SIRT1 coordinates transcriptional regulation of neural activity and modulates depression-like behaviors in the nucleus accumbens
Major depression and anxiety disorder are significant causes of disability and socio-economic burden. Despite the prevalence and considerable impact of these affective disorders, their pathophysiology remains elusive. Thus, there is an urgent need to develop novel therapeutics for these conditions. We evaluated the role of SIRT1 in regulating dysfunctional processes of reward by using chronic social defeat stress (CSDS) to induce depression- and anxiety-like behaviors. CSDS induces physiological and behavioral changes that recapitulate depression-like symptomatology and alters gene expression programs in the nucleus accumb...
Source: Biological Psychiatry - April 2, 2024 Category: Psychiatry Authors: Hee-Dae Kim, Jing Wei, Tanessa Call, Xiaokuang Ma, Nicole Teru Quintus, Alexander J. Summers, Samantha Carotenuto, Ross Johnson, Angel Nguyen, Yuehua Cui, Jin G. Park, Shenfeng Qiu, Deveroux Ferguson Tags: Archival Report Source Type: research
Erratum
to: “Cyclin-Dependent Kinase 5–Dependent BAG3 Degradation Modulates Synaptic Protein Turnover,” by Zhou et al. (Biol Psychiatry 2020; 87:756–769); https://doi.org/10.1016/j.biopsych.2019.11.013. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 1, 2024 Category: Psychiatry Tags: Erratum Source Type: research
Brain circuit derived biotypes for treatment selection in mood disorders: A critical review and illustration of a functional neuroimaging tool for clinical translation
Although the lifetime burden due to major depressive disorder is increasing, we lack tools for selecting the most effective treatments for each patient. A third to one half of patients with major depressive disorder do not respond to treatment, and we lack strategies for selecting among available treatments or expediting access to new treatment options. This critical review concentrates on functional neuroimaging as a modality of measurement for precision psychiatry. We begin by summarizing the current landscape of how functional neuroimaging-derived circuit predictors can forecast treatment outcomes in depression. (Source...
Source: Biological Psychiatry - March 27, 2024 Category: Psychiatry Authors: Evelyn Jiayi Song, Leonardo Tozzi, Leanne M. Williams Tags: Review Source Type: research
Connections From the Central Amygdala to the Bed Nucleus of the Stria Terminalis: The Role in Fear Learning
The classical fear conditioning paradigm has been used for decades to investigate the neural mechanisms of emotional learning. In this paradigm, animals associate two things with noxious stimulation: the tone preceding footshocks and the context in which footshocks occur. Both the tone and context predict danger, but in different ways. The tones are discrete and short, thus relaying precise information about the timing of footshocks. In contrast, the context is diffuse and long-lasting, delivering only ambiguous information as to when noxious stimuli are expected. (Source: Biological Psychiatry)
Source: Biological Psychiatry - March 25, 2024 Category: Psychiatry Authors: Nur Zeynep G üngör Tags: Commentary Source Type: research
The Potential of Genomics and Electronic Health Records to Invigorate Drug Development
Genetic association studies of chronic pain and psychiatric disorders have identified many DNA variants but so far have not led to new biomarkers, treatments, or improved outcomes. In part, this reflects the challenge of confidently mapping genetic variants to their causal genes. In the current issue of Biological Psychiatry, Johnston et al. (1) report a transcriptome-wide association study (TWAS) and a phenome-wide association study examining the association between a disease trait (chronic multisite pain) and gene expression, matching potential drug therapies to those perturbations. (Source: Biological Psychiatry)
Source: Biological Psychiatry - March 25, 2024 Category: Psychiatry Authors: Laurence N. Nisbet, Andrew M. McIntosh Tags: Commentary Source Type: research
Reduced Glucocorticoid Responsivity May Represent a Predisposing Marker That Leads to Additional Stress Vulnerability Traits
The phenomenon of posttraumatic stress disorder (PTSD) has puzzled clinicians and researchers for decades. Why is it that, following exposure to an apparently similar stressful event, a subset of individuals develops PTSD while others do not? What differentiates this subset of vulnerable individuals from the majority that exhibit a more resilient response profile? The answers to these questions may have substantial clinical potential, as they could enable the identification of biomarkers of stress vulnerability at close proximity or even prior to trauma exposure. (Source: Biological Psychiatry)
