Tonic NMDAR Currents in the Brain: Regulation and Cognitive Functions
Synaptically localized N-methyl-D-aspartate receptors (NMDARs) play a crucial role in important cognitive functions by mediating synaptic transmission and plasticity. In contrast, a tonic NMDAR current exists, thought to be mediated by extrasynaptic NMDARs, with a less clear function. This review provides a comprehensive overview of tonic NMDAR currents, focusing on their roles in synaptic transmission/plasticity and their impact on cognitive functions and psychiatric disorders. We discuss the roles of three endogenous ligands (i.e. (Source: Biological Psychiatry)
Source: Biological Psychiatry - March 13, 2024 Category: Psychiatry Authors: Hayoung Kim, Sunyeong Choi, Euisun Lee, Wuhyun Koh, C. Justin Lee Tags: Review Source Type: research
Brainwide Risk Scores: An Example of Psychiatric Risk Prediction From Resting-State Functional Magnetic Resonance Imaging
Mental illness represents a significant and growing source of morbidity and mortality worldwide (1). The impacts of inadequate diagnosis and treatment are felt through countless lived experiences as well as the global economic burden of years of life lost to disability and early death. Intervening early in the time course of someone ’s emerging mental illness is critical for improving outcomes. To this end, there is a major need for the development of improved tools for sensitive and specific psychiatric risk prediction. (Source: Biological Psychiatry)
Source: Biological Psychiatry - March 11, 2024 Category: Psychiatry Authors: Charles H. Schleifer Tags: Early Career Investigator Commentary Source Type: research
Identifying an Early Neuropathological Mechanism in Schizophrenia With Brain Organoids
Schizophrenia (SCZ) is a severe neuropsychiatric disorder with a spectrum of debilitating symptoms that affects more than 1% of the global population. The pathophysiology and etiology of SCZ remains largely unknown due to the intricate interplay of genetic and environmental factors. Despite its typical onset during late adolescence or early adulthood, the neurodevelopmental hypothesis shed light on the origin of SCZ. It has been proposed that disruptions in early brain development by SCZ risk factors amplify an individual ’s susceptibility to SCZ (1). (Source: Biological Psychiatry)
Source: Biological Psychiatry - March 11, 2024 Category: Psychiatry Authors: Jonghun Kim, In-Hyun Park Tags: Commentary Source Type: research
In Vivo Synaptic Density in Early Schizophrenia: Are There No Differences or Are They Too Small to Detect?
Schizophrenia is a chronic psychiatric disorder with a prevalence of approximately 1% worldwide and incurs a high annual cost of approximately $343 billion. It continues to be one of the leading causes of years lived with disability worldwide. While the precise etiology and pathophysiology of the disorder remains unknown, an array of neuropathological abnormalities have been reported in schizophrenia, including altered neuronal density, decreased neuron size, altered cortical cytoarchitecture, and reduced cortical dendritic spine density. (Source: Biological Psychiatry)
Source: Biological Psychiatry - March 11, 2024 Category: Psychiatry Authors: Rajiv Radhakrishnan Tags: Commentary Source Type: research
From Social Isolation to Social Justice: The Neuroscience of Solitary Confinement
In 2010, a 16-year-old boy named Kalief Browder was arrested in New York City for allegedly stealing a backpack. Unable to afford bail, he was sent to Rikers Island where he spent almost 2 years in solitary confinement. During that time, he became floridly psychotic. Browder maintained his innocence throughout his incarceration, and in 2013 the charges against him were dropped. But the damage was done. Though he completed his GED and started college, he continued to struggle with paranoia and depression, requiring multiple hospitalizations. (Source: Biological Psychiatry)
Source: Biological Psychiatry - March 11, 2024 Category: Psychiatry Authors: Ayala Danzig, Andrew M. Novick, Wei-li Chang, David A. Ross Tags: Clinical Commentary Source Type: research
In This Issue
Volume 95, Number 7, April 1, 2024 (Source: Biological Psychiatry)
Source: Biological Psychiatry - March 11, 2024 Category: Psychiatry Tags: In This Issue Source Type: research
Editorial Board Page
(Source: Biological Psychiatry)
Source: Biological Psychiatry - March 11, 2024 Category: Psychiatry Source Type: research
Subscribers Page
(Source: Biological Psychiatry)
Source: Biological Psychiatry - March 11, 2024 Category: Psychiatry Source Type: research
Table of Contents
(Source: Biological Psychiatry)
Source: Biological Psychiatry - March 11, 2024 Category: Psychiatry Source Type: research
Guide for Authors
