Early Infant Prefrontal Cortical Microstructure Predicts Present and Future Emotionality

High levels of infant negative emotionality (NE) and low positive emotionality (PE) predict future emotional and behavioral problems. The prefrontal cortex (PFC) supports emotional regulation, with each PFC subregion specializing in specific emotional processes. Neurite Orientation Dispersion and Density Imaging (NODDI) estimates microstructural integrity and myelination via the neurite density index (NDI) and dispersion via the orientation dispersion index (ODI), with potential to more accurately evaluate microstructural alterations in the developing brain.

Source: Biological Psychiatry - April 9, 2024 Category: Psychiatry Authors: Yicheng Zhang, Layla Banihashemi, Amelia Versace, Alyssa Samolyk, Megan Taylor, Gabrielle English, Vanessa J. Schmithorst, Vincent K. Lee, Richelle Stiffler, Haris Aslam, Ashok Panigrahy, Alison E. Hipwell, Mary L. Phillips Tags: Archival Report Source Type: research