Source: Biological Psychiatry - March 25, 2024 Category: Psychiatry Authors: Roee Admon Tags: Commentary Source Type: research
In This Issue
Volume 95, Number 8, April 15, 2024 (Source: Biological Psychiatry)
Source: Biological Psychiatry - March 25, 2024 Category: Psychiatry Tags: In This Issue Source Type: research
Editorial Board Page
(Source: Biological Psychiatry)
Source: Biological Psychiatry - March 25, 2024 Category: Psychiatry Source Type: research
Subscribers Page
(Source: Biological Psychiatry)
Source: Biological Psychiatry - March 25, 2024 Category: Psychiatry Source Type: research
Table of Contents
(Source: Biological Psychiatry)
Source: Biological Psychiatry - March 25, 2024 Category: Psychiatry Source Type: research
Guide for Authors
Biological Psychiatry, founded in 1969, is an official journal of the Society of Biological Psychiatry and the first in the Biological Psychiatry family of journals. Companion titles include Biological Psychiatry: Cognitive Neuroscience and Neuroimaging and Biological Psychiatry: Global Open Science. The Society ’s purpose is to promote excellence in scientific research and education in fields that investigate the nature, causes, mechanisms, and treatments of disorders of thought, emotion, and behavior. (Source: Biological Psychiatry)
Source: Biological Psychiatry - March 25, 2024 Category: Psychiatry Source Type: research
Muscarinic Receptor Activators as Novel Treatments for Schizophrenia
Achieving optimal treatment outcomes for individuals living with schizophrenia remains challenging, despite 70 years of drug development efforts. Many chemically distinct antipsychotics have been developed over the past seven decades with improved safety and tolerability but with only slight variation in efficacy. All currently prescribed antipsychotics act as antagonists or partial agonists at the dopamine D2 receptor. With only a few possible exceptions, antipsychotic drugs have similar and modest efficacy for treating positive symptoms and are relatively ineffective in addressing the negative and cognitive symptoms of t...
Source: Biological Psychiatry - March 25, 2024 Category: Psychiatry Authors: Steven M. Paul, Samantha E. Yohn, Stephen K. Brannan, Nichole M. Neugebauer, Alan Breier Tags: Review Source Type: research
Accelerated Cortical Thinning in Schizophrenia is Associated With Rare and Common Predisposing Variation to Schizophrenia and Neurodevelopmental Disorders
Schizophrenia is a highly heritable disorder characterized by increased cortical thinning throughout the lifespan. Studies have reported a shared genetic basis between schizophrenia and cortical thickness. However, no genes whose expression is related to abnormal cortical thinning in schizophrenia have been identified. (Source: Biological Psychiatry)
Source: Biological Psychiatry - March 21, 2024 Category: Psychiatry Authors: Javier Gonz ález-Peñas, Clara Alloza, Rachel Brouwer, Covadonga M. Díaz-Caneja, Javier Costas, Noemí González-Lois, Ana Guil Gallego, Lucía de Hoyos, Xaquín Gurriarán, Álvaro Andreu-Bernabeu, Rafael Romero-García, Lourdes Fañanas, Julio Bobes, Tags: Archival Report Source Type: research
Electroconvulsive therapy regulates brain connectome dynamics in patients with major depressive disorder
Electroconvulsive therapy (ECT) is an effective treatment for patients with major depressive disorder (MDD), but its underlying neural mechanisms remain largely unknown. The aim of this study was to identify changes in brain connectome dynamics after ECT in MDD and to explore their associations with treatment outcome. (Source: Biological Psychiatry)
Source: Biological Psychiatry - March 21, 2024 Category: Psychiatry Authors: Yuanyuan Guo, Mingrui Xia, Rong Ye, Tongjian Bai, Yue Wu, Yang Ji, Yue Yu, Gong-Jun Ji, Kai Wang, Yong He, Yanghua Tian Tags: Archival Report Source Type: research
Reduced protein stability of 11 pathogenic missense STXBP1/MUNC18-1 variants and improved disease prediction
This study aims to define a generalized disease concept for STXBP1-related disorders and improve prediction. (Source: Biological Psychiatry)
Source: Biological Psychiatry - March 13, 2024 Category: Psychiatry Authors: Timon Andr é, Annemiek A. van Berkel, Gurdeep Singh, Esam T. Abualrous, Gaurav D. Diwan, Torsten Schmenger, Lara Braun, Jörg Malsam, Ruud F. Toonen, Christian Freund, Robert B. Russell, Matthijs Verhage, Thomas H. Söllner Tags: Archival Report Source Type: research