Biological Psychiatry, founded in 1969, is an official journal of the Society of Biological Psychiatry and the first in the Biological Psychiatry family of journals. Companion titles include Biological Psychiatry: Cognitive Neuroscience and Neuroimaging and Biological Psychiatry: Global Open Science. The Society ’s purpose is to promote excellence in scientific research and education in fields that investigate the nature, causes, mechanisms, and treatments of disorders of thought, emotion, and behavior. (Source: Biological Psychiatry)
Source: Biological Psychiatry - March 11, 2024 Category: Psychiatry Source Type: research
Orbitofrontal and prelimbic cortices serve complementary roles in adapting reward seeking to learned anxiety
Anxiety is a common symptom of several mental health disorders and adversely affects motivated behaviors. Anxiety can emerge from associating risk of future harm while engaged in goal-guided actions. Using a recently developed behavioral paradigm to model this aspect of anxiety, we investigated the role of two cortical subregions, the prelimbic medial frontal cortex (PL) and lateral orbitofrontal cortex (lOFC), which have been implicated in anxiety and outcome expectation, in flexible representation of actions associated with harm risk. (Source: Biological Psychiatry)
Source: Biological Psychiatry - March 7, 2024 Category: Psychiatry Authors: David S. Jacobs, Alina P. Bogachuk, Bita Moghaddam Tags: Archival Report Source Type: research
Generalizable links between borderline personality traits and functional connectivity
Symptoms of borderline personality disorder (BPD) often manifest in adolescence, yet the underlying relationship between these debilitating symptoms and the development of functional brain networks is not well understood. Here we aimed to investigate how multivariate patterns of functional connectivity are associated with borderline personality traits in large samples of young adults and adolescents. (Source: Biological Psychiatry)
Source: Biological Psychiatry - March 7, 2024 Category: Psychiatry Authors: Golia Shafiei, Arielle S. Keller, Maxwell Bertolero, Sheila Shanmugan, Dani S. Bassett, Andrew A. Chen, Sydney Covitz, Audrey Houghton, Audrey Luo, Kahini Mehta, Taylor Salo, Russell T. Shinohara, Damien Fair, Michael N. Hallquist, Theodore D. Satterthwai Tags: Archival Report Source Type: research
Multimodal Associations of FKBP5 Methylation with Emotion-Regulatory Brain Circuits
Understanding the biological processes underlying individual differences in emotion regulation and stress responsivity is a key challenge for translational neuroscience. The gene FKBP5 is a core regulator in molecular stress signaling that is implicated in the development of psychiatric disorders. Yet it remains unclear how FKBP5 DNA methylation (DNAm) in peripheral blood relates to individual differences in measures of neural structure and function, and their relevance to daily-life stress responsivity. (Source: Biological Psychiatry)
Source: Biological Psychiatry - March 7, 2024 Category: Psychiatry Authors: Thomas L. Kremer, Junfang Chen, Anais Buhl, Oksana Berhe, Edda Bilek, Lena Geiger-Primo, Ren Ma, Carolin Moessnang, Markus Reichert, Iris Reinhard, Kristina Schwarz, Janina I. Schweiger, Fabian Streit, Stephanie H. Witt, Zhenxiang Zang, Xiaolong Zhang, Ma Tags: Archival Report Source Type: research
Isolation of Distinct Networks Driving Action and Cognition in Psychomotor Processes
Psychomotor disturbances are observed across psychiatric disorders and often present as psychomotor slowing, agitation, disorganized behavior, or catatonia. Psychomotor function includes both cognitive and motor components, but the neural circuits driving these subprocesses and how they relate to symptoms have remained elusive for centuries. (Source: Biological Psychiatry)
Source: Biological Psychiatry - March 4, 2024 Category: Psychiatry Authors: Alexandra B. Moussa-Tooks, Adam Beermann, Karlos Manzanarez Felix, Michael Coleman, Sylvain Bouix, Daphne Holt, Kathryn E. Lewandowski, Dost Öngür, Alan Breier, Martha E. Shenton, Stephan Heckers, Sebastian Walther, Roscoe O. Brady, Heather Burrell Ward Tags: Archival Report Source Type: research
The Causal Relationships Between Gut Microbiota, Brain Volume, and Intelligence: A Two-Step Mendelian Randomization Analysis
Growing evidence indicates that dynamic changes in gut microbiome can affect intelligence; however, whether these relationships are causal remains elusive. We aimed to disentangle the poorly understood causal relationship between gut microbiota and intelligence. (Source: Biological Psychiatry)
Source: Biological Psychiatry - March 1, 2024 Category: Psychiatry Authors: Shi Yao, Ji-Zhou Han, Jing Guo, Xin Wang, Long Qian, Hao Wu, Wei Shi, Ren-Jie Zhu, Jia-Hao Wang, Shan-Shan Dong, Li-Li Cui, Yan Wang, Yan Guo, Tie-Lin Yang Tags: Archival Report Source Type: research
