Moving Forward Precision Medicine in Psychiatry
Precision medicine has made significant advancements in certain fields of medicine, particularly in hematology, immunology, and oncology (1). Biomarker-directed immunotherapy has become the gold standard for lung cancer treatment, and each year new molecular targets and associated treatments are being identified (2). This approach has achieved successful outcomes in areas where molecular diagnostics were associated with specific therapies (e.g., BRAF V600 mutation and BRAF inhibitors for melanoma, BRCA1/2 mutation with PARP inhibitors for ovarian and breast cancer) or when a biomarker has allowed for the subclassification ...
Source: Biological Psychiatry - September 15, 2023 Category: Psychiatry Authors: Juan Emilio Belforte Tags: Commentary Source Type: research
The Pathway Between “You Are” and “What You Eat”
Significant connections between the brain and gut that influence mood and cognitive processes have long been hypothesized. In the 19th century, Ireland ’s psychiatrists described “the insanity of malnutrition,” a concerning correlation between rising asylum admissions and patients’ inability to acquire healthy food (1). Earlier still, Shakespeare’s Julius Caesar proclaimed, “Yond Cassius has a lean and hungry look, He thinks too much.” These rudimentary observations alluded to what is now widely recognized as the gut-brain axis, the intricate system of neural and endocrine cells in the gut that reciprocally c...
Source: Biological Psychiatry - September 15, 2023 Category: Psychiatry Authors: Sarah A. Rudzinskas Tags: Early Career Investigator Commentary Source Type: research
From Foot-Bread to Flip-Flop Circuits: What History Can Teach Us About Sleep and How to Treat It
For centuries, physicians, philosophers, and scientists have pursued the secrets of eternal youth and health. One especially colorful character was 17th century physician Tobias Venner. He was obsessed with the idea of the body ’s internal balance—how factors such as diet, exercise, and excretion affected the four humors of the body and ultimately longevity. He was particularly interested in sleep. In his book Via Recta ad Vitam Longam (The Right Way to a Long Life), he espoused his recommendations for a good night’s rest (1). (Source: Biological Psychiatry)
Source: Biological Psychiatry - September 15, 2023 Category: Psychiatry Authors: Yoel D. Green, Yaakov S. Green, Bernice N. Yau, David A. Ross Tags: Clinical Commentary Source Type: research
In This Issue
Volume 94, Number 8, October 15, 2023 (Source: Biological Psychiatry)
Source: Biological Psychiatry - September 15, 2023 Category: Psychiatry Tags: In This Issue Source Type: research
Editorial Board Page
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Source: Biological Psychiatry - September 15, 2023 Category: Psychiatry Source Type: research
Subscribers Page
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Source: Biological Psychiatry - September 15, 2023 Category: Psychiatry Source Type: research
Table of Contents
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Source: Biological Psychiatry - September 15, 2023 Category: Psychiatry Source Type: research
Guide for Authors
Biological Psychiatry, founded in 1969, is an official journal of the Society of Biological Psychiatry and the first in the Biological Psychiatry family of journals. Companion titles include Biological Psychiatry: Cognitive Neuroscience and Neuroimaging and Biological Psychiatry: Global Open Science. The Society ’s purpose is to promote excellence in scientific research and education in fields that investigate the nature, causes, mechanisms, and treatments of disorders of thought, emotion, and behavior. (Source: Biological Psychiatry)
Source: Biological Psychiatry - September 15, 2023 Category: Psychiatry Source Type: research
Adolescent alcohol exposure produces sex-specific long-term hyperalgesia via changes in central amygdala circuit function
Exposure to alcohol during adolescence produces many effects that last well into adulthood. Acute alcohol is analgesic and people living with pain report drinking alcohol to reduce pain, but chronic alcohol produces increases in pain sensitivity. (Source: Biological Psychiatry)
Source: Biological Psychiatry - September 15, 2023 Category: Psychiatry Authors: Maria E. Secci, Leslie K. Kelley, Elizabeth M. Avegno, Eleanor B. Holmgren, Lily Chen, Sydney L. Rein, Sheila A. Engi, Virginia Quinlan, Lisa Wilson, Nicholas W. Gilpin, Tiffany A. Wills Tags: Archival Report Source Type: research
Intellectual Disability and Behavioral Deficits Linked to CYFIP1 Missense Variants Disrupting Actin Polymerization
15q11.2 Deletions and duplications have been linked to autism spectrum disorder (ASD), schizophrenia, and intellectual disability (ID). Recent evidence suggests that dysfunctional Cytoplasmic FMR1 Interacting Protein 1 (CYFIP1) contributes to the clinical phenotypes observed in individuals with 15q11.2 deletion/duplication syndrome. CYFIP1 plays crucial roles in neuronal development and brain connectivity, promoting actin polymerization and regulating local protein synthesis. However, the impact of single nucleotide variants in CYFIP1 to neurodevelopmental disorders is limited. (Source: Biological Psychiatry)
Source: Biological Psychiatry - September 11, 2023 Category: Psychiatry Authors: Vittoria Mariano, Alexandros K. Kanellopoulos, Carlotta Ricci, Daniele Di Marino, Sarah C. Borrie, Sebastian Dupraz, Frank Bradke, Tilmann Achsel, Eric Legius, Sylvie Odent, Pierre Billuart, Thierry Bienvenu, Claudia Bagni Tags: Archival Report Source Type: research
How do modifiable risk factors affect Alzheimer ’s disease pathology or mitigate its effect on clinical symptom expression?
