystal, John D. Murray, Alan Anticevic, Franz X. Vollenweider Tags: Archival Report Source Type: research

Reciprocal copy number variations at 22q11.2 produce distinct and convergent neurobehavioral impairments relevant for Schizophrenia and Autism Spectrum Disorder
22q11.2 deletions and duplications are copy number variations (CNVs) that predispose to developmental neuropsychiatric disorders. Both CNVs are associated with autism spectrum disorder (ASD), while the deletion confers disproportionate risk for schizophrenia. Neurobehavioral profiles associated with these reciprocal CNVs in conjunction with brain imaging measures have not been reported. (Source: Biological Psychiatry)
Source: Biological Psychiatry - January 13, 2020 Category: Psychiatry Authors: Amy Lin, Ariana Vajdi, Leila Kushan-Wells, Gerhard Helleman, Laura Pacheco Hansen, Rachel K. Jonas, Maria Jalbrzikowski, Lyle Kingsbury, Armin Raznahan, Carrie E. Bearden Tags: Archival Report Source Type: research