A Machine Learning Analysis of Big Metabolomics Data for Classifying Depression: Model Development and Validation
Many metabolomics studies of depression have been performed, but these have been limited by their scale. A comprehensive in silico analysis of global metabolite levels in large populations could provide robust insights into the pathological mechanisms underlying depression and candidate clinical biomarkers. (Source: Biological Psychiatry)
Source: Biological Psychiatry - December 22, 2023 Category: Psychiatry Authors: Simeng Ma, Xinhui Xie, Zipeng Deng, Wei Wang, Dan Xiang, Lihua Yao, Lijun Kang, Shuxian Xu, Huiling Wang, Gaohua Wang, Jun Yang, Zhongchun Liu Tags: Archival Report Source Type: research
Transcranial Magnetic Stimulation –Electroencephalography for Biomarker Discovery in Psychiatry
Current diagnosis and treatment of psychiatric illnesses are still based on behavioral observations and self-reports, commonly leading to prolonged untreated illness. Biological markers (biomarkers) may offer an opportunity to revolutionize clinical psychiatry practice by helping provide faster and potentially more effective therapies. Transcranial magnetic stimulation concurrent with electroencephalography (TMS-EEG) is a noninvasive brain mapping methodology that can assess the functions and dynamics of specific brain circuitries in awake humans and aid in biomarker discovery. (Source: Biological Psychiatry)
Source: Biological Psychiatry - December 22, 2023 Category: Psychiatry Authors: Faranak Farzan Tags: Review Source Type: research
Comparisons of Accelerated Continuous and Intermittent Theta-burst Stimulation for Treatment-Resistant Depression and Suicidal Ideation
Suicidal ideation is a substantial clinical challenge in treatment-resistant depression (TRD). Recent work demonstrated promising antidepressant effects in TRD patients with no or mild suicidal ideation using a specific protocol termed intermittent theta burst stimulation (iTBS). Here, the author examined the clinical effects of accelerated schedules of iTBS and continuous TBS (cTBS) in patients with moderate to severe suicidal ideation. (Source: Biological Psychiatry)
Source: Biological Psychiatry - December 22, 2023 Category: Psychiatry Authors: Haoyang Zhao, Chaonan Jiang, Miaomiao Zhao, Yang Ye, Liang Yu, Ying Li, Honglin Luan, Shiyi Zhang, Pengfeng Xu, Xuanqiang Chen, Fen Pan, Desheng Shang, Xiaohan Hu, Kangyu Jin, Jingkai Chen, Tingting Mou, Shaohua Hu, Bernadette M. Fitzgibbon, Paul B. Fitzg Tags: Archival Report Source Type: research
Exaggerated Peripheral and Systemic Vasoconstriction During Trauma Recall in Post-traumatic Stress Disorder: A Co-twin Control Study
Individuals with post-traumatic stress disorder (PTSD) face an increased risk of cardiovascular disease (CVD), but the mechanisms linking PTSD to CVD remain incompletely understood. We used a co-twin control study design to test the hypothesis that individuals with PTSD exhibit augmented peripheral and systemic vasoconstriction during a personalized trauma recall task. (Source: Biological Psychiatry)
Source: Biological Psychiatry - December 22, 2023 Category: Psychiatry Authors: Zachary T. Martin, Amit J. Shah, Yi-An Ko, Shafa-at A. Sheikh, Obada Daaboul, George Haddad, Jack Goldberg, Nicholas L. Smith, Ten é T. Lewis, Arshed A. Quyyumi, J. Douglas Bremner, Viola Vaccarino Tags: Archival Report Source Type: research
A machine learning analysis of “big” metabolomics data for classifying depression: model development and validation
There have been many metabolomics studies of depression, but these have been limited by their scale. A comprehensive in silico analysis of global metabolite levels in large populations could provide robust insights into the pathological mechanisms underlying depression and candidate clinical biomarkers. (Source: Biological Psychiatry)