Epidemiological studies show that modifiable risk factors account for about 40% of the population variability in risk of developing dementia, including sporadic Alzheimer ’s disease (sAD). Recent findings suggest that these factors might also modify disease trajectories of people with autosomal dominant Alzheimer’s disease (ADAD). With positron emission tomography (PET) imaging it is now possible to study the disease many years before its clinical onset. Such stu dies can provide key knowledge regarding pathways for either the prevention of pathology or the postponement of its clinical expression. (Source: Biological Psychiatry)
Source: Biological Psychiatry - September 7, 2023 Category: Psychiatry Authors: Valentin Ourry, Alexa Pichet Binette, Fr édéric St-Onge, Cherie Strikwerda-Brown, Audrey Chagnot, Judes Poirier, John Breitner, Eider M. Arenaza-Urquijo, Jennifer S. Rabin, Rachel Buckley, Julie Gonneaud, Natalie L. Marchant, Sylvia Villeneuve Tags: Review Source Type: research
Genetically Regulated Gene Expression in the Brain Associated With Chronic Pain: Relationships With Clinical Traits and Potential for Drug Repurposing
Chronic pain is a common, poorly understood condition. Genetic studies including genome-wide association studies have identified many relevant variants, which have yet to be translated into full understanding of chronic pain. Transcriptome-wide association studies using transcriptomic imputation methods such as S-PrediXcan can help bridge this genotype-phenotype gap. (Source: Biological Psychiatry)
Source: Biological Psychiatry - September 5, 2023 Category: Psychiatry Authors: Keira J.A. Johnston, Alanna C. Cote, Emily Hicks, Jessica Johnson, Laura M. Huckins Tags: Archival Report Source Type: research
Distinct Circuits From the Central Lateral Amygdala to the Ventral Part of the Bed Nucleus of Stria Terminalis Regulate Different Fear Memory
The ability to differentiate stimuli that predict fear is critical for survival; however, the underlying molecular and circuit mechanisms remain poorly understood. (Source: Biological Psychiatry)
Source: Biological Psychiatry - September 5, 2023 Category: Psychiatry Authors: Yi Zhu, Shi-Ze Xie, Ai-Bing Peng, Xiao-Dan Yu, Chun-Yue Li, Jia-Yu Fu, Chen-Jie Shen, Shu-Xia Cao, Ying Zhang, Jiadong Chen, Xiao-Ming Li Tags: Archival Report Source Type: research
Association between taurine level in the hippocampus and major depressive disorder in young women: a proton magnetic resonance spectroscopy study at 7 Tesla
Major depressive disorder (MDD) is characterized by depressed mood or loss of interest or pleasure. Generally, women are twice as likely as men to have depression. Taurine, a type of amino acid, plays critical roles in neuronal generation, differentiation, arborization and formation of synaptic connections. Importantly, it enhances proliferation and synaptogenesis in the hippocampus. When injected into animals, taurine has an antidepressant effect. However, there is no in vivo evidence to show the association between taurine concentration in the human brain and development of MDD. (Source: Biological Psychiatry)
Source: Biological Psychiatry - September 5, 2023 Category: Psychiatry Authors: Youngkyu Song, Jee-Hyun Cho, Hyungjun Kim, Young-Ji Eum, E-Nae Cheong, Sunyoung Choi, Jeong-Heon Park, Sungho Tak, Bumwoo Park, Jin-Hun Sohn, Gyunggoo Cho, Chaejoon Cheong Tags: Archival Report Source Type: research
LHPP in glutamatergic neurons of the ventral hippocampus mediates depression-like behavior by dephosphorylating CaMKII α and ERK
Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) was recently shown to be a risk gene for major depressive disorder (MDD). LHPP has been proven to dephosphorylate the residues of histidine, serine, threonine, and tyrosine. However, much remains unknown regarding how LHPP contributes to depression. (Source: Biological Psychiatry)
Source: Biological Psychiatry - September 5, 2023 Category: Psychiatry Authors: Lvping Zhuang, Weijie Gao, Yanbing Chen, Wenting Fang, Hsuan Lo, Xiaoman Dai, Jie Zhang, Wanjing Chen, Qinyong Ye, Xiaochun Chen, Jing Zhang Tags: Priority Communication Source Type: research