Source: Biological Psychiatry - December 22, 2023 Category: Psychiatry Authors: Simeng Ma, Xinhui Xie, Zipeng Deng, Wei Wang, Dan Xiang, Lihua Yao, Lijun Kang, Shuxian Xu, Huiling Wang, Gaohua Wang, Jun Yang, Zhongchun Liu Tags: Archival Report Source Type: research
Maternal fiber intake during pregnancy and development of Attention-Deficit/Hyperactivity Disorder Symptoms Across Childhood: The Norwegian Mother, Father and Child Cohort Study (MoBa)
Epidemiological studies suggest that the maternal diet quality during pregnancy may influence the risk of neurodevelopmental disorders in the offspring. Here we investigated the associations between maternal intake of dietary fiber and ADHD symptoms in early childhood. (Source: Biological Psychiatry)
Source: Biological Psychiatry - December 22, 2023 Category: Psychiatry Authors: Berit Skretting Solberg, Liv Grimstvedt Kvalvik, Johanne Telnes Instanes, Catharina A. Hartman, Kari Klungs øyr, Lin Li, Henrik Larsson, Per Magnus, Pål Rasmus Njølstad, Stefan Johansson, Ole A. Andreassen, Nora Refsum Bakken, Mona Bekkhus, Chloe Auste Tags: Archival Report Source Type: research
TMS-EEG for Biomarker Discovery in Psychiatry
Current diagnosis and treatment of psychiatric illnesses are still based on behavioral observations and self-reports, commonly leading to prolonged untreated illness. Biological markers (biomarkers) may offer an opportunity to revolutionize clinical psychiatry practice by helping provide faster and potentially more effective therapies. Transcranial magnetic stimulation (TMS) concurrent with electroencephalography (EEG) (TMS-EEG) is a non-invasive brain mapping methodology that can assess the functions and dynamics of specific brain circuitries in awake humans and aid in biomarker discovery. (Source: Biological Psychiatry)
Source: Biological Psychiatry - December 22, 2023 Category: Psychiatry Authors: Faranak Farzan Tags: Review Source Type: research
Uncommon Protein-Coding Variants Associated With Suicide Attempt in a Diverse Sample of U.S. Army Soldiers
Suicide is a societal and public health concern of global scale. Identifying genetic risk factors for suicide attempt can characterize underlying biology and enable early interventions to prevent deaths. Recent studies have described common genetic variants for suicide-related behaviors. Here, we advance this search for genetic risk by analyzing the association between suicide attempt and uncommon variation exome-wide in a large, ancestrally diverse sample. (Source: Biological Psychiatry)
Source: Biological Psychiatry - December 21, 2023 Category: Psychiatry Authors: Matthew D. Wilkerson, Daniel Hupalo, Joshua C. Gray, Xijun Zhang, Jiawei Wang, Matthew J. Girgenti, Camille Alba, Gauthaman Sukumar, Nathaniel M. Lott, James A. Naifeh, Pablo Aliaga, Ronald C. Kessler, Clesson Turner, Harvey B. Pollard, Clifton L. Dalgard Tags: Archival Report Source Type: research
Uncommon protein-coding variants associated with suicide attempt in a diverse sample of US Army soldiers
Suicide is a societal and public health concern of global scale. Identifying genetic risk factors for suicide attempt can characterize underlying biology and enable early interventions to prevent deaths. Recent studies have described common genetic variants for suicide-related behaviors. Here, we advance this search for genetic risk by analyzing the association between suicide attempt and uncommon variation, exome-wide in a large, ancestrally diverse sample. (Source: Biological Psychiatry)
Source: Biological Psychiatry - December 21, 2023 Category: Psychiatry Authors: Matthew D. Wilkerson, Daniel Hupalo, Joshua C. Gray, Xijun Zhang, Jiawei Wang, Matthew J. Girgenti, Camille Alba, Guathaman Sukumar, Nathaniel M. Lott, James A. Naifeh, Pablo Aliaga, Ronald C. Kessler, Clesson Turner, Harvey B. Pollard, Clifton Dalgard, R Tags: Archival Report Source Type: research
Deep Brain Stimulation for Obsessive-Compulsive Disorder: Optimal stimulation sites
Deep brain stimulation (DBS) is a promising treatment option for treatment-refractory obsessive-compulsive disorder (OCD). Several stimulation targets have been used, mostly in and around the anterior limb of the internal capsule and ventral striatum (VC/VS). However, the precise target within this region remains a matter of debate. (Source: Biological Psychiatry)
Source: Biological Psychiatry - December 21, 2023 Category: Psychiatry Authors: Garance M. Meyer, Barbara Hollunder, Ningfei Li, Konstantin Butenko, Till A. Dembek, Lauren Hart, Cristina Nombela, Philip Mosley, Harith Akram, Nicola Acevedo, Benjamin M. Borron, Tina Chou, Juan Pablo Casta ño Montoya, Bryan Strange, Juan A. Barcia, Hi Tags: Archival Report Source Type: research
A Double Hit of Social and Economic Stress in Mice Precipitates Changes in Decision-Making Strategies
Economic stress can serve as a second hit for people who have already accumulated a history of adverse life experiences. How one recovers from a setback is a core feature of resilience but is seldom captured in animal studies. (Source: Biological Psychiatry)
Source: Biological Psychiatry - December 20, 2023 Category: Psychiatry Authors: Romain Durand-de Cuttoli, Freddyson J. Mart ínez-Rivera, Long Li, Angélica Minier-Toribio, Zhe Dong, Denise J. Cai, Scott J. Russo, Eric J. Nestler, Brian M. Sweis Tags: Archival Report Source Type: research
A double-hit of social and economic stress in mice precipitates changes in decision-making strategies
Economic stress can serve as a “second-hit” for those who already accumulated a history of adverse life experiences. How one recovers from a setback is a core feature of resilience but is seldom captured in animal studies. (Source: Biological Psychiatry)
Source: Biological Psychiatry - December 20, 2023 Category: Psychiatry Authors: Romain Durand-de Cuttoli, Freddyson J. Mart ínez-Rivera, Long Li, Angélica Minier-Toribio, Zhe Dong, Denise J. Cai, Scott J. Russo, Eric J. Nestler, Brian M. Sweis Tags: Archival Report Source Type: research
A single-nucleus transcriptome-wide association study implicates novel genes in depression pathogenesis
Depression, a common psychiatric illness and global public health problem, remains poorly understood across different life stages, which hampers the development of novel treatments. (Source: Biological Psychiatry)
Source: Biological Psychiatry - December 20, 2023 Category: Psychiatry Authors: Lu Zeng, Masashi Fujita, Zongmei Gao, Charles C. White, Gilad S. Green, Naomi Habib, Vilas Menon, David A. Bennett, Patricia Boyle, Hans-Ulrich Klein, Philip L. De Jager Tags: Archival Report Source Type: research
Erratum
to: “A Brainwide Risk Score for Psychiatric Disorder Evaluated in a Large Adolescent Population Reveals Increased Divergence Among Higher-Risk Groups Relative to Control Participants,” by Yan et al. (Biol Psychiatry 2024; https://doi.org/10.1016/j.biopsych.2023.09.017). (Source: Biological Psychiatry)
Source: Biological Psychiatry - December 20, 2023 Category: Psychiatry Tags: Erratum Source Type: research
Chronic Morphine Leaves a Durable Fingerprint on Whole-Brain Functional Connectivity
Opioid use disorder is a chronic relapsing disorder. The brain adapts to opioids that are taken for pain treatment or recreational use so that abstinence becomes a true challenge for individuals with opioid use disorder. Studying brain dysfunction at this stage is difficult, and human neuroimaging has provided highly heterogeneous information. (Source: Biological Psychiatry)
Source: Biological Psychiatry - December 15, 2023 Category: Psychiatry Authors: Marion Sourty, C édric Champagnol-Di Liberti, Md Taufiq Nasseef, Lola Welsch, Vincent Noblet, Emmanuel Darcq, Brigitte L. Kieffer Tags: Archival Report Source Type: research
